TY  - JOUR
AU  - Pergal, Marija
AU  - Brkljačić, Jelena
AU  - Tovilović-Kovačević, Gordana
AU  - Špírková, Milena
AU  - Kodranov, Igor
AU  - Manojlović, Dragan
AU  - Ostojić, Sanja
AU  - Knežević, Nikola Ž.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4016
AB  - Novel polyurethane nanocomposite (PUN) materials containing different surface-functionalized mesoporous silica nanoparticles (MSNs) were prepared by in situ polymerization methodology. Polyurethane network was formed from poly(dimethylsiloxane)-based macrodiol (PDMS), 4,4′-methylenediphenyldiisocyanate (MDI), and hyperbranched polyester of the second pseudo-generation (BH-20; used as crosslinking agent). PU and PU/MSN nanocomposites contained equal ratios of soft PDMS and hard MDI-BH-20 segments. Non-functionalized and surface-functionalized (with 3-(trihydroxysilyl)propyl methylphosphonate (FOMSN) and 2-[methoxy(polyethyleneoxy)6−9propyl]trimethoxysilane (PEGMSN)) MSNs were used as the nanofillers at a concentration of 1 wt%. Prepared materials were characterized by Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dynamic mechanical thermal analyses (DMTA), nanoindentation, equilibrium swelling and water absorption measurements. Characteristics of the prepared PUNs when in contact with a biological environment were assessed through testing their biocompatibility, protein adsorption and adhesion of endothelial cells. The favourable influence of MSNs on the physico-chemical and biological characteristics of these novel PUN materials was identified, which evidences their vast applicability potential as coatings for medical devices and implants.
PB  - Elsevier
T2  - Progress in Organic Coatings
T1  - Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites
VL  - 151
SP  - 106049
DO  - 10.1016/j.porgcoat.2020.106049
ER  - 

@article{
author = "Pergal, Marija and Brkljačić, Jelena and Tovilović-Kovačević, Gordana and Špírková, Milena and Kodranov, Igor and Manojlović, Dragan and Ostojić, Sanja and Knežević, Nikola Ž.",
year = "2021",
abstract = "Novel polyurethane nanocomposite (PUN) materials containing different surface-functionalized mesoporous silica nanoparticles (MSNs) were prepared by in situ polymerization methodology. Polyurethane network was formed from poly(dimethylsiloxane)-based macrodiol (PDMS), 4,4′-methylenediphenyldiisocyanate (MDI), and hyperbranched polyester of the second pseudo-generation (BH-20; used as crosslinking agent). PU and PU/MSN nanocomposites contained equal ratios of soft PDMS and hard MDI-BH-20 segments. Non-functionalized and surface-functionalized (with 3-(trihydroxysilyl)propyl methylphosphonate (FOMSN) and 2-[methoxy(polyethyleneoxy)6−9propyl]trimethoxysilane (PEGMSN)) MSNs were used as the nanofillers at a concentration of 1 wt%. Prepared materials were characterized by Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dynamic mechanical thermal analyses (DMTA), nanoindentation, equilibrium swelling and water absorption measurements. Characteristics of the prepared PUNs when in contact with a biological environment were assessed through testing their biocompatibility, protein adsorption and adhesion of endothelial cells. The favourable influence of MSNs on the physico-chemical and biological characteristics of these novel PUN materials was identified, which evidences their vast applicability potential as coatings for medical devices and implants.",
publisher = "Elsevier",
journal = "Progress in Organic Coatings",
title = "Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites",
volume = "151",
pages = "106049",
doi = "10.1016/j.porgcoat.2020.106049"
}

Pergal, M., Brkljačić, J., Tovilović-Kovačević, G., Špírková, M., Kodranov, I., Manojlović, D., Ostojić, S.,& Knežević, N. Ž.. (2021). Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites. in Progress in Organic Coatings
Elsevier., 151, 106049.
https://doi.org/10.1016/j.porgcoat.2020.106049

Pergal M, Brkljačić J, Tovilović-Kovačević G, Špírková M, Kodranov I, Manojlović D, Ostojić S, Knežević NŽ. Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites. in Progress in Organic Coatings. 2021;151:106049.
doi:10.1016/j.porgcoat.2020.106049 .

Pergal, Marija, Brkljačić, Jelena, Tovilović-Kovačević, Gordana, Špírková, Milena, Kodranov, Igor, Manojlović, Dragan, Ostojić, Sanja, Knežević, Nikola Ž., "Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites" in Progress in Organic Coatings, 151 (2021):106049,
https://doi.org/10.1016/j.porgcoat.2020.106049 . .

TY  - JOUR
AU  - Mladenović, Minja
AU  - Morgan, Ibrahim
AU  - Ilić, Nebojša
AU  - Saoud, Mohamad
AU  - Pergal, Marija
AU  - Kaluđerović, Goran N.
AU  - Knežević, Nikola Ž.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4572
AB  - Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.
PB  - MDPI
T2  - Pharmaceutics
T1  - Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers
VL  - 13
IS  - 4
SP  - 460
DO  - 10.3390/pharmaceutics13040460
ER  - 

@article{
author = "Mladenović, Minja and Morgan, Ibrahim and Ilić, Nebojša and Saoud, Mohamad and Pergal, Marija and Kaluđerović, Goran N. and Knežević, Nikola Ž.",
year = "2021",
abstract = "Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers",
volume = "13",
number = "4",
pages = "460",
doi = "10.3390/pharmaceutics13040460"
}

Mladenović, M., Morgan, I., Ilić, N., Saoud, M., Pergal, M., Kaluđerović, G. N.,& Knežević, N. Ž.. (2021). Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers. in Pharmaceutics
MDPI., 13(4), 460.
https://doi.org/10.3390/pharmaceutics13040460

Mladenović M, Morgan I, Ilić N, Saoud M, Pergal M, Kaluđerović GN, Knežević NŽ. Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers. in Pharmaceutics. 2021;13(4):460.
doi:10.3390/pharmaceutics13040460 .

Mladenović, Minja, Morgan, Ibrahim, Ilić, Nebojša, Saoud, Mohamad, Pergal, Marija, Kaluđerović, Goran N., Knežević, Nikola Ž., "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers" in Pharmaceutics, 13, no. 4 (2021):460,
https://doi.org/10.3390/pharmaceutics13040460 . .

TY  - DATA
AU  - Mladenović, Minja
AU  - Morgan, Ibrahim
AU  - Ilić, Nebojša
AU  - Saoud, Mohamad
AU  - Pergal, Marija
AU  - Kaluđerović, Goran N.
AU  - Knežević, Nikola Ž.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4573
AB  - Figure S1. Full range FTIR spectra of the synthesized materials. Figure S2. Particle size distribution of Ru-modified nanoparticles in water (top) and culture medium (bottom). Figure S3. EDS chromatograms of (a) MSN-H1[Ru]; (b) MSN-H2[Ru] and (c) MSN[Ru] with insets representing Ru mapping. Figure S4. UV/VIS spectra of supernatants at different pH values after 48 h of stirring. Figure S5. Viability of the B16F1 cells determined with CV and MTT assays treated (48 h) with pristine MSN on pH 5.0 and 7.2.
PB  - MDPI
T2  - Pharmaceutics
T1  - Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers"
UR  - https://hdl.handle.net/21.15107/rcub_cer_4573
ER  - 

@misc{
author = "Mladenović, Minja and Morgan, Ibrahim and Ilić, Nebojša and Saoud, Mohamad and Pergal, Marija and Kaluđerović, Goran N. and Knežević, Nikola Ž.",
year = "2021",
abstract = "Figure S1. Full range FTIR spectra of the synthesized materials. Figure S2. Particle size distribution of Ru-modified nanoparticles in water (top) and culture medium (bottom). Figure S3. EDS chromatograms of (a) MSN-H1[Ru]; (b) MSN-H2[Ru] and (c) MSN[Ru] with insets representing Ru mapping. Figure S4. UV/VIS spectra of supernatants at different pH values after 48 h of stirring. Figure S5. Viability of the B16F1 cells determined with CV and MTT assays treated (48 h) with pristine MSN on pH 5.0 and 7.2.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers"",
url = "https://hdl.handle.net/21.15107/rcub_cer_4573"
}

Mladenović, M., Morgan, I., Ilić, N., Saoud, M., Pergal, M., Kaluđerović, G. N.,& Knežević, N. Ž.. (2021). Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers". in Pharmaceutics
MDPI..
https://hdl.handle.net/21.15107/rcub_cer_4573

Mladenović M, Morgan I, Ilić N, Saoud M, Pergal M, Kaluđerović GN, Knežević NŽ. Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers". in Pharmaceutics. 2021;.
https://hdl.handle.net/21.15107/rcub_cer_4573 .

Mladenović, Minja, Morgan, Ibrahim, Ilić, Nebojša, Saoud, Mohamad, Pergal, Marija, Kaluđerović, Goran N., Knežević, Nikola Ž., "Supplementary material to: "Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers"" in Pharmaceutics (2021),
https://hdl.handle.net/21.15107/rcub_cer_4573 .

TY  - CONF
AU  - Pergal, Marija
AU  - Kodranov, Igor
AU  - Špirkova, Milena
AU  - Manojlović, Dragan
AU  - Ostojić, Sanja
AU  - Knežević, Nikola Ž.
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5769
AB  - Polyurethane (PU) networks based on poly(dimethylsiloxane) (PDMS) and hyperbranched polyester (HBP) possess unique properties such as chemical stability, good thermal behavior, good surface and mechanical properties, making these materials good candidates for coating applications. The silica addition in polymer typically leads to a significant improvement of mechanical and thermal properties due to good filler dispersion, good compatibility with the matrix, and the presence of a strong interaction between reinforcements and the polymer matrix.
PB  - Serbian Ceramic Society
C3  - Program and the book of abstracts - The Eight Serbian Ceramic Society Conference »Advanced Ceramics and Application«, New Frontiers in Multifunctional Material Science and Processing
T1  - Thermal and Thermomechanical Properties of Organic-Inorganic Nanocomposites Prepared from Polyurethane Network and Mesoporous Silica Nanoparticles
SP  - 66
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_cer_5769
ER  - 

@conference{
author = "Pergal, Marija and Kodranov, Igor and Špirkova, Milena and Manojlović, Dragan and Ostojić, Sanja and Knežević, Nikola Ž.",
year = "2019",
abstract = "Polyurethane (PU) networks based on poly(dimethylsiloxane) (PDMS) and hyperbranched polyester (HBP) possess unique properties such as chemical stability, good thermal behavior, good surface and mechanical properties, making these materials good candidates for coating applications. The silica addition in polymer typically leads to a significant improvement of mechanical and thermal properties due to good filler dispersion, good compatibility with the matrix, and the presence of a strong interaction between reinforcements and the polymer matrix.",
publisher = "Serbian Ceramic Society",
journal = "Program and the book of abstracts - The Eight Serbian Ceramic Society Conference »Advanced Ceramics and Application«, New Frontiers in Multifunctional Material Science and Processing",
title = "Thermal and Thermomechanical Properties of Organic-Inorganic Nanocomposites Prepared from Polyurethane Network and Mesoporous Silica Nanoparticles",
pages = "66-66",
url = "https://hdl.handle.net/21.15107/rcub_cer_5769"
}

Pergal, M., Kodranov, I., Špirkova, M., Manojlović, D., Ostojić, S.,& Knežević, N. Ž.. (2019). Thermal and Thermomechanical Properties of Organic-Inorganic Nanocomposites Prepared from Polyurethane Network and Mesoporous Silica Nanoparticles. in Program and the book of abstracts - The Eight Serbian Ceramic Society Conference »Advanced Ceramics and Application«, New Frontiers in Multifunctional Material Science and Processing
Serbian Ceramic Society., 66-66.
https://hdl.handle.net/21.15107/rcub_cer_5769

Pergal M, Kodranov I, Špirkova M, Manojlović D, Ostojić S, Knežević NŽ. Thermal and Thermomechanical Properties of Organic-Inorganic Nanocomposites Prepared from Polyurethane Network and Mesoporous Silica Nanoparticles. in Program and the book of abstracts - The Eight Serbian Ceramic Society Conference »Advanced Ceramics and Application«, New Frontiers in Multifunctional Material Science and Processing. 2019;:66-66.
https://hdl.handle.net/21.15107/rcub_cer_5769 .

Pergal, Marija, Kodranov, Igor, Špirkova, Milena, Manojlović, Dragan, Ostojić, Sanja, Knežević, Nikola Ž., "Thermal and Thermomechanical Properties of Organic-Inorganic Nanocomposites Prepared from Polyurethane Network and Mesoporous Silica Nanoparticles" in Program and the book of abstracts - The Eight Serbian Ceramic Society Conference »Advanced Ceramics and Application«, New Frontiers in Multifunctional Material Science and Processing (2019):66-66,
https://hdl.handle.net/21.15107/rcub_cer_5769 .

TY  - CONF
AU  - Pergal, Marija
AU  - Kodranov, Igor
AU  - Manojlović, Dragan
AU  - Knežević, Nikola Ž.
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5756
AB  - A series of three polyurethane nanocomposites using mesoporous silica nanoparticles (PU-MSNs) was prepared from Boltorn® hydroxy-functional hyperbranched polyester of the second pseudo generation as a cross-linking agent alpha-omega-dihydroxyethoxypropyl- poly(dimethysyloxane) and 4,4'-methylenediphenyl diisocyanate, by in situ two-step polymerization in solution.
PB  - Serbian Chemical Society
C3  - Book of Abstracts - 7th Conference of the Young Chemists of Serbia, 2.11.2019, Belgrade
T1  - Properties of nanocomposites based on polyurethanes and mesoporous silica nanoparticles
SP  - 38
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_cer_5756
ER  - 

@conference{
author = "Pergal, Marija and Kodranov, Igor and Manojlović, Dragan and Knežević, Nikola Ž.",
year = "2019",
abstract = "A series of three polyurethane nanocomposites using mesoporous silica nanoparticles (PU-MSNs) was prepared from Boltorn® hydroxy-functional hyperbranched polyester of the second pseudo generation as a cross-linking agent alpha-omega-dihydroxyethoxypropyl- poly(dimethysyloxane) and 4,4'-methylenediphenyl diisocyanate, by in situ two-step polymerization in solution.",
publisher = "Serbian Chemical Society",
journal = "Book of Abstracts - 7th Conference of the Young Chemists of Serbia, 2.11.2019, Belgrade",
title = "Properties of nanocomposites based on polyurethanes and mesoporous silica nanoparticles",
pages = "38-38",
url = "https://hdl.handle.net/21.15107/rcub_cer_5756"
}

Pergal, M., Kodranov, I., Manojlović, D.,& Knežević, N. Ž.. (2019). Properties of nanocomposites based on polyurethanes and mesoporous silica nanoparticles. in Book of Abstracts - 7th Conference of the Young Chemists of Serbia, 2.11.2019, Belgrade
Serbian Chemical Society., 38-38.
https://hdl.handle.net/21.15107/rcub_cer_5756

Pergal M, Kodranov I, Manojlović D, Knežević NŽ. Properties of nanocomposites based on polyurethanes and mesoporous silica nanoparticles. in Book of Abstracts - 7th Conference of the Young Chemists of Serbia, 2.11.2019, Belgrade. 2019;:38-38.
https://hdl.handle.net/21.15107/rcub_cer_5756 .

Pergal, Marija, Kodranov, Igor, Manojlović, Dragan, Knežević, Nikola Ž., "Properties of nanocomposites based on polyurethanes and mesoporous silica nanoparticles" in Book of Abstracts - 7th Conference of the Young Chemists of Serbia, 2.11.2019, Belgrade (2019):38-38,
https://hdl.handle.net/21.15107/rcub_cer_5756 .