TY  - JOUR
AU  - Stefanovic, Jovana
AU  - Jakovljević, Dragica
AU  - Gojgić-Cvijović, Gordana
AU  - Lazić, Miodrag L.
AU  - Vrvić, Miroslav
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1311
AB  - Nystatin, a polyene tetraene antibiotic widely used in the treatment of mycoses, was coupled with oxidized polysaccharide gum Arabic, by forming Schiff base structures between amine groups of antibiotics and aldehyde groups of modified carbohydrate. Imine conjugates synthesized in this way were reduced with sodium borohydride to secondary amines. Two imine and two amine conjugates were obtained with different nystatin content. The conjugates were characterized by UVVis, FTIR, 1H NMR spectroscopy, and thermogravimetric analysis. Solubility in water, unlike nystatin, and significant activity against Candida albicans and Aspergillus niger with minimum inhibitory concentrations in range of 3.1256.25 mu g mL-1 and 6.2525 mu g mL-1, respectively, indicate that the chemical integrity and the biological function of these compounds were retained. A comparison of stability of the conjugates in the dry form, solution and under different pH values showed that the conjugates exhibited better stability than pure drug.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Applied Polymer Science
T1  - Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates
VL  - 127
IS  - 6
SP  - 4736
EP  - 4743
DO  - 10.1002/app.38084
ER  - 

@article{
author = "Stefanovic, Jovana and Jakovljević, Dragica and Gojgić-Cvijović, Gordana and Lazić, Miodrag L. and Vrvić, Miroslav",
year = "2013",
abstract = "Nystatin, a polyene tetraene antibiotic widely used in the treatment of mycoses, was coupled with oxidized polysaccharide gum Arabic, by forming Schiff base structures between amine groups of antibiotics and aldehyde groups of modified carbohydrate. Imine conjugates synthesized in this way were reduced with sodium borohydride to secondary amines. Two imine and two amine conjugates were obtained with different nystatin content. The conjugates were characterized by UVVis, FTIR, 1H NMR spectroscopy, and thermogravimetric analysis. Solubility in water, unlike nystatin, and significant activity against Candida albicans and Aspergillus niger with minimum inhibitory concentrations in range of 3.1256.25 mu g mL-1 and 6.2525 mu g mL-1, respectively, indicate that the chemical integrity and the biological function of these compounds were retained. A comparison of stability of the conjugates in the dry form, solution and under different pH values showed that the conjugates exhibited better stability than pure drug.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Applied Polymer Science",
title = "Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates",
volume = "127",
number = "6",
pages = "4736-4743",
doi = "10.1002/app.38084"
}

Stefanovic, J., Jakovljević, D., Gojgić-Cvijović, G., Lazić, M. L.,& Vrvić, M.. (2013). Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates. in Journal of Applied Polymer Science
Wiley-Blackwell, Malden., 127(6), 4736-4743.
https://doi.org/10.1002/app.38084

Stefanovic J, Jakovljević D, Gojgić-Cvijović G, Lazić ML, Vrvić M. Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates. in Journal of Applied Polymer Science. 2013;127(6):4736-4743.
doi:10.1002/app.38084 .

Stefanovic, Jovana, Jakovljević, Dragica, Gojgić-Cvijović, Gordana, Lazić, Miodrag L., Vrvić, Miroslav, "Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates" in Journal of Applied Polymer Science, 127, no. 6 (2013):4736-4743,
https://doi.org/10.1002/app.38084 . .

TY  - JOUR
AU  - Karabegovic, Ivana T.
AU  - Vukosavljevic, Predrag V.
AU  - Novaković, Miroslav
AU  - Gorjanović, Stanislava Ž.
AU  - Dzamic, Ana M.
AU  - Lazić, Miodrag L.
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1095
AB  - Stability of bioactive compounds present in a herbal liqueur, as well as its sensory attributes were surveyed during a year - long storage under various conditions. The antioxidant activity, the total content of phenolic and flavonoid compounds, their antioxidant effectiveness, as well as antibacterial and antifungal activity, were found dependent on storage conditions and duration. The storage in the opaque green and transparent white bottles caused statistically significant changes upon 60 and 15 days, respectively. Both decrease of antioxidant activity (approximate to 30 %) and total content of phenolic compounds (approximate to 7 %) upon one year storage in the original opaque bottles placed in cardboard box was 18 % lower than upon the storage in the white bottles exposed to daylight, while decrease of total flavonoid compounds (approximate to 16 %) was 26 % lower. The most prominent changes were observed within the first six month of the storage. During the remaining storage time monitored parameters were found almost constant. Sensory analysis confirmed dynamics of changes that herbal liqueur experienced during the storage.
PB  - Inst Materials Physics, Bucharest
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Influence of the storage on bioactive compounds and sensory attributes of herbal liqueur
VL  - 7
IS  - 4
SP  - 1587
EP  - 1598
UR  - https://hdl.handle.net/21.15107/rcub_cer_1095
ER  - 

@article{
author = "Karabegovic, Ivana T. and Vukosavljevic, Predrag V. and Novaković, Miroslav and Gorjanović, Stanislava Ž. and Dzamic, Ana M. and Lazić, Miodrag L.",
year = "2012",
abstract = "Stability of bioactive compounds present in a herbal liqueur, as well as its sensory attributes were surveyed during a year - long storage under various conditions. The antioxidant activity, the total content of phenolic and flavonoid compounds, their antioxidant effectiveness, as well as antibacterial and antifungal activity, were found dependent on storage conditions and duration. The storage in the opaque green and transparent white bottles caused statistically significant changes upon 60 and 15 days, respectively. Both decrease of antioxidant activity (approximate to 30 %) and total content of phenolic compounds (approximate to 7 %) upon one year storage in the original opaque bottles placed in cardboard box was 18 % lower than upon the storage in the white bottles exposed to daylight, while decrease of total flavonoid compounds (approximate to 16 %) was 26 % lower. The most prominent changes were observed within the first six month of the storage. During the remaining storage time monitored parameters were found almost constant. Sensory analysis confirmed dynamics of changes that herbal liqueur experienced during the storage.",
publisher = "Inst Materials Physics, Bucharest",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Influence of the storage on bioactive compounds and sensory attributes of herbal liqueur",
volume = "7",
number = "4",
pages = "1587-1598",
url = "https://hdl.handle.net/21.15107/rcub_cer_1095"
}

Karabegovic, I. T., Vukosavljevic, P. V., Novaković, M., Gorjanović, S. Ž., Dzamic, A. M.,& Lazić, M. L.. (2012). Influence of the storage on bioactive compounds and sensory attributes of herbal liqueur. in Digest Journal of Nanomaterials and Biostructures
Inst Materials Physics, Bucharest., 7(4), 1587-1598.
https://hdl.handle.net/21.15107/rcub_cer_1095

Karabegovic IT, Vukosavljevic PV, Novaković M, Gorjanović SŽ, Dzamic AM, Lazić ML. Influence of the storage on bioactive compounds and sensory attributes of herbal liqueur. in Digest Journal of Nanomaterials and Biostructures. 2012;7(4):1587-1598.
https://hdl.handle.net/21.15107/rcub_cer_1095 .

Karabegovic, Ivana T., Vukosavljevic, Predrag V., Novaković, Miroslav, Gorjanović, Stanislava Ž., Dzamic, Ana M., Lazić, Miodrag L., "Influence of the storage on bioactive compounds and sensory attributes of herbal liqueur" in Digest Journal of Nanomaterials and Biostructures, 7, no. 4 (2012):1587-1598,
https://hdl.handle.net/21.15107/rcub_cer_1095 .