TY  - CONF
AU  - Petrović, Božana
AU  - Krstić, Maja
AU  - Mudrinić, Tihana
AU  - Čebela, Maria
AU  - Dutour Sikirić, Maja
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7361
AB  - Magnesium (Mg) is an essential element in the human body primarily stored in bones. Mg ions have many potential benefits for bone tissue showing excellent osteogenic inductivity [1]. The aim of this study was to synthesize Mg substituted hydroxyapatite (Mg-HAP) for application in bone tissue engineering and to assess its behaviour in conditions mimicking physiological ones. Mg-HAP was synthesized using reflux method and its structural and morphological characterization was performed by XRD, FTIR and SEM. The changes in local structure and composition after irradiation and immersion in physiological solution and simulated fluid were assessed by electron paramagnetic resonance (EPR) spectroscopy. The results of EPR analysis pointed out that irradiation did not change the composition and structure of Mg-HAP. After immersion in model media (simulated body fluid and saline solution), the small amount of by-product of synthesis disappeared after 24 h and Mg-HAP remained the only phase. Also, the radical signals in EPR spectra faded away after 28 days in model media, showing that the structure and composition of Mg-HAP both went through a kind of stabilization in simulated physiological conditions. These results make the investigated Mg-HAP promising material for application in bone tissue engineering.
PB  - Belgrade : University of Belgrade, Institute for Multidisciplinary Research
C3  - Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade
T1  - Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering
SP  - 83
EP  - 83
UR  - https://hdl.handle.net/21.15107/rcub_cer_7361
ER  - 

@conference{
author = "Petrović, Božana and Krstić, Maja and Mudrinić, Tihana and Čebela, Maria and Dutour Sikirić, Maja",
year = "2023",
abstract = "Magnesium (Mg) is an essential element in the human body primarily stored in bones. Mg ions have many potential benefits for bone tissue showing excellent osteogenic inductivity [1]. The aim of this study was to synthesize Mg substituted hydroxyapatite (Mg-HAP) for application in bone tissue engineering and to assess its behaviour in conditions mimicking physiological ones. Mg-HAP was synthesized using reflux method and its structural and morphological characterization was performed by XRD, FTIR and SEM. The changes in local structure and composition after irradiation and immersion in physiological solution and simulated fluid were assessed by electron paramagnetic resonance (EPR) spectroscopy. The results of EPR analysis pointed out that irradiation did not change the composition and structure of Mg-HAP. After immersion in model media (simulated body fluid and saline solution), the small amount of by-product of synthesis disappeared after 24 h and Mg-HAP remained the only phase. Also, the radical signals in EPR spectra faded away after 28 days in model media, showing that the structure and composition of Mg-HAP both went through a kind of stabilization in simulated physiological conditions. These results make the investigated Mg-HAP promising material for application in bone tissue engineering.",
publisher = "Belgrade : University of Belgrade, Institute for Multidisciplinary Research",
journal = "Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade",
title = "Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering",
pages = "83-83",
url = "https://hdl.handle.net/21.15107/rcub_cer_7361"
}

Petrović, B., Krstić, M., Mudrinić, T., Čebela, M.,& Dutour Sikirić, M.. (2023). Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering. in Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade
Belgrade : University of Belgrade, Institute for Multidisciplinary Research., 83-83.
https://hdl.handle.net/21.15107/rcub_cer_7361

Petrović B, Krstić M, Mudrinić T, Čebela M, Dutour Sikirić M. Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering. in Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade. 2023;:83-83.
https://hdl.handle.net/21.15107/rcub_cer_7361 .

Petrović, Božana, Krstić, Maja, Mudrinić, Tihana, Čebela, Maria, Dutour Sikirić, Maja, "Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering" in Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade (2023):83-83,
https://hdl.handle.net/21.15107/rcub_cer_7361 .

TY  - CONF
AU  - Petrović, Božana
AU  - Krstić, Maja
AU  - Mudrinić, Tihana
AU  - Čebela, Maria
AU  - Dutour Sikirić, Maja
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7019
AB  - As magnesium is an important trace element in bone and teeth, and plays a key role in bone metabolism, the aim of this study was to obtain magnesium substituted hydroxyapatite (Mg-HAP) and to assess its application potential. Upon synthesis, the changes in local structure and composition after irradiation and immersion in physiological solution and simulated fluid were followed by electron paramagnetic resonance (EPR) spectroscopy. Samples were also characterized by XRD, FTIR, SEM, EDS, AAS and TGA. The results showed that irradiation did not affect the composition and structure of Mg-HAP. After immersion in model media, the small amount of by-product of synthesis disappeared already after 24 h and Mg-HAP remained as the only phase. Also, the radical signals in EPR spectra faded or completely disappeared after 28 days in model media, which could indicate that the structure and composition of Mg-HAP both went through a kind of stabilization in conditions mimicking physiological ones. All these indicate that investigated Mg-HAP has good potential for biomedical application considering its behaviour in model media which imitate physiological conditions.
PB  - Serbian Ceramic Society
C3  - Program and the book of abstracts - Serbian Ceramic Society Conference – Advanced Ceramics and Application X, 26-27th September 2022, Belgrade, Serbia
T1  - Magnesium substituted hydroxyapatite for biomedical application
SP  - 85
EP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_cer_7019
ER  - 

@conference{
author = "Petrović, Božana and Krstić, Maja and Mudrinić, Tihana and Čebela, Maria and Dutour Sikirić, Maja",
year = "2022",
abstract = "As magnesium is an important trace element in bone and teeth, and plays a key role in bone metabolism, the aim of this study was to obtain magnesium substituted hydroxyapatite (Mg-HAP) and to assess its application potential. Upon synthesis, the changes in local structure and composition after irradiation and immersion in physiological solution and simulated fluid were followed by electron paramagnetic resonance (EPR) spectroscopy. Samples were also characterized by XRD, FTIR, SEM, EDS, AAS and TGA. The results showed that irradiation did not affect the composition and structure of Mg-HAP. After immersion in model media, the small amount of by-product of synthesis disappeared already after 24 h and Mg-HAP remained as the only phase. Also, the radical signals in EPR spectra faded or completely disappeared after 28 days in model media, which could indicate that the structure and composition of Mg-HAP both went through a kind of stabilization in conditions mimicking physiological ones. All these indicate that investigated Mg-HAP has good potential for biomedical application considering its behaviour in model media which imitate physiological conditions.",
publisher = "Serbian Ceramic Society",
journal = "Program and the book of abstracts - Serbian Ceramic Society Conference – Advanced Ceramics and Application X, 26-27th September 2022, Belgrade, Serbia",
title = "Magnesium substituted hydroxyapatite for biomedical application",
pages = "85-85",
url = "https://hdl.handle.net/21.15107/rcub_cer_7019"
}

Petrović, B., Krstić, M., Mudrinić, T., Čebela, M.,& Dutour Sikirić, M.. (2022). Magnesium substituted hydroxyapatite for biomedical application. in Program and the book of abstracts - Serbian Ceramic Society Conference – Advanced Ceramics and Application X, 26-27th September 2022, Belgrade, Serbia
Serbian Ceramic Society., 85-85.
https://hdl.handle.net/21.15107/rcub_cer_7019

Petrović B, Krstić M, Mudrinić T, Čebela M, Dutour Sikirić M. Magnesium substituted hydroxyapatite for biomedical application. in Program and the book of abstracts - Serbian Ceramic Society Conference – Advanced Ceramics and Application X, 26-27th September 2022, Belgrade, Serbia. 2022;:85-85.
https://hdl.handle.net/21.15107/rcub_cer_7019 .

Petrović, Božana, Krstić, Maja, Mudrinić, Tihana, Čebela, Maria, Dutour Sikirić, Maja, "Magnesium substituted hydroxyapatite for biomedical application" in Program and the book of abstracts - Serbian Ceramic Society Conference – Advanced Ceramics and Application X, 26-27th September 2022, Belgrade, Serbia (2022):85-85,
https://hdl.handle.net/21.15107/rcub_cer_7019 .

TY  - CONF
AU  - Petrović, Božana
AU  - Krstić, Maja
AU  - Čebela, Maria
AU  - Mudrinić, Tihana
AU  - Dutour Sikirić, Maja
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6971
AB  - Thanks to its similarity with biological apatite found in vertebrate hard tissues, calcium hydroxyapatite is one of the most investigated materials in bone tissue engineering. Since biological apatite is not stoichiometric, ion substituted hydroxyapatites are in the focus of many studies as they more closely mimic the composition of natural bone. Although there are many investigations of the influence of foreign ions on the structure and physico-chemical properties of ionsubstituted hydroxyapatites, there is no much information on their behaviour in different media. In present study, magnesium - which plays a key role in bone metabolism and silicon - which is necessary for normal skeletal development, were used as ion substitutes. The behaviour of Mg and Si substituted hydroxyapatite in simulated body fluid and physiological solution was investigated by XRD, FTIR and SEM. Obtained results confirmed great potential of these substituted hydroxyapatites for biomedical applications.
PB  - Belgrade : Institute for Multidisciplinary Research, University of Belgrade
C3  - Advanced Ceramics and Application : 6th Conference of The Serbian Society for Ceramic Materials, 6CSCS-2022, June 28-29, 2022, Belgrade, Serbia
T1  - Behaviour of Mg and Si substituted hydroxyapatites in model media
SP  - 53
EP  - 53
UR  - https://hdl.handle.net/21.15107/rcub_cer_6971
ER  - 

@conference{
author = "Petrović, Božana and Krstić, Maja and Čebela, Maria and Mudrinić, Tihana and Dutour Sikirić, Maja",
year = "2022",
abstract = "Thanks to its similarity with biological apatite found in vertebrate hard tissues, calcium hydroxyapatite is one of the most investigated materials in bone tissue engineering. Since biological apatite is not stoichiometric, ion substituted hydroxyapatites are in the focus of many studies as they more closely mimic the composition of natural bone. Although there are many investigations of the influence of foreign ions on the structure and physico-chemical properties of ionsubstituted hydroxyapatites, there is no much information on their behaviour in different media. In present study, magnesium - which plays a key role in bone metabolism and silicon - which is necessary for normal skeletal development, were used as ion substitutes. The behaviour of Mg and Si substituted hydroxyapatite in simulated body fluid and physiological solution was investigated by XRD, FTIR and SEM. Obtained results confirmed great potential of these substituted hydroxyapatites for biomedical applications.",
publisher = "Belgrade : Institute for Multidisciplinary Research, University of Belgrade",
journal = "Advanced Ceramics and Application : 6th Conference of The Serbian Society for Ceramic Materials, 6CSCS-2022, June 28-29, 2022, Belgrade, Serbia",
title = "Behaviour of Mg and Si substituted hydroxyapatites in model media",
pages = "53-53",
url = "https://hdl.handle.net/21.15107/rcub_cer_6971"
}

Petrović, B., Krstić, M., Čebela, M., Mudrinić, T.,& Dutour Sikirić, M.. (2022). Behaviour of Mg and Si substituted hydroxyapatites in model media. in Advanced Ceramics and Application : 6th Conference of The Serbian Society for Ceramic Materials, 6CSCS-2022, June 28-29, 2022, Belgrade, Serbia
Belgrade : Institute for Multidisciplinary Research, University of Belgrade., 53-53.
https://hdl.handle.net/21.15107/rcub_cer_6971

Petrović B, Krstić M, Čebela M, Mudrinić T, Dutour Sikirić M. Behaviour of Mg and Si substituted hydroxyapatites in model media. in Advanced Ceramics and Application : 6th Conference of The Serbian Society for Ceramic Materials, 6CSCS-2022, June 28-29, 2022, Belgrade, Serbia. 2022;:53-53.
https://hdl.handle.net/21.15107/rcub_cer_6971 .

Petrović, Božana, Krstić, Maja, Čebela, Maria, Mudrinić, Tihana, Dutour Sikirić, Maja, "Behaviour of Mg and Si substituted hydroxyapatites in model media" in Advanced Ceramics and Application : 6th Conference of The Serbian Society for Ceramic Materials, 6CSCS-2022, June 28-29, 2022, Belgrade, Serbia (2022):53-53,
https://hdl.handle.net/21.15107/rcub_cer_6971 .

TY  - JOUR
AU  - Petrović, Božana
AU  - Krstić, Maja
AU  - Mudrinić, Tihana
AU  - Čebela, Maria
AU  - Dutour-Sikirić, Maja
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5625
AB  - Due to its similarity with biological apatite found in vertebrate hard tissues, calcium hydroxyapatite is one of the most investigated materials in bone tissue engineering. As the biological apatite is not stoichiometric, ion substituted hydroxyapatites attract much atention since they more closely mimic the composition of natural bone. Although there are many investigations of the influence of foreign ions on the structure and physico-chemical properties of ion-substituted hydroxyapatites, there is scarse information on their behaviour in different media. In the present study, magnesium (Mg), that plays a key role in bone metabolism and silicon (Si), that is necessary for normal skeletal development, were used as ion substitutes. The behaviour of Mg and Si substituted hydroxyapatite in simulated body fluid was investigated by XRD, FTIR and SEM. Obtained results confirmed great potential of these substituted hydroxyapatites for biomedical applications.
AB  - Due to its similarity with biological apatite found in vertebrate hard tissues, calcium hydroxyapatite is one of the  most investigated materials in bone tissue engineering. As the biological apatite is not stoichiometric, ion substituted  hydroxyapatites attract much atention since they more closely mimic the composition of natural bone. Although  there are many investigations of the influence of foreign ions on the structure and physico-chemical properties of  ion-substituted hydroxyapatites, there is scarse information on their behaviour in different media.  In the present study, magnesium (Mg), that plays a key role in bone metabolism and silicon (Si), that is necessary for  normal skeletal development, were used as ion substitutes. The behaviour of Mg and Si substituted hydroxyapatite  in simulated body fluid was investigated by XRD, FTIR and SEM. Obtained results confirmed great potential of these  substituted hydroxyapatites for biomedical applications.
PB  - Beogra : Srpsko lekarsko društvo - Stomatološka sekcija
T2  - Stomatoloski glasnik Srbije / Serbian Dental Journal
T1  - Mg and Si substituted hydroxyapatite: Behaviour in simulated body fluid
VL  - 69
IS  - 2
SP  - 82
EP  - 88
DO  - 10.2298/SGS2202082P
ER  - 

@article{
author = "Petrović, Božana and Krstić, Maja and Mudrinić, Tihana and Čebela, Maria and Dutour-Sikirić, Maja",
year = "2022",
abstract = "Due to its similarity with biological apatite found in vertebrate hard tissues, calcium hydroxyapatite is one of the most investigated materials in bone tissue engineering. As the biological apatite is not stoichiometric, ion substituted hydroxyapatites attract much atention since they more closely mimic the composition of natural bone. Although there are many investigations of the influence of foreign ions on the structure and physico-chemical properties of ion-substituted hydroxyapatites, there is scarse information on their behaviour in different media. In the present study, magnesium (Mg), that plays a key role in bone metabolism and silicon (Si), that is necessary for normal skeletal development, were used as ion substitutes. The behaviour of Mg and Si substituted hydroxyapatite in simulated body fluid was investigated by XRD, FTIR and SEM. Obtained results confirmed great potential of these substituted hydroxyapatites for biomedical applications., Due to its similarity with biological apatite found in vertebrate hard tissues, calcium hydroxyapatite is one of the  most investigated materials in bone tissue engineering. As the biological apatite is not stoichiometric, ion substituted  hydroxyapatites attract much atention since they more closely mimic the composition of natural bone. Although  there are many investigations of the influence of foreign ions on the structure and physico-chemical properties of  ion-substituted hydroxyapatites, there is scarse information on their behaviour in different media.  In the present study, magnesium (Mg), that plays a key role in bone metabolism and silicon (Si), that is necessary for  normal skeletal development, were used as ion substitutes. The behaviour of Mg and Si substituted hydroxyapatite  in simulated body fluid was investigated by XRD, FTIR and SEM. Obtained results confirmed great potential of these  substituted hydroxyapatites for biomedical applications.",
publisher = "Beogra : Srpsko lekarsko društvo - Stomatološka sekcija",
journal = "Stomatoloski glasnik Srbije / Serbian Dental Journal",
title = "Mg and Si substituted hydroxyapatite: Behaviour in simulated body fluid",
volume = "69",
number = "2",
pages = "82-88",
doi = "10.2298/SGS2202082P"
}

Petrović, B., Krstić, M., Mudrinić, T., Čebela, M.,& Dutour-Sikirić, M.. (2022). Mg and Si substituted hydroxyapatite: Behaviour in simulated body fluid. in Stomatoloski glasnik Srbije / Serbian Dental Journal
Beogra : Srpsko lekarsko društvo - Stomatološka sekcija., 69(2), 82-88.
https://doi.org/10.2298/SGS2202082P

Petrović B, Krstić M, Mudrinić T, Čebela M, Dutour-Sikirić M. Mg and Si substituted hydroxyapatite: Behaviour in simulated body fluid. in Stomatoloski glasnik Srbije / Serbian Dental Journal. 2022;69(2):82-88.
doi:10.2298/SGS2202082P .

Petrović, Božana, Krstić, Maja, Mudrinić, Tihana, Čebela, Maria, Dutour-Sikirić, Maja, "Mg and Si substituted hydroxyapatite: Behaviour in simulated body fluid" in Stomatoloski glasnik Srbije / Serbian Dental Journal, 69, no. 2 (2022):82-88,
https://doi.org/10.2298/SGS2202082P . .