TY  - JOUR
AU  - Ljubijankić, N.
AU  - Begić, Sabina
AU  - Ljubović-Dedeić, A.
AU  - Stanković, Miroslav
AU  - Salimović-Bešić, I.
AU  - Jadranin, Milka
AU  - Bencun, B.
AU  - Ljubijankić, S.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2408
AB  - In this study, novel hexa coordinated ruthenium(III) complex of the type Na[RuCl2L2)] (where L = monobasic bidentate Schiff base derived from the condensation of 5-nitrosalicyladehyde with aniline) has been synthesized and characterized by electrospray ionization time-of-flight mass spectrometry, infrared spectroscopy and ultraviolet/visible spectrophotometry. Schiff base N-phenyl-5-nitrosalicylideneimine is coordinated to the ruthenium via imine nitrogen and phenolic oxygen. Mass spectra showed molecular ion (M-) at m/z 653.9641 which corresponds to [C26H18Cl2N4O6Ru]-. The in vitro antimicrobial properties of the Schiff base and the complex were tested by micro-dilution technique and agar plate assay for determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The compounds showed a higher antibacterial activity against tested Gram-positive bacteria (Staphylococcus aureus ATCC 33591 and ATCC 29213), whereas against the Gram-negative bacteria (Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603) were ineffective. The genotoxic effects of Ru(III) complex were investigated using the Cytokinesis Block Micronucleus (CBMN) assay in human lymphocytes cultures. The cell culture treated with the complex at a concentration of 3.7 µg/mL exhibit the most prominent effect of decreasing the frequency of micronucleus for 44%, while at the concentrations of 1.5 and 7.4 µg/mL effect is slightly lower (40%), compared to the control cell culture.
PB  - Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma
T2  - Rasayan Journal of Chemistry
T1  - Antimicrobial and genotoxic activity of novel ruthenium(III) complex with n-phenyl-5-nitrosalicylideneimine
VL  - 11
IS  - 4
SP  - 1511
EP  - 1518
DO  - 10.31788/RJC.2018.1145021
ER  - 

@article{
author = "Ljubijankić, N. and Begić, Sabina and Ljubović-Dedeić, A. and Stanković, Miroslav and Salimović-Bešić, I. and Jadranin, Milka and Bencun, B. and Ljubijankić, S.",
year = "2018",
abstract = "In this study, novel hexa coordinated ruthenium(III) complex of the type Na[RuCl2L2)] (where L = monobasic bidentate Schiff base derived from the condensation of 5-nitrosalicyladehyde with aniline) has been synthesized and characterized by electrospray ionization time-of-flight mass spectrometry, infrared spectroscopy and ultraviolet/visible spectrophotometry. Schiff base N-phenyl-5-nitrosalicylideneimine is coordinated to the ruthenium via imine nitrogen and phenolic oxygen. Mass spectra showed molecular ion (M-) at m/z 653.9641 which corresponds to [C26H18Cl2N4O6Ru]-. The in vitro antimicrobial properties of the Schiff base and the complex were tested by micro-dilution technique and agar plate assay for determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The compounds showed a higher antibacterial activity against tested Gram-positive bacteria (Staphylococcus aureus ATCC 33591 and ATCC 29213), whereas against the Gram-negative bacteria (Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603) were ineffective. The genotoxic effects of Ru(III) complex were investigated using the Cytokinesis Block Micronucleus (CBMN) assay in human lymphocytes cultures. The cell culture treated with the complex at a concentration of 3.7 µg/mL exhibit the most prominent effect of decreasing the frequency of micronucleus for 44%, while at the concentrations of 1.5 and 7.4 µg/mL effect is slightly lower (40%), compared to the control cell culture.",
publisher = "Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma",
journal = "Rasayan Journal of Chemistry",
title = "Antimicrobial and genotoxic activity of novel ruthenium(III) complex with n-phenyl-5-nitrosalicylideneimine",
volume = "11",
number = "4",
pages = "1511-1518",
doi = "10.31788/RJC.2018.1145021"
}

Ljubijankić, N., Begić, S., Ljubović-Dedeić, A., Stanković, M., Salimović-Bešić, I., Jadranin, M., Bencun, B.,& Ljubijankić, S.. (2018). Antimicrobial and genotoxic activity of novel ruthenium(III) complex with n-phenyl-5-nitrosalicylideneimine. in Rasayan Journal of Chemistry
Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma., 11(4), 1511-1518.
https://doi.org/10.31788/RJC.2018.1145021

Ljubijankić N, Begić S, Ljubović-Dedeić A, Stanković M, Salimović-Bešić I, Jadranin M, Bencun B, Ljubijankić S. Antimicrobial and genotoxic activity of novel ruthenium(III) complex with n-phenyl-5-nitrosalicylideneimine. in Rasayan Journal of Chemistry. 2018;11(4):1511-1518.
doi:10.31788/RJC.2018.1145021 .

Ljubijankić, N., Begić, Sabina, Ljubović-Dedeić, A., Stanković, Miroslav, Salimović-Bešić, I., Jadranin, Milka, Bencun, B., Ljubijankić, S., "Antimicrobial and genotoxic activity of novel ruthenium(III) complex with n-phenyl-5-nitrosalicylideneimine" in Rasayan Journal of Chemistry, 11, no. 4 (2018):1511-1518,
https://doi.org/10.31788/RJC.2018.1145021 . .