TY  - JOUR
AU  - Filipović, Vuk
AU  - Babić Radić, Marija M.
AU  - Vuković, Jovana S.
AU  - Vukomanović, Marija
AU  - Rubert, Marina
AU  - Hofmann, Sandra
AU  - Müller, Ralph
AU  - Tomić, Simonida Lj.
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5309
AB  - New composite 3D scaffolds were developed as a combination of synthetic polymer, poly(2-
hydroxyethyl methacrylate) (PHEMA), and a natural polymer, gelatin, with a ceramic component,
nanohydroxyapatite (ID nHAp) dopped with metal ions. The combination of a synthetic polymer,
to be able to tune the structure and the physicochemical and mechanical properties, and a natural
polymer, to ensure the specific biological functions of the scaffold, with inorganic filler was applied.
The goal was to make a new material with superior properties for applications in the biomedical
field which mimics as closely as possible the native bone extracellular matrix (ECM). Biodegrad able PHEMA hydrogel was obtained by crosslinking HEMA by poly(β-amino esters) (PBAE). The
scaffold’s physicochemical and mechanical properties, in vitro degradation, and biological activity
were assessed so to study the effects of the incorporation of nHAp in the (PHEMA/PBAE/gelatin)
hydrogel, as well as the effect of the different pore-forming methods. Cryogels had higher elasticity,
swelling, porosity, and percent of mass loss during degradation than the samples obtained by poro genation. The composite scaffolds had a higher mechanical strength, 10.14 MPa for the porogenated
samples and 5.87 MPa for the cryogels, but a slightly lower degree of swelling, percent of mass loss,
and porosity than the hybrid ones. All the scaffolds were nontoxic and had a high cell adhesion rate,
which was 15–20% higher in the composite samples. Cell metabolic activity after 2 and 7 days of
culture was higher in the composites, although not statistically different. After 28 days, cell metabolic
activity was similar in all scaffolds and the TCP control. No effect of integrating nHAp into the
scaffolds on osteogenic cell differentiation could be observed. Synergetic effects occurred which
influenced the mechanical behavior, structure, physicochemical properties, and interactions with
biological species.
PB  - MDPI
T2  - Polymers
T1  - Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(β-amino esters), and Hydroxyapatite
VL  - 14
IS  - 1
SP  - 18
DO  - 10.3390/polym14010018
ER  - 

@article{
author = "Filipović, Vuk and Babić Radić, Marija M. and Vuković, Jovana S. and Vukomanović, Marija and Rubert, Marina and Hofmann, Sandra and Müller, Ralph and Tomić, Simonida Lj.",
year = "2022",
abstract = "New composite 3D scaffolds were developed as a combination of synthetic polymer, poly(2-
hydroxyethyl methacrylate) (PHEMA), and a natural polymer, gelatin, with a ceramic component,
nanohydroxyapatite (ID nHAp) dopped with metal ions. The combination of a synthetic polymer,
to be able to tune the structure and the physicochemical and mechanical properties, and a natural
polymer, to ensure the specific biological functions of the scaffold, with inorganic filler was applied.
The goal was to make a new material with superior properties for applications in the biomedical
field which mimics as closely as possible the native bone extracellular matrix (ECM). Biodegrad able PHEMA hydrogel was obtained by crosslinking HEMA by poly(β-amino esters) (PBAE). The
scaffold’s physicochemical and mechanical properties, in vitro degradation, and biological activity
were assessed so to study the effects of the incorporation of nHAp in the (PHEMA/PBAE/gelatin)
hydrogel, as well as the effect of the different pore-forming methods. Cryogels had higher elasticity,
swelling, porosity, and percent of mass loss during degradation than the samples obtained by poro genation. The composite scaffolds had a higher mechanical strength, 10.14 MPa for the porogenated
samples and 5.87 MPa for the cryogels, but a slightly lower degree of swelling, percent of mass loss,
and porosity than the hybrid ones. All the scaffolds were nontoxic and had a high cell adhesion rate,
which was 15–20% higher in the composite samples. Cell metabolic activity after 2 and 7 days of
culture was higher in the composites, although not statistically different. After 28 days, cell metabolic
activity was similar in all scaffolds and the TCP control. No effect of integrating nHAp into the
scaffolds on osteogenic cell differentiation could be observed. Synergetic effects occurred which
influenced the mechanical behavior, structure, physicochemical properties, and interactions with
biological species.",
publisher = "MDPI",
journal = "Polymers",
title = "Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(β-amino esters), and Hydroxyapatite",
volume = "14",
number = "1",
pages = "18",
doi = "10.3390/polym14010018"
}

Filipović, V., Babić Radić, M. M., Vuković, J. S., Vukomanović, M., Rubert, M., Hofmann, S., Müller, R.,& Tomić, S. Lj.. (2022). Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(β-amino esters), and Hydroxyapatite. in Polymers
MDPI., 14(1), 18.
https://doi.org/10.3390/polym14010018

Filipović V, Babić Radić MM, Vuković JS, Vukomanović M, Rubert M, Hofmann S, Müller R, Tomić SL. Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(β-amino esters), and Hydroxyapatite. in Polymers. 2022;14(1):18.
doi:10.3390/polym14010018 .

Filipović, Vuk, Babić Radić, Marija M., Vuković, Jovana S., Vukomanović, Marija, Rubert, Marina, Hofmann, Sandra, Müller, Ralph, Tomić, Simonida Lj., "Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(β-amino esters), and Hydroxyapatite" in Polymers, 14, no. 1 (2022):18,
https://doi.org/10.3390/polym14010018 . .

TY  - JOUR
AU  - Babić Radić, Marija M.
AU  - Filipović, Vuk V.
AU  - Vuković, Jovana S.
AU  - Vukomanović, Marija
AU  - Rubert, Marina
AU  - Hofmann, Sandra
AU  - Müller, Ralph
AU  - Tomić, Simonida Lj.
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5391
AB  - Our goal was to create bioimitated scaffolding materials for biomedical purposes. The guiding idea was that we used an interpenetrating structural hierarchy of natural extracellular matrix as a “pattern” to design hydrogel scaffolds that show favorable properties for tissue regeneration. Polymeric hydrogel scaffolds are made in a simple, environmentally friendly way without additional functionalization. Gelatin and 2-hydroxyethyl methacrylate were selected to prepare interpenetrating polymeric networks and linear alginate chains were added as an interpenetrant to study their influence on the scaffold’s functionalities. Cryogelation and porogenation methods were used to obtain the designed scaffolding biomaterials. The scaffold’s structural, morphological, and mechanical properties, in vitro degradation, and cell viability properties were assessed to study the effects of the preparation method and alginate loading. Apatite as an inorganic agent was incorporated into cryogelated scaffolds to perform an extensive biological assay. Cryogelated scaffolds possess superior functionalities essential for tissue regeneration: fully hydrophilicity, degradability and mechanical features (2.08–9.75 MPa), and an optimal LDH activity. Furthermore, cryogelated scaffolds loaded with apatite showed good cell adhesion capacity, biocompatibility, and non-toxic behavior. All scaffolds performed equally in terms of metabolic activity and osteoconductivity. Cryogelated scaffolds with/without HAp could represent a new advance to promote osteoconductivity and enhance hard tissue repair. The obtained series of scaffolding biomaterials described here can provide a wide range of potential applications in the area of biomedical engineering.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Polymers
T1  - Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials
VL  - 14
IS  - 15
SP  - 3112
DO  - 10.3390/polym14153112
ER  - 

@article{
author = "Babić Radić, Marija M. and Filipović, Vuk V. and Vuković, Jovana S. and Vukomanović, Marija and Rubert, Marina and Hofmann, Sandra and Müller, Ralph and Tomić, Simonida Lj.",
year = "2022",
abstract = "Our goal was to create bioimitated scaffolding materials for biomedical purposes. The guiding idea was that we used an interpenetrating structural hierarchy of natural extracellular matrix as a “pattern” to design hydrogel scaffolds that show favorable properties for tissue regeneration. Polymeric hydrogel scaffolds are made in a simple, environmentally friendly way without additional functionalization. Gelatin and 2-hydroxyethyl methacrylate were selected to prepare interpenetrating polymeric networks and linear alginate chains were added as an interpenetrant to study their influence on the scaffold’s functionalities. Cryogelation and porogenation methods were used to obtain the designed scaffolding biomaterials. The scaffold’s structural, morphological, and mechanical properties, in vitro degradation, and cell viability properties were assessed to study the effects of the preparation method and alginate loading. Apatite as an inorganic agent was incorporated into cryogelated scaffolds to perform an extensive biological assay. Cryogelated scaffolds possess superior functionalities essential for tissue regeneration: fully hydrophilicity, degradability and mechanical features (2.08–9.75 MPa), and an optimal LDH activity. Furthermore, cryogelated scaffolds loaded with apatite showed good cell adhesion capacity, biocompatibility, and non-toxic behavior. All scaffolds performed equally in terms of metabolic activity and osteoconductivity. Cryogelated scaffolds with/without HAp could represent a new advance to promote osteoconductivity and enhance hard tissue repair. The obtained series of scaffolding biomaterials described here can provide a wide range of potential applications in the area of biomedical engineering.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Polymers",
title = "Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials",
volume = "14",
number = "15",
pages = "3112",
doi = "10.3390/polym14153112"
}

Babić Radić, M. M., Filipović, V. V., Vuković, J. S., Vukomanović, M., Rubert, M., Hofmann, S., Müller, R.,& Tomić, S. Lj.. (2022). Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials. in Polymers
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 14(15), 3112.
https://doi.org/10.3390/polym14153112

Babić Radić MM, Filipović VV, Vuković JS, Vukomanović M, Rubert M, Hofmann S, Müller R, Tomić SL. Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials. in Polymers. 2022;14(15):3112.
doi:10.3390/polym14153112 .

Babić Radić, Marija M., Filipović, Vuk V., Vuković, Jovana S., Vukomanović, Marija, Rubert, Marina, Hofmann, Sandra, Müller, Ralph, Tomić, Simonida Lj., "Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials" in Polymers, 14, no. 15 (2022):3112,
https://doi.org/10.3390/polym14153112 . .

TY  - JOUR
AU  - Babić Radić, Marija M.
AU  - Filipović, Vuk
AU  - Vukomanović, Marija
AU  - Nikodinović Runić, Jasmina
AU  - Tomić, Simonida
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5311
AB  - The design and evaluation of novel 2-hydroxyethyl methacrylate/gelatin/alginate/
graphene oxide hydrogels as innovative scaffolding biomaterials, which concurrently are the suitable
drug delivery carrier, was proposed. The hydrogels were prepared by the adapted porogen leaching
method; this is also the first time this method has been used to incorporate nanocolloidal graphene
oxide through the hydrogel and simultaneously form porous structures. The effects of a material’s
composition on its chemical, morphological, mechanical, and swelling properties, as well as on
cell viability and in vitro degradation, were assessed using Fourier transform infrared spectroscopy
(FTIR), scanning electron microscopy (SEM), measurements of Young’s modulus, gravimetric method
and MTT test, respectively. The engineered hydrogels show good swelling capacity, fully hydrophilic
surfaces, tunable porosity (from 56 to 76%) and mechanical properties (from 1.69 to 4.78 MPa),
curcumin entrapment efficiency above 99% and excellent curcumin release performances. In vitro
cytotoxicity on healthy human fibroblast (MRC5 cells) by MTT test reveal that the materials are
nontoxic and biocompatible, proposing novel hydrogels for in vivo clinical evaluation to optimize
tissue regeneration treatments by coupling the hydrogels with cells and different active agents to
create material/biofactor hybrids with new levels of biofunctionality.
PB  - MDPI
T2  - Gels
T1  - Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials
VL  - 8
IS  - 22
SP  - 2
EP  - 14
DO  - 10.3390/gels8010022
ER  - 

@article{
author = "Babić Radić, Marija M. and Filipović, Vuk and Vukomanović, Marija and Nikodinović Runić, Jasmina and Tomić, Simonida",
year = "2022",
abstract = "The design and evaluation of novel 2-hydroxyethyl methacrylate/gelatin/alginate/
graphene oxide hydrogels as innovative scaffolding biomaterials, which concurrently are the suitable
drug delivery carrier, was proposed. The hydrogels were prepared by the adapted porogen leaching
method; this is also the first time this method has been used to incorporate nanocolloidal graphene
oxide through the hydrogel and simultaneously form porous structures. The effects of a material’s
composition on its chemical, morphological, mechanical, and swelling properties, as well as on
cell viability and in vitro degradation, were assessed using Fourier transform infrared spectroscopy
(FTIR), scanning electron microscopy (SEM), measurements of Young’s modulus, gravimetric method
and MTT test, respectively. The engineered hydrogels show good swelling capacity, fully hydrophilic
surfaces, tunable porosity (from 56 to 76%) and mechanical properties (from 1.69 to 4.78 MPa),
curcumin entrapment efficiency above 99% and excellent curcumin release performances. In vitro
cytotoxicity on healthy human fibroblast (MRC5 cells) by MTT test reveal that the materials are
nontoxic and biocompatible, proposing novel hydrogels for in vivo clinical evaluation to optimize
tissue regeneration treatments by coupling the hydrogels with cells and different active agents to
create material/biofactor hybrids with new levels of biofunctionality.",
publisher = "MDPI",
journal = "Gels",
title = "Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials",
volume = "8",
number = "22",
pages = "2-14",
doi = "10.3390/gels8010022"
}

Babić Radić, M. M., Filipović, V., Vukomanović, M., Nikodinović Runić, J.,& Tomić, S.. (2022). Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials. in Gels
MDPI., 8(22), 2-14.
https://doi.org/10.3390/gels8010022

Babić Radić MM, Filipović V, Vukomanović M, Nikodinović Runić J, Tomić S. Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials. in Gels. 2022;8(22):2-14.
doi:10.3390/gels8010022 .

Babić Radić, Marija M., Filipović, Vuk, Vukomanović, Marija, Nikodinović Runić, Jasmina, Tomić, Simonida, "Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials" in Gels, 8, no. 22 (2022):2-14,
https://doi.org/10.3390/gels8010022 . .

TY  - JOUR
AU  - Antić, Katarina M.
AU  - Onjia, Antonije
AU  - Vasiljević-Radović, Dana
AU  - Veličković, Zlate
AU  - Tomić, Simonida Lj.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4897
AB  - The adsorption of Ni2+ ions from water solutions by using hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA) was studied. Hydrogel synthesis was optimized with response surface methodology (RSM). The hydrogel with the best adsorption capacity towards Ni2+ ions was chosen for further experiments. The hydrogel was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and atomic force microscopy (AFM) analysis before and after the adsorption of Ni2+ ions. Batch equilibrium experiments were conducted to investigate the influence of solution pH, hydrogel weight, ionic strength, adsorption time, temperature and initial concentration of nickel ions on the adsorption. Time-dependent adsorption fitted the best to the pseudo-second-order kinetic model. A thermodynamic study revealed that the adsorption was an exothermic and non-spontaneous process. Five isotherm models were studied, and the best fit was obtained with the Redlich–Peterson model. Consecutive adsorption/desorption studies indicated that the HEA/IA hydrogel can be efficiently used as a sorbent for the removal of Ni2+ ions from the water solution. This study develops a potential adsorbent for the effective removal of trace nickel ions.
PB  - MDPI
T2  - Gels
T1  - Removal of nickel ions from aqueous solutions by 2-hydroxyethyl acrylate/itaconic acid hydrogels optimized with response surface methodology
VL  - 7
IS  - 4
IS  - 225
DO  - 10.3390/gels7040225
ER  - 

@article{
author = "Antić, Katarina M. and Onjia, Antonije and Vasiljević-Radović, Dana and Veličković, Zlate and Tomić, Simonida Lj.",
year = "2021",
abstract = "The adsorption of Ni2+ ions from water solutions by using hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA) was studied. Hydrogel synthesis was optimized with response surface methodology (RSM). The hydrogel with the best adsorption capacity towards Ni2+ ions was chosen for further experiments. The hydrogel was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and atomic force microscopy (AFM) analysis before and after the adsorption of Ni2+ ions. Batch equilibrium experiments were conducted to investigate the influence of solution pH, hydrogel weight, ionic strength, adsorption time, temperature and initial concentration of nickel ions on the adsorption. Time-dependent adsorption fitted the best to the pseudo-second-order kinetic model. A thermodynamic study revealed that the adsorption was an exothermic and non-spontaneous process. Five isotherm models were studied, and the best fit was obtained with the Redlich–Peterson model. Consecutive adsorption/desorption studies indicated that the HEA/IA hydrogel can be efficiently used as a sorbent for the removal of Ni2+ ions from the water solution. This study develops a potential adsorbent for the effective removal of trace nickel ions.",
publisher = "MDPI",
journal = "Gels",
title = "Removal of nickel ions from aqueous solutions by 2-hydroxyethyl acrylate/itaconic acid hydrogels optimized with response surface methodology",
volume = "7",
number = "4, 225",
doi = "10.3390/gels7040225"
}

Antić, K. M., Onjia, A., Vasiljević-Radović, D., Veličković, Z.,& Tomić, S. Lj.. (2021). Removal of nickel ions from aqueous solutions by 2-hydroxyethyl acrylate/itaconic acid hydrogels optimized with response surface methodology. in Gels
MDPI., 7(4).
https://doi.org/10.3390/gels7040225

Antić KM, Onjia A, Vasiljević-Radović D, Veličković Z, Tomić SL. Removal of nickel ions from aqueous solutions by 2-hydroxyethyl acrylate/itaconic acid hydrogels optimized with response surface methodology. in Gels. 2021;7(4).
doi:10.3390/gels7040225 .

Antić, Katarina M., Onjia, Antonije, Vasiljević-Radović, Dana, Veličković, Zlate, Tomić, Simonida Lj., "Removal of nickel ions from aqueous solutions by 2-hydroxyethyl acrylate/itaconic acid hydrogels optimized with response surface methodology" in Gels, 7, no. 4 (2021),
https://doi.org/10.3390/gels7040225 . .

TY  - JOUR
AU  - Filipović, Vuk
AU  - Nedeljkovic, Biljana D. Bozic
AU  - Vukomanović, Marija
AU  - Tomić, Simonida Lj.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2440
AB  - Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.
PB  - Elsevier Sci Ltd, Oxford
T2  - Polymer Testing
T1  - Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers
VL  - 68
SP  - 270
EP  - 278
DO  - 10.1016/j.polymertesting.2018.04.024
ER  - 

@article{
author = "Filipović, Vuk and Nedeljkovic, Biljana D. Bozic and Vukomanović, Marija and Tomić, Simonida Lj.",
year = "2018",
abstract = "Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Polymer Testing",
title = "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers",
volume = "68",
pages = "270-278",
doi = "10.1016/j.polymertesting.2018.04.024"
}

Filipović, V., Nedeljkovic, B. D. B., Vukomanović, M.,& Tomić, S. Lj.. (2018). Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing
Elsevier Sci Ltd, Oxford., 68, 270-278.
https://doi.org/10.1016/j.polymertesting.2018.04.024

Filipović V, Nedeljkovic BDB, Vukomanović M, Tomić SL. Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing. 2018;68:270-278.
doi:10.1016/j.polymertesting.2018.04.024 .

Filipović, Vuk, Nedeljkovic, Biljana D. Bozic, Vukomanović, Marija, Tomić, Simonida Lj., "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers" in Polymer Testing, 68 (2018):270-278,
https://doi.org/10.1016/j.polymertesting.2018.04.024 . .

TY  - JOUR
AU  - Filipović, Vuk
AU  - Nedeljkovic, Biljana D. Bozic
AU  - Vukomanović, Marija
AU  - Tomić, Simonida Lj.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4293
AB  - Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.
PB  - Elsevier
T2  - Polymer Testing
T1  - Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers
VL  - 68
SP  - 270
EP  - 278
DO  - 10.1016/j.polymertesting.2018.04.024
ER  - 

@article{
author = "Filipović, Vuk and Nedeljkovic, Biljana D. Bozic and Vukomanović, Marija and Tomić, Simonida Lj.",
year = "2018",
abstract = "Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.",
publisher = "Elsevier",
journal = "Polymer Testing",
title = "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers",
volume = "68",
pages = "270-278",
doi = "10.1016/j.polymertesting.2018.04.024"
}

Filipović, V., Nedeljkovic, B. D. B., Vukomanović, M.,& Tomić, S. Lj.. (2018). Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing
Elsevier., 68, 270-278.
https://doi.org/10.1016/j.polymertesting.2018.04.024

Filipović V, Nedeljkovic BDB, Vukomanović M, Tomić SL. Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing. 2018;68:270-278.
doi:10.1016/j.polymertesting.2018.04.024 .

Filipović, Vuk, Nedeljkovic, Biljana D. Bozic, Vukomanović, Marija, Tomić, Simonida Lj., "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers" in Polymer Testing, 68 (2018):270-278,
https://doi.org/10.1016/j.polymertesting.2018.04.024 . .

TY  - JOUR
AU  - Antić, Katarina M.
AU  - Babić, Marija M.
AU  - Jovašević Vuković, Jovana J.
AU  - Vasiljević-Radović, Dana
AU  - Onjia, Antonije E.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida Lj.
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2898
AB  - Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal.
PB  - Amsterdam : Elsevier Science Bv
T2  - Applied Surface Science
T1  - Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution
VL  - 338
SP  - 178
EP  - 189
DO  - 10.1016/j.apsusc.2015.02.133
ER  - 

@article{
author = "Antić, Katarina M. and Babić, Marija M. and Jovašević Vuković, Jovana J. and Vasiljević-Radović, Dana and Onjia, Antonije E. and Filipović, Jovanka M. and Tomić, Simonida Lj.",
year = "2015",
abstract = "Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal.",
publisher = "Amsterdam : Elsevier Science Bv",
journal = "Applied Surface Science",
title = "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution",
volume = "338",
pages = "178-189",
doi = "10.1016/j.apsusc.2015.02.133"
}

Antić, K. M., Babić, M. M., Jovašević Vuković, J. J., Vasiljević-Radović, D., Onjia, A. E., Filipović, J. M.,& Tomić, S. Lj.. (2015). Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science
Amsterdam : Elsevier Science Bv., 338, 178-189.
https://doi.org/10.1016/j.apsusc.2015.02.133

Antić KM, Babić MM, Jovašević Vuković JJ, Vasiljević-Radović D, Onjia AE, Filipović JM, Tomić SL. Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science. 2015;338:178-189.
doi:10.1016/j.apsusc.2015.02.133 .

Antić, Katarina M., Babić, Marija M., Jovašević Vuković, Jovana J., Vasiljević-Radović, Dana, Onjia, Antonije E., Filipović, Jovanka M., Tomić, Simonida Lj., "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution" in Applied Surface Science, 338 (2015):178-189,
https://doi.org/10.1016/j.apsusc.2015.02.133 . .

TY  - JOUR
AU  - Antić, Katarina M.
AU  - Babić, Marija M.
AU  - Jovašević Vuković, Jovana J.
AU  - Vasiljević-Radović, Dana
AU  - Onjia, Antonije E.
AU  - Filipovic, Jovanka M
AU  - Tomić, Simonida Lj.
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1764
AB  - Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal.
PB  - Elsevier
T2  - Applied Surface Science
T1  - Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution
VL  - 338
SP  - 178
EP  - 189
DO  - 10.1016/j.apsusc.2015.02.133
ER  - 

@article{
author = "Antić, Katarina M. and Babić, Marija M. and Jovašević Vuković, Jovana J. and Vasiljević-Radović, Dana and Onjia, Antonije E. and Filipovic, Jovanka M and Tomić, Simonida Lj.",
year = "2015",
abstract = "Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal.",
publisher = "Elsevier",
journal = "Applied Surface Science",
title = "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution",
volume = "338",
pages = "178-189",
doi = "10.1016/j.apsusc.2015.02.133"
}

Antić, K. M., Babić, M. M., Jovašević Vuković, J. J., Vasiljević-Radović, D., Onjia, A. E., Filipovic, J. M.,& Tomić, S. Lj.. (2015). Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science
Elsevier., 338, 178-189.
https://doi.org/10.1016/j.apsusc.2015.02.133

Antić KM, Babić MM, Jovašević Vuković JJ, Vasiljević-Radović D, Onjia AE, Filipovic JM, Tomić SL. Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science. 2015;338:178-189.
doi:10.1016/j.apsusc.2015.02.133 .

Antić, Katarina M., Babić, Marija M., Jovašević Vuković, Jovana J., Vasiljević-Radović, Dana, Onjia, Antonije E., Filipovic, Jovanka M, Tomić, Simonida Lj., "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution" in Applied Surface Science, 338 (2015):178-189,
https://doi.org/10.1016/j.apsusc.2015.02.133 . .

TY  - CONF
AU  - Tomić, Simonida Lj.
AU  - Mićić, M.M.
AU  - Dłokić, D.
AU  - Vasiljević-Radović, Dana
AU  - Filipović, J.M.
AU  - Suljovrujić, E. H.
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/610
AB  - Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.
C3  - Materials and Manufacturing Processes
T1  - Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application
VL  - 24
IS  - 10-11
SP  - 1197
EP  - 1201
DO  - 10.1080/10426910903022247
ER  - 

@conference{
author = "Tomić, Simonida Lj. and Mićić, M.M. and Dłokić, D. and Vasiljević-Radović, Dana and Filipović, J.M. and Suljovrujić, E. H.",
year = "2009",
abstract = "Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.",
journal = "Materials and Manufacturing Processes",
title = "Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application",
volume = "24",
number = "10-11",
pages = "1197-1201",
doi = "10.1080/10426910903022247"
}

Tomić, S. Lj., Mićić, M.M., Dłokić, D., Vasiljević-Radović, D., Filipović, J.M.,& Suljovrujić, E. H.. (2009). Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application. in Materials and Manufacturing Processes, 24(10-11), 1197-1201.
https://doi.org/10.1080/10426910903022247

Tomić SL, Mićić M, Dłokić D, Vasiljević-Radović D, Filipović J, Suljovrujić EH. Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application. in Materials and Manufacturing Processes. 2009;24(10-11):1197-1201.
doi:10.1080/10426910903022247 .

Tomić, Simonida Lj., Mićić, M.M., Dłokić, D., Vasiljević-Radović, Dana, Filipović, J.M., Suljovrujić, E. H., "Preparation of silver(I) complexes with itaconic acid-based hydrogels for biomedical application" in Materials and Manufacturing Processes, 24, no. 10-11 (2009):1197-1201,
https://doi.org/10.1080/10426910903022247 . .