TY  - CONF
AU  - Trifković, Željko
AU  - Kotlaja, Katarina
AU  - Kop, Tatjana
AU  - Milić, Dragana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7013
AB  - Due to the presence of a large number of double bonds, fullerene C60 shows good radical scavenging properties. In order to obtain novel fulleropyrrolidine with improved antioxidant activity, we explored the synthesis of a hybrid structure containing fullerene and anisole subunit. The Prato reaction of the N-substituted glycine, aromatic aldehyde with anisole subunits and the fullerene C60 provided desired products in a satisfactory yield. The obtained compound was added to the series of similar fulleropyrrolidines and subjected to an antioxidant activity test using β–carotene-linoleic acid bleaching assay.
PB  - Belgrade : Serbian Chemical Society
PB  - Belgrade : Serbian Young Chemists’ Club
C3  - 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia
T1  - Synthesis and determination of in vitro antioxidant activities of novel fulleropyrrolidines containing aromatic subunit
SP  - 77
EP  - 77
UR  - https://hdl.handle.net/21.15107/rcub_cer_7013
ER  - 

@conference{
author = "Trifković, Željko and Kotlaja, Katarina and Kop, Tatjana and Milić, Dragana",
year = "2023",
abstract = "Due to the presence of a large number of double bonds, fullerene C60 shows good radical scavenging properties. In order to obtain novel fulleropyrrolidine with improved antioxidant activity, we explored the synthesis of a hybrid structure containing fullerene and anisole subunit. The Prato reaction of the N-substituted glycine, aromatic aldehyde with anisole subunits and the fullerene C60 provided desired products in a satisfactory yield. The obtained compound was added to the series of similar fulleropyrrolidines and subjected to an antioxidant activity test using β–carotene-linoleic acid bleaching assay.",
publisher = "Belgrade : Serbian Chemical Society, Belgrade : Serbian Young Chemists’ Club",
journal = "9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia",
title = "Synthesis and determination of in vitro antioxidant activities of novel fulleropyrrolidines containing aromatic subunit",
pages = "77-77",
url = "https://hdl.handle.net/21.15107/rcub_cer_7013"
}

Trifković, Ž., Kotlaja, K., Kop, T.,& Milić, D.. (2023). Synthesis and determination of in vitro antioxidant activities of novel fulleropyrrolidines containing aromatic subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia
Belgrade : Serbian Chemical Society., 77-77.
https://hdl.handle.net/21.15107/rcub_cer_7013

Trifković Ž, Kotlaja K, Kop T, Milić D. Synthesis and determination of in vitro antioxidant activities of novel fulleropyrrolidines containing aromatic subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia. 2023;:77-77.
https://hdl.handle.net/21.15107/rcub_cer_7013 .

Trifković, Željko, Kotlaja, Katarina, Kop, Tatjana, Milić, Dragana, "Synthesis and determination of in vitro antioxidant activities of novel fulleropyrrolidines containing aromatic subunit" in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia (2023):77-77,
https://hdl.handle.net/21.15107/rcub_cer_7013 .

TY  - CONF
AU  - Kotlaja, Katarina
AU  - Trifković, Željko
AU  - Kop, Tatjana
AU  - Milić, Dragana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7014
AB  - Due to the presence of a large number of double bonds, fullerene C60 shows good antioxidant and moderate anti-inflammatory properties. At the same time, natural product vanillin, thanks to its phenolic subunit expresses the same activities, although in a lesser extent. Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and vanillin. The Prato reaction of the glycine derivative, vanillin and the fullerene C60 provided desired products in satisfactory yields. DPPH radical scavenging activity and β-carotene-linoleic acid bleaching assay were used to determine antioxidant activity, while 
for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained fulleropyrrolidines showed significantly better biological activity in comparison with starting compound.
PB  - Belgrade : Serbian Chemical Society
PB  - Belgrade : Serbian Young Chemists’ Club
C3  - 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia
T1  - Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit
SP  - 74
EP  - 74
UR  - https://hdl.handle.net/21.15107/rcub_cer_7014
ER  - 

@conference{
author = "Kotlaja, Katarina and Trifković, Željko and Kop, Tatjana and Milić, Dragana",
year = "2023",
abstract = "Due to the presence of a large number of double bonds, fullerene C60 shows good antioxidant and moderate anti-inflammatory properties. At the same time, natural product vanillin, thanks to its phenolic subunit expresses the same activities, although in a lesser extent. Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and vanillin. The Prato reaction of the glycine derivative, vanillin and the fullerene C60 provided desired products in satisfactory yields. DPPH radical scavenging activity and β-carotene-linoleic acid bleaching assay were used to determine antioxidant activity, while 
for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained fulleropyrrolidines showed significantly better biological activity in comparison with starting compound.",
publisher = "Belgrade : Serbian Chemical Society, Belgrade : Serbian Young Chemists’ Club",
journal = "9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia",
title = "Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit",
pages = "74-74",
url = "https://hdl.handle.net/21.15107/rcub_cer_7014"
}

Kotlaja, K., Trifković, Ž., Kop, T.,& Milić, D.. (2023). Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia
Belgrade : Serbian Chemical Society., 74-74.
https://hdl.handle.net/21.15107/rcub_cer_7014

Kotlaja K, Trifković Ž, Kop T, Milić D. Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia. 2023;:74-74.
https://hdl.handle.net/21.15107/rcub_cer_7014 .

Kotlaja, Katarina, Trifković, Željko, Kop, Tatjana, Milić, Dragana, "Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit" in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia (2023):74-74,
https://hdl.handle.net/21.15107/rcub_cer_7014 .

TY  - CONF
AU  - Trifković, Željko
AU  - Kotlaja, Katarina
AU  - Kop, Tatjana
AU  - Milić, Dragana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6895
AB  - Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and phenol. The Prato reaction of the glycine derivative, aromatic aldehydes with phenol subunit and the fullerene C60 provided desired products in satisfactory yields (Figure 1). DPPH radical scavenging activity and β–carotene-linoleic acid bleaching assay were used to determinate antioxidant activity, while for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained results indicated that performed synthesis gave rise to 
compounds with dual activity.
PB  - Belgrade : Serbian Chemical Society
PB  - Belgrade : Serbian Young Chemists’ Club
C3  - 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia
T1  - Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit
SP  - 76
EP  - 76
UR  - https://hdl.handle.net/21.15107/rcub_cer_6895
ER  - 

@conference{
author = "Trifković, Željko and Kotlaja, Katarina and Kop, Tatjana and Milić, Dragana",
year = "2023",
abstract = "Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and phenol. The Prato reaction of the glycine derivative, aromatic aldehydes with phenol subunit and the fullerene C60 provided desired products in satisfactory yields (Figure 1). DPPH radical scavenging activity and β–carotene-linoleic acid bleaching assay were used to determinate antioxidant activity, while for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained results indicated that performed synthesis gave rise to 
compounds with dual activity.",
publisher = "Belgrade : Serbian Chemical Society, Belgrade : Serbian Young Chemists’ Club",
journal = "9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia",
title = "Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit",
pages = "76-76",
url = "https://hdl.handle.net/21.15107/rcub_cer_6895"
}

Trifković, Ž., Kotlaja, K., Kop, T.,& Milić, D.. (2023). Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia
Belgrade : Serbian Chemical Society., 76-76.
https://hdl.handle.net/21.15107/rcub_cer_6895

Trifković Ž, Kotlaja K, Kop T, Milić D. Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia. 2023;:76-76.
https://hdl.handle.net/21.15107/rcub_cer_6895 .

Trifković, Željko, Kotlaja, Katarina, Kop, Tatjana, Milić, Dragana, "Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit" in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia (2023):76-76,
https://hdl.handle.net/21.15107/rcub_cer_6895 .

TY  - CONF
AU  - Kotlaja, Katarina
AU  - Trifković, Željko
AU  - Kop, Tatjana
AU  - Milić, Dragana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7012
AB  - Fullerene is one of carbon allotropes with extremely low solubility in aqueous solvents and most organic solvents, but high potential of application in various areas, such as medicine, photovoltaics and materials. To overcome this obstacle, fullerene needs to be functionalized. The Prato reaction is decent synthetic method that provides N- and C-substituted fulleropyrrolidines. We optimized the conditions of the Prato reaction in order to obtain fulleropyrrolidines containing phenol (3d) and protected phenol subunits (3a, 3b). (Figure 1) The desired products were purified by dry-flash chromatography and obtained in satisfactory yields.
PB  - Belgrade : Serbian Chemical Society
PB  - Belgrade : Serbian Young Chemists’ Club
C3  - 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia
T1  - Mono- and disubstituted fulleropyrrolidines: synthesis and optimization of reaction conditions
SP  - 75
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_cer_7012
ER  - 

@conference{
author = "Kotlaja, Katarina and Trifković, Željko and Kop, Tatjana and Milić, Dragana",
year = "2023",
abstract = "Fullerene is one of carbon allotropes with extremely low solubility in aqueous solvents and most organic solvents, but high potential of application in various areas, such as medicine, photovoltaics and materials. To overcome this obstacle, fullerene needs to be functionalized. The Prato reaction is decent synthetic method that provides N- and C-substituted fulleropyrrolidines. We optimized the conditions of the Prato reaction in order to obtain fulleropyrrolidines containing phenol (3d) and protected phenol subunits (3a, 3b). (Figure 1) The desired products were purified by dry-flash chromatography and obtained in satisfactory yields.",
publisher = "Belgrade : Serbian Chemical Society, Belgrade : Serbian Young Chemists’ Club",
journal = "9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia",
title = "Mono- and disubstituted fulleropyrrolidines: synthesis and optimization of reaction conditions",
pages = "75-75",
url = "https://hdl.handle.net/21.15107/rcub_cer_7012"
}

Kotlaja, K., Trifković, Ž., Kop, T.,& Milić, D.. (2023). Mono- and disubstituted fulleropyrrolidines: synthesis and optimization of reaction conditions. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia
Belgrade : Serbian Chemical Society., 75-75.
https://hdl.handle.net/21.15107/rcub_cer_7012

Kotlaja K, Trifković Ž, Kop T, Milić D. Mono- and disubstituted fulleropyrrolidines: synthesis and optimization of reaction conditions. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia. 2023;:75-75.
https://hdl.handle.net/21.15107/rcub_cer_7012 .

Kotlaja, Katarina, Trifković, Željko, Kop, Tatjana, Milić, Dragana, "Mono- and disubstituted fulleropyrrolidines: synthesis and optimization of reaction conditions" in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia (2023):75-75,
https://hdl.handle.net/21.15107/rcub_cer_7012 .