TY  - JOUR
AU  - Tomić, Mirko
AU  - Ignjatović, D.
AU  - Tovilović, Gordana
AU  - Andrić, Deana
AU  - Roglić, Goran
AU  - Kostić Rajačić, Slađana
PY  - 2007
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/354
AB  - Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and α1-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D2 pKi binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized d-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Two new phenylpiperazines with atypical antipsychotic potential
VL  - 17
IS  - 21
SP  - 5749
EP  - 5753
DO  - 10.1016/j.bmcl.2007.08.066
ER  - 

@article{
author = "Tomić, Mirko and Ignjatović, D. and Tovilović, Gordana and Andrić, Deana and Roglić, Goran and Kostić Rajačić, Slađana",
year = "2007",
abstract = "Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and α1-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D2 pKi binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized d-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Two new phenylpiperazines with atypical antipsychotic potential",
volume = "17",
number = "21",
pages = "5749-5753",
doi = "10.1016/j.bmcl.2007.08.066"
}

Tomić, M., Ignjatović, D., Tovilović, G., Andrić, D., Roglić, G.,& Kostić Rajačić, S.. (2007). Two new phenylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters
Oxford : Pergamon-Elsevier Science Ltd., 17(21), 5749-5753.
https://doi.org/10.1016/j.bmcl.2007.08.066

Tomić M, Ignjatović D, Tovilović G, Andrić D, Roglić G, Kostić Rajačić S. Two new phenylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters. 2007;17(21):5749-5753.
doi:10.1016/j.bmcl.2007.08.066 .

Tomić, Mirko, Ignjatović, D., Tovilović, Gordana, Andrić, Deana, Roglić, Goran, Kostić Rajačić, Slađana, "Two new phenylpiperazines with atypical antipsychotic potential" in Bioorganic and Medicinal Chemistry Letters, 17, no. 21 (2007):5749-5753,
https://doi.org/10.1016/j.bmcl.2007.08.066 . .

TY  - JOUR
AU  - Tomić, Mirko
AU  - Kundaković, M
AU  - Butorović, B
AU  - Janać, B
AU  - Andrić, Deana
AU  - Roglić, Goran
AU  - Ignjatović, D
AU  - Kostić Rajačić, Slađana
PY  - 2004
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2820
AB  - Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and α 1 receptors. Two compounds with benztriazole group had a 5-HT 2A /D 2 binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D 2 , 5-HT 2A and α1 receptors and a higher affinity for 5-HT 1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. © 2004 Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
VL  - 14
IS  - 16
SP  - 4263
EP  - 4266
DO  - 10.1016/j.bmcl.2004.06.005
ER  - 

@article{
author = "Tomić, Mirko and Kundaković, M and Butorović, B and Janać, B and Andrić, Deana and Roglić, Goran and Ignjatović, D and Kostić Rajačić, Slađana",
year = "2004",
abstract = "Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and α 1 receptors. Two compounds with benztriazole group had a 5-HT 2A /D 2 binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D 2 , 5-HT 2A and α1 receptors and a higher affinity for 5-HT 1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. © 2004 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential",
volume = "14",
number = "16",
pages = "4263-4266",
doi = "10.1016/j.bmcl.2004.06.005"
}

Tomić, M., Kundaković, M., Butorović, B., Janać, B., Andrić, D., Roglić, G., Ignjatović, D.,& Kostić Rajačić, S.. (2004). Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters
Elsevier., 14(16), 4263-4266.
https://doi.org/10.1016/j.bmcl.2004.06.005

Tomić M, Kundaković M, Butorović B, Janać B, Andrić D, Roglić G, Ignjatović D, Kostić Rajačić S. Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters. 2004;14(16):4263-4266.
doi:10.1016/j.bmcl.2004.06.005 .

Tomić, Mirko, Kundaković, M, Butorović, B, Janać, B, Andrić, Deana, Roglić, Goran, Ignjatović, D, Kostić Rajačić, Slađana, "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential" in Bioorganic and Medicinal Chemistry Letters, 14, no. 16 (2004):4263-4266,
https://doi.org/10.1016/j.bmcl.2004.06.005 . .