TY  - JOUR
AU  - Stanojevic, A.
AU  - Markovic, V. M.
AU  - Čupić, Željko
AU  - Vukojevic, V.
AU  - Kolar-Anić, Ljiljana
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2254
AB  - A model was developed that can be used to study the effect of gradual cholesterol intake by food on the HPA axis dynamics. Namely, well defined oscillatory dynamics of vital neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis has proven to be necessary for maintaining regular basal physiology and formulating appropriate stress response to various types of perturbations. Cholesterol, as a precursor of all steroid HPA axis hormones, can alter the dynamics of HPA axis. To analyse its particular influence on the HPA axis dynamics we used stoichiometric model of HPA axis activity, and simulate cholesterol perturbations in the form of finite duration pulses, with asymmetrically distributed concentration profile. Our numerical simulations showed that there is a complex, nonlinear dependence between the HPA axis responsiveness and different forms of applied cholesterol concentration pulses, indicating the significance of kinetic modelling, and dynamical systems theory for the understanding of large-scale self-regulatory, and homeostatic processes within this neuroendocrine system.
PB  - Maik Nauka/Interperiodica/Springer, New York
T2  - Russian Journal of Physical Chemistry A
T1  - Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile
VL  - 91
IS  - 13
SP  - 2600
EP  - 2607
DO  - 10.1134/S0036024417130027
ER  - 

@article{
author = "Stanojevic, A. and Markovic, V. M. and Čupić, Željko and Vukojevic, V. and Kolar-Anić, Ljiljana",
year = "2017",
abstract = "A model was developed that can be used to study the effect of gradual cholesterol intake by food on the HPA axis dynamics. Namely, well defined oscillatory dynamics of vital neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis has proven to be necessary for maintaining regular basal physiology and formulating appropriate stress response to various types of perturbations. Cholesterol, as a precursor of all steroid HPA axis hormones, can alter the dynamics of HPA axis. To analyse its particular influence on the HPA axis dynamics we used stoichiometric model of HPA axis activity, and simulate cholesterol perturbations in the form of finite duration pulses, with asymmetrically distributed concentration profile. Our numerical simulations showed that there is a complex, nonlinear dependence between the HPA axis responsiveness and different forms of applied cholesterol concentration pulses, indicating the significance of kinetic modelling, and dynamical systems theory for the understanding of large-scale self-regulatory, and homeostatic processes within this neuroendocrine system.",
publisher = "Maik Nauka/Interperiodica/Springer, New York",
journal = "Russian Journal of Physical Chemistry A",
title = "Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile",
volume = "91",
number = "13",
pages = "2600-2607",
doi = "10.1134/S0036024417130027"
}

Stanojevic, A., Markovic, V. M., Čupić, Ž., Vukojevic, V.,& Kolar-Anić, L.. (2017). Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile. in Russian Journal of Physical Chemistry A
Maik Nauka/Interperiodica/Springer, New York., 91(13), 2600-2607.
https://doi.org/10.1134/S0036024417130027

Stanojevic A, Markovic VM, Čupić Ž, Vukojevic V, Kolar-Anić L. Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile. in Russian Journal of Physical Chemistry A. 2017;91(13):2600-2607.
doi:10.1134/S0036024417130027 .

Stanojevic, A., Markovic, V. M., Čupić, Željko, Vukojevic, V., Kolar-Anić, Ljiljana, "Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile" in Russian Journal of Physical Chemistry A, 91, no. 13 (2017):2600-2607,
https://doi.org/10.1134/S0036024417130027 . .