TY  - JOUR
AU  - Dimitrijević, Jelena
AU  - Solovjova, Natalija
AU  - Bukonjić, Andriana M.
AU  - Tomović, Dušan Lj.
AU  - Milinković, Mirjana
AU  - Caković, Angelina
AU  - Bogojeski, Jovana
AU  - Ratković, Zoran R.
AU  - Janjić, Goran
AU  - Rakić, Aleksandra
AU  - Arsenijević, Nebojša N.
AU  - Milovanović, Marija Z.
AU  - Milovanović, Jelena Z.
AU  - Radić, Gordana P.
AU  - Jevtić, Verica V.
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7060
AB  - The numerous side effects of platinum based chemotherapy has led to the design of new therapeutics with platinum replaced by another transition metal. Here, we investigated the interactions of previously reported copper(II) complexes containing S-isoalkyl derivatives, the salicylic acid with guanosine-5′-monophosphate and calf thymus DNA (CT-DNA) and their antitumor effects, in a colon carcinoma model. All three copper(II) complexes exhibited an affinity for binding to CT-DNA, but there was no indication of intercalation or the displacement of ethidium bromide. Molecular docking studies revealed a significant affinity of the complexes for binding to the minor groove of B-form DNA, which coincided with DNA elongation, and a higher affinity for binding to Z-form DNA, supporting the hypothesis that the complex binding to CT-DNA induces a local transition from B-form to Z-form DNA. These complexes show a moderate, but selective cytotoxic effect toward colon cancer cells in vitro. Binuclear complex of copper(II) with S-isoamyl derivative of thiosalicylic acid showed the highest cytotoxic effect, arrested tumor cells in the G2/M phase of the cell cycle, and significantly reduced the expression of inflammatory molecules pro-IL-1β, TNF-α, ICAM-1, and VCAM-1 in the tissue of primary heterotopic murine colon cancer, which was accompanied by a significantly reduced tumor growth and metastases in the lung and liver.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Docking studies, cytotoxicity evaluation and interactions of binuclear copper(ii) complexes with s-isoalkyl derivatives of thiosalicylic acid with some relevant biomolecules
VL  - 24
IS  - 15
SP  - 12504
DO  - 10.3390/ijms241512504
ER  - 

@article{
author = "Dimitrijević, Jelena and Solovjova, Natalija and Bukonjić, Andriana M. and Tomović, Dušan Lj. and Milinković, Mirjana and Caković, Angelina and Bogojeski, Jovana and Ratković, Zoran R. and Janjić, Goran and Rakić, Aleksandra and Arsenijević, Nebojša N. and Milovanović, Marija Z. and Milovanović, Jelena Z. and Radić, Gordana P. and Jevtić, Verica V.",
year = "2023",
abstract = "The numerous side effects of platinum based chemotherapy has led to the design of new therapeutics with platinum replaced by another transition metal. Here, we investigated the interactions of previously reported copper(II) complexes containing S-isoalkyl derivatives, the salicylic acid with guanosine-5′-monophosphate and calf thymus DNA (CT-DNA) and their antitumor effects, in a colon carcinoma model. All three copper(II) complexes exhibited an affinity for binding to CT-DNA, but there was no indication of intercalation or the displacement of ethidium bromide. Molecular docking studies revealed a significant affinity of the complexes for binding to the minor groove of B-form DNA, which coincided with DNA elongation, and a higher affinity for binding to Z-form DNA, supporting the hypothesis that the complex binding to CT-DNA induces a local transition from B-form to Z-form DNA. These complexes show a moderate, but selective cytotoxic effect toward colon cancer cells in vitro. Binuclear complex of copper(II) with S-isoamyl derivative of thiosalicylic acid showed the highest cytotoxic effect, arrested tumor cells in the G2/M phase of the cell cycle, and significantly reduced the expression of inflammatory molecules pro-IL-1β, TNF-α, ICAM-1, and VCAM-1 in the tissue of primary heterotopic murine colon cancer, which was accompanied by a significantly reduced tumor growth and metastases in the lung and liver.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Docking studies, cytotoxicity evaluation and interactions of binuclear copper(ii) complexes with s-isoalkyl derivatives of thiosalicylic acid with some relevant biomolecules",
volume = "24",
number = "15",
pages = "12504",
doi = "10.3390/ijms241512504"
}

Dimitrijević, J., Solovjova, N., Bukonjić, A. M., Tomović, D. Lj., Milinković, M., Caković, A., Bogojeski, J., Ratković, Z. R., Janjić, G., Rakić, A., Arsenijević, N. N., Milovanović, M. Z., Milovanović, J. Z., Radić, G. P.,& Jevtić, V. V.. (2023). Docking studies, cytotoxicity evaluation and interactions of binuclear copper(ii) complexes with s-isoalkyl derivatives of thiosalicylic acid with some relevant biomolecules. in International Journal of Molecular Sciences
MDPI., 24(15), 12504.
https://doi.org/10.3390/ijms241512504

Dimitrijević J, Solovjova N, Bukonjić AM, Tomović DL, Milinković M, Caković A, Bogojeski J, Ratković ZR, Janjić G, Rakić A, Arsenijević NN, Milovanović MZ, Milovanović JZ, Radić GP, Jevtić VV. Docking studies, cytotoxicity evaluation and interactions of binuclear copper(ii) complexes with s-isoalkyl derivatives of thiosalicylic acid with some relevant biomolecules. in International Journal of Molecular Sciences. 2023;24(15):12504.
doi:10.3390/ijms241512504 .

Dimitrijević, Jelena, Solovjova, Natalija, Bukonjić, Andriana M., Tomović, Dušan Lj., Milinković, Mirjana, Caković, Angelina, Bogojeski, Jovana, Ratković, Zoran R., Janjić, Goran, Rakić, Aleksandra, Arsenijević, Nebojša N., Milovanović, Marija Z., Milovanović, Jelena Z., Radić, Gordana P., Jevtić, Verica V., "Docking studies, cytotoxicity evaluation and interactions of binuclear copper(ii) complexes with s-isoalkyl derivatives of thiosalicylic acid with some relevant biomolecules" in International Journal of Molecular Sciences, 24, no. 15 (2023):12504,
https://doi.org/10.3390/ijms241512504 . .

TY  - CONF
AU  - Milovanović, Jelena
AU  - Ilić, Bojan
AU  - Radulović, Niko
AU  - Mladenović, Marko
AU  - Novaković, Irena
AU  - Makarov, Slobodan E.
AU  - Divac Rankov, Aleksandra
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5781
AB  - Ciljevi ove studije bili su: 1) ispitivanje citotoksičnog potencijala različitih estara linoleinske kiseline (butil-, pentil-, heksil-, heptil-, oktil-, nonil-, fentil- i 3-fenilpropil- linoleat) detektovanih u odbrambenim sekretima dve vrsta stonoga iz reda Julida - Megaphyllum unillineatum (C. L. Koch, 1838) i M. bosniense (Verrhoeff, 1897) na vijabilnost ćelija raka debelog creva (SW480) i 2) analiza vijabilnost SW480 ćelija nakon tretiranja ekstraktima odbrambenih sekreta pomenutih vrsta.
PB  - Entomološko društvo Srbije
C3  - Zbornik rezimea - XIII Simpozijum entomologa Srbije sa medjunarodnim učešćem, 14-16. 09. 2022., Pirot
T1  - Citotoksični potencijal ekstrakata i odabranih estara iz odbrambenih sekreta vrsta Megahphyllum bosniense i M. unilineatum (Diplopoda: julida) prema ćelijama raka debelog creva
SP  - 61
EP  - 61
UR  - https://hdl.handle.net/21.15107/rcub_cer_5781
ER  - 

@conference{
author = "Milovanović, Jelena and Ilić, Bojan and Radulović, Niko and Mladenović, Marko and Novaković, Irena and Makarov, Slobodan E. and Divac Rankov, Aleksandra",
year = "2022",
abstract = "Ciljevi ove studije bili su: 1) ispitivanje citotoksičnog potencijala različitih estara linoleinske kiseline (butil-, pentil-, heksil-, heptil-, oktil-, nonil-, fentil- i 3-fenilpropil- linoleat) detektovanih u odbrambenim sekretima dve vrsta stonoga iz reda Julida - Megaphyllum unillineatum (C. L. Koch, 1838) i M. bosniense (Verrhoeff, 1897) na vijabilnost ćelija raka debelog creva (SW480) i 2) analiza vijabilnost SW480 ćelija nakon tretiranja ekstraktima odbrambenih sekreta pomenutih vrsta.",
publisher = "Entomološko društvo Srbije",
journal = "Zbornik rezimea - XIII Simpozijum entomologa Srbije sa medjunarodnim učešćem, 14-16. 09. 2022., Pirot",
title = "Citotoksični potencijal ekstrakata i odabranih estara iz odbrambenih sekreta vrsta Megahphyllum bosniense i M. unilineatum (Diplopoda: julida) prema ćelijama raka debelog creva",
pages = "61-61",
url = "https://hdl.handle.net/21.15107/rcub_cer_5781"
}

Milovanović, J., Ilić, B., Radulović, N., Mladenović, M., Novaković, I., Makarov, S. E.,& Divac Rankov, A.. (2022). Citotoksični potencijal ekstrakata i odabranih estara iz odbrambenih sekreta vrsta Megahphyllum bosniense i M. unilineatum (Diplopoda: julida) prema ćelijama raka debelog creva. in Zbornik rezimea - XIII Simpozijum entomologa Srbije sa medjunarodnim učešćem, 14-16. 09. 2022., Pirot
Entomološko društvo Srbije., 61-61.
https://hdl.handle.net/21.15107/rcub_cer_5781

Milovanović J, Ilić B, Radulović N, Mladenović M, Novaković I, Makarov SE, Divac Rankov A. Citotoksični potencijal ekstrakata i odabranih estara iz odbrambenih sekreta vrsta Megahphyllum bosniense i M. unilineatum (Diplopoda: julida) prema ćelijama raka debelog creva. in Zbornik rezimea - XIII Simpozijum entomologa Srbije sa medjunarodnim učešćem, 14-16. 09. 2022., Pirot. 2022;:61-61.
https://hdl.handle.net/21.15107/rcub_cer_5781 .

Milovanović, Jelena, Ilić, Bojan, Radulović, Niko, Mladenović, Marko, Novaković, Irena, Makarov, Slobodan E., Divac Rankov, Aleksandra, "Citotoksični potencijal ekstrakata i odabranih estara iz odbrambenih sekreta vrsta Megahphyllum bosniense i M. unilineatum (Diplopoda: julida) prema ćelijama raka debelog creva" in Zbornik rezimea - XIII Simpozijum entomologa Srbije sa medjunarodnim učešćem, 14-16. 09. 2022., Pirot (2022):61-61,
https://hdl.handle.net/21.15107/rcub_cer_5781 .

TY  - JOUR
AU  - Arsenijević, Dragana
AU  - Stojanović, Bojana
AU  - Milovanović, Jelena
AU  - Arsenijević, Aleksandar
AU  - Simić, Miloš
AU  - Pergal, Marija
AU  - Kodranov, Igor
AU  - Cvetković, Olga
AU  - Vojvodić, Danilo
AU  - Ristanović, Elizabeta
AU  - Manojlović, Dragan
AU  - Milovanović, Marija
AU  - Arsenijević, Nebojša
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4835
AB  - The main biologically active components of plants belonging to the genus Allium, responsible for their biological activities, including anti-inflammatory, antioxidant and immunomodulatory, are organosulfur compounds. The aim of this study was to synthetize the mixture of dipropyl polysul-fides (DPPS) and to test their biological activity in acute hepatitis. C57BL/6 mice were administered orally with DPPS 6 h before intravenous injection of Concanavalin A (ConA). Liver inflammation, necrosis and hepatocytes apoptosis were determined by histological analyses. Cytokines in liver tissue were determined by ELISA, expression of adhesive molecules and enzymes by RT PCR, while liver mononuclear cells were analyzed by flow cytometry. DPPS pretreatment significantly attenuated liver inflammation and injury, as evidenced by biochemical and histopathological observations. In DPPS-pretreated mice, messenger RNA levels of adhesion molecules and NADPH oxidase complex were significantly reduced, while the expression of SOD enzymes was enhanced. DPPS pretreatment decreased protein level of inflammatory cytokines and increased percentage of T regulatory cells in the livers of ConA mice. DPPS showed hepatoprotective effects in ConA-induced hepatitis, charac-terized by attenuation of inflammation and affection of Th17/Treg balance in favor of T regulatory cells and implicating potential therapeutic usage of DPPS mixture in inflammatory liver diseases.
PB  - MDPI
T2  - Nutrients
T1  - Hepatoprotective effect of mixture of dipropyl polysulfides in concanavalin a-induced hepatitis
VL  - 13
IS  - 3
SP  - 1
EP  - 15
DO  - 10.3390/nu13031022
ER  - 

@article{
author = "Arsenijević, Dragana and Stojanović, Bojana and Milovanović, Jelena and Arsenijević, Aleksandar and Simić, Miloš and Pergal, Marija and Kodranov, Igor and Cvetković, Olga and Vojvodić, Danilo and Ristanović, Elizabeta and Manojlović, Dragan and Milovanović, Marija and Arsenijević, Nebojša",
year = "2021",
abstract = "The main biologically active components of plants belonging to the genus Allium, responsible for their biological activities, including anti-inflammatory, antioxidant and immunomodulatory, are organosulfur compounds. The aim of this study was to synthetize the mixture of dipropyl polysul-fides (DPPS) and to test their biological activity in acute hepatitis. C57BL/6 mice were administered orally with DPPS 6 h before intravenous injection of Concanavalin A (ConA). Liver inflammation, necrosis and hepatocytes apoptosis were determined by histological analyses. Cytokines in liver tissue were determined by ELISA, expression of adhesive molecules and enzymes by RT PCR, while liver mononuclear cells were analyzed by flow cytometry. DPPS pretreatment significantly attenuated liver inflammation and injury, as evidenced by biochemical and histopathological observations. In DPPS-pretreated mice, messenger RNA levels of adhesion molecules and NADPH oxidase complex were significantly reduced, while the expression of SOD enzymes was enhanced. DPPS pretreatment decreased protein level of inflammatory cytokines and increased percentage of T regulatory cells in the livers of ConA mice. DPPS showed hepatoprotective effects in ConA-induced hepatitis, charac-terized by attenuation of inflammation and affection of Th17/Treg balance in favor of T regulatory cells and implicating potential therapeutic usage of DPPS mixture in inflammatory liver diseases.",
publisher = "MDPI",
journal = "Nutrients",
title = "Hepatoprotective effect of mixture of dipropyl polysulfides in concanavalin a-induced hepatitis",
volume = "13",
number = "3",
pages = "1-15",
doi = "10.3390/nu13031022"
}

Arsenijević, D., Stojanović, B., Milovanović, J., Arsenijević, A., Simić, M., Pergal, M., Kodranov, I., Cvetković, O., Vojvodić, D., Ristanović, E., Manojlović, D., Milovanović, M.,& Arsenijević, N.. (2021). Hepatoprotective effect of mixture of dipropyl polysulfides in concanavalin a-induced hepatitis. in Nutrients
MDPI., 13(3), 1-15.
https://doi.org/10.3390/nu13031022

Arsenijević D, Stojanović B, Milovanović J, Arsenijević A, Simić M, Pergal M, Kodranov I, Cvetković O, Vojvodić D, Ristanović E, Manojlović D, Milovanović M, Arsenijević N. Hepatoprotective effect of mixture of dipropyl polysulfides in concanavalin a-induced hepatitis. in Nutrients. 2021;13(3):1-15.
doi:10.3390/nu13031022 .

Arsenijević, Dragana, Stojanović, Bojana, Milovanović, Jelena, Arsenijević, Aleksandar, Simić, Miloš, Pergal, Marija, Kodranov, Igor, Cvetković, Olga, Vojvodić, Danilo, Ristanović, Elizabeta, Manojlović, Dragan, Milovanović, Marija, Arsenijević, Nebojša, "Hepatoprotective effect of mixture of dipropyl polysulfides in concanavalin a-induced hepatitis" in Nutrients, 13, no. 3 (2021):1-15,
https://doi.org/10.3390/nu13031022 . .

TY  - JOUR
AU  - Đorđević, Dragana B.
AU  - Milovanović, Jelena
AU  - Jurisević, Milena
AU  - Stojanović, Bojana
AU  - Cvetković, Olga
AU  - Pergal, Marija
AU  - Ristanović, Elizabeta
AU  - Vojvodić, Danilo
AU  - Simić, Miloš
AU  - Manojlović, Dragan
AU  - Milovanović, Marija
AU  - Arsenijević, Nebojsa
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3421
AB  - Copper serves as a limiting factor for multiple steps of tumour progression, including angiogenesis, growth and metastasis. High levels of copper have been found in a wide spectrum of human cancers. Antitumour activities of copper-chelating drugs have been reported in animal models. Organosulfur compounds (diallyl sulfide, DAS; diallyl disulfide, DADS; S-ethylcysteine, SEC; N-acetylcysteine, NAC) derived from garlic exhibit marked copper-chelating activity. We analysed a mixture of fifteen n-propyl polysulfides (DPPS) for potential antitumour activity against several murine tumour cell lines, including colon carcinoma (CT26), mammary carcinoma (4T1) and melanoma cell lines (B16F10), and compared the effects with the antiproliferative effect in highly proliferative murine mesenchymal stem cells (mMSCs). The effects of the mixture of n-propyl polysulfides (100%) on cell viability were determined using MTT assays. Cell apoptosis was analysed using Annexin V-FITC/PI assays.The results of the MTT assays indicate that this standardized mixture of n-propyl polysulfides has a strong, dose-dependent cytotoxic effect against all three of the tested tumour cell lines (CT26, 4T1, B16F10). The cytotoxic effect of the n-propyl polysulfide mixture against the CT26 and B16F10 cell lines was much stronger than that of cisplatin and was significantly weaker in mMSCs, which are non-cancerous and highly proliferative cells, than in cancer cells. Flow cytometric analysis of CT26 and 4T1 cells revealed that apoptosis was not the dominant mechanism of cell death induced by the n-propyl polysulfide mixture. The n-propyl polysulfide mixture exerted highly cytotoxic activity against murine colon carcinoma and melanoma cell lines, but its antiproliferative activity against mMSCs was significantly lower than that of cisplatin.
AB  - Bakar učestvuje u različitim fazama progresije tumora, u angiogenezi, rastu i metastaziranju. Povećane vrednosti bakra u serumu i u tkivu tumora, karakteristika su različitih vrsta tumora kod ljudi. U animalnim eksperimentalnim modelima, supstance (lekovi) koje heliraju bakar ispoljavaju anti-tumorski efekat. Helatori bakra su i organosumporna jedinjenja, izolovana iz belog luka. U ovoj studiji analizirali smo potencijalnu anti-tumorsku aktivnost smeše petnaest različitih n-propil polisulfi da na nekoliko mišjih ćelijskih linija tumora: karcinom kolona (CT26), karcinom dojke (4T1) i melanom (B16F10). Aktivnost ove smeše na tumorskim linijama, uporedili smo sa antiproliferativnim efektom na mezenhimalne matične ćelije miša (engl. murine mesenchymal stem cells, mMSC). Efekat smeše n-propil polisulfi da (100%) na vijabilnost ćelija ispitali smo MTT testom. Apoptozu ćelija smo analizirali koristeći Annexin V-FITC/PI test. Rezultati MTT testa ukazuju da standardizovana smeša n-propil polisulfi da ima jak citotoksični, dozno-zavisni, efekat na sve tri testirane ćelijske linije tumora (CT26, 4T1, B16F10). Smeša n-propil polisulfi da ispoljava izraženiji citotoksični efekat na CT26 i B16F10 linije u odnosu na cisplatinu. Citotoksični efekat ove smeše na mMSC je značajno slabiji poredeći sa efektom cisplatine, što ukazuje na selektivnije dejstvo. Analiza CT26 i 4T1 ćelija protočnom citometrijom pokazala je da apoptoza nije glavni oblik smrti ćelija, koju uzrokuje smeša n-propil polisulfi - da. Smeša n-propil polisulfi da ispoljava jaču citotoksičnu aktivnost na ćelijskim linijama mišjeg karcinoma kolona i melanoma i slabiju aktivnost na mMSC u poređenju sa efektom cisplatine.
T2  - Serbian Journal of Experimental and Clinical Research
T1  - Antitumour effect of a mixture of n-propyl polysulfides In vitro
T1  - Antitumorski efekti smeše n-propil polisulfida in vitro
VL  - 20
IS  - 4
SP  - 295
EP  - 300
DO  - 10.1515/sjecr-2017-0069
ER  - 

@article{
author = "Đorđević, Dragana B. and Milovanović, Jelena and Jurisević, Milena and Stojanović, Bojana and Cvetković, Olga and Pergal, Marija and Ristanović, Elizabeta and Vojvodić, Danilo and Simić, Miloš and Manojlović, Dragan and Milovanović, Marija and Arsenijević, Nebojsa",
year = "2019",
abstract = "Copper serves as a limiting factor for multiple steps of tumour progression, including angiogenesis, growth and metastasis. High levels of copper have been found in a wide spectrum of human cancers. Antitumour activities of copper-chelating drugs have been reported in animal models. Organosulfur compounds (diallyl sulfide, DAS; diallyl disulfide, DADS; S-ethylcysteine, SEC; N-acetylcysteine, NAC) derived from garlic exhibit marked copper-chelating activity. We analysed a mixture of fifteen n-propyl polysulfides (DPPS) for potential antitumour activity against several murine tumour cell lines, including colon carcinoma (CT26), mammary carcinoma (4T1) and melanoma cell lines (B16F10), and compared the effects with the antiproliferative effect in highly proliferative murine mesenchymal stem cells (mMSCs). The effects of the mixture of n-propyl polysulfides (100%) on cell viability were determined using MTT assays. Cell apoptosis was analysed using Annexin V-FITC/PI assays.The results of the MTT assays indicate that this standardized mixture of n-propyl polysulfides has a strong, dose-dependent cytotoxic effect against all three of the tested tumour cell lines (CT26, 4T1, B16F10). The cytotoxic effect of the n-propyl polysulfide mixture against the CT26 and B16F10 cell lines was much stronger than that of cisplatin and was significantly weaker in mMSCs, which are non-cancerous and highly proliferative cells, than in cancer cells. Flow cytometric analysis of CT26 and 4T1 cells revealed that apoptosis was not the dominant mechanism of cell death induced by the n-propyl polysulfide mixture. The n-propyl polysulfide mixture exerted highly cytotoxic activity against murine colon carcinoma and melanoma cell lines, but its antiproliferative activity against mMSCs was significantly lower than that of cisplatin., Bakar učestvuje u različitim fazama progresije tumora, u angiogenezi, rastu i metastaziranju. Povećane vrednosti bakra u serumu i u tkivu tumora, karakteristika su različitih vrsta tumora kod ljudi. U animalnim eksperimentalnim modelima, supstance (lekovi) koje heliraju bakar ispoljavaju anti-tumorski efekat. Helatori bakra su i organosumporna jedinjenja, izolovana iz belog luka. U ovoj studiji analizirali smo potencijalnu anti-tumorsku aktivnost smeše petnaest različitih n-propil polisulfi da na nekoliko mišjih ćelijskih linija tumora: karcinom kolona (CT26), karcinom dojke (4T1) i melanom (B16F10). Aktivnost ove smeše na tumorskim linijama, uporedili smo sa antiproliferativnim efektom na mezenhimalne matične ćelije miša (engl. murine mesenchymal stem cells, mMSC). Efekat smeše n-propil polisulfi da (100%) na vijabilnost ćelija ispitali smo MTT testom. Apoptozu ćelija smo analizirali koristeći Annexin V-FITC/PI test. Rezultati MTT testa ukazuju da standardizovana smeša n-propil polisulfi da ima jak citotoksični, dozno-zavisni, efekat na sve tri testirane ćelijske linije tumora (CT26, 4T1, B16F10). Smeša n-propil polisulfi da ispoljava izraženiji citotoksični efekat na CT26 i B16F10 linije u odnosu na cisplatinu. Citotoksični efekat ove smeše na mMSC je značajno slabiji poredeći sa efektom cisplatine, što ukazuje na selektivnije dejstvo. Analiza CT26 i 4T1 ćelija protočnom citometrijom pokazala je da apoptoza nije glavni oblik smrti ćelija, koju uzrokuje smeša n-propil polisulfi - da. Smeša n-propil polisulfi da ispoljava jaču citotoksičnu aktivnost na ćelijskim linijama mišjeg karcinoma kolona i melanoma i slabiju aktivnost na mMSC u poređenju sa efektom cisplatine.",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "Antitumour effect of a mixture of n-propyl polysulfides In vitro, Antitumorski efekti smeše n-propil polisulfida in vitro",
volume = "20",
number = "4",
pages = "295-300",
doi = "10.1515/sjecr-2017-0069"
}

Đorđević, D. B., Milovanović, J., Jurisević, M., Stojanović, B., Cvetković, O., Pergal, M., Ristanović, E., Vojvodić, D., Simić, M., Manojlović, D., Milovanović, M.,& Arsenijević, N.. (2019). Antitumour effect of a mixture of n-propyl polysulfides In vitro. in Serbian Journal of Experimental and Clinical Research, 20(4), 295-300.
https://doi.org/10.1515/sjecr-2017-0069

Đorđević DB, Milovanović J, Jurisević M, Stojanović B, Cvetković O, Pergal M, Ristanović E, Vojvodić D, Simić M, Manojlović D, Milovanović M, Arsenijević N. Antitumour effect of a mixture of n-propyl polysulfides In vitro. in Serbian Journal of Experimental and Clinical Research. 2019;20(4):295-300.
doi:10.1515/sjecr-2017-0069 .

Đorđević, Dragana B., Milovanović, Jelena, Jurisević, Milena, Stojanović, Bojana, Cvetković, Olga, Pergal, Marija, Ristanović, Elizabeta, Vojvodić, Danilo, Simić, Miloš, Manojlović, Dragan, Milovanović, Marija, Arsenijević, Nebojsa, "Antitumour effect of a mixture of n-propyl polysulfides In vitro" in Serbian Journal of Experimental and Clinical Research, 20, no. 4 (2019):295-300,
https://doi.org/10.1515/sjecr-2017-0069 . .