TY  - JOUR
AU  - Bulatović, Mirna
AU  - Kaluderovic, Milena R
AU  - Mojic, Marija
AU  - Zmejkovski, Bojana
AU  - Hey-Hawkins, Evamarie
AU  - Vidakovic, Melita
AU  - Grdovic, Nevena
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela D.
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1650
AB  - (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV), [PtCl4(iBu(2)eddp)]. shows an improved pharmacological profile in comparison to cisplatin. This is manifested through accelerated dying process led by necrotic cell death, reflected through mitochondrial collapse, strong ATP depletion and reactive oxygen species production. Loss of mitochondrial potential was further followed with intensive apoptosis that finalized with DNA fragmentation. Different dynamic of tumoricidal action could be partly ascribed to less affected repair mechanisms in comparison to cisplatin. Importantly, [PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts suggesting different intracellular response of normal vs. tumor cells. This selectivity toward malignant phenotype is further confirmed by retained tumoricidal potential in hypoxic conditions, while cisplatin became completely inefficient.
PB  - Elsevier
T2  - European Journal of Pharmacology
T1  - Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions
VL  - 760
SP  - 136
EP  - 144
DO  - 10.1016/j.ejphar.2015.04.012
ER  - 

@article{
author = "Bulatović, Mirna and Kaluderovic, Milena R and Mojic, Marija and Zmejkovski, Bojana and Hey-Hawkins, Evamarie and Vidakovic, Melita and Grdovic, Nevena and Kaluđerović, Goran N. and Mijatović, Sanja and Maksimović-Ivanić, Danijela D.",
year = "2015",
abstract = "(O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV), [PtCl4(iBu(2)eddp)]. shows an improved pharmacological profile in comparison to cisplatin. This is manifested through accelerated dying process led by necrotic cell death, reflected through mitochondrial collapse, strong ATP depletion and reactive oxygen species production. Loss of mitochondrial potential was further followed with intensive apoptosis that finalized with DNA fragmentation. Different dynamic of tumoricidal action could be partly ascribed to less affected repair mechanisms in comparison to cisplatin. Importantly, [PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts suggesting different intracellular response of normal vs. tumor cells. This selectivity toward malignant phenotype is further confirmed by retained tumoricidal potential in hypoxic conditions, while cisplatin became completely inefficient.",
publisher = "Elsevier",
journal = "European Journal of Pharmacology",
title = "Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions",
volume = "760",
pages = "136-144",
doi = "10.1016/j.ejphar.2015.04.012"
}

Bulatović, M., Kaluderovic, M. R., Mojic, M., Zmejkovski, B., Hey-Hawkins, E., Vidakovic, M., Grdovic, N., Kaluđerović, G. N., Mijatović, S.,& Maksimović-Ivanić, D. D.. (2015). Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology
Elsevier., 760, 136-144.
https://doi.org/10.1016/j.ejphar.2015.04.012

Bulatović M, Kaluderovic MR, Mojic M, Zmejkovski B, Hey-Hawkins E, Vidakovic M, Grdovic N, Kaluđerović GN, Mijatović S, Maksimović-Ivanić DD. Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology. 2015;760:136-144.
doi:10.1016/j.ejphar.2015.04.012 .

Bulatović, Mirna, Kaluderovic, Milena R, Mojic, Marija, Zmejkovski, Bojana, Hey-Hawkins, Evamarie, Vidakovic, Melita, Grdovic, Nevena, Kaluđerović, Goran N., Mijatović, Sanja, Maksimović-Ivanić, Danijela D., "Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions" in European Journal of Pharmacology, 760 (2015):136-144,
https://doi.org/10.1016/j.ejphar.2015.04.012 . .

TY  - JOUR
AU  - Gómez-Ruiz, Santiago
AU  - Kaluđerović, Goran N.
AU  - Prashar, Sanjiv
AU  - Hey-Hawkins, Evamarie
AU  - Erić, Aleksandra
AU  - Žižak, Željko
AU  - Juranić, Zorica
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4125
AB  - The reaction of 3-methoxyphenylacetic acid (3-MPAH), 4-methoxyphenylacetic acid (4-MPAH), 2,5-
dimethyl-3-furoic acid (DMFUH) or 1,4-benzodioxane-6-carboxylic acid (BZDOH) with triphenyltin(IV)
chloride (1:1) or diphenyltin(IV) dichloride (2:1) in the presence of triethylamine yielded the compounds
[SnPh3(3-MPA)] (1), [SnPh3(4-MPA)] (2), [SnPh3(DMFU)] (3), [SnPh3(BZDO)] (4), [SnPh2(3-MPA)2] (5),
[SnPh2(4-MPA)2] (6), [SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8), respectively. The tetranuclear complex
[{Me2(DMFU)SnOSn(DMFU)Me2}2] (9) was prepared by the reaction of dimethyltin(IV) oxide and 2,5-
dimethyl-3-furoic acid (DMFUH). The molecular structures of 3, 4 and 9, were determined by X-ray diffraction
studies. The cytotoxic activity of the carboxylic acids (3-MPAH, 4-MPAH, BZDOH and DMFUH)
and di (5–8) and triphenyltin(IV) complexes (2–4) was tested against tumor cell lines human adenocarcinoma
HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal
immunocompetent cells, peripheral blood mononuclear cells PBMC. Triphenyltin(IV) complexes show
higher activities than the diphenyltin(IV) derivatives. The most active compound is [SnPh3(DMFU)] (3)
with IC50 value of 0.15  } 0.01, 0.051  } 0.004, 0.074  } 0.004, 0.20  } 0.01, 0.15  } 0.02 on HeLa, K562, Femx,
rested and stimulated PBMC, respectively, while the most selective are [SnPh2(3-MPA)2] (5),
[SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8). Compounds 3, 5, 7 and 8 present higher activities than cisplatin
in all the tested cells and relative high selectivity especially on K562 cells.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes
VL  - 102
IS  - 12
SP  - 2087
EP  - 2096
DO  - 10.1016/j.jinorgbio.2008.07.009
ER  - 

@article{
author = "Gómez-Ruiz, Santiago and Kaluđerović, Goran N. and Prashar, Sanjiv and Hey-Hawkins, Evamarie and Erić, Aleksandra and Žižak, Željko and Juranić, Zorica",
year = "2008",
abstract = "The reaction of 3-methoxyphenylacetic acid (3-MPAH), 4-methoxyphenylacetic acid (4-MPAH), 2,5-
dimethyl-3-furoic acid (DMFUH) or 1,4-benzodioxane-6-carboxylic acid (BZDOH) with triphenyltin(IV)
chloride (1:1) or diphenyltin(IV) dichloride (2:1) in the presence of triethylamine yielded the compounds
[SnPh3(3-MPA)] (1), [SnPh3(4-MPA)] (2), [SnPh3(DMFU)] (3), [SnPh3(BZDO)] (4), [SnPh2(3-MPA)2] (5),
[SnPh2(4-MPA)2] (6), [SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8), respectively. The tetranuclear complex
[{Me2(DMFU)SnOSn(DMFU)Me2}2] (9) was prepared by the reaction of dimethyltin(IV) oxide and 2,5-
dimethyl-3-furoic acid (DMFUH). The molecular structures of 3, 4 and 9, were determined by X-ray diffraction
studies. The cytotoxic activity of the carboxylic acids (3-MPAH, 4-MPAH, BZDOH and DMFUH)
and di (5–8) and triphenyltin(IV) complexes (2–4) was tested against tumor cell lines human adenocarcinoma
HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal
immunocompetent cells, peripheral blood mononuclear cells PBMC. Triphenyltin(IV) complexes show
higher activities than the diphenyltin(IV) derivatives. The most active compound is [SnPh3(DMFU)] (3)
with IC50 value of 0.15  } 0.01, 0.051  } 0.004, 0.074  } 0.004, 0.20  } 0.01, 0.15  } 0.02 on HeLa, K562, Femx,
rested and stimulated PBMC, respectively, while the most selective are [SnPh2(3-MPA)2] (5),
[SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8). Compounds 3, 5, 7 and 8 present higher activities than cisplatin
in all the tested cells and relative high selectivity especially on K562 cells.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes",
volume = "102",
number = "12",
pages = "2087-2096",
doi = "10.1016/j.jinorgbio.2008.07.009"
}

Gómez-Ruiz, S., Kaluđerović, G. N., Prashar, S., Hey-Hawkins, E., Erić, A., Žižak, Ž.,& Juranić, Z.. (2008). Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes. in Journal of Inorganic Biochemistry
Elsevier., 102(12), 2087-2096.
https://doi.org/10.1016/j.jinorgbio.2008.07.009

Gómez-Ruiz S, Kaluđerović GN, Prashar S, Hey-Hawkins E, Erić A, Žižak Ž, Juranić Z. Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes. in Journal of Inorganic Biochemistry. 2008;102(12):2087-2096.
doi:10.1016/j.jinorgbio.2008.07.009 .

Gómez-Ruiz, Santiago, Kaluđerović, Goran N., Prashar, Sanjiv, Hey-Hawkins, Evamarie, Erić, Aleksandra, Žižak, Željko, Juranić, Zorica, "Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes" in Journal of Inorganic Biochemistry, 102, no. 12 (2008):2087-2096,
https://doi.org/10.1016/j.jinorgbio.2008.07.009 . .