@conference{
author = "Mudrinić, Tihana and Ignjatović, Aleksandar and Mojović, Zorica and Jovanović, Dušan and Mojović, Miloš and Bačić, Goran",
year = "2012",
abstract = "The diagnosis of amyotrophic lateral sclerosis (ALS) based on ALS functional rating score (ALSFRS) is often shown to be unreliable and false. On the other hand, it is a fact that MRI studies of a brain of ALS patients showthe presence of iron deposits in precentral gyruses of gray matter (PGGM), meaning that blood-brain barrier is compromised. Therefore, various studies have been performed with the goal to detect excess of iron in the cerebrospinal fluid (CSF) of ALS patients (e.g. EPR detection of •OH radicals as products of Fenton reaction after supplementation of H2O2 to the CSF). Unfortunately, no acceptable correlation could emerge, probably caused by the presence of a range of iron complexes in CSF. Therefore, a different approach to detect iron states in CFS is required. The aim of thisworkwas to determine if there is a specific feature in CSF that distinguishes patients with ALS from those with purely motor peripheral neuropathy (PN) and healthy control subjects. CSF obtained from ALS patients and normal controls were analyzed using the technique of cyclic voltammetry. The results show that, at potential of 1.1 - 1.2 V vs. Ag/AgCl electrode, for the ALS patients, the plateau appeared and the potential of oxygen evolutionwas shifted toward more positive values. These voltammogram features were not present for the control patients. The cyclic voltammetry is fast and inexpensive technique and showed to be promising candidate for evaluating new biomarkers for ALS.",
publisher = "Biophysical Society of Serbia",
journal = "Book of Abstracts - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia",
title = "Cyclic voltammetry in diagnosis of ALS",
pages = "75-75",
url = "https://hdl.handle.net/21.15107/rcub_cer_7016"
}