TY  - CONF
AU  - Božić Cvijan, Bojana
AU  - Korać, Jelena
AU  - Stanković, Dalibor
AU  - Stanić, Marina
AU  - Romanović, Mima
AU  - Bogdanović Pristov, Jelena
AU  - Spasić, Snežana
AU  - Popović-Bijelić, Ana
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5018
AB  - Cilj rada je analiza interakcije jona bakra i β-laktamskih antibiotika (penicilin G, ampicilin, amoksicilin, cefaleksin, cefaklor, ceftazidim, ceftriakson i meropenem) i posledičnih promena inhibitornih efekata antibiotika na sojevima Escherichia coli i Staphylococcus aureus.
AB  - The aim of this study was to analyze interactions of copper ions with β-lactam antibiotics (penicillin G, ampicillin, amoxicillin, cephalexin, cefaclor, ceftriaxone, ceftazidime and meropenem), and the resulting impact on the antimicrobial activity of the mentioned antibiotics against Escherichia coli and Staphylococcus aureus.
PB  - Srpsko farmakološko društvo/ Serbian Pharmacological Society
C3  - 14. Kongres farmakologa i 4. Kongres kliničke farmakologije srbije sa međunarodnim učešćem /14th Serbian congress of pharmacologists and 4th Serbian congress of clinical pharmacology with international participation,Novi Sad 18-21 septembra 2019
T1  - Uticaj jona bakra na antibakterijsku aktivnost β-laktamskih antibiotika
T1  - The impact of copper ions on antibacterial activity of β-lactam antibotics
SP  - 83
EP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_cer_5018
ER  - 

@conference{
author = "Božić Cvijan, Bojana and Korać, Jelena and Stanković, Dalibor and Stanić, Marina and Romanović, Mima and Bogdanović Pristov, Jelena and Spasić, Snežana and Popović-Bijelić, Ana and Spasojević, Ivan and Bajčetić, Milica",
year = "2019",
abstract = "Cilj rada je analiza interakcije jona bakra i β-laktamskih antibiotika (penicilin G, ampicilin, amoksicilin, cefaleksin, cefaklor, ceftazidim, ceftriakson i meropenem) i posledičnih promena inhibitornih efekata antibiotika na sojevima Escherichia coli i Staphylococcus aureus., The aim of this study was to analyze interactions of copper ions with β-lactam antibiotics (penicillin G, ampicillin, amoxicillin, cephalexin, cefaclor, ceftriaxone, ceftazidime and meropenem), and the resulting impact on the antimicrobial activity of the mentioned antibiotics against Escherichia coli and Staphylococcus aureus.",
publisher = "Srpsko farmakološko društvo/ Serbian Pharmacological Society",
journal = "14. Kongres farmakologa i 4. Kongres kliničke farmakologije srbije sa međunarodnim učešćem /14th Serbian congress of pharmacologists and 4th Serbian congress of clinical pharmacology with international participation,Novi Sad 18-21 septembra 2019",
title = "Uticaj jona bakra na antibakterijsku aktivnost β-laktamskih antibiotika, The impact of copper ions on antibacterial activity of β-lactam antibotics",
pages = "83-85",
url = "https://hdl.handle.net/21.15107/rcub_cer_5018"
}

Božić Cvijan, B., Korać, J., Stanković, D., Stanić, M., Romanović, M., Bogdanović Pristov, J., Spasić, S., Popović-Bijelić, A., Spasojević, I.,& Bajčetić, M.. (2019). Uticaj jona bakra na antibakterijsku aktivnost β-laktamskih antibiotika. in 14. Kongres farmakologa i 4. Kongres kliničke farmakologije srbije sa međunarodnim učešćem /14th Serbian congress of pharmacologists and 4th Serbian congress of clinical pharmacology with international participation,Novi Sad 18-21 septembra 2019
Srpsko farmakološko društvo/ Serbian Pharmacological Society., 83-85.
https://hdl.handle.net/21.15107/rcub_cer_5018

Božić Cvijan B, Korać J, Stanković D, Stanić M, Romanović M, Bogdanović Pristov J, Spasić S, Popović-Bijelić A, Spasojević I, Bajčetić M. Uticaj jona bakra na antibakterijsku aktivnost β-laktamskih antibiotika. in 14. Kongres farmakologa i 4. Kongres kliničke farmakologije srbije sa međunarodnim učešćem /14th Serbian congress of pharmacologists and 4th Serbian congress of clinical pharmacology with international participation,Novi Sad 18-21 septembra 2019. 2019;:83-85.
https://hdl.handle.net/21.15107/rcub_cer_5018 .

Božić Cvijan, Bojana, Korać, Jelena, Stanković, Dalibor, Stanić, Marina, Romanović, Mima, Bogdanović Pristov, Jelena, Spasić, Snežana, Popović-Bijelić, Ana, Spasojević, Ivan, Bajčetić, Milica, "Uticaj jona bakra na antibakterijsku aktivnost β-laktamskih antibiotika" in 14. Kongres farmakologa i 4. Kongres kliničke farmakologije srbije sa međunarodnim učešćem /14th Serbian congress of pharmacologists and 4th Serbian congress of clinical pharmacology with international participation,Novi Sad 18-21 septembra 2019 (2019):83-85,
https://hdl.handle.net/21.15107/rcub_cer_5018 .

TY  - JOUR
AU  - Božić, Bojana
AU  - Korać, Jelena
AU  - Stanković, Dalibor
AU  - Stanić, Marina
AU  - Romanović, Mima
AU  - Bogdanović Pristov, Jelena
AU  - Spasić, Snežana
AU  - Popović-Bjelić, Ana
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4281
AB  - An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight β-lactam antibiotics using UV–Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These β-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1:1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis.
PB  - Elsevier
T2  - Free Radical Biology and Medicine
T1  - Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity
VL  - 129
SP  - 279
EP  - 285
DO  - 10.1016/j.freeradbiomed.2018.09.038
ER  - 

@article{
author = "Božić, Bojana and Korać, Jelena and Stanković, Dalibor and Stanić, Marina and Romanović, Mima and Bogdanović Pristov, Jelena and Spasić, Snežana and Popović-Bjelić, Ana and Spasojević, Ivan and Bajčetić, Milica",
year = "2018",
abstract = "An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight β-lactam antibiotics using UV–Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These β-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1:1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis.",
publisher = "Elsevier",
journal = "Free Radical Biology and Medicine",
title = "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity",
volume = "129",
pages = "279-285",
doi = "10.1016/j.freeradbiomed.2018.09.038"
}

Božić, B., Korać, J., Stanković, D., Stanić, M., Romanović, M., Bogdanović Pristov, J., Spasić, S., Popović-Bjelić, A., Spasojević, I.,& Bajčetić, M.. (2018). Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity. in Free Radical Biology and Medicine
Elsevier., 129, 279-285.
https://doi.org/10.1016/j.freeradbiomed.2018.09.038

Božić B, Korać J, Stanković D, Stanić M, Romanović M, Bogdanović Pristov J, Spasić S, Popović-Bjelić A, Spasojević I, Bajčetić M. Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity. in Free Radical Biology and Medicine. 2018;129:279-285.
doi:10.1016/j.freeradbiomed.2018.09.038 .

Božić, Bojana, Korać, Jelena, Stanković, Dalibor, Stanić, Marina, Romanović, Mima, Bogdanović Pristov, Jelena, Spasić, Snežana, Popović-Bjelić, Ana, Spasojević, Ivan, Bajčetić, Milica, "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity" in Free Radical Biology and Medicine, 129 (2018):279-285,
https://doi.org/10.1016/j.freeradbiomed.2018.09.038 . .

TY  - DATA
AU  - Božić, Bojana
AU  - Korać, Jelena
AU  - Stanković, Dalibor
AU  - Stanić, Marina
AU  - Romanović, Mima
AU  - Bogdanović Pristov, Jelena
AU  - Spasić, Snežana
AU  - Popović-Bjelić, Ana
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4489
AB  - Figure S1. Speciation diagrams of Cu2+ in the phosphate buffer. Diagrams were prepared in Hydra-Medusa Software, using the presented parameters.
PB  - Elsevier
T2  - Free Radical Biology and Medicine
T1  - Supporting Information for: "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity"
UR  - https://hdl.handle.net/21.15107/rcub_cer_4489
ER  - 

@misc{
author = "Božić, Bojana and Korać, Jelena and Stanković, Dalibor and Stanić, Marina and Romanović, Mima and Bogdanović Pristov, Jelena and Spasić, Snežana and Popović-Bjelić, Ana and Spasojević, Ivan and Bajčetić, Milica",
year = "2018",
abstract = "Figure S1. Speciation diagrams of Cu2+ in the phosphate buffer. Diagrams were prepared in Hydra-Medusa Software, using the presented parameters.",
publisher = "Elsevier",
journal = "Free Radical Biology and Medicine",
title = "Supporting Information for: "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity"",
url = "https://hdl.handle.net/21.15107/rcub_cer_4489"
}

Božić, B., Korać, J., Stanković, D., Stanić, M., Romanović, M., Bogdanović Pristov, J., Spasić, S., Popović-Bjelić, A., Spasojević, I.,& Bajčetić, M.. (2018). Supporting Information for: "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity". in Free Radical Biology and Medicine
Elsevier..
https://hdl.handle.net/21.15107/rcub_cer_4489

Božić B, Korać J, Stanković D, Stanić M, Romanović M, Bogdanović Pristov J, Spasić S, Popović-Bjelić A, Spasojević I, Bajčetić M. Supporting Information for: "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity". in Free Radical Biology and Medicine. 2018;.
https://hdl.handle.net/21.15107/rcub_cer_4489 .

Božić, Bojana, Korać, Jelena, Stanković, Dalibor, Stanić, Marina, Romanović, Mima, Bogdanović Pristov, Jelena, Spasić, Snežana, Popović-Bjelić, Ana, Spasojević, Ivan, Bajčetić, Milica, "Supporting Information for: "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity"" in Free Radical Biology and Medicine (2018),
https://hdl.handle.net/21.15107/rcub_cer_4489 .