TY  - JOUR
AU  - Karaman, M.
AU  - Janjušević, L.
AU  - Jakovljević, Dragica
AU  - Šibul, F.
AU  - Pejin, Boris
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2214
AB  - This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of α and ß glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 ± 0.59 μg/mL) and high potential for reduction of Fe3+ ions (174.11 ± 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 μg), the same extract exhibited a moderate anti-AChE activity (10 μg) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 ± 0.31 μg/mL, 197.68 ± 9.47 mg eq. AA/g d.w. and 0.1 μg, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine.
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract
SP  - 1
EP  - 5
DO  - 10.1080/14786419.2017.1422183
ER  - 

@article{
author = "Karaman, M. and Janjušević, L. and Jakovljević, Dragica and Šibul, F. and Pejin, Boris",
year = "2017",
abstract = "This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of α and ß glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 ± 0.59 μg/mL) and high potential for reduction of Fe3+ ions (174.11 ± 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 μg), the same extract exhibited a moderate anti-AChE activity (10 μg) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 ± 0.31 μg/mL, 197.68 ± 9.47 mg eq. AA/g d.w. and 0.1 μg, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine.",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract",
pages = "1-5",
doi = "10.1080/14786419.2017.1422183"
}

Karaman, M., Janjušević, L., Jakovljević, D., Šibul, F.,& Pejin, B.. (2017). Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract. in Natural Product Research
Taylor and Francis Ltd.., 1-5.
https://doi.org/10.1080/14786419.2017.1422183

Karaman M, Janjušević L, Jakovljević D, Šibul F, Pejin B. Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract. in Natural Product Research. 2017;:1-5.
doi:10.1080/14786419.2017.1422183 .

Karaman, M., Janjušević, L., Jakovljević, Dragica, Šibul, F., Pejin, Boris, "Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract" in Natural Product Research (2017):1-5,
https://doi.org/10.1080/14786419.2017.1422183 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tešanović, K.
AU  - Jakovljević, Dragica
AU  - Kaišarević, S.
AU  - Šibul, F.
AU  - Rašeta, M.
AU  - Karaman, M.
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2226
AB  - The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity
SP  - 1
EP  - 5
DO  - 10.1080/14786419.2017.1405417
ER  - 

@article{
author = "Pejin, Boris and Tešanović, K. and Jakovljević, Dragica and Kaišarević, S. and Šibul, F. and Rašeta, M. and Karaman, M.",
year = "2017",
abstract = "The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity",
pages = "1-5",
doi = "10.1080/14786419.2017.1405417"
}

Pejin, B., Tešanović, K., Jakovljević, D., Kaišarević, S., Šibul, F., Rašeta, M.,& Karaman, M.. (2017). The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research
Taylor and Francis Ltd.., 1-5.
https://doi.org/10.1080/14786419.2017.1405417

Pejin B, Tešanović K, Jakovljević D, Kaišarević S, Šibul F, Rašeta M, Karaman M. The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research. 2017;:1-5.
doi:10.1080/14786419.2017.1405417 .

Pejin, Boris, Tešanović, K., Jakovljević, Dragica, Kaišarević, S., Šibul, F., Rašeta, M., Karaman, M., "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity" in Natural Product Research (2017):1-5,
https://doi.org/10.1080/14786419.2017.1405417 . .