TY  - JOUR
AU  - Stanojević, A
AU  - Marković, V M
AU  - Maćešić, Stevan
AU  - Kolar-Anić, Ljiljana
AU  - Vukojević, V
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2920
AB  - The sex hormone testosterone (TTS) and the hypothalamic–pituitary–adrenal (HPA) axis mutually control one another’s activity, wherein TTS suppresses corticotrophin releasing hormone (CRH) stimulated HPA axis activity, whereas the activation of HPA axis has an inhibitory effect on TTS secretion. With an intention to explain these phenomena, a network reaction model is developed from the previously postulated stoichiometric models for HPA activity where main dynamic behaviors are controlled by two catalytic steps (one autocatalytic and one autoinhibitory) with respect to cortisol, both found experimentally. The capacity of the model to emulate TTS effects on HPA axis dynamics and its response to acute CRH-induced stress is examined using numerical simulations. Model predictions are compared with empirically obtained results reported in the literature. Thus, the reaction kinetic examinations of nonlinear biochemical transformations that constitute the HPA axis, including the negative feedback effect of TTS on HPA axis activity, recapitulates the well-established fact that TTS dampens HPA axis basal activity, decreasing both cortisol level and the amplitude of ultradian cortisol oscillations. The model also replicates TTS inhibitory action on the HPA axis response to acute environmental challenges, particularly CRH-induced stress. In addition, kinetic modelling revealed that TTS induced reduction in ultradian cortisol amplitude arises because the system moves towards a supercritical Hopf bifurcation as TTS is being increased. © 2017, The Author(s).
PB  - Springer Netherlands
T2  - Reaction Kinetics, Mechanisms and Catalysis
T1  - Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress
VL  - 123
IS  - 1
SP  - 17
EP  - 30
DO  - 10.1007/s11144-017-1315-7
ER  - 

@article{
author = "Stanojević, A and Marković, V M and Maćešić, Stevan and Kolar-Anić, Ljiljana and Vukojević, V",
year = "2018",
abstract = "The sex hormone testosterone (TTS) and the hypothalamic–pituitary–adrenal (HPA) axis mutually control one another’s activity, wherein TTS suppresses corticotrophin releasing hormone (CRH) stimulated HPA axis activity, whereas the activation of HPA axis has an inhibitory effect on TTS secretion. With an intention to explain these phenomena, a network reaction model is developed from the previously postulated stoichiometric models for HPA activity where main dynamic behaviors are controlled by two catalytic steps (one autocatalytic and one autoinhibitory) with respect to cortisol, both found experimentally. The capacity of the model to emulate TTS effects on HPA axis dynamics and its response to acute CRH-induced stress is examined using numerical simulations. Model predictions are compared with empirically obtained results reported in the literature. Thus, the reaction kinetic examinations of nonlinear biochemical transformations that constitute the HPA axis, including the negative feedback effect of TTS on HPA axis activity, recapitulates the well-established fact that TTS dampens HPA axis basal activity, decreasing both cortisol level and the amplitude of ultradian cortisol oscillations. The model also replicates TTS inhibitory action on the HPA axis response to acute environmental challenges, particularly CRH-induced stress. In addition, kinetic modelling revealed that TTS induced reduction in ultradian cortisol amplitude arises because the system moves towards a supercritical Hopf bifurcation as TTS is being increased. © 2017, The Author(s).",
publisher = "Springer Netherlands",
journal = "Reaction Kinetics, Mechanisms and Catalysis",
title = "Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress",
volume = "123",
number = "1",
pages = "17-30",
doi = "10.1007/s11144-017-1315-7"
}

Stanojević, A., Marković, V. M., Maćešić, S., Kolar-Anić, L.,& Vukojević, V.. (2018). Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress. in Reaction Kinetics, Mechanisms and Catalysis
Springer Netherlands., 123(1), 17-30.
https://doi.org/10.1007/s11144-017-1315-7

Stanojević A, Marković VM, Maćešić S, Kolar-Anić L, Vukojević V. Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress. in Reaction Kinetics, Mechanisms and Catalysis. 2018;123(1):17-30.
doi:10.1007/s11144-017-1315-7 .

Stanojević, A, Marković, V M, Maćešić, Stevan, Kolar-Anić, Ljiljana, Vukojević, V, "Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress" in Reaction Kinetics, Mechanisms and Catalysis, 123, no. 1 (2018):17-30,
https://doi.org/10.1007/s11144-017-1315-7 . .

TY  - JOUR
AU  - Stanković, Ivana
AU  - Marković, V. M.
AU  - Kolar-Anić, Ljiljana
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6137
AB  - Reply to the comment by Silvano Romano: Silvano Romano Russ. J. Phys. Chem. A. 87 (12), (2013) on the paper I. M. Stankovic, V. M. Markovic, and Lj. Z. Kolar-Anic, Russ. J. Phys. Chem. A. 85 (13), 2257 (2011).
PB  - Pleiades Publishing
T2  - Russian Journal of Physical Chemistry A
T1  - Reply to the comment by Silvano Romano [1] on the paper [2]
VL  - 87
IS  - 12
SP  - 2113
EP  - 2113
DO  - 10.1134/S0036024413120339
ER  - 

@article{
author = "Stanković, Ivana and Marković, V. M. and Kolar-Anić, Ljiljana",
year = "2013",
abstract = "Reply to the comment by Silvano Romano: Silvano Romano Russ. J. Phys. Chem. A. 87 (12), (2013) on the paper I. M. Stankovic, V. M. Markovic, and Lj. Z. Kolar-Anic, Russ. J. Phys. Chem. A. 85 (13), 2257 (2011).",
publisher = "Pleiades Publishing",
journal = "Russian Journal of Physical Chemistry A",
title = "Reply to the comment by Silvano Romano [1] on the paper [2]",
volume = "87",
number = "12",
pages = "2113-2113",
doi = "10.1134/S0036024413120339"
}

Stanković, I., Marković, V. M.,& Kolar-Anić, L.. (2013). Reply to the comment by Silvano Romano [1] on the paper [2]. in Russian Journal of Physical Chemistry A
Pleiades Publishing., 87(12), 2113-2113.
https://doi.org/10.1134/S0036024413120339

Stanković I, Marković VM, Kolar-Anić L. Reply to the comment by Silvano Romano [1] on the paper [2]. in Russian Journal of Physical Chemistry A. 2013;87(12):2113-2113.
doi:10.1134/S0036024413120339 .

Stanković, Ivana, Marković, V. M., Kolar-Anić, Ljiljana, "Reply to the comment by Silvano Romano [1] on the paper [2]" in Russian Journal of Physical Chemistry A, 87, no. 12 (2013):2113-2113,
https://doi.org/10.1134/S0036024413120339 . .

TY  - JOUR
AU  - Stanković, Ivana M.
AU  - Marković, V. M.
AU  - Kolar-Anić, Ljiljana
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6082
AB  - Partition function and thermodynamic parameters of the system open with respect to energy E,
volume V and number of particles N, whereas temperature T, chemical potential μ and pressure P were kept
constant, were considered by the procedure proposed by Gibbs. The mean values of variable energy, volume
and number of particles were obtained by universal expression for such values. The entropy was determined
by its general statistical definition. The thermodynamic potential and other thermodynamic quantities were
also turned out naturally.
PB  - Pleiades Publishing
T2  - Russian Journal of Physical Chemistry A
T1  - System with Variable Energy, Volume and Number of Particles: Evaluation of Partition Function and Thermodynamic Quantities
VL  - 85
IS  - 13
SP  - 2257
EP  - 2263
DO  - 10.1134/S0036024411130280
ER  - 

@article{
author = "Stanković, Ivana M. and Marković, V. M. and Kolar-Anić, Ljiljana",
year = "2011",
abstract = "Partition function and thermodynamic parameters of the system open with respect to energy E,
volume V and number of particles N, whereas temperature T, chemical potential μ and pressure P were kept
constant, were considered by the procedure proposed by Gibbs. The mean values of variable energy, volume
and number of particles were obtained by universal expression for such values. The entropy was determined
by its general statistical definition. The thermodynamic potential and other thermodynamic quantities were
also turned out naturally.",
publisher = "Pleiades Publishing",
journal = "Russian Journal of Physical Chemistry A",
title = "System with Variable Energy, Volume and Number of Particles: Evaluation of Partition Function and Thermodynamic Quantities",
volume = "85",
number = "13",
pages = "2257-2263",
doi = "10.1134/S0036024411130280"
}

Stanković, I. M., Marković, V. M.,& Kolar-Anić, L.. (2011). System with Variable Energy, Volume and Number of Particles: Evaluation of Partition Function and Thermodynamic Quantities. in Russian Journal of Physical Chemistry A
Pleiades Publishing., 85(13), 2257-2263.
https://doi.org/10.1134/S0036024411130280

Stanković IM, Marković VM, Kolar-Anić L. System with Variable Energy, Volume and Number of Particles: Evaluation of Partition Function and Thermodynamic Quantities. in Russian Journal of Physical Chemistry A. 2011;85(13):2257-2263.
doi:10.1134/S0036024411130280 .

Stanković, Ivana M., Marković, V. M., Kolar-Anić, Ljiljana, "System with Variable Energy, Volume and Number of Particles: Evaluation of Partition Function and Thermodynamic Quantities" in Russian Journal of Physical Chemistry A, 85, no. 13 (2011):2257-2263,
https://doi.org/10.1134/S0036024411130280 . .