TY  - JOUR
AU  - Mitić, Dragana
AU  - Miodragović, Đenana
AU  - Sladić, Dušan
AU  - Vitnik, Željko
AU  - Miodragović, Zoran
AU  - Anđelković, Katarina
AU  - Radulović, Milanka
AU  - Juranić, Nenad
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/425
AB  - In this study, the first complexes of Zn(II) with the N-benzyloxycar- bonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1H-NMR, 13C-NMR and 2D-NMR spectroscopy. On the basis of the experimental data, tetrahedral geometry of the Zn(II) complexes was proposed. A very good agreement between the NMR and DFT calculated data was obtained. Investigation of antimicrobial activity of the newly synthesized complexes was also performed. It was established that [Zn(N-Boc-S-ala)2] was selective and acts only on Candida albicans.
AB  - U ovom radu su sintetizovani prvi kompleksi Zn(II) sa N-benziloksikarbonil-S-alaninato ligandom (N-Boc-S-ala). Kompleksi su okarakterisani elementalnom analizom, konduktometrijskim merenjem, IR, 1H-NMR, 13C-NMR i 2D-NMR spektroskopijom. Tetraedarska geometrija Zn(II) kompleksa pretpostavljena je na osnovu eksperimentalnih podataka. Dobijeno je veoma dobro slaganje između NMR i DFT podataka. Ispitivana je antimikrobna aktivnost novosintetizovanih kompleksa. Ustanovljeno je da je [Zn(N-Boc-S-ala)2] kompleks selektivan i da deluje samo na gljivu Candida albicans.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine
T1  - Sinteza, NMR i DFT proračunavanja i ispitivanje antimikrobne aktivnosti Zn(II) kompleksa sa N-benziloksikarbonil-S-alaninom
VL  - 73
IS  - 8-9
SP  - 815
EP  - 824
DO  - 10.2298/JSC0809815M
ER  - 

@article{
author = "Mitić, Dragana and Miodragović, Đenana and Sladić, Dušan and Vitnik, Željko and Miodragović, Zoran and Anđelković, Katarina and Radulović, Milanka and Juranić, Nenad",
year = "2008",
abstract = "In this study, the first complexes of Zn(II) with the N-benzyloxycar- bonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1H-NMR, 13C-NMR and 2D-NMR spectroscopy. On the basis of the experimental data, tetrahedral geometry of the Zn(II) complexes was proposed. A very good agreement between the NMR and DFT calculated data was obtained. Investigation of antimicrobial activity of the newly synthesized complexes was also performed. It was established that [Zn(N-Boc-S-ala)2] was selective and acts only on Candida albicans., U ovom radu su sintetizovani prvi kompleksi Zn(II) sa N-benziloksikarbonil-S-alaninato ligandom (N-Boc-S-ala). Kompleksi su okarakterisani elementalnom analizom, konduktometrijskim merenjem, IR, 1H-NMR, 13C-NMR i 2D-NMR spektroskopijom. Tetraedarska geometrija Zn(II) kompleksa pretpostavljena je na osnovu eksperimentalnih podataka. Dobijeno je veoma dobro slaganje između NMR i DFT podataka. Ispitivana je antimikrobna aktivnost novosintetizovanih kompleksa. Ustanovljeno je da je [Zn(N-Boc-S-ala)2] kompleks selektivan i da deluje samo na gljivu Candida albicans.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine, Sinteza, NMR i DFT proračunavanja i ispitivanje antimikrobne aktivnosti Zn(II) kompleksa sa N-benziloksikarbonil-S-alaninom",
volume = "73",
number = "8-9",
pages = "815-824",
doi = "10.2298/JSC0809815M"
}

Mitić, D., Miodragović, Đ., Sladić, D., Vitnik, Ž., Miodragović, Z., Anđelković, K., Radulović, M.,& Juranić, N.. (2008). Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 73(8-9), 815-824.
https://doi.org/10.2298/JSC0809815M

Mitić D, Miodragović Đ, Sladić D, Vitnik Ž, Miodragović Z, Anđelković K, Radulović M, Juranić N. Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine. in Journal of the Serbian Chemical Society. 2008;73(8-9):815-824.
doi:10.2298/JSC0809815M .

Mitić, Dragana, Miodragović, Đenana, Sladić, Dušan, Vitnik, Željko, Miodragović, Zoran, Anđelković, Katarina, Radulović, Milanka, Juranić, Nenad, "Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine" in Journal of the Serbian Chemical Society, 73, no. 8-9 (2008):815-824,
https://doi.org/10.2298/JSC0809815M . .

TY  - JOUR
AU  - Miodragović, Đenana
AU  - Bogdanović, Goran
AU  - Miodragović, Zoran
AU  - Radulović, Milanka
AU  - Novaković, Slađana
AU  - Kaluđerović, Goran N.
AU  - Kozlowski, Henryk
PY  - 2006
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4121
AB  - Crystal structure of a novel cobalt(III) complex with antiulcer drug famotidine and ethylenediamine was determined. This is the second structure of a transition metal complex with famotidine resolved by a single crystal X-ray analysis, in which famotidine shows different mode of coordination than that observed in the other cases. Drug molecule is coordinated to metal ion as a tetradentate ligand through guanidine N6, thiazole N4, thioether S2 and terminal N3 atom. Two NH 2 groups (N3H 2 and N6H 2 ) are deprotonated and drug coordinates as dianion. In the asymmetric unit, one chloride anion and one water molecule were found to complete the complex stoichiometry. The structure of the complex is abundant in atoms, which can be involved in hydrogen bond formation either as hydrogen acceptors or hydrogen donors. Because of that, a great number of hydrogen bonds dominates the crystal packing. Beside the hydrogen bonds, there are two interesting noncovalent interactions: CH ... π and NH ... π within the famotidine anion, which stabilize the complex structure. The π ... π stacking interactions between neighboring complex cations are also observed. Antibacterial and antifungal activity of famotidine and its newly synthesized complex against representative bacteria: Escherichia coli, Staphilococcus aureus and Micrococcus lysodeikticus and fungi: Aspergillus niger and Candida albicans were examined. The results indicate a higher selectivity of the famotidine-Co(III) complex, as well as better growth inhibitory activity (lower MIC values (MIC, minimal inhibitory concentration)) in comparison with the drug alone.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex
VL  - 100
IS  - 9
SP  - 1568
EP  - 1574
DO  - 10.1016/j.jinorgbio.2006.05.009
ER  - 

@article{
author = "Miodragović, Đenana and Bogdanović, Goran and Miodragović, Zoran and Radulović, Milanka and Novaković, Slađana and Kaluđerović, Goran N. and Kozlowski, Henryk",
year = "2006",
abstract = "Crystal structure of a novel cobalt(III) complex with antiulcer drug famotidine and ethylenediamine was determined. This is the second structure of a transition metal complex with famotidine resolved by a single crystal X-ray analysis, in which famotidine shows different mode of coordination than that observed in the other cases. Drug molecule is coordinated to metal ion as a tetradentate ligand through guanidine N6, thiazole N4, thioether S2 and terminal N3 atom. Two NH 2 groups (N3H 2 and N6H 2 ) are deprotonated and drug coordinates as dianion. In the asymmetric unit, one chloride anion and one water molecule were found to complete the complex stoichiometry. The structure of the complex is abundant in atoms, which can be involved in hydrogen bond formation either as hydrogen acceptors or hydrogen donors. Because of that, a great number of hydrogen bonds dominates the crystal packing. Beside the hydrogen bonds, there are two interesting noncovalent interactions: CH ... π and NH ... π within the famotidine anion, which stabilize the complex structure. The π ... π stacking interactions between neighboring complex cations are also observed. Antibacterial and antifungal activity of famotidine and its newly synthesized complex against representative bacteria: Escherichia coli, Staphilococcus aureus and Micrococcus lysodeikticus and fungi: Aspergillus niger and Candida albicans were examined. The results indicate a higher selectivity of the famotidine-Co(III) complex, as well as better growth inhibitory activity (lower MIC values (MIC, minimal inhibitory concentration)) in comparison with the drug alone.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex",
volume = "100",
number = "9",
pages = "1568-1574",
doi = "10.1016/j.jinorgbio.2006.05.009"
}

Miodragović, Đ., Bogdanović, G., Miodragović, Z., Radulović, M., Novaković, S., Kaluđerović, G. N.,& Kozlowski, H.. (2006). Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex. in Journal of Inorganic Biochemistry
Elsevier., 100(9), 1568-1574.
https://doi.org/10.1016/j.jinorgbio.2006.05.009

Miodragović Đ, Bogdanović G, Miodragović Z, Radulović M, Novaković S, Kaluđerović GN, Kozlowski H. Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex. in Journal of Inorganic Biochemistry. 2006;100(9):1568-1574.
doi:10.1016/j.jinorgbio.2006.05.009 .

Miodragović, Đenana, Bogdanović, Goran, Miodragović, Zoran, Radulović, Milanka, Novaković, Slađana, Kaluđerović, Goran N., Kozlowski, Henryk, "Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex" in Journal of Inorganic Biochemistry, 100, no. 9 (2006):1568-1574,
https://doi.org/10.1016/j.jinorgbio.2006.05.009 . .

TY  - JOUR
AU  - Miodragović, Đenana
AU  - Milosavljević, Slobodan
AU  - Malinar, Mijat J
AU  - Ćelap, Milenko B
AU  - Todorović, Nina
AU  - Juranić, Nenad
PY  - 2002
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3998
AB  - Rotamer population of S -tyrosinato and S -phenylalaninato ligands side groups in diastereomers of (1,2-diaminoethane) bis ( S -aminocarboxylato)cobalt(III) complexes is calculated by vicinal and proton coupling constant analysis. The effect of noncovalent intra- and interligand interactions on the population of rotamers in D 2 O solution is discussed. It has been established that in all the complexes investigated the most abundant is rotamer t , in which aromatic voluminous moiety and carboxylic group are in an anti position. In almost all complexes the lowest content is of rotamer g , in which these two groups are in the nearest position. Relatively high population of rotamer h in complex 5 tyr , in spite of high steric hindrances, is due to intra- and interligand NH interactions.
PB  - Taylor & Francis
T2  - Enantiomer
T1  - Mixed cobalt(III) complexes with aromatic amino acids and diamine. Part IV. Influence of noncovalent intraand interligand interactions on rotamer population of the S-phenylalaninato and S-tyrosinato side groups in (1,2-diaminoethane)bis(S-aminocarboxylato)cobalt(III) complexes
VL  - 7
IS  - 6
SP  - 375
EP  - 382
DO  - 10.1080/10242430215714
ER  - 

@article{
author = "Miodragović, Đenana and Milosavljević, Slobodan and Malinar, Mijat J and Ćelap, Milenko B and Todorović, Nina and Juranić, Nenad",
year = "2002",
abstract = "Rotamer population of S -tyrosinato and S -phenylalaninato ligands side groups in diastereomers of (1,2-diaminoethane) bis ( S -aminocarboxylato)cobalt(III) complexes is calculated by vicinal and proton coupling constant analysis. The effect of noncovalent intra- and interligand interactions on the population of rotamers in D 2 O solution is discussed. It has been established that in all the complexes investigated the most abundant is rotamer t , in which aromatic voluminous moiety and carboxylic group are in an anti position. In almost all complexes the lowest content is of rotamer g , in which these two groups are in the nearest position. Relatively high population of rotamer h in complex 5 tyr , in spite of high steric hindrances, is due to intra- and interligand NH interactions.",
publisher = "Taylor & Francis",
journal = "Enantiomer",
title = "Mixed cobalt(III) complexes with aromatic amino acids and diamine. Part IV. Influence of noncovalent intraand interligand interactions on rotamer population of the S-phenylalaninato and S-tyrosinato side groups in (1,2-diaminoethane)bis(S-aminocarboxylato)cobalt(III) complexes",
volume = "7",
number = "6",
pages = "375-382",
doi = "10.1080/10242430215714"
}

Miodragović, Đ., Milosavljević, S., Malinar, M. J., Ćelap, M. B., Todorović, N.,& Juranić, N.. (2002). Mixed cobalt(III) complexes with aromatic amino acids and diamine. Part IV. Influence of noncovalent intraand interligand interactions on rotamer population of the S-phenylalaninato and S-tyrosinato side groups in (1,2-diaminoethane)bis(S-aminocarboxylato)cobalt(III) complexes. in Enantiomer
Taylor & Francis., 7(6), 375-382.
https://doi.org/10.1080/10242430215714

Miodragović Đ, Milosavljević S, Malinar MJ, Ćelap MB, Todorović N, Juranić N. Mixed cobalt(III) complexes with aromatic amino acids and diamine. Part IV. Influence of noncovalent intraand interligand interactions on rotamer population of the S-phenylalaninato and S-tyrosinato side groups in (1,2-diaminoethane)bis(S-aminocarboxylato)cobalt(III) complexes. in Enantiomer. 2002;7(6):375-382.
doi:10.1080/10242430215714 .

Miodragović, Đenana, Milosavljević, Slobodan, Malinar, Mijat J, Ćelap, Milenko B, Todorović, Nina, Juranić, Nenad, "Mixed cobalt(III) complexes with aromatic amino acids and diamine. Part IV. Influence of noncovalent intraand interligand interactions on rotamer population of the S-phenylalaninato and S-tyrosinato side groups in (1,2-diaminoethane)bis(S-aminocarboxylato)cobalt(III) complexes" in Enantiomer, 7, no. 6 (2002):375-382,
https://doi.org/10.1080/10242430215714 . .