TY  - JOUR
AU  - Jokić, Ivana
AU  - Jakšić, Olga
AU  - Frantlović, Miloš
AU  - Jakšić, Zoran
AU  - Guha, Koushik
AU  - Rao, Karumuri Srinivasa
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4024
AB  - The importance of adsorption-based biochemical/biological sensors in biochemistry and biophysics is paramount. Their temporal response gives information about the presence of a biochemical/biological analyte, its concentration and its interactions with the adsorption sites (which may be an integral part of the surface itself or immobilized functionalizing molecules). Mathematical models of the temporal response taking into account as many relevant effects as possible are essential for obtaining reliable information. We present a novel model taking into account the bimodal affinity of a sensing surface (adsorption occurs on two distinct site types), and the adsorption-caused depletion of the analyte from the sample. We perform qualitative and quantitative analysis of the analyte depletion influence on the bimodal adsorption, and of the influence of the sensing surface inhomogeneity on the sensor temporal response, for different analyte concentrations and different fractions of two types of adsorption sites. Since the presented mathematical model deals with the realistic cases of the sensing surface non-uniformity and the finite amount of analyte present in the sensor reaction chamber, it enables improved accuracy in interpreting the measurement data. Our results are general, i.e. valid for any adsorption sensor (microcantilevers, plasmonics) and for arbitrary sensor dimensions.
PB  - Springer
T2  - Microsystem Technologies
T1  - Temporal response of biochemical and biological sensors with bimodal surface adsorption from a finite sample
DO  - 10.1007/s00542-020-05051-w
ER  - 

@article{
author = "Jokić, Ivana and Jakšić, Olga and Frantlović, Miloš and Jakšić, Zoran and Guha, Koushik and Rao, Karumuri Srinivasa",
year = "2020",
abstract = "The importance of adsorption-based biochemical/biological sensors in biochemistry and biophysics is paramount. Their temporal response gives information about the presence of a biochemical/biological analyte, its concentration and its interactions with the adsorption sites (which may be an integral part of the surface itself or immobilized functionalizing molecules). Mathematical models of the temporal response taking into account as many relevant effects as possible are essential for obtaining reliable information. We present a novel model taking into account the bimodal affinity of a sensing surface (adsorption occurs on two distinct site types), and the adsorption-caused depletion of the analyte from the sample. We perform qualitative and quantitative analysis of the analyte depletion influence on the bimodal adsorption, and of the influence of the sensing surface inhomogeneity on the sensor temporal response, for different analyte concentrations and different fractions of two types of adsorption sites. Since the presented mathematical model deals with the realistic cases of the sensing surface non-uniformity and the finite amount of analyte present in the sensor reaction chamber, it enables improved accuracy in interpreting the measurement data. Our results are general, i.e. valid for any adsorption sensor (microcantilevers, plasmonics) and for arbitrary sensor dimensions.",
publisher = "Springer",
journal = "Microsystem Technologies",
title = "Temporal response of biochemical and biological sensors with bimodal surface adsorption from a finite sample",
doi = "10.1007/s00542-020-05051-w"
}

Jokić, I., Jakšić, O., Frantlović, M., Jakšić, Z., Guha, K.,& Rao, K. S.. (2020). Temporal response of biochemical and biological sensors with bimodal surface adsorption from a finite sample. in Microsystem Technologies
Springer..
https://doi.org/10.1007/s00542-020-05051-w

Jokić I, Jakšić O, Frantlović M, Jakšić Z, Guha K, Rao KS. Temporal response of biochemical and biological sensors with bimodal surface adsorption from a finite sample. in Microsystem Technologies. 2020;.
doi:10.1007/s00542-020-05051-w .

Jokić, Ivana, Jakšić, Olga, Frantlović, Miloš, Jakšić, Zoran, Guha, Koushik, Rao, Karumuri Srinivasa, "Temporal response of biochemical and biological sensors with bimodal surface adsorption from a finite sample" in Microsystem Technologies (2020),
https://doi.org/10.1007/s00542-020-05051-w . .