TY  - JOUR
AU  - Pavlović, Marijana
AU  - Tadić, Ana
AU  - Gligorijević, Nevenka
AU  - Poljarević, Jelena
AU  - Petrović, Tamara G.
AU  - Dojčinović, Biljana
AU  - Savić, Aleksandar
AU  - Radulović, Siniša
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3634
AB  - Inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) showed remarkable clinical efficacy in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3-aminobenzamide (3-AB), 2-amino-4-methylbenzamide (L1) and 3-amino-N-methylbenzamide (L2), were coordinated to the ruthenium(II) ion, to form potential drugs affecting DNA and inhibiting PARP enzyme. The four conjugated complexes of formula: C1 [(ƞ6-toluene)Ru(L1)Cl]PF6, C2 [(ƞ6-p-cymene)Ru(L1)Cl]PF6, C3 [(ƞ6-toluene)Ru(L2)Cl2] and C4 [(ƞ6-p-cymene)Ru(L2)Cl2], have been synthesized and characterized. Colorimetric 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay showed the highest antiproliferative activity of C1 in HCC1937, MDA-MB-231, and MCF-7 breast cancer cells. Efficiency of inhibition of PARP-1 enzymatic activity in vitro decreased in order: C2 > C4 > 3-AB>C1 > C3. ICP-MS study of intracellular accumulation and distribution in BRCA1-mutated HCC1937 revealed that C1-C4 entered cells within 24 h. The complex C1 showed the highest intracellular accumulation, nuclear-targeting properties, and exhibited the highest DNA binding (39.2 ± 0.6 pg of Ru per μg of DNA) that resulted in the cell cycle arrest in the S phase.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells
VL  - 210
SP  - 111155
DO  - 10.1016/j.jinorgbio.2020.111155
ER  - 

@article{
author = "Pavlović, Marijana and Tadić, Ana and Gligorijević, Nevenka and Poljarević, Jelena and Petrović, Tamara G. and Dojčinović, Biljana and Savić, Aleksandar and Radulović, Siniša",
year = "2020",
abstract = "Inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) showed remarkable clinical efficacy in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3-aminobenzamide (3-AB), 2-amino-4-methylbenzamide (L1) and 3-amino-N-methylbenzamide (L2), were coordinated to the ruthenium(II) ion, to form potential drugs affecting DNA and inhibiting PARP enzyme. The four conjugated complexes of formula: C1 [(ƞ6-toluene)Ru(L1)Cl]PF6, C2 [(ƞ6-p-cymene)Ru(L1)Cl]PF6, C3 [(ƞ6-toluene)Ru(L2)Cl2] and C4 [(ƞ6-p-cymene)Ru(L2)Cl2], have been synthesized and characterized. Colorimetric 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay showed the highest antiproliferative activity of C1 in HCC1937, MDA-MB-231, and MCF-7 breast cancer cells. Efficiency of inhibition of PARP-1 enzymatic activity in vitro decreased in order: C2 > C4 > 3-AB>C1 > C3. ICP-MS study of intracellular accumulation and distribution in BRCA1-mutated HCC1937 revealed that C1-C4 entered cells within 24 h. The complex C1 showed the highest intracellular accumulation, nuclear-targeting properties, and exhibited the highest DNA binding (39.2 ± 0.6 pg of Ru per μg of DNA) that resulted in the cell cycle arrest in the S phase.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells",
volume = "210",
pages = "111155",
doi = "10.1016/j.jinorgbio.2020.111155"
}

Pavlović, M., Tadić, A., Gligorijević, N., Poljarević, J., Petrović, T. G., Dojčinović, B., Savić, A.,& Radulović, S.. (2020). Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. in Journal of Inorganic Biochemistry
Elsevier., 210, 111155.
https://doi.org/10.1016/j.jinorgbio.2020.111155

Pavlović M, Tadić A, Gligorijević N, Poljarević J, Petrović TG, Dojčinović B, Savić A, Radulović S. Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. in Journal of Inorganic Biochemistry. 2020;210:111155.
doi:10.1016/j.jinorgbio.2020.111155 .

Pavlović, Marijana, Tadić, Ana, Gligorijević, Nevenka, Poljarević, Jelena, Petrović, Tamara G., Dojčinović, Biljana, Savić, Aleksandar, Radulović, Siniša, "Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells" in Journal of Inorganic Biochemistry, 210 (2020):111155,
https://doi.org/10.1016/j.jinorgbio.2020.111155 . .

TY  - JOUR
AU  - Pavlović, Marijana
AU  - Tadić, Ana
AU  - Gligorijević, Nevenka
AU  - Poljarević, Jelena
AU  - Petrović, Tamara G.
AU  - Dojčinović, Biljana
AU  - Savić, Aleksandar
AU  - Radulović, Siniša
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3713
AB  - Inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) showed remarkable clinical efficacy in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3-aminobenzamide (3-AB), 2-amino-4-methylbenzamide (L1) and 3-amino-N-methylbenzamide (L2), were coordinated to the ruthenium(II) ion, to form potential drugs affecting DNA and inhibiting PARP enzyme. The four conjugated complexes of formula: C1 [(ƞ6-toluene)Ru(L1)Cl]PF6, C2 [(ƞ6-p-cymene)Ru(L1)Cl]PF6, C3 [(ƞ6-toluene)Ru(L2)Cl2] and C4 [(ƞ6-p-cymene)Ru(L2)Cl2], have been synthesized and characterized. Colorimetric 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay showed the highest antiproliferative activity of C1 in HCC1937, MDA-MB-231, and MCF-7 breast cancer cells. Efficiency of inhibition of PARP-1 enzymatic activity in vitro decreased in order: C2 > C4 > 3-AB>C1 > C3. ICP-MS study of intracellular accumulation and distribution in BRCA1-mutated HCC1937 revealed that C1-C4 entered cells within 24 h. The complex C1 showed the highest intracellular accumulation, nuclear-targeting properties, and exhibited the highest DNA binding (39.2 ± 0.6 pg of Ru per μg of DNA) that resulted in the cell cycle arrest in the S phase.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells
VL  - 210
SP  - 111155
DO  - 10.1016/j.jinorgbio.2020.111155
ER  - 

@article{
author = "Pavlović, Marijana and Tadić, Ana and Gligorijević, Nevenka and Poljarević, Jelena and Petrović, Tamara G. and Dojčinović, Biljana and Savić, Aleksandar and Radulović, Siniša",
year = "2020",
abstract = "Inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) showed remarkable clinical efficacy in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3-aminobenzamide (3-AB), 2-amino-4-methylbenzamide (L1) and 3-amino-N-methylbenzamide (L2), were coordinated to the ruthenium(II) ion, to form potential drugs affecting DNA and inhibiting PARP enzyme. The four conjugated complexes of formula: C1 [(ƞ6-toluene)Ru(L1)Cl]PF6, C2 [(ƞ6-p-cymene)Ru(L1)Cl]PF6, C3 [(ƞ6-toluene)Ru(L2)Cl2] and C4 [(ƞ6-p-cymene)Ru(L2)Cl2], have been synthesized and characterized. Colorimetric 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay showed the highest antiproliferative activity of C1 in HCC1937, MDA-MB-231, and MCF-7 breast cancer cells. Efficiency of inhibition of PARP-1 enzymatic activity in vitro decreased in order: C2 > C4 > 3-AB>C1 > C3. ICP-MS study of intracellular accumulation and distribution in BRCA1-mutated HCC1937 revealed that C1-C4 entered cells within 24 h. The complex C1 showed the highest intracellular accumulation, nuclear-targeting properties, and exhibited the highest DNA binding (39.2 ± 0.6 pg of Ru per μg of DNA) that resulted in the cell cycle arrest in the S phase.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells",
volume = "210",
pages = "111155",
doi = "10.1016/j.jinorgbio.2020.111155"
}

Pavlović, M., Tadić, A., Gligorijević, N., Poljarević, J., Petrović, T. G., Dojčinović, B., Savić, A.,& Radulović, S.. (2020). Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. in Journal of Inorganic Biochemistry
Elsevier., 210, 111155.
https://doi.org/10.1016/j.jinorgbio.2020.111155

Pavlović M, Tadić A, Gligorijević N, Poljarević J, Petrović TG, Dojčinović B, Savić A, Radulović S. Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. in Journal of Inorganic Biochemistry. 2020;210:111155.
doi:10.1016/j.jinorgbio.2020.111155 .

Pavlović, Marijana, Tadić, Ana, Gligorijević, Nevenka, Poljarević, Jelena, Petrović, Tamara G., Dojčinović, Biljana, Savić, Aleksandar, Radulović, Siniša, "Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells" in Journal of Inorganic Biochemistry, 210 (2020):111155,
https://doi.org/10.1016/j.jinorgbio.2020.111155 . .

TY  - JOUR
AU  - Savić, Aleksandar
AU  - Gligorijević, Nevenka
AU  - Aranđelović, Sandra
AU  - Dojčinović, Biljana
AU  - Kaczmarek, Anna M.
AU  - Radulović, Siniša
AU  - Van Deun, Rik
AU  - Van Hecke, Kristof
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3352
AB  - The monocationic chloro complexes containing chelating N∩N ligands: [(η6-p-cymene)Ru(L1–4)Cl]+ (1–4), where L1 = 4-methyl-1,10-phenantroline, L2 = dipyrido[3,2-a:2′,3′-c]phenazine, L3 = 11-chloro-dipyrido[3,2-a:2′,3′-c]phenazine, L4 = 11-nitro-dipyrido[3,2-a:2′,3′-c]phenazine; p-cymene = 1-methyl-4-isopropylbenzene) have been prepared and characterized as the hexafluorophosphate salts. The biological activity of 1–4 has been investigated in selected 2D monolayer cell cultures (A549, PANC-1, MDA-MB-231, MRC-5). All investigated ruthenium complexes showed similar or even better cytotoxicity to cisplatin. However, there was no significant reduction in growth of PANC-1 cells in a 3D cell culture of multicellular tumor spheroids (MCTS) after treatment with 2–4, while the cisplatin treatment induced retardation in MCTS growth. Flow cytometry analysis of the cell cycle of PANC-1 cells shows that 3 caused changes of cell cycle phase distribution characterized by slight accumulation of cells in the G2-M phase. Absence of the Sub-G1 phase in the cell cycle of the treated cells indicated that there was no fragmentation of DNA for the analyzed time intervals (48 and 72 h treatment). Fluorescent microscopy, after acridine orange/ethidium bromide staining, revealed that the investigated ruthenium complexes induced some characteristics of apoptotic morphology (shrinking and condensation of chromatin) with notably preserved integrity of the plasma membrane. Investigation of cellular uptake and DNA - fraction accumulation performed by inductively coupled plasma mass spectrometry in PANC-1 cells with equimolar concentrations (5 μM) of 2–4 and cisplatin showed more efficient cellular uptake and DNA - fraction accumulation of complex 3 compared to complexes 2 and 4.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity
VL  - 202
SP  - 110869
SP  - 110869
DO  - 10.1016/j.jinorgbio.2019.110869
ER  - 

@article{
author = "Savić, Aleksandar and Gligorijević, Nevenka and Aranđelović, Sandra and Dojčinović, Biljana and Kaczmarek, Anna M. and Radulović, Siniša and Van Deun, Rik and Van Hecke, Kristof",
year = "2020",
abstract = "The monocationic chloro complexes containing chelating N∩N ligands: [(η6-p-cymene)Ru(L1–4)Cl]+ (1–4), where L1 = 4-methyl-1,10-phenantroline, L2 = dipyrido[3,2-a:2′,3′-c]phenazine, L3 = 11-chloro-dipyrido[3,2-a:2′,3′-c]phenazine, L4 = 11-nitro-dipyrido[3,2-a:2′,3′-c]phenazine; p-cymene = 1-methyl-4-isopropylbenzene) have been prepared and characterized as the hexafluorophosphate salts. The biological activity of 1–4 has been investigated in selected 2D monolayer cell cultures (A549, PANC-1, MDA-MB-231, MRC-5). All investigated ruthenium complexes showed similar or even better cytotoxicity to cisplatin. However, there was no significant reduction in growth of PANC-1 cells in a 3D cell culture of multicellular tumor spheroids (MCTS) after treatment with 2–4, while the cisplatin treatment induced retardation in MCTS growth. Flow cytometry analysis of the cell cycle of PANC-1 cells shows that 3 caused changes of cell cycle phase distribution characterized by slight accumulation of cells in the G2-M phase. Absence of the Sub-G1 phase in the cell cycle of the treated cells indicated that there was no fragmentation of DNA for the analyzed time intervals (48 and 72 h treatment). Fluorescent microscopy, after acridine orange/ethidium bromide staining, revealed that the investigated ruthenium complexes induced some characteristics of apoptotic morphology (shrinking and condensation of chromatin) with notably preserved integrity of the plasma membrane. Investigation of cellular uptake and DNA - fraction accumulation performed by inductively coupled plasma mass spectrometry in PANC-1 cells with equimolar concentrations (5 μM) of 2–4 and cisplatin showed more efficient cellular uptake and DNA - fraction accumulation of complex 3 compared to complexes 2 and 4.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity",
volume = "202",
pages = "110869-110869",
doi = "10.1016/j.jinorgbio.2019.110869"
}

Savić, A., Gligorijević, N., Aranđelović, S., Dojčinović, B., Kaczmarek, A. M., Radulović, S., Van Deun, R.,& Van Hecke, K.. (2020). Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity. in Journal of Inorganic Biochemistry
Elsevier., 202, 110869.
https://doi.org/10.1016/j.jinorgbio.2019.110869

Savić A, Gligorijević N, Aranđelović S, Dojčinović B, Kaczmarek AM, Radulović S, Van Deun R, Van Hecke K. Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity. in Journal of Inorganic Biochemistry. 2020;202:110869.
doi:10.1016/j.jinorgbio.2019.110869 .

Savić, Aleksandar, Gligorijević, Nevenka, Aranđelović, Sandra, Dojčinović, Biljana, Kaczmarek, Anna M., Radulović, Siniša, Van Deun, Rik, Van Hecke, Kristof, "Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity" in Journal of Inorganic Biochemistry, 202 (2020):110869,
https://doi.org/10.1016/j.jinorgbio.2019.110869 . .

TY  - JOUR
AU  - Pavlović, Marijana
AU  - Nikolić, Stefan
AU  - Gligorijević, Nevenka
AU  - Dojčinović, Biljana
AU  - Aranđelović, Sandra
AU  - Grgurić-Šipka, Sanja
AU  - Radulović, Siniša
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2963
AB  - Three new ruthenium(II)-arene complexes with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline (ppf) of general formula: C1 ([(ƞ 6 -benzene)Ru(ppf)Cl]PF 6 , C2 ([(ƞ 6 -toluene)Ru(ppf)Cl]PF 6 ) and C3 ([(ƞ 6 -p-cymene)Ru(ppf)Cl]PF 6 ) have been synthesized. The structures of complexes were determined by elemental analysis, IR, ESI–MS, as well as with 1 H and 13 C NMR spectroscopy. Cytotoxic activity has been evaluated in three different human neoplastic cell lines (A549, A375, LS 174T) and in one human non-tumor cell line (MRC-5), by the MTT assay. Complexes C1–C3 showed IC 50 values in the micromolar range below 100 µM. Complex C3, carrying ƞ 6 -p-cymene as the arene ligand, exhibited cytoselective activity toward human malignant melanoma A375 cells (IC 50 = 15.8 ± 2.7 µM), and has been selected for further analyses of its biological effects. Drug-accumulation study performed in the A375 cells disclosed that C3 possess lower ability of entering the cells compared to cisplatin and distributes approximately equally in the cytosol and membrane/organelle fraction of cells. Investigations in the 3D model of A375 cells, disclosed different effects of the complex C3 and cisplatin on growth of multicellular tumor spheroids (MCTSs). While the size of cisplatin-treated MCTSs decreased with time, MCTSs treated with C3 continued to growth. Differences in structural organization and biological activity of this type of ruthenium(II)-arene complexes versus cisplatin in A375 malignant melanoma cells pointed out their different modes of action, and necessity for further biological studies and optimizations for potential applications.
PB  - Springer Link
T2  - Journal of Biological Inorganic Chemistry
T1  - New organoruthenium compounds with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline: synthesis, characterization, cytotoxicity, and investigation of mechanism of action
VL  - 24
IS  - 2
SP  - 297
EP  - 310
DO  - 10.1007/s00775-019-01647-4
ER  - 

@article{
author = "Pavlović, Marijana and Nikolić, Stefan and Gligorijević, Nevenka and Dojčinović, Biljana and Aranđelović, Sandra and Grgurić-Šipka, Sanja and Radulović, Siniša",
year = "2019",
abstract = "Three new ruthenium(II)-arene complexes with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline (ppf) of general formula: C1 ([(ƞ 6 -benzene)Ru(ppf)Cl]PF 6 , C2 ([(ƞ 6 -toluene)Ru(ppf)Cl]PF 6 ) and C3 ([(ƞ 6 -p-cymene)Ru(ppf)Cl]PF 6 ) have been synthesized. The structures of complexes were determined by elemental analysis, IR, ESI–MS, as well as with 1 H and 13 C NMR spectroscopy. Cytotoxic activity has been evaluated in three different human neoplastic cell lines (A549, A375, LS 174T) and in one human non-tumor cell line (MRC-5), by the MTT assay. Complexes C1–C3 showed IC 50 values in the micromolar range below 100 µM. Complex C3, carrying ƞ 6 -p-cymene as the arene ligand, exhibited cytoselective activity toward human malignant melanoma A375 cells (IC 50 = 15.8 ± 2.7 µM), and has been selected for further analyses of its biological effects. Drug-accumulation study performed in the A375 cells disclosed that C3 possess lower ability of entering the cells compared to cisplatin and distributes approximately equally in the cytosol and membrane/organelle fraction of cells. Investigations in the 3D model of A375 cells, disclosed different effects of the complex C3 and cisplatin on growth of multicellular tumor spheroids (MCTSs). While the size of cisplatin-treated MCTSs decreased with time, MCTSs treated with C3 continued to growth. Differences in structural organization and biological activity of this type of ruthenium(II)-arene complexes versus cisplatin in A375 malignant melanoma cells pointed out their different modes of action, and necessity for further biological studies and optimizations for potential applications.",
publisher = "Springer Link",
journal = "Journal of Biological Inorganic Chemistry",
title = "New organoruthenium compounds with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline: synthesis, characterization, cytotoxicity, and investigation of mechanism of action",
volume = "24",
number = "2",
pages = "297-310",
doi = "10.1007/s00775-019-01647-4"
}

Pavlović, M., Nikolić, S., Gligorijević, N., Dojčinović, B., Aranđelović, S., Grgurić-Šipka, S.,& Radulović, S.. (2019). New organoruthenium compounds with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline: synthesis, characterization, cytotoxicity, and investigation of mechanism of action. in Journal of Biological Inorganic Chemistry
Springer Link., 24(2), 297-310.
https://doi.org/10.1007/s00775-019-01647-4

Pavlović M, Nikolić S, Gligorijević N, Dojčinović B, Aranđelović S, Grgurić-Šipka S, Radulović S. New organoruthenium compounds with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline: synthesis, characterization, cytotoxicity, and investigation of mechanism of action. in Journal of Biological Inorganic Chemistry. 2019;24(2):297-310.
doi:10.1007/s00775-019-01647-4 .

Pavlović, Marijana, Nikolić, Stefan, Gligorijević, Nevenka, Dojčinović, Biljana, Aranđelović, Sandra, Grgurić-Šipka, Sanja, Radulović, Siniša, "New organoruthenium compounds with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline: synthesis, characterization, cytotoxicity, and investigation of mechanism of action" in Journal of Biological Inorganic Chemistry, 24, no. 2 (2019):297-310,
https://doi.org/10.1007/s00775-019-01647-4 . .

TY  - JOUR
AU  - Damnjanović, B.
AU  - Novković, M.
AU  - Vesić, Aleksandra
AU  - Živković, M.
AU  - Radulović, Siniša
AU  - Vukov, D.
AU  - Anđelković, A.
AU  - Cvijanović, D.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2387
AB  - Massive gravel excavation is one of the most destructive forces affecting riverine habitats in Europe. However, gravel pit lakes are also recognized as valuable wildlife refuge areas. Different hydromorphological characteristics of gravel pits may influence aquatic biota differently. Optimal selection of gravel excavation procedures may create favorable conditions for ecosystem diversity. The aim of this study was to correlate hydromorphological variables against macrophyte composition and metrics in gravel pit lakes along the lower course of the Drina River. Field research was carried out at 18 gravel pit lakes (60 survey sectors) and four fluvial lakes (13 survey sectors), during the summer months of 2015, 2016 and 2018. The role of hydromorphological variables in structuring macrophyte assemblages was tested using the partial Canonical Correspondence Analysis, while the Generalized Linear Model was performed to test the ability of selected hydromorphological attributes to predict macrophyte quantitative metrics. The results demonstrated high habitat quality and conservation value of the gravel pit lakes compared to natural sites. Hydromorphological predictors for different macrophyte assemblages were defined. General recommendation is that two pit types should be excavated within a single extraction field, with the minimal impact to the riparian and shore zones. The first type should be located up to 100 m from river main channel, having area < 1000 m2 and a relative depth ratio > 5%. The second type should be optimally located 300 m form river main channel, with maximum depth of 3–4 m, surface area of 10,000–20,000 m2, and a relative depth ratio < 5%.
PB  - Springer Netherlands
T2  - Wetlands Ecology and Management
T1  - Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia)
DO  - 10.1007/s11273-018-9641-8
ER  - 

@article{
author = "Damnjanović, B. and Novković, M. and Vesić, Aleksandra and Živković, M. and Radulović, Siniša and Vukov, D. and Anđelković, A. and Cvijanović, D.",
year = "2018",
abstract = "Massive gravel excavation is one of the most destructive forces affecting riverine habitats in Europe. However, gravel pit lakes are also recognized as valuable wildlife refuge areas. Different hydromorphological characteristics of gravel pits may influence aquatic biota differently. Optimal selection of gravel excavation procedures may create favorable conditions for ecosystem diversity. The aim of this study was to correlate hydromorphological variables against macrophyte composition and metrics in gravel pit lakes along the lower course of the Drina River. Field research was carried out at 18 gravel pit lakes (60 survey sectors) and four fluvial lakes (13 survey sectors), during the summer months of 2015, 2016 and 2018. The role of hydromorphological variables in structuring macrophyte assemblages was tested using the partial Canonical Correspondence Analysis, while the Generalized Linear Model was performed to test the ability of selected hydromorphological attributes to predict macrophyte quantitative metrics. The results demonstrated high habitat quality and conservation value of the gravel pit lakes compared to natural sites. Hydromorphological predictors for different macrophyte assemblages were defined. General recommendation is that two pit types should be excavated within a single extraction field, with the minimal impact to the riparian and shore zones. The first type should be located up to 100 m from river main channel, having area < 1000 m2 and a relative depth ratio > 5%. The second type should be optimally located 300 m form river main channel, with maximum depth of 3–4 m, surface area of 10,000–20,000 m2, and a relative depth ratio < 5%.",
publisher = "Springer Netherlands",
journal = "Wetlands Ecology and Management",
title = "Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia)",
doi = "10.1007/s11273-018-9641-8"
}

Damnjanović, B., Novković, M., Vesić, A., Živković, M., Radulović, S., Vukov, D., Anđelković, A.,& Cvijanović, D.. (2018). Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia). in Wetlands Ecology and Management
Springer Netherlands..
https://doi.org/10.1007/s11273-018-9641-8

Damnjanović B, Novković M, Vesić A, Živković M, Radulović S, Vukov D, Anđelković A, Cvijanović D. Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia). in Wetlands Ecology and Management. 2018;.
doi:10.1007/s11273-018-9641-8 .

Damnjanović, B., Novković, M., Vesić, Aleksandra, Živković, M., Radulović, Siniša, Vukov, D., Anđelković, A., Cvijanović, D., "Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia)" in Wetlands Ecology and Management (2018),
https://doi.org/10.1007/s11273-018-9641-8 . .

TY  - JOUR
AU  - Gligorijević, Nevenka
AU  - Todorović, Tamara
AU  - Radulović, Siniša
AU  - Sladić, Dušan
AU  - Filipović, N.
AU  - Gođevac, Dejan
AU  - Jeremić, D.
AU  - Anđelković, Katarina
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/596
AB  - New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones
VL  - 44
IS  - 4
SP  - 1623
EP  - 1629
DO  - 10.1016/j.ejmech.2008.07.033
ER  - 

@article{
author = "Gligorijević, Nevenka and Todorović, Tamara and Radulović, Siniša and Sladić, Dušan and Filipović, N. and Gođevac, Dejan and Jeremić, D. and Anđelković, Katarina",
year = "2009",
abstract = "New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones",
volume = "44",
number = "4",
pages = "1623-1629",
doi = "10.1016/j.ejmech.2008.07.033"
}

Gligorijević, N., Todorović, T., Radulović, S., Sladić, D., Filipović, N., Gođevac, D., Jeremić, D.,& Anđelković, K.. (2009). Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 44(4), 1623-1629.
https://doi.org/10.1016/j.ejmech.2008.07.033

Gligorijević N, Todorović T, Radulović S, Sladić D, Filipović N, Gođevac D, Jeremić D, Anđelković K. Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones. in European Journal of Medicinal Chemistry. 2009;44(4):1623-1629.
doi:10.1016/j.ejmech.2008.07.033 .

Gligorijević, Nevenka, Todorović, Tamara, Radulović, Siniša, Sladić, Dušan, Filipović, N., Gođevac, Dejan, Jeremić, D., Anđelković, Katarina, "Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones" in European Journal of Medicinal Chemistry, 44, no. 4 (2009):1623-1629,
https://doi.org/10.1016/j.ejmech.2008.07.033 . .

TY  - JOUR
AU  - Atrrog, A.A.B.
AU  - Natić, Maja
AU  - Tosti, Tomislav
AU  - Milojković-Opsenica, Dušanka
AU  - Dordević, I.
AU  - Tešević, Vele
AU  - Jadranin, Milka
AU  - Milosavljević, Slobodan
AU  - Lazić, M.
AU  - Radulović, Siniša
AU  - Tešić, Živoslav
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/567
AB  - In this study 10 guaianolide-type sesquiterpene γ-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters and C0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright
T2  - Biomedical Chromatography
T1  - Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro
VL  - 23
IS  - 3
SP  - 250
EP  - 256
DO  - 10.1002/bmc.1091
ER  - 

@article{
author = "Atrrog, A.A.B. and Natić, Maja and Tosti, Tomislav and Milojković-Opsenica, Dušanka and Dordević, I. and Tešević, Vele and Jadranin, Milka and Milosavljević, Slobodan and Lazić, M. and Radulović, Siniša and Tešić, Živoslav",
year = "2009",
abstract = "In this study 10 guaianolide-type sesquiterpene γ-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters and C0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright",
journal = "Biomedical Chromatography",
title = "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro",
volume = "23",
number = "3",
pages = "250-256",
doi = "10.1002/bmc.1091"
}

Atrrog, A.A.B., Natić, M., Tosti, T., Milojković-Opsenica, D., Dordević, I., Tešević, V., Jadranin, M., Milosavljević, S., Lazić, M., Radulović, S.,& Tešić, Ž.. (2009). Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography, 23(3), 250-256.
https://doi.org/10.1002/bmc.1091

Atrrog A, Natić M, Tosti T, Milojković-Opsenica D, Dordević I, Tešević V, Jadranin M, Milosavljević S, Lazić M, Radulović S, Tešić Ž. Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography. 2009;23(3):250-256.
doi:10.1002/bmc.1091 .

Atrrog, A.A.B., Natić, Maja, Tosti, Tomislav, Milojković-Opsenica, Dušanka, Dordević, I., Tešević, Vele, Jadranin, Milka, Milosavljević, Slobodan, Lazić, M., Radulović, Siniša, Tešić, Živoslav, "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro" in Biomedical Chromatography, 23, no. 3 (2009):250-256,
https://doi.org/10.1002/bmc.1091 . .

TY  - JOUR
AU  - Juranić, Zorica
AU  - Stevović, Lj.
AU  - Drakulić, Branko
AU  - Stanojković, Tatjana
AU  - Radulović, Siniša
AU  - Juranić, Ivan
PY  - 1999
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4403
AB  - The bacteriostatic activity of some of alkyl substituted (E)-β-(benzoyl)acrylic acids was shown earlier. The aim of this study was to investigate the antiproliferative action of 19 alkyl-, or halogeno-, or methoxy-, or acetamido-substituted (E)-β-(benzoyl)acrylic acids, against human cervix carcinoma, HeLa, cells. Target HeLa cells were continuously treated with increasing concentrations of substituted (E)-β-(benzoyl)acrylic acids during two days. The MTT test was used for assessment of the antiproliferative action of this group of compounds. Treatment of HeLa cells with 4-methyl-, 4-fluoro-, 4-chloro-, 4-bromo-and 4-methoxy-derivatives of (E)-β-(benzoyl) acrylic acid leads to the expression of cytostatic activity against HeLa cells (IC50 were in the range from 31-40 μM). Their antiproliferative action was less than that of the basic compound (E)-β-(benzoyl)acrylic acid whose IC50 was 28.5 μM. The 3,4-dimethyl-, 2,4-dimethyl-and 2,5-dimethyl-derivatives as well as the 4-ethyl-and 3,4-dichloro-and 2,4-dichloro-derivatives, have stronger cytostatic activity than the correspoding monosubstituted and parent compound. Their IC50 were 18.5 μM; 17.5 μM; 17.0 μM; 17.5 μM; 22.0 μM and 18 μM, respectively. The 4-iso-propyl-and 4-n-butyl-derivatives excited higher cytostatic activity than the compounds with a lower number of methylene -CH2-groups in the substitutent. Their IC50 were 14.5 μM and 6.5 μM respectively. The 2,5-di-iso-propyl-and 4-tert-butyl-derivatives expressed the most strong antiproliferative action against the investigated HeLa cells, IC50 being 4.5 μM and 5.5 μM, respectively. The investigated compounds affected the survival of HeLa cells, expressing a strong structure-activity relationship of the Hansch type.
AB  - Još ranije je pokazana bakteriostatska aktivnost nekih alkil supstituisanih
(E)-b-(benzoil)akrilnih kiselina. Cilj ovog rada je bio proučavanje antiproliferativnog dejstva 19 (E)-b-(benzoil)akrilnih kiselina, alkil-, ili halogeno-, ili metoksi-, ili acetamido-supstituisnaih, na ćelije humnog karcinoma grlića materice,
HeLa ćelije. Ciljne HeLa ćelije, su kontinualno tretirane rastućim koncentracijama
supstituisanih (E)-b-(benzoil)akrilnih kiselina tokom dva dana. MTT test je
korišćen za utvrđanje antiproliferativnog dejstva ovog jedinjenja. Tretiranje HeLa
ćelija 4-metil-, 4-fluoro, 4-hloro-, 4-bromo- i 4-metoksi-derivatima (E)-b-(benzoil)akrilne kiseline dovelo je do ispoljavanja citostatske aktivnosti prema HeLa
ćelijama (IC50 su između 31.40 mM). Njihovo antiproliferativno dejstvo je bilo manje
nego kod osnovnog jedinjenja, (E)-b-(benzoil)akrilne kiseline, čije IC50 je bilo 28,5 mM.
3,4-Dimetil-, 2,4-dimetil- i 2,5-dimetil- supstituisani, kao i 4-etil- te 3,4-dihloro-i
2,4- dihloro- derivati, imaju jaču citostatsku aktivnost od odgovarajućeg monosupstituisanog i osnovnog jedinjenja.Njihove IC50 vrednosti su 18,5 mM; 17,5 mM, 17,0 mM; 17,5
mM; 22,0 mMi18mM, u navedenom redosledu. 4-iso-Propil- i 4-n-butil-derivati pokazuju
višu citostatsku aktivnost od jedinjenja sa manjim brojem metilenskih –CH2. grupa u
supstituentu. Wihove IC50 vrednosti su 14,5 mM odnosno 6,5 mM. 2,5-Di-iso-propil- i
4-tert-butil- derivati ispoqavaju najjače antiproliferativno dejstvo prema ispitivanim HeLa ćelijama, IC50 su 4,5 mM i 5,5 mM u navedenom redosledu. Proučavana
jedinjenja utiču na pre.ivqavawe HeLa ćelija, ispoljavajunji izrazitu relaciju Hanschovog tipa između strukture i biološke aktivnosti.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Substitued (E)-β-(benzoyl)acrylic acids suppressed survival of neoplastic human HeLa cells
T1  - Umanjeno preživljavanje neoplastičkih humanih  HeLa ćelija supstituisanim  (E)-b-(benzoil) akrilnim kiselinama
VL  - 64
IS  - 9
SP  - 505
EP  - 512
DO  - 10.2298/jsc9909505j
ER  - 

@article{
author = "Juranić, Zorica and Stevović, Lj. and Drakulić, Branko and Stanojković, Tatjana and Radulović, Siniša and Juranić, Ivan",
year = "1999",
abstract = "The bacteriostatic activity of some of alkyl substituted (E)-β-(benzoyl)acrylic acids was shown earlier. The aim of this study was to investigate the antiproliferative action of 19 alkyl-, or halogeno-, or methoxy-, or acetamido-substituted (E)-β-(benzoyl)acrylic acids, against human cervix carcinoma, HeLa, cells. Target HeLa cells were continuously treated with increasing concentrations of substituted (E)-β-(benzoyl)acrylic acids during two days. The MTT test was used for assessment of the antiproliferative action of this group of compounds. Treatment of HeLa cells with 4-methyl-, 4-fluoro-, 4-chloro-, 4-bromo-and 4-methoxy-derivatives of (E)-β-(benzoyl) acrylic acid leads to the expression of cytostatic activity against HeLa cells (IC50 were in the range from 31-40 μM). Their antiproliferative action was less than that of the basic compound (E)-β-(benzoyl)acrylic acid whose IC50 was 28.5 μM. The 3,4-dimethyl-, 2,4-dimethyl-and 2,5-dimethyl-derivatives as well as the 4-ethyl-and 3,4-dichloro-and 2,4-dichloro-derivatives, have stronger cytostatic activity than the correspoding monosubstituted and parent compound. Their IC50 were 18.5 μM; 17.5 μM; 17.0 μM; 17.5 μM; 22.0 μM and 18 μM, respectively. The 4-iso-propyl-and 4-n-butyl-derivatives excited higher cytostatic activity than the compounds with a lower number of methylene -CH2-groups in the substitutent. Their IC50 were 14.5 μM and 6.5 μM respectively. The 2,5-di-iso-propyl-and 4-tert-butyl-derivatives expressed the most strong antiproliferative action against the investigated HeLa cells, IC50 being 4.5 μM and 5.5 μM, respectively. The investigated compounds affected the survival of HeLa cells, expressing a strong structure-activity relationship of the Hansch type., Još ranije je pokazana bakteriostatska aktivnost nekih alkil supstituisanih
(E)-b-(benzoil)akrilnih kiselina. Cilj ovog rada je bio proučavanje antiproliferativnog dejstva 19 (E)-b-(benzoil)akrilnih kiselina, alkil-, ili halogeno-, ili metoksi-, ili acetamido-supstituisnaih, na ćelije humnog karcinoma grlića materice,
HeLa ćelije. Ciljne HeLa ćelije, su kontinualno tretirane rastućim koncentracijama
supstituisanih (E)-b-(benzoil)akrilnih kiselina tokom dva dana. MTT test je
korišćen za utvrđanje antiproliferativnog dejstva ovog jedinjenja. Tretiranje HeLa
ćelija 4-metil-, 4-fluoro, 4-hloro-, 4-bromo- i 4-metoksi-derivatima (E)-b-(benzoil)akrilne kiseline dovelo je do ispoljavanja citostatske aktivnosti prema HeLa
ćelijama (IC50 su između 31.40 mM). Njihovo antiproliferativno dejstvo je bilo manje
nego kod osnovnog jedinjenja, (E)-b-(benzoil)akrilne kiseline, čije IC50 je bilo 28,5 mM.
3,4-Dimetil-, 2,4-dimetil- i 2,5-dimetil- supstituisani, kao i 4-etil- te 3,4-dihloro-i
2,4- dihloro- derivati, imaju jaču citostatsku aktivnost od odgovarajućeg monosupstituisanog i osnovnog jedinjenja.Njihove IC50 vrednosti su 18,5 mM; 17,5 mM, 17,0 mM; 17,5
mM; 22,0 mMi18mM, u navedenom redosledu. 4-iso-Propil- i 4-n-butil-derivati pokazuju
višu citostatsku aktivnost od jedinjenja sa manjim brojem metilenskih –CH2. grupa u
supstituentu. Wihove IC50 vrednosti su 14,5 mM odnosno 6,5 mM. 2,5-Di-iso-propil- i
4-tert-butil- derivati ispoqavaju najjače antiproliferativno dejstvo prema ispitivanim HeLa ćelijama, IC50 su 4,5 mM i 5,5 mM u navedenom redosledu. Proučavana
jedinjenja utiču na pre.ivqavawe HeLa ćelija, ispoljavajunji izrazitu relaciju Hanschovog tipa između strukture i biološke aktivnosti.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Substitued (E)-β-(benzoyl)acrylic acids suppressed survival of neoplastic human HeLa cells, Umanjeno preživljavanje neoplastičkih humanih  HeLa ćelija supstituisanim  (E)-b-(benzoil) akrilnim kiselinama",
volume = "64",
number = "9",
pages = "505-512",
doi = "10.2298/jsc9909505j"
}

Juranić, Z., Stevović, Lj., Drakulić, B., Stanojković, T., Radulović, S.,& Juranić, I.. (1999). Substitued (E)-β-(benzoyl)acrylic acids suppressed survival of neoplastic human HeLa cells. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 64(9), 505-512.
https://doi.org/10.2298/jsc9909505j

Juranić Z, Stevović L, Drakulić B, Stanojković T, Radulović S, Juranić I. Substitued (E)-β-(benzoyl)acrylic acids suppressed survival of neoplastic human HeLa cells. in Journal of the Serbian Chemical Society. 1999;64(9):505-512.
doi:10.2298/jsc9909505j .

Juranić, Zorica, Stevović, Lj., Drakulić, Branko, Stanojković, Tatjana, Radulović, Siniša, Juranić, Ivan, "Substitued (E)-β-(benzoyl)acrylic acids suppressed survival of neoplastic human HeLa cells" in Journal of the Serbian Chemical Society, 64, no. 9 (1999):505-512,
https://doi.org/10.2298/jsc9909505j . .