TY  - JOUR
AU  - Zmejkovski, Bojana
AU  - Kaluđerović, Goran N.
AU  - Gómez-Ruiz, S.
AU  - Žižak, Željko
AU  - Steinborn, D.
AU  - Schmidt, H.
AU  - Paschke, Reinhard
AU  - Juranić, Zorica
AU  - Sabo, Tibor
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/578
AB  - New R2eddip-type esters (R = cyclopentyl, L3·2HCl 1.5H2O; cyclohexyl, L4·2HCl·H2O) and corresponding palladium(II) complexes, [PdCl2L3] (3) and [PdCl2L4]·H2O (4), as well as [PdCl2L2] (2; L2 diisobutyl ester of eddip) were synthesized and characterized by IR, 1H and 13C NMR spectroscopies and elemental analysis. The crystal structure of L3·2HCl·2CHCl3 was resolved and is given herein. The NMR spectroscopy confirmed the presence of two isomers (from three possible) for each palladium(II) complex. DFT calculations support the formation of two diastereoisomers. In addition, antitumoral investigations were performed and these investigations also included the diisopropyl ester of eddip (L1) and corresponding palladium(II) complex, [PdCl2L1] (1). In vitro antiproliferative activity was determined against several tumor cell lines HeLa, Fem-x, K562 and rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear cells -PBMCs) using MTT test.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Palladium(II) complexes with R2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexes
VL  - 44
IS  - 9
SP  - 3452
EP  - 3458
DO  - 10.1016/j.ejmech.2009.02.002
ER  - 

@article{
author = "Zmejkovski, Bojana and Kaluđerović, Goran N. and Gómez-Ruiz, S. and Žižak, Željko and Steinborn, D. and Schmidt, H. and Paschke, Reinhard and Juranić, Zorica and Sabo, Tibor",
year = "2009",
abstract = "New R2eddip-type esters (R = cyclopentyl, L3·2HCl 1.5H2O; cyclohexyl, L4·2HCl·H2O) and corresponding palladium(II) complexes, [PdCl2L3] (3) and [PdCl2L4]·H2O (4), as well as [PdCl2L2] (2; L2 diisobutyl ester of eddip) were synthesized and characterized by IR, 1H and 13C NMR spectroscopies and elemental analysis. The crystal structure of L3·2HCl·2CHCl3 was resolved and is given herein. The NMR spectroscopy confirmed the presence of two isomers (from three possible) for each palladium(II) complex. DFT calculations support the formation of two diastereoisomers. In addition, antitumoral investigations were performed and these investigations also included the diisopropyl ester of eddip (L1) and corresponding palladium(II) complex, [PdCl2L1] (1). In vitro antiproliferative activity was determined against several tumor cell lines HeLa, Fem-x, K562 and rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear cells -PBMCs) using MTT test.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Palladium(II) complexes with R2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexes",
volume = "44",
number = "9",
pages = "3452-3458",
doi = "10.1016/j.ejmech.2009.02.002"
}

Zmejkovski, B., Kaluđerović, G. N., Gómez-Ruiz, S., Žižak, Ž., Steinborn, D., Schmidt, H., Paschke, R., Juranić, Z.,& Sabo, T.. (2009). Palladium(II) complexes with R2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexes. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 44(9), 3452-3458.
https://doi.org/10.1016/j.ejmech.2009.02.002

Zmejkovski B, Kaluđerović GN, Gómez-Ruiz S, Žižak Ž, Steinborn D, Schmidt H, Paschke R, Juranić Z, Sabo T. Palladium(II) complexes with R2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexes. in European Journal of Medicinal Chemistry. 2009;44(9):3452-3458.
doi:10.1016/j.ejmech.2009.02.002 .

Zmejkovski, Bojana, Kaluđerović, Goran N., Gómez-Ruiz, S., Žižak, Željko, Steinborn, D., Schmidt, H., Paschke, Reinhard, Juranić, Zorica, Sabo, Tibor, "Palladium(II) complexes with R2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexes" in European Journal of Medicinal Chemistry, 44, no. 9 (2009):3452-3458,
https://doi.org/10.1016/j.ejmech.2009.02.002 . .

TY  - JOUR
AU  - Radanović, Dušanka
AU  - Kalucrossed, D Signerović G.
AU  - Gómez-Ruiz, S.
AU  - Sladić, Dušan
AU  - Šumar-Ristović, Maja
AU  - Brčeski, Ilija
AU  - Anđelković, Katarina
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/602
AB  - In an attempt to synthesize a Cr(III) complex of 2′-[1-(2-pyridinyl) ethylidene]oxamohydrazide an azine product 2-{1-[(1-(2-pyridinio)ethylidene) hydrazono]ethyl}pyridinium diperchlorate was obtained by an electrophilic acyl substitution catalyzed by Cr(III). Its structure was determined by X-ray crystal analysis and showed significant changes in comparison to the corresponding unprotonated compound. The 2-{1-[(1-(2-pyridinio)ethylidene)hydrazono]ethyl} pyridinium diperchlorate crystallizes in the space group P21/n of the monoclinic crystal system with unit cell parameters a = 14.3809(3) Å, b = 24.1516(5) Å, c = 15.4471(3) Å, β = 99.930(2)°, V = 5284.74(19) Å3 and Z = 12, i.e. three molecules per asymmetric unit.
T2  - Journal of Chemical Crystallography
T1  - Crystal structure of 2-{1-[(1-(2-pyridinio)ethylidene)hydrazono]ethyl} pyridinium diperchlorate, the product of template condensation in the presence of Cr(III)
VL  - 39
IS  - 2
SP  - 138
EP  - 142
DO  - 10.1007/s10870-008-9443-6
ER  - 

@article{
author = "Radanović, Dušanka and Kalucrossed, D Signerović G. and Gómez-Ruiz, S. and Sladić, Dušan and Šumar-Ristović, Maja and Brčeski, Ilija and Anđelković, Katarina",
year = "2009",
abstract = "In an attempt to synthesize a Cr(III) complex of 2′-[1-(2-pyridinyl) ethylidene]oxamohydrazide an azine product 2-{1-[(1-(2-pyridinio)ethylidene) hydrazono]ethyl}pyridinium diperchlorate was obtained by an electrophilic acyl substitution catalyzed by Cr(III). Its structure was determined by X-ray crystal analysis and showed significant changes in comparison to the corresponding unprotonated compound. The 2-{1-[(1-(2-pyridinio)ethylidene)hydrazono]ethyl} pyridinium diperchlorate crystallizes in the space group P21/n of the monoclinic crystal system with unit cell parameters a = 14.3809(3) Å, b = 24.1516(5) Å, c = 15.4471(3) Å, β = 99.930(2)°, V = 5284.74(19) Å3 and Z = 12, i.e. three molecules per asymmetric unit.",
journal = "Journal of Chemical Crystallography",
title = "Crystal structure of 2-{1-[(1-(2-pyridinio)ethylidene)hydrazono]ethyl} pyridinium diperchlorate, the product of template condensation in the presence of Cr(III)",
volume = "39",
number = "2",
pages = "138-142",
doi = "10.1007/s10870-008-9443-6"
}

Radanović, D., Kalucrossed, D. S. G., Gómez-Ruiz, S., Sladić, D., Šumar-Ristović, M., Brčeski, I.,& Anđelković, K.. (2009). Crystal structure of 2-{1-[(1-(2-pyridinio)ethylidene)hydrazono]ethyl} pyridinium diperchlorate, the product of template condensation in the presence of Cr(III). in Journal of Chemical Crystallography, 39(2), 138-142.
https://doi.org/10.1007/s10870-008-9443-6

Radanović D, Kalucrossed DSG, Gómez-Ruiz S, Sladić D, Šumar-Ristović M, Brčeski I, Anđelković K. Crystal structure of 2-{1-[(1-(2-pyridinio)ethylidene)hydrazono]ethyl} pyridinium diperchlorate, the product of template condensation in the presence of Cr(III). in Journal of Chemical Crystallography. 2009;39(2):138-142.
doi:10.1007/s10870-008-9443-6 .

Radanović, Dušanka, Kalucrossed, D Signerović G., Gómez-Ruiz, S., Sladić, Dušan, Šumar-Ristović, Maja, Brčeski, Ilija, Anđelković, Katarina, "Crystal structure of 2-{1-[(1-(2-pyridinio)ethylidene)hydrazono]ethyl} pyridinium diperchlorate, the product of template condensation in the presence of Cr(III)" in Journal of Chemical Crystallography, 39, no. 2 (2009):138-142,
https://doi.org/10.1007/s10870-008-9443-6 . .