TY  - JOUR
AU  - Janicijevic, Jelena
AU  - Krajisnik, Danina
AU  - Calija, Bojan
AU  - Dobricic, Vladimir
AU  - Dakovic, Aleksandra
AU  - Krstić, Jugoslav
AU  - Marković, Marija
AU  - Milic, Jela
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1589
AB  - Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.
PB  - Elsevier
T2  - Materials Science & Engineering C-Materials For Biological Applications
T1  - Inorganically modified diatomite as a potential prolonged-release drug carrier
VL  - 42
SP  - 412
EP  - 420
DO  - 10.1016/j.msec.2014.05.052
ER  - 

@article{
author = "Janicijevic, Jelena and Krajisnik, Danina and Calija, Bojan and Dobricic, Vladimir and Dakovic, Aleksandra and Krstić, Jugoslav and Marković, Marija and Milic, Jela",
year = "2014",
abstract = "Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.",
publisher = "Elsevier",
journal = "Materials Science & Engineering C-Materials For Biological Applications",
title = "Inorganically modified diatomite as a potential prolonged-release drug carrier",
volume = "42",
pages = "412-420",
doi = "10.1016/j.msec.2014.05.052"
}

Janicijevic, J., Krajisnik, D., Calija, B., Dobricic, V., Dakovic, A., Krstić, J., Marković, M.,& Milic, J.. (2014). Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C-Materials For Biological Applications
Elsevier., 42, 412-420.
https://doi.org/10.1016/j.msec.2014.05.052

Janicijevic J, Krajisnik D, Calija B, Dobricic V, Dakovic A, Krstić J, Marković M, Milic J. Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C-Materials For Biological Applications. 2014;42:412-420.
doi:10.1016/j.msec.2014.05.052 .

Janicijevic, Jelena, Krajisnik, Danina, Calija, Bojan, Dobricic, Vladimir, Dakovic, Aleksandra, Krstić, Jugoslav, Marković, Marija, Milic, Jela, "Inorganically modified diatomite as a potential prolonged-release drug carrier" in Materials Science & Engineering C-Materials For Biological Applications, 42 (2014):412-420,
https://doi.org/10.1016/j.msec.2014.05.052 . .

TY  - JOUR
AU  - Kragovic, Milan
AU  - Dakovic, Aleksandra
AU  - Marković, Marija
AU  - Krstić, Jugoslav
AU  - Gatta, G. Diego
AU  - Rotiroti, Nicola
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1209
AB  - The influence of contact time, temperature and particle size on lead sorption by the natural and Fe(III)-modified zeolites was investigated. Characterization of the natural and Fe(III)-modified zeolite before and after lead sorption was performed by determination of textural properties, by scanning electron microscopy and X-ray spectroscopy in energy-dispersive mode (SEM-EDS), transmission electron microscopy (TEM) and X-ray powder diffraction (XRPD) analysis. Lead sorption kinetics at 303-333 K, best represented by the pseudo-second order model and activation energy (13.5 and 8.5 kJ/mol for the natural and Fe(III)-modified zeolite respectively) confirmed an activated chemical sorption. Desorption experiments indicated that lead was irreversibly sorbed on both zeolites. XRPD, TEM and SEM results showed that modification of the natural zeolite with Fe(III) ions did not change its crystal structure and iron is mainly located at the zeolite surface, likely in form of amorphous iron oxy-hydroxides. Specific surface area significantly increases after modification of the natural zeolite with Fe(III) ions (from 30.2 for the natural to 52.5 m(2)/g for Fe(III)-modified zeolite). Characterization of both lead saturated sorbents suggested that besides ion exchange, lead is both chemisorbed and precipitated at their surfaces, and presence of amorphous iron in Fe(III)-modified zeolite favors sorption of lead.
PB  - Elsevier
T2  - Applied Surface Science
T1  - Characterization of lead sorption by the natural and Fe(III)-modified zeolite
VL  - 283
SP  - 764
EP  - 774
DO  - 10.1016/j.apsusc.2013.07.016
ER  - 

@article{
author = "Kragovic, Milan and Dakovic, Aleksandra and Marković, Marija and Krstić, Jugoslav and Gatta, G. Diego and Rotiroti, Nicola",
year = "2013",
abstract = "The influence of contact time, temperature and particle size on lead sorption by the natural and Fe(III)-modified zeolites was investigated. Characterization of the natural and Fe(III)-modified zeolite before and after lead sorption was performed by determination of textural properties, by scanning electron microscopy and X-ray spectroscopy in energy-dispersive mode (SEM-EDS), transmission electron microscopy (TEM) and X-ray powder diffraction (XRPD) analysis. Lead sorption kinetics at 303-333 K, best represented by the pseudo-second order model and activation energy (13.5 and 8.5 kJ/mol for the natural and Fe(III)-modified zeolite respectively) confirmed an activated chemical sorption. Desorption experiments indicated that lead was irreversibly sorbed on both zeolites. XRPD, TEM and SEM results showed that modification of the natural zeolite with Fe(III) ions did not change its crystal structure and iron is mainly located at the zeolite surface, likely in form of amorphous iron oxy-hydroxides. Specific surface area significantly increases after modification of the natural zeolite with Fe(III) ions (from 30.2 for the natural to 52.5 m(2)/g for Fe(III)-modified zeolite). Characterization of both lead saturated sorbents suggested that besides ion exchange, lead is both chemisorbed and precipitated at their surfaces, and presence of amorphous iron in Fe(III)-modified zeolite favors sorption of lead.",
publisher = "Elsevier",
journal = "Applied Surface Science",
title = "Characterization of lead sorption by the natural and Fe(III)-modified zeolite",
volume = "283",
pages = "764-774",
doi = "10.1016/j.apsusc.2013.07.016"
}

Kragovic, M., Dakovic, A., Marković, M., Krstić, J., Gatta, G. D.,& Rotiroti, N.. (2013). Characterization of lead sorption by the natural and Fe(III)-modified zeolite. in Applied Surface Science
Elsevier., 283, 764-774.
https://doi.org/10.1016/j.apsusc.2013.07.016

Kragovic M, Dakovic A, Marković M, Krstić J, Gatta GD, Rotiroti N. Characterization of lead sorption by the natural and Fe(III)-modified zeolite. in Applied Surface Science. 2013;283:764-774.
doi:10.1016/j.apsusc.2013.07.016 .

Kragovic, Milan, Dakovic, Aleksandra, Marković, Marija, Krstić, Jugoslav, Gatta, G. Diego, Rotiroti, Nicola, "Characterization of lead sorption by the natural and Fe(III)-modified zeolite" in Applied Surface Science, 283 (2013):764-774,
https://doi.org/10.1016/j.apsusc.2013.07.016 . .