Ignjatović, Nenad

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Authority KeyName Variants
orcid::0000-0002-5749-094X
  • Ignjatović, Nenad (32)
  • Ignjatović, Nenad L. (2)
Projects
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) New approach in designing materials for energy conversion and energy storage systems
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200175 (Institute of Technical Sciences of SASA, Belgrade) Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them
Electrochemical synthesis and characterization of nanostructured functional materials for application in new technologies Synthesis, characterization and biological investigation of steroid derivatives and their molecular aggregates
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200252 (State University of Novi Pazar) Advanced technologies for monitoring and environmental protection from chemical pollutants and radiation burden
AdCatFC - Advanced Catalysts for Low Temperature Fuel Cells: From Model System to Sustainable Catalysts The study of physicochemical and biochemical processes in living environment that have impacts on pollution and the investigation of possibilities for minimizing the consequences
Synthesis and characterization of novel functional polymers and polymeric nanocomposites Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković')
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200052 (Mining and Metallurgy Institute, Bor) Modifikacija, sinteza i analiza nanostrukturnih materijala jonskim snopovima, gama zračenjem i vakuumskim deponovanjem
Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou United States National Institutes of Health (NIH), Grant R00-DE021416
United States National Institutes of Health (NIH) / National Institute of Dental and Craniofacial Research (NIDCR), Grant K99-DE021416 United States National Institutes of Health - R00-DE021416
United States National Institutes of Health - R00/DE-021416

Author's Bibliography

Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants

Pantović Pavlović, Marijana; Ignjatović, Nenad; Panić, Vladimir; Mirkov, Ivana; Kulaš, Jelena; Malešević, Anastasija; Pavlović, Miroslav

(Basel, Switzerland : MDPI, 2023)

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Ignjatović, Nenad
AU  - Panić, Vladimir
AU  - Mirkov, Ivana
AU  - Kulaš, Jelena
AU  - Malešević, Anastasija
AU  - Pavlović, Miroslav
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6556
AB  - The aim of this work is in situ anodization/anaphoretic deposition of a nano amorphous calcium phosphate (ACP)/chitosan oligosaccharide lactate (ChOL) multifunctional hybrid coating decorated with selenium (Se) on a titanium substrate and in vivo investigation of its immunomodulatory and anti-inflammatory effect. Investigating phenomena at the implant–tissue interface of interest for controlled inflammation and immunomodulation was also the aim of the research. In our earlier research, we designed coatings based on ACP and ChOL on titanium with anticorrosive, antibacterial and biocompatible properties, while in the presented results we show that selenium addition makes this coating an immunomodulator. The immunomodulatory effect of the novel hybrid coating is characterized by the examination of the functional aspects in the tissue around the implant (in vivo): proinflammatory cytokines’ gene expression, M1 (iNOS) and M2 (Arg1) macrophages, fibrous capsule formation (TGF-β) and vascularization (VEGF). The EDS, FTIR and XRD analyses prove the formation of a ACP/ChOL/Se multifunctional hybrid coating on Ti and the presence of Se. A higher M2/M1 macrophage ratio in the ACP/ChOL/Se-coated implants compared to pure titanium implants (a higher level of Arg1 expression) is noted at all time points examined (after 7, 14 and 28 days). Lower inflammation measured by gene expression of proinflammatory cytokines IL-1β and TNF, lower expression of TGF-β in the surrounding tissue and higher IL-6 expression (solely at day 7 post-implantation) is noted in presence of the ACP/ChOL/Se-coated implants.
PB  - Basel, Switzerland : MDPI
T2  - Journal of Functional Biomaterials
T1  - Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants
VL  - 14
IS  - 4
SP  - 227
DO  - 10.3390/jfb14040227
ER  - 
@article{
author = "Pantović Pavlović, Marijana and Ignjatović, Nenad and Panić, Vladimir and Mirkov, Ivana and Kulaš, Jelena and Malešević, Anastasija and Pavlović, Miroslav",
year = "2023",
abstract = "The aim of this work is in situ anodization/anaphoretic deposition of a nano amorphous calcium phosphate (ACP)/chitosan oligosaccharide lactate (ChOL) multifunctional hybrid coating decorated with selenium (Se) on a titanium substrate and in vivo investigation of its immunomodulatory and anti-inflammatory effect. Investigating phenomena at the implant–tissue interface of interest for controlled inflammation and immunomodulation was also the aim of the research. In our earlier research, we designed coatings based on ACP and ChOL on titanium with anticorrosive, antibacterial and biocompatible properties, while in the presented results we show that selenium addition makes this coating an immunomodulator. The immunomodulatory effect of the novel hybrid coating is characterized by the examination of the functional aspects in the tissue around the implant (in vivo): proinflammatory cytokines’ gene expression, M1 (iNOS) and M2 (Arg1) macrophages, fibrous capsule formation (TGF-β) and vascularization (VEGF). The EDS, FTIR and XRD analyses prove the formation of a ACP/ChOL/Se multifunctional hybrid coating on Ti and the presence of Se. A higher M2/M1 macrophage ratio in the ACP/ChOL/Se-coated implants compared to pure titanium implants (a higher level of Arg1 expression) is noted at all time points examined (after 7, 14 and 28 days). Lower inflammation measured by gene expression of proinflammatory cytokines IL-1β and TNF, lower expression of TGF-β in the surrounding tissue and higher IL-6 expression (solely at day 7 post-implantation) is noted in presence of the ACP/ChOL/Se-coated implants.",
publisher = "Basel, Switzerland : MDPI",
journal = "Journal of Functional Biomaterials",
title = "Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants",
volume = "14",
number = "4",
pages = "227",
doi = "10.3390/jfb14040227"
}
Pantović Pavlović, M., Ignjatović, N., Panić, V., Mirkov, I., Kulaš, J., Malešević, A.,& Pavlović, M.. (2023). Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants. in Journal of Functional Biomaterials
Basel, Switzerland : MDPI., 14(4), 227.
https://doi.org/10.3390/jfb14040227
Pantović Pavlović M, Ignjatović N, Panić V, Mirkov I, Kulaš J, Malešević A, Pavlović M. Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants. in Journal of Functional Biomaterials. 2023;14(4):227.
doi:10.3390/jfb14040227 .
Pantović Pavlović, Marijana, Ignjatović, Nenad, Panić, Vladimir, Mirkov, Ivana, Kulaš, Jelena, Malešević, Anastasija, Pavlović, Miroslav, "Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants" in Journal of Functional Biomaterials, 14, no. 4 (2023):227,
https://doi.org/10.3390/jfb14040227 . .
2
2

Influence of Morphology of Sn Dendrites as Sub-layer on Electrolcatalytic Performance of Sn-Pd Electrocatalysts

Nikolić, Nebojša D.; Lović, Jelena D.; Ignjatović, Nenad; Dimitrijević, Silvana B.

(Lausanne, Switzerland : International Society of Electrochemistry, 2023)

TY  - CONF
AU  - Nikolić, Nebojša D.
AU  - Lović, Jelena D.
AU  - Ignjatović, Nenad
AU  - Dimitrijević, Silvana B.
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6573
AB  - Sn-Pd electrocatalysts convenient for a possible application in direct ethanol fuel cell were produced by two electrochemical deposition method. In the first step, Sn dendrites of various degree of ramification were electrodeposited by potentiostatically on cathodic potentials of –1200, –1400, –1600 and –1800 mV vs. Ag/AgCl. Electrodeposition of tin was performed from 20 g/l SnCl2 × 2H2O in 250 g/l NaOH electrolyte at the room temperature on Cu electrodes. In the second step, Pd was electrodeposited galvanostatically at a current density of –5 mA cm-2 on the electrodes with electrodeposited Sn dendrites. Electrodeposition of Pd was performed from 1 M NH4Cl and 0.01 M PdCl2 at the room temperature. The processes of electrochemical deposition of Sn and Pd were performed with amounts of the electricity of 400 and 267 mC, giving an atomic ratio synthesized the electrocatalysts of 60 at.% Sn‒40 at.% Pd. Morpological and elemental analysis of the Sn-Pd electrocatalysts was performed by scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDS), respectively. The particle size distribution (PSD) was used to estimate a size of Sn dendrites.
PB  - Lausanne, Switzerland : International Society of Electrochemistry
C3  - 74th Annual Meeting of the International Society of Electrochemistry, "Bridging Scientific Disciplines to Address the World’s Challenges," Program, 3 - 8 September 2023 Lyon, France
T1  - Influence of Morphology of Sn Dendrites as Sub-layer on Electrolcatalytic Performance of Sn-Pd Electrocatalysts
SP  - S09-P-038
UR  - https://hdl.handle.net/21.15107/rcub_cer_6573
ER  - 
@conference{
author = "Nikolić, Nebojša D. and Lović, Jelena D. and Ignjatović, Nenad and Dimitrijević, Silvana B.",
year = "2023",
abstract = "Sn-Pd electrocatalysts convenient for a possible application in direct ethanol fuel cell were produced by two electrochemical deposition method. In the first step, Sn dendrites of various degree of ramification were electrodeposited by potentiostatically on cathodic potentials of –1200, –1400, –1600 and –1800 mV vs. Ag/AgCl. Electrodeposition of tin was performed from 20 g/l SnCl2 × 2H2O in 250 g/l NaOH electrolyte at the room temperature on Cu electrodes. In the second step, Pd was electrodeposited galvanostatically at a current density of –5 mA cm-2 on the electrodes with electrodeposited Sn dendrites. Electrodeposition of Pd was performed from 1 M NH4Cl and 0.01 M PdCl2 at the room temperature. The processes of electrochemical deposition of Sn and Pd were performed with amounts of the electricity of 400 and 267 mC, giving an atomic ratio synthesized the electrocatalysts of 60 at.% Sn‒40 at.% Pd. Morpological and elemental analysis of the Sn-Pd electrocatalysts was performed by scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDS), respectively. The particle size distribution (PSD) was used to estimate a size of Sn dendrites.",
publisher = "Lausanne, Switzerland : International Society of Electrochemistry",
journal = "74th Annual Meeting of the International Society of Electrochemistry, "Bridging Scientific Disciplines to Address the World’s Challenges," Program, 3 - 8 September 2023 Lyon, France",
title = "Influence of Morphology of Sn Dendrites as Sub-layer on Electrolcatalytic Performance of Sn-Pd Electrocatalysts",
pages = "S09-P-038",
url = "https://hdl.handle.net/21.15107/rcub_cer_6573"
}
Nikolić, N. D., Lović, J. D., Ignjatović, N.,& Dimitrijević, S. B.. (2023). Influence of Morphology of Sn Dendrites as Sub-layer on Electrolcatalytic Performance of Sn-Pd Electrocatalysts. in 74th Annual Meeting of the International Society of Electrochemistry, "Bridging Scientific Disciplines to Address the World’s Challenges," Program, 3 - 8 September 2023 Lyon, France
Lausanne, Switzerland : International Society of Electrochemistry., S09-P-038.
https://hdl.handle.net/21.15107/rcub_cer_6573
Nikolić ND, Lović JD, Ignjatović N, Dimitrijević SB. Influence of Morphology of Sn Dendrites as Sub-layer on Electrolcatalytic Performance of Sn-Pd Electrocatalysts. in 74th Annual Meeting of the International Society of Electrochemistry, "Bridging Scientific Disciplines to Address the World’s Challenges," Program, 3 - 8 September 2023 Lyon, France. 2023;:S09-P-038.
https://hdl.handle.net/21.15107/rcub_cer_6573 .
Nikolić, Nebojša D., Lović, Jelena D., Ignjatović, Nenad, Dimitrijević, Silvana B., "Influence of Morphology of Sn Dendrites as Sub-layer on Electrolcatalytic Performance of Sn-Pd Electrocatalysts" in 74th Annual Meeting of the International Society of Electrochemistry, "Bridging Scientific Disciplines to Address the World’s Challenges," Program, 3 - 8 September 2023 Lyon, France (2023):S09-P-038,
https://hdl.handle.net/21.15107/rcub_cer_6573 .

A Novel Two-Step Electrochemical Deposition Method for Sn-Pd Electrocatalyst Synthesis for a Potential Application in Direct Ethanol Fuel Cells

Lović, Jelena; Eraković Pantović, Sanja; Rakočević, Lazar; Ignjatović, Nenad L.; Dimitrijević, Silvana; Nikolić, Nebojša D.

(MDPI, 2023)

TY  - JOUR
AU  - Lović, Jelena
AU  - Eraković Pantović, Sanja
AU  - Rakočević, Lazar
AU  - Ignjatović, Nenad L.
AU  - Dimitrijević, Silvana
AU  - Nikolić, Nebojša D.
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5515
AB  - Sn-Pd electrocatalysts with a constant atomic ratio of 60 at.% Sn‒40 at.% Pd suitable for 
potential application in direct ethanol fuel cells were synthesized using a novel two-step electrodeposition method. First, Sn was electrodeposited in various forms of dendrites, from spear-like and needle-like to individual fern-like dendrites to a network of intertwined fern-like dendrites, by varying the cathodic potential and then performing electrodeposition of Pd at a constant current 
density in the second step. A morphological and elemental analysis of Sn and Sn-Pd electrocatalysts was performed using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS) techniques, while the size of Sn dendrites was analyzed using the particle size distribution (PSD) method. Cyclic voltammetry (CV) and chronoamperometry were applied in order to study the catalytic behavior of Sn-Pd electrocatalysts in the ethanol oxidation reaction (EOR), while CO stripping was used to estimate the antipoisoning capability of the electrocatalysts. The Sn surface morphology of the sub-layer was highly correlated with the electrocatalytic activity of the examined Sn-Pd electrocatalysts. The high activity it presented towards the EOR showed the suitability of the Sn-Pd electrocatalyst constructed from individual fern-like Sn dendrites as a sub-layer. Compared to Pd alone, this Sn-Pd catalyst showed more than 3 times higher activity and improved EOR kinetics. This enhancement in the catalytic activity of the Sn-Pd electrocatalysts is attributed to both the morphological characteristics of Sn as a sub-layer and the bifunctional effect.
PB  - MDPI
T2  - Processes
T1  - A Novel Two-Step Electrochemical Deposition Method for  Sn-Pd Electrocatalyst Synthesis for a Potential Application in  Direct Ethanol Fuel Cells
VL  - 11
IS  - 1
SP  - 120
DO  - 10.3390/pr11010120
ER  - 
@article{
author = "Lović, Jelena and Eraković Pantović, Sanja and Rakočević, Lazar and Ignjatović, Nenad L. and Dimitrijević, Silvana and Nikolić, Nebojša D.",
year = "2023",
abstract = "Sn-Pd electrocatalysts with a constant atomic ratio of 60 at.% Sn‒40 at.% Pd suitable for 
potential application in direct ethanol fuel cells were synthesized using a novel two-step electrodeposition method. First, Sn was electrodeposited in various forms of dendrites, from spear-like and needle-like to individual fern-like dendrites to a network of intertwined fern-like dendrites, by varying the cathodic potential and then performing electrodeposition of Pd at a constant current 
density in the second step. A morphological and elemental analysis of Sn and Sn-Pd electrocatalysts was performed using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS) techniques, while the size of Sn dendrites was analyzed using the particle size distribution (PSD) method. Cyclic voltammetry (CV) and chronoamperometry were applied in order to study the catalytic behavior of Sn-Pd electrocatalysts in the ethanol oxidation reaction (EOR), while CO stripping was used to estimate the antipoisoning capability of the electrocatalysts. The Sn surface morphology of the sub-layer was highly correlated with the electrocatalytic activity of the examined Sn-Pd electrocatalysts. The high activity it presented towards the EOR showed the suitability of the Sn-Pd electrocatalyst constructed from individual fern-like Sn dendrites as a sub-layer. Compared to Pd alone, this Sn-Pd catalyst showed more than 3 times higher activity and improved EOR kinetics. This enhancement in the catalytic activity of the Sn-Pd electrocatalysts is attributed to both the morphological characteristics of Sn as a sub-layer and the bifunctional effect.",
publisher = "MDPI",
journal = "Processes",
title = "A Novel Two-Step Electrochemical Deposition Method for  Sn-Pd Electrocatalyst Synthesis for a Potential Application in  Direct Ethanol Fuel Cells",
volume = "11",
number = "1",
pages = "120",
doi = "10.3390/pr11010120"
}
Lović, J., Eraković Pantović, S., Rakočević, L., Ignjatović, N. L., Dimitrijević, S.,& Nikolić, N. D.. (2023). A Novel Two-Step Electrochemical Deposition Method for  Sn-Pd Electrocatalyst Synthesis for a Potential Application in  Direct Ethanol Fuel Cells. in Processes
MDPI., 11(1), 120.
https://doi.org/10.3390/pr11010120
Lović J, Eraković Pantović S, Rakočević L, Ignjatović NL, Dimitrijević S, Nikolić ND. A Novel Two-Step Electrochemical Deposition Method for  Sn-Pd Electrocatalyst Synthesis for a Potential Application in  Direct Ethanol Fuel Cells. in Processes. 2023;11(1):120.
doi:10.3390/pr11010120 .
Lović, Jelena, Eraković Pantović, Sanja, Rakočević, Lazar, Ignjatović, Nenad L., Dimitrijević, Silvana, Nikolić, Nebojša D., "A Novel Two-Step Electrochemical Deposition Method for  Sn-Pd Electrocatalyst Synthesis for a Potential Application in  Direct Ethanol Fuel Cells" in Processes, 11, no. 1 (2023):120,
https://doi.org/10.3390/pr11010120 . .
2

Advanced hybrid composite coatings based on calcium phosphate on titanium for potential biomedical applications

Pantović-Pavlović, Marijana; Ignjatović, Nenad; Panić, Vladimir; Pavlović, Miroslav M.

(Split : Central and EasternEuropeanCommittee for Thermal Analysis and Calorimetry (CEEC-TAC), 2022)

TY  - CONF
AU  - Pantović-Pavlović, Marijana
AU  - Ignjatović, Nenad
AU  - Panić, Vladimir
AU  - Pavlović, Miroslav M.
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5539
AB  - This paper deals with the issue of defining a new method of anodizing/anaphoretic deposition for the application of calcium phosphate and hybrid coatings based on calcium phosphate ceramics on titanium and anodized titanium coatings with improved properties. Hybrid coatings consisted of chitosan oligolactate (ChOL) and ChOL with Se as immunomodulatory oligoelement. The paper contributes to solving the problem of multi-stage pre-treatment and posttreatment of titanium and oxidized titanium surface to obtain a coating on the substrate, adhesion of the coating, antimicrobial and cytotoxic properties that occur in biomaterials, as well as reduced immune inflammatory response of the organism. It primarily deals with the creation and optimization of a new in situ anodizing/anaphoretic deposition process for obtaining multifunctional composite biomaterials. The in situ method results in improved adhesion bioactive coating, increased bioactivity and biocompatibility with increased antimicrobial properties and absence of cytotoxicity. The studied biomaterials have improved properties such as: corrosion resistance, absence of toxicity to the human body and adequate strength, which enables their potential use in medicine and dentistry. The aim of the research was to define new in situ anodizing/anaphoretic deposition process and adequate modification of process parameters for application of composite calcium phosphate coatings on titanium and its alloys, wherein innovation is reflected in combining calcium phosphate coating synthesis and surface modification by partially incorporating a ceramic coating into the crystalline structure of the substrate. The characterization of the coatings obtained in this manner was performed by various physico-chemical, biochemical and biological methods. These characterization techniques included: AFM, SEM, FE-SEM, roughness testing, XRD, FTIR, bioactivity, biocompatibility, cytotoxicity, antimicrobial activity and in vivo testing.
PB  - Split : Central and EasternEuropeanCommittee for Thermal Analysis and Calorimetry (CEEC-TAC)
C3  - Book of abstracts of the ISt Central and Eastern European Conference on Physical Chemistry and Materials Science (CEEC-PCMS1))
T1  - Advanced hybrid composite coatings based on calcium phosphate on titanium for potential biomedical applications
SP  - 44
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_dais_13653
ER  - 
@conference{
author = "Pantović-Pavlović, Marijana and Ignjatović, Nenad and Panić, Vladimir and Pavlović, Miroslav M.",
year = "2022",
abstract = "This paper deals with the issue of defining a new method of anodizing/anaphoretic deposition for the application of calcium phosphate and hybrid coatings based on calcium phosphate ceramics on titanium and anodized titanium coatings with improved properties. Hybrid coatings consisted of chitosan oligolactate (ChOL) and ChOL with Se as immunomodulatory oligoelement. The paper contributes to solving the problem of multi-stage pre-treatment and posttreatment of titanium and oxidized titanium surface to obtain a coating on the substrate, adhesion of the coating, antimicrobial and cytotoxic properties that occur in biomaterials, as well as reduced immune inflammatory response of the organism. It primarily deals with the creation and optimization of a new in situ anodizing/anaphoretic deposition process for obtaining multifunctional composite biomaterials. The in situ method results in improved adhesion bioactive coating, increased bioactivity and biocompatibility with increased antimicrobial properties and absence of cytotoxicity. The studied biomaterials have improved properties such as: corrosion resistance, absence of toxicity to the human body and adequate strength, which enables their potential use in medicine and dentistry. The aim of the research was to define new in situ anodizing/anaphoretic deposition process and adequate modification of process parameters for application of composite calcium phosphate coatings on titanium and its alloys, wherein innovation is reflected in combining calcium phosphate coating synthesis and surface modification by partially incorporating a ceramic coating into the crystalline structure of the substrate. The characterization of the coatings obtained in this manner was performed by various physico-chemical, biochemical and biological methods. These characterization techniques included: AFM, SEM, FE-SEM, roughness testing, XRD, FTIR, bioactivity, biocompatibility, cytotoxicity, antimicrobial activity and in vivo testing.",
publisher = "Split : Central and EasternEuropeanCommittee for Thermal Analysis and Calorimetry (CEEC-TAC)",
journal = "Book of abstracts of the ISt Central and Eastern European Conference on Physical Chemistry and Materials Science (CEEC-PCMS1))",
title = "Advanced hybrid composite coatings based on calcium phosphate on titanium for potential biomedical applications",
pages = "44-44",
url = "https://hdl.handle.net/21.15107/rcub_dais_13653"
}
Pantović-Pavlović, M., Ignjatović, N., Panić, V.,& Pavlović, M. M.. (2022). Advanced hybrid composite coatings based on calcium phosphate on titanium for potential biomedical applications. in Book of abstracts of the ISt Central and Eastern European Conference on Physical Chemistry and Materials Science (CEEC-PCMS1))
Split : Central and EasternEuropeanCommittee for Thermal Analysis and Calorimetry (CEEC-TAC)., 44-44.
https://hdl.handle.net/21.15107/rcub_dais_13653
Pantović-Pavlović M, Ignjatović N, Panić V, Pavlović MM. Advanced hybrid composite coatings based on calcium phosphate on titanium for potential biomedical applications. in Book of abstracts of the ISt Central and Eastern European Conference on Physical Chemistry and Materials Science (CEEC-PCMS1)). 2022;:44-44.
https://hdl.handle.net/21.15107/rcub_dais_13653 .
Pantović-Pavlović, Marijana, Ignjatović, Nenad, Panić, Vladimir, Pavlović, Miroslav M., "Advanced hybrid composite coatings based on calcium phosphate on titanium for potential biomedical applications" in Book of abstracts of the ISt Central and Eastern European Conference on Physical Chemistry and Materials Science (CEEC-PCMS1)) (2022):44-44,
https://hdl.handle.net/21.15107/rcub_dais_13653 .

Novel Calcium Phosphate Coatings with Selenum on Titanium

Pantović-Pavlović, Marijana; Ignjatović, Nenad; Panić, Vladimir; Pavlović, Miroslav M.

(Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM, 2022)

TY  - CONF
AU  - Pantović-Pavlović, Marijana
AU  - Ignjatović, Nenad
AU  - Panić, Vladimir
AU  - Pavlović, Miroslav M.
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5540
AB  - This paper deals with the deposition of calcium phosphate and hybrid coatings based on calcium phosphate ceramics on titanium with improved properties by in situ anodization/anaphoretic deposition process. Hybrid coatings consisted of chitosan oligolactate (ChOL) and ChOL with Se as immunomodulatory oligoelement. The paper contributes to solving the problem of multi-stage pre-treatment and post-treatment of titanium and oxidized titanium surface to obtain a coating on the substrate, adhesion of the coating, antimicrobial and cytotoxic properties that occur in biomaterials, as well as reduced immune inflammatory response of the organism. The in situ method results in improved adhesion bioactive coating, increased bioactivity and biocompatibility with increased antimicrobial properties and absence of cytotoxicity. The studied biomaterials have improved properties such as: corrosion resistance, absence of toxicity to the human body and adequate strength, which enables their potential use in medicine and dentistry. The innovation is reflected in combining calcium phosphate coating synthesis and surface modification by partially incorporating a ceramic coating into the crystalline structure of the substrate. The characterization of the coatings obtained in this manner was performed by various physico-chemical, biochemical and biological methods. These characterization techniques included: FE-SEM, XRD, FTIR, cytotoxicity and in vivo testing.
PB  - Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM
C3  - Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXIII YuCorr International Conference = XXIII YuCorr Međunarodna konferencija, May 16-19, 2022, Divčibare, Serbia
T1  - Novel Calcium Phosphate Coatings with Selenum on Titanium
SP  - poster-102
UR  - https://hdl.handle.net/21.15107/rcub_dais_13652
ER  - 
@conference{
author = "Pantović-Pavlović, Marijana and Ignjatović, Nenad and Panić, Vladimir and Pavlović, Miroslav M.",
year = "2022",
abstract = "This paper deals with the deposition of calcium phosphate and hybrid coatings based on calcium phosphate ceramics on titanium with improved properties by in situ anodization/anaphoretic deposition process. Hybrid coatings consisted of chitosan oligolactate (ChOL) and ChOL with Se as immunomodulatory oligoelement. The paper contributes to solving the problem of multi-stage pre-treatment and post-treatment of titanium and oxidized titanium surface to obtain a coating on the substrate, adhesion of the coating, antimicrobial and cytotoxic properties that occur in biomaterials, as well as reduced immune inflammatory response of the organism. The in situ method results in improved adhesion bioactive coating, increased bioactivity and biocompatibility with increased antimicrobial properties and absence of cytotoxicity. The studied biomaterials have improved properties such as: corrosion resistance, absence of toxicity to the human body and adequate strength, which enables their potential use in medicine and dentistry. The innovation is reflected in combining calcium phosphate coating synthesis and surface modification by partially incorporating a ceramic coating into the crystalline structure of the substrate. The characterization of the coatings obtained in this manner was performed by various physico-chemical, biochemical and biological methods. These characterization techniques included: FE-SEM, XRD, FTIR, cytotoxicity and in vivo testing.",
publisher = "Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM",
journal = "Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXIII YuCorr International Conference = XXIII YuCorr Međunarodna konferencija, May 16-19, 2022, Divčibare, Serbia",
title = "Novel Calcium Phosphate Coatings with Selenum on Titanium",
pages = "poster-102",
url = "https://hdl.handle.net/21.15107/rcub_dais_13652"
}
Pantović-Pavlović, M., Ignjatović, N., Panić, V.,& Pavlović, M. M.. (2022). Novel Calcium Phosphate Coatings with Selenum on Titanium. in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXIII YuCorr International Conference = XXIII YuCorr Međunarodna konferencija, May 16-19, 2022, Divčibare, Serbia
Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM., poster-102.
https://hdl.handle.net/21.15107/rcub_dais_13652
Pantović-Pavlović M, Ignjatović N, Panić V, Pavlović MM. Novel Calcium Phosphate Coatings with Selenum on Titanium. in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXIII YuCorr International Conference = XXIII YuCorr Međunarodna konferencija, May 16-19, 2022, Divčibare, Serbia. 2022;:poster-102.
https://hdl.handle.net/21.15107/rcub_dais_13652 .
Pantović-Pavlović, Marijana, Ignjatović, Nenad, Panić, Vladimir, Pavlović, Miroslav M., "Novel Calcium Phosphate Coatings with Selenum on Titanium" in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXIII YuCorr International Conference = XXIII YuCorr Međunarodna konferencija, May 16-19, 2022, Divčibare, Serbia (2022):poster-102,
https://hdl.handle.net/21.15107/rcub_dais_13652 .

Upoređivanje bioaktivnosti, citotoksičnosti, antimikrobnih i korozivnih svojstava keramičkih prevlaka sa i bez polimera na titanu

Pantović Pavlović, Marijana R.; Pavlović, Miroslav M.; Stevanović, Jasmina S.; Panić, Vladimir; Ignjatović, Nenad

(Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM, 2021)

TY  - CONF
AU  - Pantović Pavlović, Marijana R.
AU  - Pavlović, Miroslav M.
AU  - Stevanović, Jasmina S.
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5268
AB  - Kalcijum fosfati (CP), među kojima su amorfni kalcijum fosfat (ACP) i hidroksiapatit (HAp), zajedno sa slojevima Ti i TiO2, pronašli su ogromnu primenu u preventivnoj i regenerativnoj medicini zbog svoje odlične biokompatibilnosti, netoksičnih svojstava i sposobnosti da učestvuju u metaboličnim procesima organizama. U ovom radu je prikazana citotoksičnost multifunkcionalnih i hibridnih kompozitnih prevlaka amorfnog kalcijum fosfata (ACP) i hitozan laktata (ChOL) na ćelijskoj liniji humanih fibroblasta pluća MRC-5. ACP/TiO2 i ACP/TiO2/ChOL prevlake su taložene novim procesom in situ anodizacije/anaforetske depozicije pri konstantnom naponu od 60 V tokom 180 s na 25 ° C. Testovi citotoksičnosti pokazali su da nije bilo značajnog smanjenja preživljavanja zdravih ćelija MRC-5 u kompozitnim uzorcima Ti i ACP/TiO2, dok je došlo do povećanja broja viabilnih ćelija u uzorku ACP/TiO2/ChOL. Pokazano je poboljšanje ćelijske proliferacije, diferencijacije i viabilnosti ćelija. Uzorak koji sadrži ACP/TiO2/ChOL prevlaku pokazao je negativnu citotoksičnost u DET i u MTT testovima. Zabeležen je veći oporavak humanih ćelija fibroblasta pluća MRC-5 u poređenju sa kontrolnim uzorkom posle 48 h oporavka. Iz ovih rezultata može se zaključiti da multifunkcionalna kompozitna prevlaka ACP/TiO2/ChOL nije samo necitotoksična, već prisustvo ChOL-a u prevlaci poboljšava ćelijsku proliferaciju, diferencijaciju i viabilnost ćelija. Na osnovu dobijenih rezultata može se zaključiti da oba kompozitna materijala koji su korišćeni u studijama nisu citotoksični za korišćene ćelijske linije, te da 5 tež.% ChOL-a ima pozitivan efekat na netoksičnost materijala. Na osnovu prikazanih rezultata u ovom radu i prethodnih objavljenih rezultata fizičko-hemijskih i bioaktivnih svojstava kompozitnog materijala ACP/TiO2/ChOL, može se zaključiti da bi dalji razvoj, kao i potencijalne pretkliničke studije bili u velikoj meri opravdani.
AB  - Calcium phosphates (CP), amongst which amorphous calcium phosphate (ACP) and hydroxyapatite (HAp), along with Ti and TiO2 layers, have found vast applications in preventive and regenerative medicine due to their excellent biocompatibility, nontoxic properties and ability to participate in the normal metabolism of organisms. In this paper cytotoxicity of amorphous calcium phosphate (ACP) and chitosan lactate (ChOL) multifunctional and hybrid composite coatings on MRC-5 human lung fibroblast cell line is presented. ACP/TiO2 and ACP/TiO2/ChOL are deposited by coatings new in situ anodization/anaphoretic deposition process at constant voltage of 60 V for 180 s at 25 °C. Cytotoxicity tests showed that there was no significant decrease in the survival of healthy MRC-5 cells in the Ti and ACP/TiO2 composite samples, while there was an increase in the number of viable cells in the ACP/TiO2/ChOL sample. There is improved cell proliferation, differentiation and cell viability in the later. Sample containing ACP/TiO2/ChOL coating showed negative cytotoxicity in both DET and MTT tests. Greater recovery of MRC-5 human lung fibroblasts cells was observed compared to the control sample after 48 h of recovery. From these results, it can be concluded that not only the ACP/TiO2/ChOL multifunctional composite coating is non-cytotoxic, but the presence of ChOL in the coating improves cell proliferation, differentiation and cell viability. Based on the obtained results, it can be concluded that both composite materials used in the studies are non-cytotoxic to the cell lines used, and that 5 wt.% of ChOL has a positive effect on the non-toxicity of the material. Based on presented results in this paper and previous published results of the physicochemical and bioactive properties of the ACP/TiO2/ChOL composite material, it can be concluded that further development as well as potential preclinical studies would be largely justified.
PB  - Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM
C3  - Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXII YuCorr International Conference = XXI YuCorr [Jugoslovenska korozija] Međunarodna konferencija, September 13-16, 2021, Tara Mountain, Serbia
T1  - Upoređivanje bioaktivnosti, citotoksičnosti, antimikrobnih i korozivnih svojstava keramičkih prevlaka sa i bez polimera na titanu
T1  - Comparison of bioactivity, cytotoxicity, antimicrobial and corrosive behavior of ceramic coatings with and without polymer on titanium
SP  - INVITED-21
UR  - https://hdl.handle.net/21.15107/rcub_dais_12363
ER  - 
@conference{
author = "Pantović Pavlović, Marijana R. and Pavlović, Miroslav M. and Stevanović, Jasmina S. and Panić, Vladimir and Ignjatović, Nenad",
year = "2021",
abstract = "Kalcijum fosfati (CP), među kojima su amorfni kalcijum fosfat (ACP) i hidroksiapatit (HAp), zajedno sa slojevima Ti i TiO2, pronašli su ogromnu primenu u preventivnoj i regenerativnoj medicini zbog svoje odlične biokompatibilnosti, netoksičnih svojstava i sposobnosti da učestvuju u metaboličnim procesima organizama. U ovom radu je prikazana citotoksičnost multifunkcionalnih i hibridnih kompozitnih prevlaka amorfnog kalcijum fosfata (ACP) i hitozan laktata (ChOL) na ćelijskoj liniji humanih fibroblasta pluća MRC-5. ACP/TiO2 i ACP/TiO2/ChOL prevlake su taložene novim procesom in situ anodizacije/anaforetske depozicije pri konstantnom naponu od 60 V tokom 180 s na 25 ° C. Testovi citotoksičnosti pokazali su da nije bilo značajnog smanjenja preživljavanja zdravih ćelija MRC-5 u kompozitnim uzorcima Ti i ACP/TiO2, dok je došlo do povećanja broja viabilnih ćelija u uzorku ACP/TiO2/ChOL. Pokazano je poboljšanje ćelijske proliferacije, diferencijacije i viabilnosti ćelija. Uzorak koji sadrži ACP/TiO2/ChOL prevlaku pokazao je negativnu citotoksičnost u DET i u MTT testovima. Zabeležen je veći oporavak humanih ćelija fibroblasta pluća MRC-5 u poređenju sa kontrolnim uzorkom posle 48 h oporavka. Iz ovih rezultata može se zaključiti da multifunkcionalna kompozitna prevlaka ACP/TiO2/ChOL nije samo necitotoksična, već prisustvo ChOL-a u prevlaci poboljšava ćelijsku proliferaciju, diferencijaciju i viabilnost ćelija. Na osnovu dobijenih rezultata može se zaključiti da oba kompozitna materijala koji su korišćeni u studijama nisu citotoksični za korišćene ćelijske linije, te da 5 tež.% ChOL-a ima pozitivan efekat na netoksičnost materijala. Na osnovu prikazanih rezultata u ovom radu i prethodnih objavljenih rezultata fizičko-hemijskih i bioaktivnih svojstava kompozitnog materijala ACP/TiO2/ChOL, može se zaključiti da bi dalji razvoj, kao i potencijalne pretkliničke studije bili u velikoj meri opravdani., Calcium phosphates (CP), amongst which amorphous calcium phosphate (ACP) and hydroxyapatite (HAp), along with Ti and TiO2 layers, have found vast applications in preventive and regenerative medicine due to their excellent biocompatibility, nontoxic properties and ability to participate in the normal metabolism of organisms. In this paper cytotoxicity of amorphous calcium phosphate (ACP) and chitosan lactate (ChOL) multifunctional and hybrid composite coatings on MRC-5 human lung fibroblast cell line is presented. ACP/TiO2 and ACP/TiO2/ChOL are deposited by coatings new in situ anodization/anaphoretic deposition process at constant voltage of 60 V for 180 s at 25 °C. Cytotoxicity tests showed that there was no significant decrease in the survival of healthy MRC-5 cells in the Ti and ACP/TiO2 composite samples, while there was an increase in the number of viable cells in the ACP/TiO2/ChOL sample. There is improved cell proliferation, differentiation and cell viability in the later. Sample containing ACP/TiO2/ChOL coating showed negative cytotoxicity in both DET and MTT tests. Greater recovery of MRC-5 human lung fibroblasts cells was observed compared to the control sample after 48 h of recovery. From these results, it can be concluded that not only the ACP/TiO2/ChOL multifunctional composite coating is non-cytotoxic, but the presence of ChOL in the coating improves cell proliferation, differentiation and cell viability. Based on the obtained results, it can be concluded that both composite materials used in the studies are non-cytotoxic to the cell lines used, and that 5 wt.% of ChOL has a positive effect on the non-toxicity of the material. Based on presented results in this paper and previous published results of the physicochemical and bioactive properties of the ACP/TiO2/ChOL composite material, it can be concluded that further development as well as potential preclinical studies would be largely justified.",
publisher = "Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM",
journal = "Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXII YuCorr International Conference = XXI YuCorr [Jugoslovenska korozija] Međunarodna konferencija, September 13-16, 2021, Tara Mountain, Serbia",
title = "Upoređivanje bioaktivnosti, citotoksičnosti, antimikrobnih i korozivnih svojstava keramičkih prevlaka sa i bez polimera na titanu, Comparison of bioactivity, cytotoxicity, antimicrobial and corrosive behavior of ceramic coatings with and without polymer on titanium",
pages = "INVITED-21",
url = "https://hdl.handle.net/21.15107/rcub_dais_12363"
}
Pantović Pavlović, M. R., Pavlović, M. M., Stevanović, J. S., Panić, V.,& Ignjatović, N.. (2021). Upoređivanje bioaktivnosti, citotoksičnosti, antimikrobnih i korozivnih svojstava keramičkih prevlaka sa i bez polimera na titanu. in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXII YuCorr International Conference = XXI YuCorr [Jugoslovenska korozija] Međunarodna konferencija, September 13-16, 2021, Tara Mountain, Serbia
Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM., INVITED-21.
https://hdl.handle.net/21.15107/rcub_dais_12363
Pantović Pavlović MR, Pavlović MM, Stevanović JS, Panić V, Ignjatović N. Upoređivanje bioaktivnosti, citotoksičnosti, antimikrobnih i korozivnih svojstava keramičkih prevlaka sa i bez polimera na titanu. in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXII YuCorr International Conference = XXI YuCorr [Jugoslovenska korozija] Međunarodna konferencija, September 13-16, 2021, Tara Mountain, Serbia. 2021;:INVITED-21.
https://hdl.handle.net/21.15107/rcub_dais_12363 .
Pantović Pavlović, Marijana R., Pavlović, Miroslav M., Stevanović, Jasmina S., Panić, Vladimir, Ignjatović, Nenad, "Upoređivanje bioaktivnosti, citotoksičnosti, antimikrobnih i korozivnih svojstava keramičkih prevlaka sa i bez polimera na titanu" in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings = Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova / XXII YuCorr International Conference = XXI YuCorr [Jugoslovenska korozija] Međunarodna konferencija, September 13-16, 2021, Tara Mountain, Serbia (2021):INVITED-21,
https://hdl.handle.net/21.15107/rcub_dais_12363 .

Cytotoxicity of Multifunctional Composites of Amorphous Calcium Phosphate Containing Chitosan on Titanium Obtained by Novel in Situ Anodic Process

Pantović Pavlović, Marijana; Pavlović, Miroslav; Nikolić, Nebojša D.; Kojić, Vesna V.; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(Zvornik : Faculty of Technology, 2021)

TY  - CONF
AU  - Pantović Pavlović, Marijana
AU  - Pavlović, Miroslav
AU  - Nikolić, Nebojša D.
AU  - Kojić, Vesna V.
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6561
AB  - Calcium phosphates (CP), amongst which amorphous calcium phosphate (ACP) and hydroxyapatite (HAp), along with Ti and TiO2 layers, have found vast applications in preventive and regenerative medicine due to their excellent biocompatibility, nontoxic properties and ability to participate in the normal metabolism of organisms. In this paper cytotoxicity of amorphous calcium phosphate (ACP) and chitosan lactate (ChOL) multifunctional and hybrid composite coatings on MRC-5 human lung fibroblast cell line is presented. ACP/TiO2 and ACP/TiO2/ChOL are deposited by coatings new in situ anodization/anaphoretic deposition process at constant voltage of 60 V for 180 s at 25 °C. Cytotoxicity tests showed that there was no significant decrease in the survival of healthy MRC-5 cells in the Ti and ACP/TiO2 composite samples, while there was an increase in the number of viable cells in the ACP/TiO2/ChOL sample. There is improved cell proliferation, differentiation and cell viability in the later. Sample containing ACP/TiO2/ChOL coating showed negative cytotoxicity in both DET and MTT tests. Greater recovery of MRC-5 human lung fibroblasts cells was observed compared to the control sample after 48 h of recovery. From these results, it can be concluded that not only the ACP/TiO2/ChOL multifunctional composite coating is non-cytotoxic, but the presence of ChOL in the coating improves cell proliferation, differentiation and cell viability. Based on the obtained results, it can be concluded that both composite materials used in the studies are non-cytotoxic to the cell lines used, and that 5 wt.% of ChOL has a positive effect on the non-toxicity of the material. Based on presented results in this paper and previous published results of the physicochemical and bioactive properties of the ACP/TiO2/ChOL composite material, it can be concluded that further development as well as potential preclinical studies would be largely justified.
PB  - Zvornik : Faculty of Technology
C3  - Book of Abstracts - VII International Congress Engineering, Environment and Materials in Process Industry, March 17-19, 2021, Jahorina, Republic of Srpska, Bosnia and Herzegovina
T1  - Cytotoxicity of Multifunctional Composites of Amorphous Calcium Phosphate Containing Chitosan on Titanium Obtained by Novel in Situ Anodic Process
SP  - 230
EP  - 230
UR  - https://hdl.handle.net/21.15107/rcub_cer_6561
ER  - 
@conference{
author = "Pantović Pavlović, Marijana and Pavlović, Miroslav and Nikolić, Nebojša D. and Kojić, Vesna V. and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2021",
abstract = "Calcium phosphates (CP), amongst which amorphous calcium phosphate (ACP) and hydroxyapatite (HAp), along with Ti and TiO2 layers, have found vast applications in preventive and regenerative medicine due to their excellent biocompatibility, nontoxic properties and ability to participate in the normal metabolism of organisms. In this paper cytotoxicity of amorphous calcium phosphate (ACP) and chitosan lactate (ChOL) multifunctional and hybrid composite coatings on MRC-5 human lung fibroblast cell line is presented. ACP/TiO2 and ACP/TiO2/ChOL are deposited by coatings new in situ anodization/anaphoretic deposition process at constant voltage of 60 V for 180 s at 25 °C. Cytotoxicity tests showed that there was no significant decrease in the survival of healthy MRC-5 cells in the Ti and ACP/TiO2 composite samples, while there was an increase in the number of viable cells in the ACP/TiO2/ChOL sample. There is improved cell proliferation, differentiation and cell viability in the later. Sample containing ACP/TiO2/ChOL coating showed negative cytotoxicity in both DET and MTT tests. Greater recovery of MRC-5 human lung fibroblasts cells was observed compared to the control sample after 48 h of recovery. From these results, it can be concluded that not only the ACP/TiO2/ChOL multifunctional composite coating is non-cytotoxic, but the presence of ChOL in the coating improves cell proliferation, differentiation and cell viability. Based on the obtained results, it can be concluded that both composite materials used in the studies are non-cytotoxic to the cell lines used, and that 5 wt.% of ChOL has a positive effect on the non-toxicity of the material. Based on presented results in this paper and previous published results of the physicochemical and bioactive properties of the ACP/TiO2/ChOL composite material, it can be concluded that further development as well as potential preclinical studies would be largely justified.",
publisher = "Zvornik : Faculty of Technology",
journal = "Book of Abstracts - VII International Congress Engineering, Environment and Materials in Process Industry, March 17-19, 2021, Jahorina, Republic of Srpska, Bosnia and Herzegovina",
title = "Cytotoxicity of Multifunctional Composites of Amorphous Calcium Phosphate Containing Chitosan on Titanium Obtained by Novel in Situ Anodic Process",
pages = "230-230",
url = "https://hdl.handle.net/21.15107/rcub_cer_6561"
}
Pantović Pavlović, M., Pavlović, M., Nikolić, N. D., Kojić, V. V., Stevanović, J., Panić, V.,& Ignjatović, N.. (2021). Cytotoxicity of Multifunctional Composites of Amorphous Calcium Phosphate Containing Chitosan on Titanium Obtained by Novel in Situ Anodic Process. in Book of Abstracts - VII International Congress Engineering, Environment and Materials in Process Industry, March 17-19, 2021, Jahorina, Republic of Srpska, Bosnia and Herzegovina
Zvornik : Faculty of Technology., 230-230.
https://hdl.handle.net/21.15107/rcub_cer_6561
Pantović Pavlović M, Pavlović M, Nikolić ND, Kojić VV, Stevanović J, Panić V, Ignjatović N. Cytotoxicity of Multifunctional Composites of Amorphous Calcium Phosphate Containing Chitosan on Titanium Obtained by Novel in Situ Anodic Process. in Book of Abstracts - VII International Congress Engineering, Environment and Materials in Process Industry, March 17-19, 2021, Jahorina, Republic of Srpska, Bosnia and Herzegovina. 2021;:230-230.
https://hdl.handle.net/21.15107/rcub_cer_6561 .
Pantović Pavlović, Marijana, Pavlović, Miroslav, Nikolić, Nebojša D., Kojić, Vesna V., Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Cytotoxicity of Multifunctional Composites of Amorphous Calcium Phosphate Containing Chitosan on Titanium Obtained by Novel in Situ Anodic Process" in Book of Abstracts - VII International Congress Engineering, Environment and Materials in Process Industry, March 17-19, 2021, Jahorina, Republic of Srpska, Bosnia and Herzegovina (2021):230-230,
https://hdl.handle.net/21.15107/rcub_cer_6561 .

Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties

Pantović Pavlović, Marijana; Stanojević, Boris P.; Pavlović, Miroslav M.; Mihailović, Marija; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(American Chemical Society (ACS), 2021)

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Stanojević, Boris P.
AU  - Pavlović, Miroslav M.
AU  - Mihailović, Marija
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/11739
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4793
AB  - The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate. The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL. The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases. Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability. It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2. This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance. In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF). There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy. While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min. The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
PB  - American Chemical Society (ACS)
T2  - ACS Biomaterials Science & Engineering
T1  - Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties
VL  - 7
IS  - 7
SP  - 3088
EP  - 3102
DO  - 10.1021/acsbiomaterials.1c00035
ER  - 
@article{
author = "Pantović Pavlović, Marijana and Stanojević, Boris P. and Pavlović, Miroslav M. and Mihailović, Marija and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2021",
abstract = "The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate. The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL. The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases. Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability. It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2. This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance. In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF). There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy. While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min. The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.",
publisher = "American Chemical Society (ACS)",
journal = "ACS Biomaterials Science & Engineering",
title = "Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties",
volume = "7",
number = "7",
pages = "3088-3102",
doi = "10.1021/acsbiomaterials.1c00035"
}
Pantović Pavlović, M., Stanojević, B. P., Pavlović, M. M., Mihailović, M., Stevanović, J., Panić, V.,& Ignjatović, N.. (2021). Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties. in ACS Biomaterials Science & Engineering
American Chemical Society (ACS)., 7(7), 3088-3102.
https://doi.org/10.1021/acsbiomaterials.1c00035
Pantović Pavlović M, Stanojević BP, Pavlović MM, Mihailović M, Stevanović J, Panić V, Ignjatović N. Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties. in ACS Biomaterials Science & Engineering. 2021;7(7):3088-3102.
doi:10.1021/acsbiomaterials.1c00035 .
Pantović Pavlović, Marijana, Stanojević, Boris P., Pavlović, Miroslav M., Mihailović, Marija, Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties" in ACS Biomaterials Science & Engineering, 7, no. 7 (2021):3088-3102,
https://doi.org/10.1021/acsbiomaterials.1c00035 . .
2
16
1
14

Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties

Pantović Pavlović, Marijana; Stanojević, Boris P.; Pavlović, Miroslav M.; Mihailović, Marija; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(American Chemical Society (ACS), 2021)

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Stanojević, Boris P.
AU  - Pavlović, Miroslav M.
AU  - Mihailović, Marija
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4794
AB  - The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate. The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL. The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases. Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability. It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2. This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance. In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF). There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy. While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min. The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
PB  - American Chemical Society (ACS)
T2  - ACS Biomaterials Science & Engineering
T1  - Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties
VL  - 7
IS  - 7
SP  - 3088
EP  - 3102
DO  - 10.1021/acsbiomaterials.1c00035
ER  - 
@article{
author = "Pantović Pavlović, Marijana and Stanojević, Boris P. and Pavlović, Miroslav M. and Mihailović, Marija and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2021",
abstract = "The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate. The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL. The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases. Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability. It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2. This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance. In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF). There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy. While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min. The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.",
publisher = "American Chemical Society (ACS)",
journal = "ACS Biomaterials Science & Engineering",
title = "Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties",
volume = "7",
number = "7",
pages = "3088-3102",
doi = "10.1021/acsbiomaterials.1c00035"
}
Pantović Pavlović, M., Stanojević, B. P., Pavlović, M. M., Mihailović, M., Stevanović, J., Panić, V.,& Ignjatović, N.. (2021). Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties. in ACS Biomaterials Science & Engineering
American Chemical Society (ACS)., 7(7), 3088-3102.
https://doi.org/10.1021/acsbiomaterials.1c00035
Pantović Pavlović M, Stanojević BP, Pavlović MM, Mihailović M, Stevanović J, Panić V, Ignjatović N. Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties. in ACS Biomaterials Science & Engineering. 2021;7(7):3088-3102.
doi:10.1021/acsbiomaterials.1c00035 .
Pantović Pavlović, Marijana, Stanojević, Boris P., Pavlović, Miroslav M., Mihailović, Marija, Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties" in ACS Biomaterials Science & Engineering, 7, no. 7 (2021):3088-3102,
https://doi.org/10.1021/acsbiomaterials.1c00035 . .
2
16
1
14

Supplementary information for: “Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.”

Pantović Pavlović, Marijana; Stanojević, Boris; Pavlović, Miroslav M.; Mihailović, Marija; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(American Chemical Society (ACS), 2021)

TY  - DATA
AU  - Pantović Pavlović, Marijana
AU  - Stanojević, Boris
AU  - Pavlović, Miroslav M.
AU  - Mihailović, Marija
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4795
AB  - The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate. Supplementary information: The ANOVA results of antimicrobial activity on S. aureus are shown in Table S1 and the ANOVA results of antimicrobial activity on P. aeruginosa are shown in Table S2. The analysis showed significant difference at the 5% level of confidence.
PB  - American Chemical Society (ACS)
T2  - ACS Biomaterials Science & Engineering
T1  - Supplementary information for: “Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.”
VL  - 7
IS  - 7
UR  - https://hdl.handle.net/21.15107/rcub_cer_4795
ER  - 
@misc{
author = "Pantović Pavlović, Marijana and Stanojević, Boris and Pavlović, Miroslav M. and Mihailović, Marija and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2021",
abstract = "The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate. Supplementary information: The ANOVA results of antimicrobial activity on S. aureus are shown in Table S1 and the ANOVA results of antimicrobial activity on P. aeruginosa are shown in Table S2. The analysis showed significant difference at the 5% level of confidence.",
publisher = "American Chemical Society (ACS)",
journal = "ACS Biomaterials Science & Engineering",
title = "Supplementary information for: “Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.”",
volume = "7",
number = "7",
url = "https://hdl.handle.net/21.15107/rcub_cer_4795"
}
Pantović Pavlović, M., Stanojević, B., Pavlović, M. M., Mihailović, M., Stevanović, J., Panić, V.,& Ignjatović, N.. (2021). Supplementary information for: “Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.”. in ACS Biomaterials Science & Engineering
American Chemical Society (ACS)., 7(7).
https://hdl.handle.net/21.15107/rcub_cer_4795
Pantović Pavlović M, Stanojević B, Pavlović MM, Mihailović M, Stevanović J, Panić V, Ignjatović N. Supplementary information for: “Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.”. in ACS Biomaterials Science & Engineering. 2021;7(7).
https://hdl.handle.net/21.15107/rcub_cer_4795 .
Pantović Pavlović, Marijana, Stanojević, Boris, Pavlović, Miroslav M., Mihailović, Marija, Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Supplementary information for: “Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.”" in ACS Biomaterials Science & Engineering, 7, no. 7 (2021),
https://hdl.handle.net/21.15107/rcub_cer_4795 .

Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition

Pantović Pavlović, Marijana; Pavlović, Miroslav M.; Kovačina, Jovanka; Stanojević, Boris P.; Stevanović, Jasmina S.; Panić, Vladimir; Ignjatović, Nenad L.

(Belgrade : Serbian Chemical Society, 2021)

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Pavlović, Miroslav M.
AU  - Kovačina, Jovanka
AU  - Stanojević, Boris P.
AU  - Stevanović, Jasmina S.
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad L.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4800
AB  - The cytotoxicity of amorphous calcium phosphate (ACP) and chitosan lactate (ChOL) multifunctional and hybrid composite coatings on MRC-5 human lung fibroblast cell line was elucidated. ACP/TiO2 and ACP/TiO2/ /ChOL were deposited onto Ti by a novel in situ anodization/anaphoretic process at constant voltage. Cytotoxicity tests showed that there was no significant decrease in the survival of healthy MRC-5 cells exposed to composite samples without chitosan lactate, while there was an increase in the number of viable cells in the sample containing ChOL. These findings show that there was improved cell proliferation, differentiation and cell viability in the ChOL-containing sample, which makes ACP/TiO2/ChOL coating a good candidate for applications in medicine and stomatology.
AB  - Приказани су резултати испитивања цитотоксичности мултифункционалних и хиб-
ридних композитних превлака на бази аморфног калцијум-фосфата (ACP) и хитозан-
-олиголактата (ChOL) на титану према MRC-5 ћелијској линији хуманих фибробласта
плућа. ACP/TiO2 и ACP/TiO2/ChOL су исталожени новим in situ поступком анодизације/
/анафоретског таложења под константним напоном од 60 V током 180 s на 25 °C. Тес-
тови цитотоксичности су показали да није дошло до значајног смањења преживљавања
здравих MRC-5 ћелија код композита који не садржи ChOL, док је код оних са додатим
ChOL дошло до повећања броја одрживих ћелија. Резултати показују да је побољшана
пролиферација, диференцијација и одрживост ћелија у узорку са ChOL, што овај узорак
чини добрим кандидатом за примену у медицини и стоматологији.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition
T1  - Citotoksičnost multifunkcionalnih kompozitnih prevlaka od amorfnog kalcijum-fosfata na titanu dobijenih in sity anodizacijom/anaforetskim taloženjem
VL  - 86
IS  - 6
SP  - 555
EP  - 559
DO  - 10.2298/JSC210211024P
ER  - 
@article{
author = "Pantović Pavlović, Marijana and Pavlović, Miroslav M. and Kovačina, Jovanka and Stanojević, Boris P. and Stevanović, Jasmina S. and Panić, Vladimir and Ignjatović, Nenad L.",
year = "2021",
abstract = "The cytotoxicity of amorphous calcium phosphate (ACP) and chitosan lactate (ChOL) multifunctional and hybrid composite coatings on MRC-5 human lung fibroblast cell line was elucidated. ACP/TiO2 and ACP/TiO2/ /ChOL were deposited onto Ti by a novel in situ anodization/anaphoretic process at constant voltage. Cytotoxicity tests showed that there was no significant decrease in the survival of healthy MRC-5 cells exposed to composite samples without chitosan lactate, while there was an increase in the number of viable cells in the sample containing ChOL. These findings show that there was improved cell proliferation, differentiation and cell viability in the ChOL-containing sample, which makes ACP/TiO2/ChOL coating a good candidate for applications in medicine and stomatology., Приказани су резултати испитивања цитотоксичности мултифункционалних и хиб-
ридних композитних превлака на бази аморфног калцијум-фосфата (ACP) и хитозан-
-олиголактата (ChOL) на титану према MRC-5 ћелијској линији хуманих фибробласта
плућа. ACP/TiO2 и ACP/TiO2/ChOL су исталожени новим in situ поступком анодизације/
/анафоретског таложења под константним напоном од 60 V током 180 s на 25 °C. Тес-
тови цитотоксичности су показали да није дошло до значајног смањења преживљавања
здравих MRC-5 ћелија код композита који не садржи ChOL, док је код оних са додатим
ChOL дошло до повећања броја одрживих ћелија. Резултати показују да је побољшана
пролиферација, диференцијација и одрживост ћелија у узорку са ChOL, што овај узорак
чини добрим кандидатом за примену у медицини и стоматологији.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition, Citotoksičnost multifunkcionalnih kompozitnih prevlaka od amorfnog kalcijum-fosfata na titanu dobijenih in sity anodizacijom/anaforetskim taloženjem",
volume = "86",
number = "6",
pages = "555-559",
doi = "10.2298/JSC210211024P"
}
Pantović Pavlović, M., Pavlović, M. M., Kovačina, J., Stanojević, B. P., Stevanović, J. S., Panić, V.,& Ignjatović, N. L.. (2021). Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 86(6), 555-559.
https://doi.org/10.2298/JSC210211024P
Pantović Pavlović M, Pavlović MM, Kovačina J, Stanojević BP, Stevanović JS, Panić V, Ignjatović NL. Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition. in Journal of the Serbian Chemical Society. 2021;86(6):555-559.
doi:10.2298/JSC210211024P .
Pantović Pavlović, Marijana, Pavlović, Miroslav M., Kovačina, Jovanka, Stanojević, Boris P., Stevanović, Jasmina S., Panić, Vladimir, Ignjatović, Nenad L., "Cytotoxicity of amorphous calcium phosphate multifunctional composite coatings on titanium obtained by in situ anodization/anaphoretic deposition" in Journal of the Serbian Chemical Society, 86, no. 6 (2021):555-559,
https://doi.org/10.2298/JSC210211024P . .
3
1
5

Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate

Pantović Pavlović, Marijana; Pavlović, Miroslav M.; Eraković, Sanja; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(Elsevier, 2020)

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Pavlović, Miroslav M.
AU  - Eraković, Sanja
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2020
UR  - http://www.sciencedirect.com/science/article/pii/S0167577X19317537
UR  - http://dais.sanu.ac.rs/123456789/6914
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3321
AB  - In this paper novel in situ one-step simultaneous anaphoretic deposition process of amorphous calcium phosphate (ACP) and titanium oxide (TiOx) with and without chitosan oligosaccharide lactate (ChOL) on titanium substrate was performed. The coatings were investigated by SEM, XRD and FTIR techniques, whereas roughness and adhesion were measured. It was shown that novel process occurs, with improved coatings adhesion and excellent coverage of the surface. At 90 V the surface is smoother, and there is possibility for crystallization of the components at prolonged deposition times.
PB  - Elsevier
T2  - Materials Letters
T1  - Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate
VL  - 261
SP  - 127121
DO  - 10.1016/j.matlet.2019.127121
ER  - 
@article{
author = "Pantović Pavlović, Marijana and Pavlović, Miroslav M. and Eraković, Sanja and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2020",
abstract = "In this paper novel in situ one-step simultaneous anaphoretic deposition process of amorphous calcium phosphate (ACP) and titanium oxide (TiOx) with and without chitosan oligosaccharide lactate (ChOL) on titanium substrate was performed. The coatings were investigated by SEM, XRD and FTIR techniques, whereas roughness and adhesion were measured. It was shown that novel process occurs, with improved coatings adhesion and excellent coverage of the surface. At 90 V the surface is smoother, and there is possibility for crystallization of the components at prolonged deposition times.",
publisher = "Elsevier",
journal = "Materials Letters",
title = "Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate",
volume = "261",
pages = "127121",
doi = "10.1016/j.matlet.2019.127121"
}
Pantović Pavlović, M., Pavlović, M. M., Eraković, S., Stevanović, J., Panić, V.,& Ignjatović, N.. (2020). Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate. in Materials Letters
Elsevier., 261, 127121.
https://doi.org/10.1016/j.matlet.2019.127121
Pantović Pavlović M, Pavlović MM, Eraković S, Stevanović J, Panić V, Ignjatović N. Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate. in Materials Letters. 2020;261:127121.
doi:10.1016/j.matlet.2019.127121 .
Pantović Pavlović, Marijana, Pavlović, Miroslav M., Eraković, Sanja, Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate" in Materials Letters, 261 (2020):127121,
https://doi.org/10.1016/j.matlet.2019.127121 . .
12
4
14

Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate

Pantović Pavlović, Marijana; Pavlović, Miroslav M.; Eraković, Sanja; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(Elsevier, 2020)

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Pavlović, Miroslav M.
AU  - Eraković, Sanja
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2020
UR  - http://www.sciencedirect.com/science/article/pii/S0167577X19317537
UR  - http://dais.sanu.ac.rs/123456789/6915
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3322
AB  - In this paper novel in situ one-step simultaneous anaphoretic deposition process of amorphous calcium phosphate (ACP) and titanium oxide (TiOx) with and without chitosan oligosaccharide lactate (ChOL) on titanium substrate was performed. The coatings were investigated by SEM, XRD and FTIR techniques, whereas roughness and adhesion were measured. It was shown that novel process occurs, with improved coatings adhesion and excellent coverage of the surface. At 90 V the surface is smoother, and there is possibility for crystallization of the components at prolonged deposition times.
PB  - Elsevier
T2  - Materials Letters
T1  - Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate
VL  - 261
SP  - 127121
DO  - 10.1016/j.matlet.2019.127121
ER  - 
@article{
author = "Pantović Pavlović, Marijana and Pavlović, Miroslav M. and Eraković, Sanja and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2020",
abstract = "In this paper novel in situ one-step simultaneous anaphoretic deposition process of amorphous calcium phosphate (ACP) and titanium oxide (TiOx) with and without chitosan oligosaccharide lactate (ChOL) on titanium substrate was performed. The coatings were investigated by SEM, XRD and FTIR techniques, whereas roughness and adhesion were measured. It was shown that novel process occurs, with improved coatings adhesion and excellent coverage of the surface. At 90 V the surface is smoother, and there is possibility for crystallization of the components at prolonged deposition times.",
publisher = "Elsevier",
journal = "Materials Letters",
title = "Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate",
volume = "261",
pages = "127121",
doi = "10.1016/j.matlet.2019.127121"
}
Pantović Pavlović, M., Pavlović, M. M., Eraković, S., Stevanović, J., Panić, V.,& Ignjatović, N.. (2020). Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate. in Materials Letters
Elsevier., 261, 127121.
https://doi.org/10.1016/j.matlet.2019.127121
Pantović Pavlović M, Pavlović MM, Eraković S, Stevanović J, Panić V, Ignjatović N. Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate. in Materials Letters. 2020;261:127121.
doi:10.1016/j.matlet.2019.127121 .
Pantović Pavlović, Marijana, Pavlović, Miroslav M., Eraković, Sanja, Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Simultaneous anodization/anaphoretic electrodeposition synthesis of nano calcium phosphate/titanium oxide composite coatings assisted with chitosan oligosaccharide lactate" in Materials Letters, 261 (2020):127121,
https://doi.org/10.1016/j.matlet.2019.127121 . .
12
4
14

Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium

Pantović Pavlović, Marijana; Eraković, Sanja; Pavlović, Miroslav M.; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(Elsevier, 2019)

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Eraković, Sanja
AU  - Pavlović, Miroslav M.
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2496
AB  - In-situ synthesis of HAp/TiO2 coating on titanium was performed via anaphoretic deposition of HAp and simultaneous anodization of Ti to produce highly adherent and strengthened composite coating. The prepared coatings were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and electron dispersive spectroscopy. HAp on anodized titanium was prepared at constant voltage of 60 V and deposition time of 45 s, which provided uniform and adherent HAp/TiO2 composite coating on Ti. Since smaller size of HAp crystals within highly porous coating structures is of improved binding ability to various biomolecules, our coating is expected to be of excellent coverage and compactness. The obtained coating can be good candidate for bone implants due to reduced brittleness and improved adhesion.
PB  - Elsevier
T2  - Surface and Coatings Technology
T1  - Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium
VL  - 358
SP  - 688
EP  - 694
DO  - 10.1016/j.surfcoat.2018.12.003
ER  - 
@article{
author = "Pantović Pavlović, Marijana and Eraković, Sanja and Pavlović, Miroslav M. and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2019",
abstract = "In-situ synthesis of HAp/TiO2 coating on titanium was performed via anaphoretic deposition of HAp and simultaneous anodization of Ti to produce highly adherent and strengthened composite coating. The prepared coatings were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and electron dispersive spectroscopy. HAp on anodized titanium was prepared at constant voltage of 60 V and deposition time of 45 s, which provided uniform and adherent HAp/TiO2 composite coating on Ti. Since smaller size of HAp crystals within highly porous coating structures is of improved binding ability to various biomolecules, our coating is expected to be of excellent coverage and compactness. The obtained coating can be good candidate for bone implants due to reduced brittleness and improved adhesion.",
publisher = "Elsevier",
journal = "Surface and Coatings Technology",
title = "Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium",
volume = "358",
pages = "688-694",
doi = "10.1016/j.surfcoat.2018.12.003"
}
Pantović Pavlović, M., Eraković, S., Pavlović, M. M., Stevanović, J., Panić, V.,& Ignjatović, N.. (2019). Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium. in Surface and Coatings Technology
Elsevier., 358, 688-694.
https://doi.org/10.1016/j.surfcoat.2018.12.003
Pantović Pavlović M, Eraković S, Pavlović MM, Stevanović J, Panić V, Ignjatović N. Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium. in Surface and Coatings Technology. 2019;358:688-694.
doi:10.1016/j.surfcoat.2018.12.003 .
Pantović Pavlović, Marijana, Eraković, Sanja, Pavlović, Miroslav M., Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium" in Surface and Coatings Technology, 358 (2019):688-694,
https://doi.org/10.1016/j.surfcoat.2018.12.003 . .
15
8
18

Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium

Pantović Pavlović, Marijana; Eraković, Sanja; Pavlović, Miroslav M.; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(Elsevier, 2019)

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Eraković, Sanja
AU  - Pavlović, Miroslav M.
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2019
UR  - http://www.sciencedirect.com/science/article/pii/S0257897218313148
UR  - http://dais.sanu.ac.rs/123456789/4556
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2609
AB  - In-situ synthesis of HAp/TiO2 coating on titanium was performed via anaphoretic deposition of HAp and simultaneous anodization of Ti to produce highly adherent and strengthened composite coating. The prepared coatings were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and electron dispersive spectroscopy. HAp on anodized titanium was prepared at constant voltage of 60 V and deposition time of 45 s, which provided uniform and adherent HAp/TiO2 composite coating on Ti. Since smaller size of HAp crystals within highly porous coating structures is of improved binding ability to various biomolecules, our coating is expected to be of excellent coverage and compactness. The obtained coating can be good candidate for bone implants due to reduced brittleness and improved adhesion.
PB  - Elsevier
T2  - Surface and Coatings Technology
T1  - Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium
VL  - 358
SP  - 688
EP  - 694
DO  - 10.1016/j.surfcoat.2018.12.003
ER  - 
@article{
author = "Pantović Pavlović, Marijana and Eraković, Sanja and Pavlović, Miroslav M. and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2019",
abstract = "In-situ synthesis of HAp/TiO2 coating on titanium was performed via anaphoretic deposition of HAp and simultaneous anodization of Ti to produce highly adherent and strengthened composite coating. The prepared coatings were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and electron dispersive spectroscopy. HAp on anodized titanium was prepared at constant voltage of 60 V and deposition time of 45 s, which provided uniform and adherent HAp/TiO2 composite coating on Ti. Since smaller size of HAp crystals within highly porous coating structures is of improved binding ability to various biomolecules, our coating is expected to be of excellent coverage and compactness. The obtained coating can be good candidate for bone implants due to reduced brittleness and improved adhesion.",
publisher = "Elsevier",
journal = "Surface and Coatings Technology",
title = "Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium",
volume = "358",
pages = "688-694",
doi = "10.1016/j.surfcoat.2018.12.003"
}
Pantović Pavlović, M., Eraković, S., Pavlović, M. M., Stevanović, J., Panić, V.,& Ignjatović, N.. (2019). Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium. in Surface and Coatings Technology
Elsevier., 358, 688-694.
https://doi.org/10.1016/j.surfcoat.2018.12.003
Pantović Pavlović M, Eraković S, Pavlović MM, Stevanović J, Panić V, Ignjatović N. Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium. in Surface and Coatings Technology. 2019;358:688-694.
doi:10.1016/j.surfcoat.2018.12.003 .
Pantović Pavlović, Marijana, Eraković, Sanja, Pavlović, Miroslav M., Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Anaphoretical/oxidative approach to the in-situ synthesis of adherent hydroxyapatite/titanium oxide composite coatings on titanium" in Surface and Coatings Technology, 358 (2019):688-694,
https://doi.org/10.1016/j.surfcoat.2018.12.003 . .
15
8
18

Relationship between the properties of an interlayer formed by in situ Ti anodization and anaphoretically deposited hydroxyapatite

Pantović Pavlović, Marijana; Pavlović, Miroslav M.; Eraković, Sanja; Barudžija, Tanja; Stevanović, Jasmina; Ignjatović, Nenad; Panić, Vladimir

(Belgrade : Serbian Chemical Society, 2019)

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Pavlović, Miroslav M.
AU  - Eraković, Sanja
AU  - Barudžija, Tanja
AU  - Stevanović, Jasmina
AU  - Ignjatović, Nenad
AU  - Panić, Vladimir
PY  - 2019
UR  - https://www.shd-pub.org.rs/index.php/JSCS/article/view/8524
UR  - http://dais.sanu.ac.rs/123456789/6916
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3327
AB  - The optimization of the anodization process of Ti substrate for in situ synthesis of hydroxyapatite/titanium oxide composite coatings on titanium substrate was accomplished. The anodization was performed under 30, 60 and 90 V cell voltage, and the morphology of treated surface, as well as linear and surface roughness, were analysed by field emission-scanning electron micro­scopy, atomic force microscopy and roughness tester. It was shown by linear and surface roughness analyses that titanium anodized under 60 V has the high­est roughness, whereas at 90 V the flattening of the surface occurs. As the highest surface roughness results emerged at 60 V, the novel process of com­po­site anHAp/TiO2 coating synthesis, which comprises simultaneous processes of TiO2 formation and HAp deposition, as well as HAp impregnation within TiO2 surface layer, was performed at this voltage. Ti substrate surface was completely covered by composite coating, with no visible cracks. The adhesion quantified according to ASTM D3359-02 standard is considerably improved with respect to the coatings obtained by cathaphoretic processes, with no need of subsequent sintering.
AB  - Процесом анодизације титанског супстрата у циљу накнадне in-situ анафортеске синтезе композитних превлака хидроксиапатит/титан-оксид формиран је оксидни слој на титанској подлози. Анодизација је рађена на напонима на ћелији од 30, 60 и 90 V, а
испитивани су морфологија третиране површине, као и линеарна и површинска храпавост, помоћу FE-SEM, AFM и тестера храпавости, редом. Анализом линеарне и површинске храпавости показано је да титан анодизован на 60 V има највећу храпавост, док при анодизацији на 90 V долази до равнања површине. Како је највећа храпавост површине добијена при анодизацији на 60 V, нови процес композитне синтезе anHAp/TiO2 превлака, који се састоји од истовремених процеса формирања TiO2, анафоретског таложења HAp и уградње HAp у ТiО2 матрицу, изведен је при овом напону. Површин титанске подлоге је била потпуно покривена композитном превлаком, без видљивих
пукотина, док је адхезија, квантификована ASTM D3359-02 стандардом, знатно побољшана у поређењу са истим превлакама добијеним катафоретским процесима, чак и без накнадног синтеровања превлаке.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Relationship between the properties of an interlayer formed by in situ Ti anodization and anaphoretically deposited hydroxyapatite
T1  - Својства међуслоја насталог Ti анодизацијом и in-situ анафоретски исталоженог хидроксиапатита
VL  - 84
IS  - 11
SP  - 1305
EP  - 1318
DO  - 10.2298/JSC190730105P
ER  - 
@article{
author = "Pantović Pavlović, Marijana and Pavlović, Miroslav M. and Eraković, Sanja and Barudžija, Tanja and Stevanović, Jasmina and Ignjatović, Nenad and Panić, Vladimir",
year = "2019",
abstract = "The optimization of the anodization process of Ti substrate for in situ synthesis of hydroxyapatite/titanium oxide composite coatings on titanium substrate was accomplished. The anodization was performed under 30, 60 and 90 V cell voltage, and the morphology of treated surface, as well as linear and surface roughness, were analysed by field emission-scanning electron micro­scopy, atomic force microscopy and roughness tester. It was shown by linear and surface roughness analyses that titanium anodized under 60 V has the high­est roughness, whereas at 90 V the flattening of the surface occurs. As the highest surface roughness results emerged at 60 V, the novel process of com­po­site anHAp/TiO2 coating synthesis, which comprises simultaneous processes of TiO2 formation and HAp deposition, as well as HAp impregnation within TiO2 surface layer, was performed at this voltage. Ti substrate surface was completely covered by composite coating, with no visible cracks. The adhesion quantified according to ASTM D3359-02 standard is considerably improved with respect to the coatings obtained by cathaphoretic processes, with no need of subsequent sintering., Процесом анодизације титанског супстрата у циљу накнадне in-situ анафортеске синтезе композитних превлака хидроксиапатит/титан-оксид формиран је оксидни слој на титанској подлози. Анодизација је рађена на напонима на ћелији од 30, 60 и 90 V, а
испитивани су морфологија третиране површине, као и линеарна и површинска храпавост, помоћу FE-SEM, AFM и тестера храпавости, редом. Анализом линеарне и површинске храпавости показано је да титан анодизован на 60 V има највећу храпавост, док при анодизацији на 90 V долази до равнања површине. Како је највећа храпавост површине добијена при анодизацији на 60 V, нови процес композитне синтезе anHAp/TiO2 превлака, који се састоји од истовремених процеса формирања TiO2, анафоретског таложења HAp и уградње HAp у ТiО2 матрицу, изведен је при овом напону. Површин титанске подлоге је била потпуно покривена композитном превлаком, без видљивих
пукотина, док је адхезија, квантификована ASTM D3359-02 стандардом, знатно побољшана у поређењу са истим превлакама добијеним катафоретским процесима, чак и без накнадног синтеровања превлаке.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Relationship between the properties of an interlayer formed by in situ Ti anodization and anaphoretically deposited hydroxyapatite, Својства међуслоја насталог Ti анодизацијом и in-situ анафоретски исталоженог хидроксиапатита",
volume = "84",
number = "11",
pages = "1305-1318",
doi = "10.2298/JSC190730105P"
}
Pantović Pavlović, M., Pavlović, M. M., Eraković, S., Barudžija, T., Stevanović, J., Ignjatović, N.,& Panić, V.. (2019). Relationship between the properties of an interlayer formed by in situ Ti anodization and anaphoretically deposited hydroxyapatite. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 84(11), 1305-1318.
https://doi.org/10.2298/JSC190730105P
Pantović Pavlović M, Pavlović MM, Eraković S, Barudžija T, Stevanović J, Ignjatović N, Panić V. Relationship between the properties of an interlayer formed by in situ Ti anodization and anaphoretically deposited hydroxyapatite. in Journal of the Serbian Chemical Society. 2019;84(11):1305-1318.
doi:10.2298/JSC190730105P .
Pantović Pavlović, Marijana, Pavlović, Miroslav M., Eraković, Sanja, Barudžija, Tanja, Stevanović, Jasmina, Ignjatović, Nenad, Panić, Vladimir, "Relationship between the properties of an interlayer formed by in situ Ti anodization and anaphoretically deposited hydroxyapatite" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1305-1318,
https://doi.org/10.2298/JSC190730105P . .
3
3
6

Influence of process parameters of simultaneous anodization/anaphoretic electrodeposition synthesis of hydroxyapatite/titanium oxide composite coatings on adhesion

Pantović Pavlović, Marijana; Pavlović, Miroslav M.; Eraković, Sanja; Stevanović, Jasmina; Ignjatović, Nenad; Panić, Vladimir

(Padova : Societa chimica italiana, Divisione di Elettrochimica, 2019)

TY  - CONF
AU  - Pantović Pavlović, Marijana
AU  - Pavlović, Miroslav M.
AU  - Eraković, Sanja
AU  - Stevanović, Jasmina
AU  - Ignjatović, Nenad
AU  - Panić, Vladimir
PY  - 2019
UR  - http://dais.sanu.ac.rs/123456789/7008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3328
AB  - In-situ synthesis of hydroxyapatite/titanium oxide (HAp/TiO2) coating on titanium was performed via anaphoretic deposition of hydroxyapatite (HAp) and simultaneous anodization of Ti to produce highly adherent and strengthened composite coating. The influence of electric potential, time, electrolyte concentration and pH value of the anodization process on titanium surface roughness and anodization of titanium was examined, as well as influence of same process parameters on adhesion strength and compactness of composite HAp/TiO2 coatings was investigated. Prior to novel in situ method of synthesis of hydroxyapatite/titanium oxide composite coatings by simultaneous anodization/anaphoretic electrodeposition described in this manuscript, optimization of anodization process of titanium was performed. Anodization was executed under different electric potentials and different distances of counter electrodes from working electrodes, but all anodization processes had constant quantity of electric charge. Characterization of titanium samples, prepared from grade 6 Ti, and having rectangular contact surfaces of 10×10×0.89 mm included SEM/EDS analyses, X-ray diffraction analyses, AFM surface topography, morphology and roughness analyses and linear measurements of roughness.A chemical precipitation method was used to prepare hydroxyapatite powder by the reaction of calcium oxide (obtained by calcination of CaCO3 for 5 h at 1000 °C in air) and phosphoric acid. A stoichiometric amount of the calcium oxide was stirred in distilled water and phosphoric acid was added drop wise to the suspension in order to obtain hydroxyapatite powder, Ca10(PO4)6(OH)2.Two types of HAp coatings were prepared, in order to compare the adhesion, morphology and consistency of the HAp and composite HAp/TiO2 on Ti, namely cathaphoretic and anaphoretic coatings, respectively [1,2]. The prepared coatings were characterized by field emission scanning electron microscopy, X-ray diffraction and electron dispersive spectroscopy. Adhesion was investigated by ASTM D 3359 – 97 Test method B. Uniform and adherent HAp/TiO2 composite coating on Ti was obtained. Since smaller size of HAp crystals within highly porous coating structures is of improved binding ability to various biomolecules, our coating is expected to be of excellent coverage and compactness. The obtained coating can be good candidate for bone implants due to improved adhesion.
PB  - Padova : Societa chimica italiana, Divisione di Elettrochimica
C3  - Program and the Book of Abstracts / Giornate dell’Elettrochimica Italiana GEI 2019, 8-12 September 2019 Padova, Italy
T1  - Influence of process parameters of simultaneous anodization/anaphoretic electrodeposition synthesis of hydroxyapatite/titanium oxide composite coatings on adhesion
SP  - 124
EP  - 124
UR  - https://hdl.handle.net/21.15107/rcub_dais_7008
ER  - 
@conference{
author = "Pantović Pavlović, Marijana and Pavlović, Miroslav M. and Eraković, Sanja and Stevanović, Jasmina and Ignjatović, Nenad and Panić, Vladimir",
year = "2019",
abstract = "In-situ synthesis of hydroxyapatite/titanium oxide (HAp/TiO2) coating on titanium was performed via anaphoretic deposition of hydroxyapatite (HAp) and simultaneous anodization of Ti to produce highly adherent and strengthened composite coating. The influence of electric potential, time, electrolyte concentration and pH value of the anodization process on titanium surface roughness and anodization of titanium was examined, as well as influence of same process parameters on adhesion strength and compactness of composite HAp/TiO2 coatings was investigated. Prior to novel in situ method of synthesis of hydroxyapatite/titanium oxide composite coatings by simultaneous anodization/anaphoretic electrodeposition described in this manuscript, optimization of anodization process of titanium was performed. Anodization was executed under different electric potentials and different distances of counter electrodes from working electrodes, but all anodization processes had constant quantity of electric charge. Characterization of titanium samples, prepared from grade 6 Ti, and having rectangular contact surfaces of 10×10×0.89 mm included SEM/EDS analyses, X-ray diffraction analyses, AFM surface topography, morphology and roughness analyses and linear measurements of roughness.A chemical precipitation method was used to prepare hydroxyapatite powder by the reaction of calcium oxide (obtained by calcination of CaCO3 for 5 h at 1000 °C in air) and phosphoric acid. A stoichiometric amount of the calcium oxide was stirred in distilled water and phosphoric acid was added drop wise to the suspension in order to obtain hydroxyapatite powder, Ca10(PO4)6(OH)2.Two types of HAp coatings were prepared, in order to compare the adhesion, morphology and consistency of the HAp and composite HAp/TiO2 on Ti, namely cathaphoretic and anaphoretic coatings, respectively [1,2]. The prepared coatings were characterized by field emission scanning electron microscopy, X-ray diffraction and electron dispersive spectroscopy. Adhesion was investigated by ASTM D 3359 – 97 Test method B. Uniform and adherent HAp/TiO2 composite coating on Ti was obtained. Since smaller size of HAp crystals within highly porous coating structures is of improved binding ability to various biomolecules, our coating is expected to be of excellent coverage and compactness. The obtained coating can be good candidate for bone implants due to improved adhesion.",
publisher = "Padova : Societa chimica italiana, Divisione di Elettrochimica",
journal = "Program and the Book of Abstracts / Giornate dell’Elettrochimica Italiana GEI 2019, 8-12 September 2019 Padova, Italy",
title = "Influence of process parameters of simultaneous anodization/anaphoretic electrodeposition synthesis of hydroxyapatite/titanium oxide composite coatings on adhesion",
pages = "124-124",
url = "https://hdl.handle.net/21.15107/rcub_dais_7008"
}
Pantović Pavlović, M., Pavlović, M. M., Eraković, S., Stevanović, J., Ignjatović, N.,& Panić, V.. (2019). Influence of process parameters of simultaneous anodization/anaphoretic electrodeposition synthesis of hydroxyapatite/titanium oxide composite coatings on adhesion. in Program and the Book of Abstracts / Giornate dell’Elettrochimica Italiana GEI 2019, 8-12 September 2019 Padova, Italy
Padova : Societa chimica italiana, Divisione di Elettrochimica., 124-124.
https://hdl.handle.net/21.15107/rcub_dais_7008
Pantović Pavlović M, Pavlović MM, Eraković S, Stevanović J, Ignjatović N, Panić V. Influence of process parameters of simultaneous anodization/anaphoretic electrodeposition synthesis of hydroxyapatite/titanium oxide composite coatings on adhesion. in Program and the Book of Abstracts / Giornate dell’Elettrochimica Italiana GEI 2019, 8-12 September 2019 Padova, Italy. 2019;:124-124.
https://hdl.handle.net/21.15107/rcub_dais_7008 .
Pantović Pavlović, Marijana, Pavlović, Miroslav M., Eraković, Sanja, Stevanović, Jasmina, Ignjatović, Nenad, Panić, Vladimir, "Influence of process parameters of simultaneous anodization/anaphoretic electrodeposition synthesis of hydroxyapatite/titanium oxide composite coatings on adhesion" in Program and the Book of Abstracts / Giornate dell’Elettrochimica Italiana GEI 2019, 8-12 September 2019 Padova, Italy (2019):124-124,
https://hdl.handle.net/21.15107/rcub_dais_7008 .

Novel in-situ synthesis of hydroxyapatite/titanium oxide composite coatings on titanium by simultaneous anodization/anaphoretic electrodeposition

Pantović Pavlović, Marijana; Pavlović, Miroslav M.; Eraković, Sanja; Veselinović, Ljiljana; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(Zvornik : Faculty of Technology, 2019)

TY  - CONF
AU  - Pantović Pavlović, Marijana
AU  - Pavlović, Miroslav M.
AU  - Eraković, Sanja
AU  - Veselinović, Ljiljana
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2019
UR  - http://dais.sanu.ac.rs/123456789/6226
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3331
AB  - In-situ synthesis of HAp/TiO2 coating on titanium was performed via anaphoretic deposition of HAp and simultaneous anodization of Ti to produce highly adherent and strengthened composite coating. The prepared coatings were characterized by field emission scanning electron microscopy, X-ray diffraction and electron dispersive spectroscopy. HAp on anodized titanium was prepared at constant voltage of 60 V and deposition time of 45 s, which provided uniform and adherent HAp/TiO2 composite coating on Ti. Since smaller size of HAp crystals within highly porous coating structures is of improved binding ability to various biomolecules, our coating is expected to be of excellent coverage and compactness. The obtained coating can be good candidate for bone implants due to reduced brittleness and improved adhesion.
PB  - Zvornik : Faculty of Technology
C3  - Proceedings / VI International Congress "Engineering, Ecology and Materials in the Processing Industry", Jahorina, March 11-13, 2019
T1  - Novel in-situ synthesis of hydroxyapatite/titanium oxide composite coatings on titanium by simultaneous anodization/anaphoretic electrodeposition
SP  - 630
EP  - 635
UR  - https://hdl.handle.net/21.15107/rcub_dais_6226
ER  - 
@conference{
author = "Pantović Pavlović, Marijana and Pavlović, Miroslav M. and Eraković, Sanja and Veselinović, Ljiljana and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2019",
abstract = "In-situ synthesis of HAp/TiO2 coating on titanium was performed via anaphoretic deposition of HAp and simultaneous anodization of Ti to produce highly adherent and strengthened composite coating. The prepared coatings were characterized by field emission scanning electron microscopy, X-ray diffraction and electron dispersive spectroscopy. HAp on anodized titanium was prepared at constant voltage of 60 V and deposition time of 45 s, which provided uniform and adherent HAp/TiO2 composite coating on Ti. Since smaller size of HAp crystals within highly porous coating structures is of improved binding ability to various biomolecules, our coating is expected to be of excellent coverage and compactness. The obtained coating can be good candidate for bone implants due to reduced brittleness and improved adhesion.",
publisher = "Zvornik : Faculty of Technology",
journal = "Proceedings / VI International Congress "Engineering, Ecology and Materials in the Processing Industry", Jahorina, March 11-13, 2019",
title = "Novel in-situ synthesis of hydroxyapatite/titanium oxide composite coatings on titanium by simultaneous anodization/anaphoretic electrodeposition",
pages = "630-635",
url = "https://hdl.handle.net/21.15107/rcub_dais_6226"
}
Pantović Pavlović, M., Pavlović, M. M., Eraković, S., Veselinović, L., Stevanović, J., Panić, V.,& Ignjatović, N.. (2019). Novel in-situ synthesis of hydroxyapatite/titanium oxide composite coatings on titanium by simultaneous anodization/anaphoretic electrodeposition. in Proceedings / VI International Congress "Engineering, Ecology and Materials in the Processing Industry", Jahorina, March 11-13, 2019
Zvornik : Faculty of Technology., 630-635.
https://hdl.handle.net/21.15107/rcub_dais_6226
Pantović Pavlović M, Pavlović MM, Eraković S, Veselinović L, Stevanović J, Panić V, Ignjatović N. Novel in-situ synthesis of hydroxyapatite/titanium oxide composite coatings on titanium by simultaneous anodization/anaphoretic electrodeposition. in Proceedings / VI International Congress "Engineering, Ecology and Materials in the Processing Industry", Jahorina, March 11-13, 2019. 2019;:630-635.
https://hdl.handle.net/21.15107/rcub_dais_6226 .
Pantović Pavlović, Marijana, Pavlović, Miroslav M., Eraković, Sanja, Veselinović, Ljiljana, Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Novel in-situ synthesis of hydroxyapatite/titanium oxide composite coatings on titanium by simultaneous anodization/anaphoretic electrodeposition" in Proceedings / VI International Congress "Engineering, Ecology and Materials in the Processing Industry", Jahorina, March 11-13, 2019 (2019):630-635,
https://hdl.handle.net/21.15107/rcub_dais_6226 .

In situ synthesis and characterization of hydroxyapatite/titanium oxide coatings derived by anodization and anaphoretic deposition

Pantović Pavlović, Marijana; Pavlović, Miroslav M.; Eraković, Sanja; Barudžija, Tanja; Stevanović, Jasmina; Ignjatović, Nenad; Panić, Vladimir

(Novi Sad : Faculty of Technology, 2019)

TY  - CONF
AU  - Pantović Pavlović, Marijana
AU  - Pavlović, Miroslav M.
AU  - Eraković, Sanja
AU  - Barudžija, Tanja
AU  - Stevanović, Jasmina
AU  - Ignjatović, Nenad
AU  - Panić, Vladimir
PY  - 2019
UR  - http://dais.sanu.ac.rs/123456789/6983
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3333
AB  - Titanium substrates were electrochemically treated by novel in-situ synthesis method to produce anaphoretic hydroxyapatite/titanium oxide (HAp/TiO2) coating. This synthesis method was performed via anaphoretic deposition of hydroxyapatite and simultaneous anodization of Ti in order to produce highly adherent and strengthened composite coating, where the influence of electric potential, time, electrolyte concentration and pH value of the anodization process on titanium surface roughness and adhesion strength of composite HAp/TiO2 coatings was examined. In situ synthesis was performed in different solutions containing different concentrations of NaOH, HAp and ethanol at different values of time and constant voltage. The effects of anodizing voltage on the morphology and bioactivity of the HAp coating and on the bonding strength between the HAp coating and the anodized substrates were investigated. A modified chemical precipitation method was used to prepare hydroxyapatite powder by the reaction of stoichiometric amount of calcium oxide and phosphoric acid. Prior to novel in situ synthesis of HAp/TiO2 composite coatings, optimization of anodization process of titanium was performed. Anodization was executed under different electric potentials and different distances of counter electrodes from working electrodes, but all experiments had constant quantity of electric charge. Results indicated that highly ordered amorphous TiO2 surface is formed on the Ti substrate after anodic oxidation. Characterization of titanium samples having rectangular contact surfaces of 10×10×0.89 mm included SEM/EDS analyses, X-ray diffraction analyses, AFM surface topography, morphology and roughness analyses and linear measurements of roughness. The prepared coatings were characterized by FE-SEM, XRD and EDS. Adhesion was investigated by ASTM D 3359–97 Test method B. Uniform and adherent HAp/TiO2 composite coating on Ti was obtained. The results of simulated body fluid immersing experiments suggest that obtained HAp coating exhibits promising bioactivity. The obtained coating can be good candidate for bone implants due to improved adhesion.
PB  - Novi Sad : Faculty of Technology
C3  - Programme and book of abstracts / 13th Conference for Young Scientists in Ceramics (CYSC-2017), October 16-19, 2019, Novi Sad
T1  - In situ synthesis and characterization of hydroxyapatite/titanium oxide coatings derived by anodization and anaphoretic deposition
SP  - 131
EP  - 131
UR  - https://hdl.handle.net/21.15107/rcub_dais_6983
ER  - 
@conference{
author = "Pantović Pavlović, Marijana and Pavlović, Miroslav M. and Eraković, Sanja and Barudžija, Tanja and Stevanović, Jasmina and Ignjatović, Nenad and Panić, Vladimir",
year = "2019",
abstract = "Titanium substrates were electrochemically treated by novel in-situ synthesis method to produce anaphoretic hydroxyapatite/titanium oxide (HAp/TiO2) coating. This synthesis method was performed via anaphoretic deposition of hydroxyapatite and simultaneous anodization of Ti in order to produce highly adherent and strengthened composite coating, where the influence of electric potential, time, electrolyte concentration and pH value of the anodization process on titanium surface roughness and adhesion strength of composite HAp/TiO2 coatings was examined. In situ synthesis was performed in different solutions containing different concentrations of NaOH, HAp and ethanol at different values of time and constant voltage. The effects of anodizing voltage on the morphology and bioactivity of the HAp coating and on the bonding strength between the HAp coating and the anodized substrates were investigated. A modified chemical precipitation method was used to prepare hydroxyapatite powder by the reaction of stoichiometric amount of calcium oxide and phosphoric acid. Prior to novel in situ synthesis of HAp/TiO2 composite coatings, optimization of anodization process of titanium was performed. Anodization was executed under different electric potentials and different distances of counter electrodes from working electrodes, but all experiments had constant quantity of electric charge. Results indicated that highly ordered amorphous TiO2 surface is formed on the Ti substrate after anodic oxidation. Characterization of titanium samples having rectangular contact surfaces of 10×10×0.89 mm included SEM/EDS analyses, X-ray diffraction analyses, AFM surface topography, morphology and roughness analyses and linear measurements of roughness. The prepared coatings were characterized by FE-SEM, XRD and EDS. Adhesion was investigated by ASTM D 3359–97 Test method B. Uniform and adherent HAp/TiO2 composite coating on Ti was obtained. The results of simulated body fluid immersing experiments suggest that obtained HAp coating exhibits promising bioactivity. The obtained coating can be good candidate for bone implants due to improved adhesion.",
publisher = "Novi Sad : Faculty of Technology",
journal = "Programme and book of abstracts / 13th Conference for Young Scientists in Ceramics (CYSC-2017), October 16-19, 2019, Novi Sad",
title = "In situ synthesis and characterization of hydroxyapatite/titanium oxide coatings derived by anodization and anaphoretic deposition",
pages = "131-131",
url = "https://hdl.handle.net/21.15107/rcub_dais_6983"
}
Pantović Pavlović, M., Pavlović, M. M., Eraković, S., Barudžija, T., Stevanović, J., Ignjatović, N.,& Panić, V.. (2019). In situ synthesis and characterization of hydroxyapatite/titanium oxide coatings derived by anodization and anaphoretic deposition. in Programme and book of abstracts / 13th Conference for Young Scientists in Ceramics (CYSC-2017), October 16-19, 2019, Novi Sad
Novi Sad : Faculty of Technology., 131-131.
https://hdl.handle.net/21.15107/rcub_dais_6983
Pantović Pavlović M, Pavlović MM, Eraković S, Barudžija T, Stevanović J, Ignjatović N, Panić V. In situ synthesis and characterization of hydroxyapatite/titanium oxide coatings derived by anodization and anaphoretic deposition. in Programme and book of abstracts / 13th Conference for Young Scientists in Ceramics (CYSC-2017), October 16-19, 2019, Novi Sad. 2019;:131-131.
https://hdl.handle.net/21.15107/rcub_dais_6983 .
Pantović Pavlović, Marijana, Pavlović, Miroslav M., Eraković, Sanja, Barudžija, Tanja, Stevanović, Jasmina, Ignjatović, Nenad, Panić, Vladimir, "In situ synthesis and characterization of hydroxyapatite/titanium oxide coatings derived by anodization and anaphoretic deposition" in Programme and book of abstracts / 13th Conference for Young Scientists in Ceramics (CYSC-2017), October 16-19, 2019, Novi Sad (2019):131-131,
https://hdl.handle.net/21.15107/rcub_dais_6983 .

Surface modification of titanium implants by adherent hydroxyapatite/titanium oxide composite coatings using novel in-situ synthesis

Pantović Pavlović, Marijana; Eraković, Sanja; Pavlović, Miroslav M.; Veselinović, Ljiljana; Stevanović, Jasmina; Panić, Vladimir; Ignjatović, Nenad

(International Association of Physical Chemists, 2019)

TY  - CONF
AU  - Pantović Pavlović, Marijana
AU  - Eraković, Sanja
AU  - Pavlović, Miroslav M.
AU  - Veselinović, Ljiljana
AU  - Stevanović, Jasmina
AU  - Panić, Vladimir
AU  - Ignjatović, Nenad
PY  - 2019
UR  - http://dais.sanu.ac.rs/123456789/6244
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3335
AB  - The medical devices based on titanium and its alloys are widely used in the repair and replacement of a degraded or inhibited func-tion of locomotor system [1]. Ti and its alloys exhibit high mechanical strength, good workability, resistant to corrosion and low cost. Although, they are widely used as orthopedic and dental implants their inability to interact with living tissue will inhibit their biological fixation and osseoin-tegration [2]. Therefore, to improve the hard-tissue compatibility of Ti various sur-face treatments have been developed for the inorganic coating formation [3]. The hyd-roxyapatite (HAp, Ca10(PO4)6(OH)2) with superior osteogenic activity is a competitive approach to make novel coatings for titanium implants applications. HAp is a calcium phosphate very similar to the inorganic part of the human bone and hard tissues both in morphology and compo-sition. Herein, in-situ synthesis of HAp/TiO2 coating on titanium was performed via ana-phoretic deposition of HAp and simulta-neous anodization of Ti to produce highly adherent and strengthened composite coating. It can be seen that morphology of Ti substrate of anHAP/TiO2 coating is of tubular shape, and tube formation occurs mainly due to competing processes of anodization and electrophoretic deposition of HAp. anHAp/TiO2 coating does not need sintering process, and simultaneous Ti anodization and HAp deposition occur, where HAp crystals incorporate in the anodized Ti surface. From the presented results it can be concluded that novel suggested process of in situ simultaneous anHAp/TiO2 deposition with Ti surface anodization gives much better results that cathaphoretic deposition regarding adhesion.
PB  - International Association of Physical Chemists
C3  - Book of abstracts / 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, Split, Croatia, May 27-30, 2019
T1  - Surface modification of titanium implants by adherent hydroxyapatite/titanium oxide composite coatings using novel in-situ synthesis
SP  - 120
EP  - 120
UR  - https://hdl.handle.net/21.15107/rcub_dais_6244
ER  - 
@conference{
author = "Pantović Pavlović, Marijana and Eraković, Sanja and Pavlović, Miroslav M. and Veselinović, Ljiljana and Stevanović, Jasmina and Panić, Vladimir and Ignjatović, Nenad",
year = "2019",
abstract = "The medical devices based on titanium and its alloys are widely used in the repair and replacement of a degraded or inhibited func-tion of locomotor system [1]. Ti and its alloys exhibit high mechanical strength, good workability, resistant to corrosion and low cost. Although, they are widely used as orthopedic and dental implants their inability to interact with living tissue will inhibit their biological fixation and osseoin-tegration [2]. Therefore, to improve the hard-tissue compatibility of Ti various sur-face treatments have been developed for the inorganic coating formation [3]. The hyd-roxyapatite (HAp, Ca10(PO4)6(OH)2) with superior osteogenic activity is a competitive approach to make novel coatings for titanium implants applications. HAp is a calcium phosphate very similar to the inorganic part of the human bone and hard tissues both in morphology and compo-sition. Herein, in-situ synthesis of HAp/TiO2 coating on titanium was performed via ana-phoretic deposition of HAp and simulta-neous anodization of Ti to produce highly adherent and strengthened composite coating. It can be seen that morphology of Ti substrate of anHAP/TiO2 coating is of tubular shape, and tube formation occurs mainly due to competing processes of anodization and electrophoretic deposition of HAp. anHAp/TiO2 coating does not need sintering process, and simultaneous Ti anodization and HAp deposition occur, where HAp crystals incorporate in the anodized Ti surface. From the presented results it can be concluded that novel suggested process of in situ simultaneous anHAp/TiO2 deposition with Ti surface anodization gives much better results that cathaphoretic deposition regarding adhesion.",
publisher = "International Association of Physical Chemists",
journal = "Book of abstracts / 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, Split, Croatia, May 27-30, 2019",
title = "Surface modification of titanium implants by adherent hydroxyapatite/titanium oxide composite coatings using novel in-situ synthesis",
pages = "120-120",
url = "https://hdl.handle.net/21.15107/rcub_dais_6244"
}
Pantović Pavlović, M., Eraković, S., Pavlović, M. M., Veselinović, L., Stevanović, J., Panić, V.,& Ignjatović, N.. (2019). Surface modification of titanium implants by adherent hydroxyapatite/titanium oxide composite coatings using novel in-situ synthesis. in Book of abstracts / 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, Split, Croatia, May 27-30, 2019
International Association of Physical Chemists., 120-120.
https://hdl.handle.net/21.15107/rcub_dais_6244
Pantović Pavlović M, Eraković S, Pavlović MM, Veselinović L, Stevanović J, Panić V, Ignjatović N. Surface modification of titanium implants by adherent hydroxyapatite/titanium oxide composite coatings using novel in-situ synthesis. in Book of abstracts / 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, Split, Croatia, May 27-30, 2019. 2019;:120-120.
https://hdl.handle.net/21.15107/rcub_dais_6244 .
Pantović Pavlović, Marijana, Eraković, Sanja, Pavlović, Miroslav M., Veselinović, Ljiljana, Stevanović, Jasmina, Panić, Vladimir, Ignjatović, Nenad, "Surface modification of titanium implants by adherent hydroxyapatite/titanium oxide composite coatings using novel in-situ synthesis" in Book of abstracts / 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, Split, Croatia, May 27-30, 2019 (2019):120-120,
https://hdl.handle.net/21.15107/rcub_dais_6244 .

Optimization of the preparation of novel polymer/clay nanocomposites

Marković, Bojana; Stefanović, Ivan; Popović, Aleksandar R.; Ignjatović, Nenad; Nastasović, Aleksandra

(Belgrade : Institute for Multidisciplinary Research, 2019)

TY  - CONF
AU  - Marković, Bojana
AU  - Stefanović, Ivan
AU  - Popović, Aleksandar R.
AU  - Ignjatović, Nenad
AU  - Nastasović, Aleksandra
PY  - 2019
UR  - http://dais.sanu.ac.rs/123456789/7007
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3325
AB  - Recent advances in material technologies have resulted in the preparation of novel polymer/clay composites with improved thermal, mechanical, optoelectronic/ magnetic properties and increased biodegradability [1]. In this study, six samples of poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (PGME) nanocomposites with organically-modified montmorillonite clay Cloisite 30B® (C30B), were prepared via suspension copolymerization. In order to obtain nanocomposites with fine spherical beads of regular shape and satisfying thermal stability the optimization of the synthesis conditions was performed. Firstly, the influence of the poly(N-vinyl pyrrolidone) (PVP) quantity in the aqueous phase was varied (1, 3 and 5 wt.%) at a constant stirring rate of 250 rpm and constant clay content C30B (10 wt.%). In the second phase of the optimization of the preparation, samples with a constant composition of the composite reaction mixture (5 wt.% PVP and 10 wt.% C30B) at a stirring rate of 250, 325 and 400 rpm, were prepared. According to the obtained results, it was concluded that the optimal conditions for preparation of these composites are 5 wt.% of PVP and 400 rpm. The prepared nanocomposites were characterized with Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA) in air. The structure of the prepared nanocomposites was confirmed with FTIR spectroscopy. According to the obtained SEM microphotographs the fine spherical beads, with desired size and homogeneous morphology, were prepared. Furthermore, SEM analysis was also showed that clay nanoparticles are homogeneously dispersed both inside surface and cross-section area. The incorporation of C30B clay increased the thermal stability of the prepared polymer/clay nanocomposites in comparison to the pure PGME copolymer.
PB  - Belgrade : Institute for Multidisciplinary Research
C3  - Programme and the Book of Abstracts / 5th Conference of The Serbian Society for Ceramic Materials, 5CSCS-2019, June 11-13, 2019, Belgrade, Serbia
T1  - Optimization of the preparation of novel polymer/clay nanocomposites
SP  - 114
EP  - 114
UR  - https://hdl.handle.net/21.15107/rcub_dais_7007
ER  - 
@conference{
author = "Marković, Bojana and Stefanović, Ivan and Popović, Aleksandar R. and Ignjatović, Nenad and Nastasović, Aleksandra",
year = "2019",
abstract = "Recent advances in material technologies have resulted in the preparation of novel polymer/clay composites with improved thermal, mechanical, optoelectronic/ magnetic properties and increased biodegradability [1]. In this study, six samples of poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (PGME) nanocomposites with organically-modified montmorillonite clay Cloisite 30B® (C30B), were prepared via suspension copolymerization. In order to obtain nanocomposites with fine spherical beads of regular shape and satisfying thermal stability the optimization of the synthesis conditions was performed. Firstly, the influence of the poly(N-vinyl pyrrolidone) (PVP) quantity in the aqueous phase was varied (1, 3 and 5 wt.%) at a constant stirring rate of 250 rpm and constant clay content C30B (10 wt.%). In the second phase of the optimization of the preparation, samples with a constant composition of the composite reaction mixture (5 wt.% PVP and 10 wt.% C30B) at a stirring rate of 250, 325 and 400 rpm, were prepared. According to the obtained results, it was concluded that the optimal conditions for preparation of these composites are 5 wt.% of PVP and 400 rpm. The prepared nanocomposites were characterized with Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA) in air. The structure of the prepared nanocomposites was confirmed with FTIR spectroscopy. According to the obtained SEM microphotographs the fine spherical beads, with desired size and homogeneous morphology, were prepared. Furthermore, SEM analysis was also showed that clay nanoparticles are homogeneously dispersed both inside surface and cross-section area. The incorporation of C30B clay increased the thermal stability of the prepared polymer/clay nanocomposites in comparison to the pure PGME copolymer.",
publisher = "Belgrade : Institute for Multidisciplinary Research",
journal = "Programme and the Book of Abstracts / 5th Conference of The Serbian Society for Ceramic Materials, 5CSCS-2019, June 11-13, 2019, Belgrade, Serbia",
title = "Optimization of the preparation of novel polymer/clay nanocomposites",
pages = "114-114",
url = "https://hdl.handle.net/21.15107/rcub_dais_7007"
}
Marković, B., Stefanović, I., Popović, A. R., Ignjatović, N.,& Nastasović, A.. (2019). Optimization of the preparation of novel polymer/clay nanocomposites. in Programme and the Book of Abstracts / 5th Conference of The Serbian Society for Ceramic Materials, 5CSCS-2019, June 11-13, 2019, Belgrade, Serbia
Belgrade : Institute for Multidisciplinary Research., 114-114.
https://hdl.handle.net/21.15107/rcub_dais_7007
Marković B, Stefanović I, Popović AR, Ignjatović N, Nastasović A. Optimization of the preparation of novel polymer/clay nanocomposites. in Programme and the Book of Abstracts / 5th Conference of The Serbian Society for Ceramic Materials, 5CSCS-2019, June 11-13, 2019, Belgrade, Serbia. 2019;:114-114.
https://hdl.handle.net/21.15107/rcub_dais_7007 .
Marković, Bojana, Stefanović, Ivan, Popović, Aleksandar R., Ignjatović, Nenad, Nastasović, Aleksandra, "Optimization of the preparation of novel polymer/clay nanocomposites" in Programme and the Book of Abstracts / 5th Conference of The Serbian Society for Ceramic Materials, 5CSCS-2019, June 11-13, 2019, Belgrade, Serbia (2019):114-114,
https://hdl.handle.net/21.15107/rcub_dais_7007 .

Influence of the Shape of Copper Powder Particles on the Crystal Structure and Some Decisive Characteristics of the Metal Powders

Avramović, Ljiljana; Maksimović, Vesna M.; Baščarević, Zvezdana; Ignjatović, Nenad; Bugarin, Mile; Marković, Radmila; Nikolić, Nebojša D.

(MDPI, 2019)

TY  - JOUR
AU  - Avramović, Ljiljana
AU  - Maksimović, Vesna M.
AU  - Baščarević, Zvezdana
AU  - Ignjatović, Nenad
AU  - Bugarin, Mile
AU  - Marković, Radmila
AU  - Nikolić, Nebojša D.
PY  - 2019
UR  - https://www.mdpi.com/2075-4701/9/1/56
UR  - http://dais.sanu.ac.rs/123456789/4770
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2608
AB  - Three different forms of Cu powder particles obtained by either galvanostatic electrolysis or a non-electrolytic method were analyzed by a scanning electron microscope (SEM), X-ray diffraction (XRD) and particle size distribution (PSD). Electrolytic procedures were performed under different hydrogen evolution conditions, leading to the formation of either 3D branched dendrites or disperse cauliflower-like particles. The third type of particles were compact agglomerates of the Cu grains, whose structural characteristics indicated that they were formed by a non-electrolytic method. Unlike the sharp tips that characterize the usual form of Cu dendrites, the ends of both the trunk and branches were globules in the formed dendrites, indicating that a novel type of Cu dendrites was formed in this investigation. Although the macro structures of the particles were extremely varied, they had very similar micro structures because they were constructed by spherical grains. The Cu crystallites were randomly oriented in the dendrites and compact agglomerates of the Cu grains, while the disperse cauliflower-like particles showed (220) and (311) preferred orientation. This indicates that the applied current density affects not only the morphology of the particles, but also their crystal structure. The best performance, defined by the largest specific surface area and the smallest particle size, was by the galvanostatically produced powder consisting of disperse cauliflower-like particles.
PB  - MDPI
T2  - Metals
T1  - Influence of the Shape of Copper Powder Particles on the Crystal Structure and Some Decisive Characteristics of the Metal Powders
VL  - 9
IS  - 1
SP  - 56
DO  - 10.3390/met9010056
ER  - 
@article{
author = "Avramović, Ljiljana and Maksimović, Vesna M. and Baščarević, Zvezdana and Ignjatović, Nenad and Bugarin, Mile and Marković, Radmila and Nikolić, Nebojša D.",
year = "2019",
abstract = "Three different forms of Cu powder particles obtained by either galvanostatic electrolysis or a non-electrolytic method were analyzed by a scanning electron microscope (SEM), X-ray diffraction (XRD) and particle size distribution (PSD). Electrolytic procedures were performed under different hydrogen evolution conditions, leading to the formation of either 3D branched dendrites or disperse cauliflower-like particles. The third type of particles were compact agglomerates of the Cu grains, whose structural characteristics indicated that they were formed by a non-electrolytic method. Unlike the sharp tips that characterize the usual form of Cu dendrites, the ends of both the trunk and branches were globules in the formed dendrites, indicating that a novel type of Cu dendrites was formed in this investigation. Although the macro structures of the particles were extremely varied, they had very similar micro structures because they were constructed by spherical grains. The Cu crystallites were randomly oriented in the dendrites and compact agglomerates of the Cu grains, while the disperse cauliflower-like particles showed (220) and (311) preferred orientation. This indicates that the applied current density affects not only the morphology of the particles, but also their crystal structure. The best performance, defined by the largest specific surface area and the smallest particle size, was by the galvanostatically produced powder consisting of disperse cauliflower-like particles.",
publisher = "MDPI",
journal = "Metals",
title = "Influence of the Shape of Copper Powder Particles on the Crystal Structure and Some Decisive Characteristics of the Metal Powders",
volume = "9",
number = "1",
pages = "56",
doi = "10.3390/met9010056"
}
Avramović, L., Maksimović, V. M., Baščarević, Z., Ignjatović, N., Bugarin, M., Marković, R.,& Nikolić, N. D.. (2019). Influence of the Shape of Copper Powder Particles on the Crystal Structure and Some Decisive Characteristics of the Metal Powders. in Metals
MDPI., 9(1), 56.
https://doi.org/10.3390/met9010056
Avramović L, Maksimović VM, Baščarević Z, Ignjatović N, Bugarin M, Marković R, Nikolić ND. Influence of the Shape of Copper Powder Particles on the Crystal Structure and Some Decisive Characteristics of the Metal Powders. in Metals. 2019;9(1):56.
doi:10.3390/met9010056 .
Avramović, Ljiljana, Maksimović, Vesna M., Baščarević, Zvezdana, Ignjatović, Nenad, Bugarin, Mile, Marković, Radmila, Nikolić, Nebojša D., "Influence of the Shape of Copper Powder Particles on the Crystal Structure and Some Decisive Characteristics of the Metal Powders" in Metals, 9, no. 1 (2019):56,
https://doi.org/10.3390/met9010056 . .
25
15
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Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions

Nikolić, Nebojša D.; Avramović, Ljiljana; Ivanović, Evica; Maksimović, Vesna M.; Baščarević, Zvezdana; Ignjatović, Nenad

(Elsevier, 2019)

TY  - JOUR
AU  - Nikolić, Nebojša D.
AU  - Avramović, Ljiljana
AU  - Ivanović, Evica
AU  - Maksimović, Vesna M.
AU  - Baščarević, Zvezdana
AU  - Ignjatović, Nenad
PY  - 2019
UR  - http://www.sciencedirect.com/science/article/pii/S100363261965034X
UR  - http://dais.sanu.ac.rs/123456789/6371
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3048
AB  - Production of copper powders by the potentiostatic electrolysis under different hydrogen evolution conditions was investigated. Copper powders were characterized by the scanning electron microscope (SEM), X-ray diffraction (XRD), particle size distribution (PSD), and by the determination of the specific surface area (SSA) of the formed powders. Depending on quantity of hydrogen generated during electrolysis, the two types of particles were formed: dendrites and cauliflower-like particles. The dendrites were formed without, while cauliflower-like particles with the quantity of evolved hydrogen enough to achieve strong effect on hydrodynamic conditions in the near-electrode layer. Although macro structure of the particles was very different, they showed similar micro structure. Namely, both types of the particles consisted of small agglomerates of approximately spherical Cu grains at the micro level. The existence of the spherical morphology was just responsible for random orientation of Cu crystallites in both types of particles. The SSA of cauliflower-like particles was more than two times larger than that of the dendrites, while their size was considerably smaller than that of the dendritic particles. In this way, the useful benefit of Cu powder formation in the conditions of vigorous hydrogen evolution is shown.
PB  - Elsevier
T2  - Transactions of Nonferrous Metals Society of China
T1  - Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions
VL  - 29
IS  - 6
SP  - 1275
EP  - 1284
DO  - 10.1016/S1003-6326(19)65034-X
ER  - 
@article{
author = "Nikolić, Nebojša D. and Avramović, Ljiljana and Ivanović, Evica and Maksimović, Vesna M. and Baščarević, Zvezdana and Ignjatović, Nenad",
year = "2019",
abstract = "Production of copper powders by the potentiostatic electrolysis under different hydrogen evolution conditions was investigated. Copper powders were characterized by the scanning electron microscope (SEM), X-ray diffraction (XRD), particle size distribution (PSD), and by the determination of the specific surface area (SSA) of the formed powders. Depending on quantity of hydrogen generated during electrolysis, the two types of particles were formed: dendrites and cauliflower-like particles. The dendrites were formed without, while cauliflower-like particles with the quantity of evolved hydrogen enough to achieve strong effect on hydrodynamic conditions in the near-electrode layer. Although macro structure of the particles was very different, they showed similar micro structure. Namely, both types of the particles consisted of small agglomerates of approximately spherical Cu grains at the micro level. The existence of the spherical morphology was just responsible for random orientation of Cu crystallites in both types of particles. The SSA of cauliflower-like particles was more than two times larger than that of the dendrites, while their size was considerably smaller than that of the dendritic particles. In this way, the useful benefit of Cu powder formation in the conditions of vigorous hydrogen evolution is shown.",
publisher = "Elsevier",
journal = "Transactions of Nonferrous Metals Society of China",
title = "Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions",
volume = "29",
number = "6",
pages = "1275-1284",
doi = "10.1016/S1003-6326(19)65034-X"
}
Nikolić, N. D., Avramović, L., Ivanović, E., Maksimović, V. M., Baščarević, Z.,& Ignjatović, N.. (2019). Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions. in Transactions of Nonferrous Metals Society of China
Elsevier., 29(6), 1275-1284.
https://doi.org/10.1016/S1003-6326(19)65034-X
Nikolić ND, Avramović L, Ivanović E, Maksimović VM, Baščarević Z, Ignjatović N. Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions. in Transactions of Nonferrous Metals Society of China. 2019;29(6):1275-1284.
doi:10.1016/S1003-6326(19)65034-X .
Nikolić, Nebojša D., Avramović, Ljiljana, Ivanović, Evica, Maksimović, Vesna M., Baščarević, Zvezdana, Ignjatović, Nenad, "Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions" in Transactions of Nonferrous Metals Society of China, 29, no. 6 (2019):1275-1284,
https://doi.org/10.1016/S1003-6326(19)65034-X . .
17
15
20

Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions

Nikolić, Nebojša D.; Avramović, Ljiljana; Ivanović, Evica; Maksimović, Vesna M.; Baščarević, Zvezdana; Ignjatović, Nenad

(Elsevier, 2019)

TY  - JOUR
AU  - Nikolić, Nebojša D.
AU  - Avramović, Ljiljana
AU  - Ivanović, Evica
AU  - Maksimović, Vesna M.
AU  - Baščarević, Zvezdana
AU  - Ignjatović, Nenad
PY  - 2019
UR  - http://www.sciencedirect.com/science/article/pii/S100363261965034X
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3049
AB  - Production of copper powders by the potentiostatic electrolysis under different hydrogen evolution conditions was investigated. Copper powders were characterized by the scanning electron microscope (SEM), X-ray diffraction (XRD), particle size distribution (PSD), and by the determination of the specific surface area (SSA) of the formed powders. Depending on quantity of hydrogen generated during electrolysis, the two types of particles were formed: dendrites and cauliflower-like particles. The dendrites were formed without, while cauliflower-like particles with the quantity of evolved hydrogen enough to achieve strong effect on hydrodynamic conditions in the near-electrode layer. Although macro structure of the particles was very different, they showed similar micro structure. Namely, both types of the particles consisted of small agglomerates of approximately spherical Cu grains at the micro level. The existence of the spherical morphology was just responsible for random orientation of Cu crystallites in both types of particles. The SSA of cauliflower-like particles was more than two times larger than that of the dendrites, while their size was considerably smaller than that of the dendritic particles. In this way, the useful benefit of Cu powder formation in the conditions of vigorous hydrogen evolution is shown.
PB  - Elsevier
T2  - Transactions of Nonferrous Metals Society of China
T1  - Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions
VL  - 29
IS  - 6
SP  - 1275
EP  - 1284
DO  - 10.1016/S1003-6326(19)65034-X
ER  - 
@article{
author = "Nikolić, Nebojša D. and Avramović, Ljiljana and Ivanović, Evica and Maksimović, Vesna M. and Baščarević, Zvezdana and Ignjatović, Nenad",
year = "2019",
abstract = "Production of copper powders by the potentiostatic electrolysis under different hydrogen evolution conditions was investigated. Copper powders were characterized by the scanning electron microscope (SEM), X-ray diffraction (XRD), particle size distribution (PSD), and by the determination of the specific surface area (SSA) of the formed powders. Depending on quantity of hydrogen generated during electrolysis, the two types of particles were formed: dendrites and cauliflower-like particles. The dendrites were formed without, while cauliflower-like particles with the quantity of evolved hydrogen enough to achieve strong effect on hydrodynamic conditions in the near-electrode layer. Although macro structure of the particles was very different, they showed similar micro structure. Namely, both types of the particles consisted of small agglomerates of approximately spherical Cu grains at the micro level. The existence of the spherical morphology was just responsible for random orientation of Cu crystallites in both types of particles. The SSA of cauliflower-like particles was more than two times larger than that of the dendrites, while their size was considerably smaller than that of the dendritic particles. In this way, the useful benefit of Cu powder formation in the conditions of vigorous hydrogen evolution is shown.",
publisher = "Elsevier",
journal = "Transactions of Nonferrous Metals Society of China",
title = "Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions",
volume = "29",
number = "6",
pages = "1275-1284",
doi = "10.1016/S1003-6326(19)65034-X"
}
Nikolić, N. D., Avramović, L., Ivanović, E., Maksimović, V. M., Baščarević, Z.,& Ignjatović, N.. (2019). Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions. in Transactions of Nonferrous Metals Society of China
Elsevier., 29(6), 1275-1284.
https://doi.org/10.1016/S1003-6326(19)65034-X
Nikolić ND, Avramović L, Ivanović E, Maksimović VM, Baščarević Z, Ignjatović N. Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions. in Transactions of Nonferrous Metals Society of China. 2019;29(6):1275-1284.
doi:10.1016/S1003-6326(19)65034-X .
Nikolić, Nebojša D., Avramović, Ljiljana, Ivanović, Evica, Maksimović, Vesna M., Baščarević, Zvezdana, Ignjatović, Nenad, "Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions" in Transactions of Nonferrous Metals Society of China, 29, no. 6 (2019):1275-1284,
https://doi.org/10.1016/S1003-6326(19)65034-X . .
17
15
19

Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells

Ignjatović, Nenad; Sakač, Marija; Kuzminac, Ivana; Kojić, Vesna V.; Marković, Smilja B.; Vasiljević-Radović, Dana; Wu, Victoria; Uskoković, Vuk; Uskoković, Dragan

(Royal Society of Chemistry, 2018)

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Sakač, Marija
AU  - Kuzminac, Ivana
AU  - Kojić, Vesna V.
AU  - Marković, Smilja B.
AU  - Vasiljević-Radović, Dana
AU  - Wu, Victoria
AU  - Uskoković, Vuk
AU  - Uskoković, Dragan
PY  - 2018
UR  - http://dais.sanu.ac.rs/123456789/4066
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3146
AB  - Low targeting efficiency and fast metabolism of antineoplastic drugs are hindrances to effective chemotherapies and there is an ongoing search for better drugs, but also better carriers. Steroid derivatives, 3β-hydroxy-16-hydroxymino-androst-5-en-17-one (A) and 3β,17β-dihydroxy-16-hydroxymino-androst-5-ene (B) as cancer growth inhibitors were chemically synthesized and captured in a carrier composed of hydroxyapatite (HAp) nanoparticles coated with chitosan oligosaccharide lactate (ChOLS). The only difference between the two derivatives is that A has a carbonyl group at the C17 position of the five-membered ring and B has a hydroxyl. This small difference in the structure resulted not only in different physicochemical properties of the A- and B-loaded HAp/ChOSL, but also in different biological activities. The morphology of drug-loaded HAp/ChOSL particles was spherical, but the size depended on the drug identity: d50 = 138 nm for A-loaded HAp/ChOSL and d50 = 223 nm for B-loaded HAp/ChOSL. Cell-selective toxicity was tested against human breast carcinoma (MCF7 and MDA-MB-231), human lung carcinoma (A549) and human lung fibroblasts (MRC-5). The small selectivity of pure derivatives A and B toward breast cancer cells became drastically increased when they were delivered using HAp/ChOSL particles. Whereas the ratio of the cytotoxicity imposed onto breast cancer cells and the cytotoxicity imposed onto healthy MRC-5 fibroblasts ranged from 1.5 to 1.7 for pure A and from 1.5 to 2.3 for pure derivative B depending on the concentration, it increased to 5.4 for A-loaded HAp/ChOSL and 5.1 for B-loaded HAp/ChOSL. FACS analysis demonstrated poor uptake of HAp/ChOSL particles by MCF7 cells, suggesting that the drug release occurs extracellularly. The augmented activity of the drugs was most likely due to sustained release, although the favorable positive charge of the carrier, allowing it to adhere to the negatively charged plasma membrane and release the drugs steadily and directly to the hydrophobic cell membrane milieu, was delineated as a possible complementary mechanism.
PB  - Royal Society of Chemistry
T2  - Journal of Materials Chemistry B
T1  - Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells
VL  - 6
SP  - 6957
EP  - 6968
DO  - 10.1039/C8TB01995A
ER  - 
@article{
author = "Ignjatović, Nenad and Sakač, Marija and Kuzminac, Ivana and Kojić, Vesna V. and Marković, Smilja B. and Vasiljević-Radović, Dana and Wu, Victoria and Uskoković, Vuk and Uskoković, Dragan",
year = "2018",
abstract = "Low targeting efficiency and fast metabolism of antineoplastic drugs are hindrances to effective chemotherapies and there is an ongoing search for better drugs, but also better carriers. Steroid derivatives, 3β-hydroxy-16-hydroxymino-androst-5-en-17-one (A) and 3β,17β-dihydroxy-16-hydroxymino-androst-5-ene (B) as cancer growth inhibitors were chemically synthesized and captured in a carrier composed of hydroxyapatite (HAp) nanoparticles coated with chitosan oligosaccharide lactate (ChOLS). The only difference between the two derivatives is that A has a carbonyl group at the C17 position of the five-membered ring and B has a hydroxyl. This small difference in the structure resulted not only in different physicochemical properties of the A- and B-loaded HAp/ChOSL, but also in different biological activities. The morphology of drug-loaded HAp/ChOSL particles was spherical, but the size depended on the drug identity: d50 = 138 nm for A-loaded HAp/ChOSL and d50 = 223 nm for B-loaded HAp/ChOSL. Cell-selective toxicity was tested against human breast carcinoma (MCF7 and MDA-MB-231), human lung carcinoma (A549) and human lung fibroblasts (MRC-5). The small selectivity of pure derivatives A and B toward breast cancer cells became drastically increased when they were delivered using HAp/ChOSL particles. Whereas the ratio of the cytotoxicity imposed onto breast cancer cells and the cytotoxicity imposed onto healthy MRC-5 fibroblasts ranged from 1.5 to 1.7 for pure A and from 1.5 to 2.3 for pure derivative B depending on the concentration, it increased to 5.4 for A-loaded HAp/ChOSL and 5.1 for B-loaded HAp/ChOSL. FACS analysis demonstrated poor uptake of HAp/ChOSL particles by MCF7 cells, suggesting that the drug release occurs extracellularly. The augmented activity of the drugs was most likely due to sustained release, although the favorable positive charge of the carrier, allowing it to adhere to the negatively charged plasma membrane and release the drugs steadily and directly to the hydrophobic cell membrane milieu, was delineated as a possible complementary mechanism.",
publisher = "Royal Society of Chemistry",
journal = "Journal of Materials Chemistry B",
title = "Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells",
volume = "6",
pages = "6957-6968",
doi = "10.1039/C8TB01995A"
}
Ignjatović, N., Sakač, M., Kuzminac, I., Kojić, V. V., Marković, S. B., Vasiljević-Radović, D., Wu, V., Uskoković, V.,& Uskoković, D.. (2018). Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells. in Journal of Materials Chemistry B
Royal Society of Chemistry., 6, 6957-6968.
https://doi.org/10.1039/C8TB01995A
Ignjatović N, Sakač M, Kuzminac I, Kojić VV, Marković SB, Vasiljević-Radović D, Wu V, Uskoković V, Uskoković D. Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells. in Journal of Materials Chemistry B. 2018;6:6957-6968.
doi:10.1039/C8TB01995A .
Ignjatović, Nenad, Sakač, Marija, Kuzminac, Ivana, Kojić, Vesna V., Marković, Smilja B., Vasiljević-Radović, Dana, Wu, Victoria, Uskoković, Vuk, Uskoković, Dragan, "Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells" in Journal of Materials Chemistry B, 6 (2018):6957-6968,
https://doi.org/10.1039/C8TB01995A . .
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