TY  - JOUR
AU  - Lović, Jelena
AU  - Mašulović, Aleksandra
AU  - Lađarević, Jelena
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Avramov Ivić, Milka
AU  - Mijin, Dušan
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6601
AB  - In this work, the electrooxidation ability of nine pyridones was evaluated using cyclic
(CV) and square-wave voltammetry (SWV) in Britton–Robinson (BR) aqueous buffer solutions on a
glassy carbon electrode (GC). The dependence of electrochemical activity on pyridone structure was
elucidated by means of experimentally obtained spectra and quantum chemical calculations. Firstly, it
was shown that electrochemical activity is determined by the –OH group as a substituent in position
6 of the pyridone ring. By coupling the experimentally obtained UV-Vis spectra and DFT calculations,
the most stable forms, both protonated and deprotonated, were defined. The calculated values are
consistent with the electrochemical behavior observed, indicating that the deprotonated anionic form
was the most electrochemically active. Moreover, the impact of the substituent in position 3 of the
pyridone scaffold was discussed
PB  - MDPI
T2  - Applied Sciences
T1  - Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study
VL  - 13
IS  - 18
SP  - 10276
EP  - 
DO  - 10.3390/ app131810276
ER  - 

@article{
author = "Lović, Jelena and Mašulović, Aleksandra and Lađarević, Jelena and Vitnik, Vesna and Vitnik, Željko and Avramov Ivić, Milka and Mijin, Dušan",
year = "2023",
abstract = "In this work, the electrooxidation ability of nine pyridones was evaluated using cyclic
(CV) and square-wave voltammetry (SWV) in Britton–Robinson (BR) aqueous buffer solutions on a
glassy carbon electrode (GC). The dependence of electrochemical activity on pyridone structure was
elucidated by means of experimentally obtained spectra and quantum chemical calculations. Firstly, it
was shown that electrochemical activity is determined by the –OH group as a substituent in position
6 of the pyridone ring. By coupling the experimentally obtained UV-Vis spectra and DFT calculations,
the most stable forms, both protonated and deprotonated, were defined. The calculated values are
consistent with the electrochemical behavior observed, indicating that the deprotonated anionic form
was the most electrochemically active. Moreover, the impact of the substituent in position 3 of the
pyridone scaffold was discussed",
publisher = "MDPI",
journal = "Applied Sciences",
title = "Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study",
volume = "13",
number = "18",
pages = "10276-",
doi = "10.3390/ app131810276"
}

Lović, J., Mašulović, A., Lađarević, J., Vitnik, V., Vitnik, Ž., Avramov Ivić, M.,& Mijin, D.. (2023). Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study. in Applied Sciences
MDPI., 13(18), 10276-.
https://doi.org/10.3390/ app131810276

Lović J, Mašulović A, Lađarević J, Vitnik V, Vitnik Ž, Avramov Ivić M, Mijin D. Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study. in Applied Sciences. 2023;13(18):10276-.
doi:10.3390/ app131810276 .

Lović, Jelena, Mašulović, Aleksandra, Lađarević, Jelena, Vitnik, Vesna, Vitnik, Željko, Avramov Ivić, Milka, Mijin, Dušan, "Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study" in Applied Sciences, 13, no. 18 (2023):10276-,
https://doi.org/10.3390/ app131810276 . .

TY  - CONF
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Bogdanović, Aleksandra
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
AU  - Avramov -  Ivić, Milka
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6186
AB  - Duloxetine hydrochloride ( D U L ) , a naphth) I ether amine, inhibits the
uptake of serotonin and norepinephrine. The electrochemical behavior of D U L
was determined by cyclic voltammetry ( C V ) in phosphate buffer solution at gold
electrode by varying pH and scan rate. The electroanalytical application was
studied with the aid of differential pulse voltammetry (DPV) in sodium
bicarbonate solution. A linear response ranged from 5x10'^ M to 10'" M. The
validation of the DPV method was carried out by determine of the limit of
detection (LOD) and limit of quantitation (LOQ) and the calculate values were
4.6 X 10"'' and 2 x 10'^' M, respective!). The proposed DPV method has been
successfully applied to assessment DUL as standard and in Taita® tablets and
standard spiked with human serum.
PB  - Sarajevo : Faculty of Science University of Sarajevo
C3  - Bulletin of the Chemists and Technologists of Bosnia and Herzegovina
T1  - Electrochemical determination of duloxetine hydrochloride at gold electrode
SP  - 42
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_cer_6186
ER  - 

@conference{
author = "Lović, Jelena and Mijin, Dušan and Bogdanović, Aleksandra and Vuković, Dragan and Petrović, Slobodan and Avramov -  Ivić, Milka",
year = "2022",
abstract = "Duloxetine hydrochloride ( D U L ) , a naphth) I ether amine, inhibits the
uptake of serotonin and norepinephrine. The electrochemical behavior of D U L
was determined by cyclic voltammetry ( C V ) in phosphate buffer solution at gold
electrode by varying pH and scan rate. The electroanalytical application was
studied with the aid of differential pulse voltammetry (DPV) in sodium
bicarbonate solution. A linear response ranged from 5x10'^ M to 10'" M. The
validation of the DPV method was carried out by determine of the limit of
detection (LOD) and limit of quantitation (LOQ) and the calculate values were
4.6 X 10"'' and 2 x 10'^' M, respective!). The proposed DPV method has been
successfully applied to assessment DUL as standard and in Taita® tablets and
standard spiked with human serum.",
publisher = "Sarajevo : Faculty of Science University of Sarajevo",
journal = "Bulletin of the Chemists and Technologists of Bosnia and Herzegovina",
title = "Electrochemical determination of duloxetine hydrochloride at gold electrode",
pages = "42-42",
url = "https://hdl.handle.net/21.15107/rcub_cer_6186"
}

Lović, J., Mijin, D., Bogdanović, A., Vuković, D., Petrović, S.,& Avramov -  Ivić, M.. (2022). Electrochemical determination of duloxetine hydrochloride at gold electrode. in Bulletin of the Chemists and Technologists of Bosnia and Herzegovina
Sarajevo : Faculty of Science University of Sarajevo., 42-42.
https://hdl.handle.net/21.15107/rcub_cer_6186

Lović J, Mijin D, Bogdanović A, Vuković D, Petrović S, Avramov -  Ivić M. Electrochemical determination of duloxetine hydrochloride at gold electrode. in Bulletin of the Chemists and Technologists of Bosnia and Herzegovina. 2022;:42-42.
https://hdl.handle.net/21.15107/rcub_cer_6186 .

Lović, Jelena, Mijin, Dušan, Bogdanović, Aleksandra, Vuković, Dragan, Petrović, Slobodan, Avramov -  Ivić, Milka, "Electrochemical determination of duloxetine hydrochloride at gold electrode" in Bulletin of the Chemists and Technologists of Bosnia and Herzegovina (2022):42-42,
https://hdl.handle.net/21.15107/rcub_cer_6186 .

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov -  Ivić, Milka
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5171
AB  - Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DUL
standard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidation
at the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standard
concentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification
(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DUL
concentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons and
electrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes were
proposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DUL
quantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after
4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquid
chromatography (HPLC)
PB  - The Electrochemical Society
T2  - Journal of The Electrochemical Society
T1  - Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation
DO  - 10.1149/1945-7111/ac7e74
ER  - 

@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Tadić, Vanja and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov -  Ivić, Milka",
year = "2022",
abstract = "Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DUL
standard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidation
at the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standard
concentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification
(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DUL
concentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons and
electrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes were
proposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DUL
quantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after
4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquid
chromatography (HPLC)",
publisher = "The Electrochemical Society",
journal = "Journal of The Electrochemical Society",
title = "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation",
doi = "10.1149/1945-7111/ac7e74"
}

Lović, J., Bogdanović, A., Tadić, V., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov -  Ivić, M.. (2022). Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society
The Electrochemical Society..
https://doi.org/10.1149/1945-7111/ac7e74

Lović J, Bogdanović A, Tadić V, Mijin D, Vuković D, Petrović SD, Avramov -  Ivić M. Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society. 2022;.
doi:10.1149/1945-7111/ac7e74 .

Lović, Jelena, Bogdanović, Aleksandra, Tadić, Vanja, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov -  Ivić, Milka, "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation" in Journal of The Electrochemical Society (2022),
https://doi.org/10.1149/1945-7111/ac7e74 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
AU  - Avramov Ivić, Milka
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5221
AB  - Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.
PB  - ESG
T2  - International Journal of Electrochemical Science
T1  - Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode
VL  - 17
SP  - 220928
DO  - 10.20964/2022.09.36
ER  - 

@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan and Avramov Ivić, Milka",
year = "2022",
abstract = "Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.",
publisher = "ESG",
journal = "International Journal of Electrochemical Science",
title = "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode",
volume = "17",
pages = "220928",
doi = "10.20964/2022.09.36"
}

Lović, J., Bogdanović, A., Mijin, D., Vuković, D., Petrović, S.,& Avramov Ivić, M.. (2022). Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science
ESG., 17, 220928.
https://doi.org/10.20964/2022.09.36

Lović J, Bogdanović A, Mijin D, Vuković D, Petrović S, Avramov Ivić M. Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science. 2022;17:220928.
doi:10.20964/2022.09.36 .

Lović, Jelena, Bogdanović, Aleksandra, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan, Avramov Ivić, Milka, "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode" in International Journal of Electrochemical Science, 17 (2022):220928,
https://doi.org/10.20964/2022.09.36 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Trišović, Nemanja
AU  - Andrić, Filip
AU  - Mladenović, Aleksandar R.
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4246
AB  - The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin
(HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1–0.5 μM with a limit of detection (LOD) of 2.0 × 10–8 M and a limit of quantification (LOQ) of 6.7 × 10–8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 μM was obtained with a LOD of 2.6 × 10–8 M and a LOQ of 8.8 × 10–8 M. The gold electrode
revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10–8 and 8.6 × 10–8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.
PB  - Springer
T2  - Monatshefte für Chemie - Chemical Monthly
T1  - Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution
SP  - 185
EP  - 192
DO  - 10.1007/s00706-021-02745-3
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Trišović, Nemanja and Andrić, Filip and Mladenović, Aleksandar R. and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2021",
abstract = "The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin
(HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1–0.5 μM with a limit of detection (LOD) of 2.0 × 10–8 M and a limit of quantification (LOQ) of 6.7 × 10–8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 μM was obtained with a LOD of 2.6 × 10–8 M and a LOQ of 8.8 × 10–8 M. The gold electrode
revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10–8 and 8.6 × 10–8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.",
publisher = "Springer",
journal = "Monatshefte für Chemie - Chemical Monthly",
title = "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution",
pages = "185-192",
doi = "10.1007/s00706-021-02745-3"
}

Lović, J., Lađarević, J., Trišović, N., Andrić, F., Mladenović, A. R., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov Ivić, M.. (2021). Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte für Chemie - Chemical Monthly
Springer., 185-192.
https://doi.org/10.1007/s00706-021-02745-3

Lović J, Lađarević J, Trišović N, Andrić F, Mladenović AR, Mijin D, Vuković D, Petrović SD, Avramov Ivić M. Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte für Chemie - Chemical Monthly. 2021;:185-192.
doi:10.1007/s00706-021-02745-3 .

Lović, Jelena, Lađarević, Jelena, Trišović, Nemanja, Andrić, Filip, Mladenović, Aleksandar R., Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution" in Monatshefte für Chemie - Chemical Monthly (2021):185-192,
https://doi.org/10.1007/s00706-021-02745-3 . .

TY  - CONF
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Avramov -  Ivić, Milka
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4875
AB  - The electrochemical characterization of sertraline standard at gold electrode was at first performed by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). Namely, (2-hydroxypropyl)-β-cyclodextrin (HPβCD) sertraline inclusion complexe was employed to enhance the electrode sensitivity of the drug determination. Using the proposed SWV technique, the anodic current peak of sertraline oxidation was linear within a concentration range of 0.1–0.5 μM with a limit of detection (LOD) of 2.0  10-8 M and a limit of quantification (LOQ) of 6.7  10-8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 μM was obtained with a LOD of 2.6  10-8 M and a LOQ of 8.8  10-8 μM. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation.
AB  - Elektrohemijska karakterizacija standarda sertralina je urađena cikličnom voltametrijom(CV) u pH 8.4 bicarbonatnom puferu. Elektroda od zlata je zatim testirana za kvantitativno određivanje sertralina koristeći voltametriju sa pravougaonim impulsima (SWV). Inkluzioni kompleks (2-hydroxypropyl)-β-cyclodextrin (HPβCD) sertralina je testiran u cilju poboljšanja osetljivosti electrode za kvantitativno određivanje leka. 
SWV tehnikom je pokazano da je anodni strujni vrh oksidacije sertralina linearan u opsegu koncentracija 0.1–0.5 μM uz granicu detekcije (LOD) od 2.0  10-8 M i granicu kvantifikacije (LOQ) od 6.7  10-8 M. Inkluzioni kompleks sertralina sa HPβCD je ispoljio linearnost u opsegu koncentracija od 0.1–0.9 μM uz LOD of 2.6  10-8 M i LOQ od 8.8  10-8 μM. Analizom eksperimentalnih podataka može se zaklučiti da je osetljivost electrode od zlata za određivanje sertraline porasla više od pet puta kada je lek vezan u inkluzioni kompleks. Primenljivost razvijene metode je potvrđena uspešnim određivanjem leka u farmaceutskim oblicima.
PB  - Belgrade : Serbian Society of Corrosion and Materials Protection UISKOZAM
C3  - Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija
T1  - Electrochemical quantitative determination of sertraline in pharmaceutical formulation using a gold electrode in bicarbonate solution
T1  - Elektrohemijsko kvantitativno određivanje sertralina u farmaceutskim proizvodima na elektrod iod zlata u bikarbonatnom elektrolitu
SP  - Oral 37
EP  - Oral 41
UR  - https://hdl.handle.net/21.15107/rcub_cer_4875
ER  - 

@conference{
author = "Lović, Jelena and Mijin, Dušan and Avramov -  Ivić, Milka",
year = "2021",
abstract = "The electrochemical characterization of sertraline standard at gold electrode was at first performed by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). Namely, (2-hydroxypropyl)-β-cyclodextrin (HPβCD) sertraline inclusion complexe was employed to enhance the electrode sensitivity of the drug determination. Using the proposed SWV technique, the anodic current peak of sertraline oxidation was linear within a concentration range of 0.1–0.5 μM with a limit of detection (LOD) of 2.0  10-8 M and a limit of quantification (LOQ) of 6.7  10-8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 μM was obtained with a LOD of 2.6  10-8 M and a LOQ of 8.8  10-8 μM. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation., Elektrohemijska karakterizacija standarda sertralina je urađena cikličnom voltametrijom(CV) u pH 8.4 bicarbonatnom puferu. Elektroda od zlata je zatim testirana za kvantitativno određivanje sertralina koristeći voltametriju sa pravougaonim impulsima (SWV). Inkluzioni kompleks (2-hydroxypropyl)-β-cyclodextrin (HPβCD) sertralina je testiran u cilju poboljšanja osetljivosti electrode za kvantitativno određivanje leka. 
SWV tehnikom je pokazano da je anodni strujni vrh oksidacije sertralina linearan u opsegu koncentracija 0.1–0.5 μM uz granicu detekcije (LOD) od 2.0  10-8 M i granicu kvantifikacije (LOQ) od 6.7  10-8 M. Inkluzioni kompleks sertralina sa HPβCD je ispoljio linearnost u opsegu koncentracija od 0.1–0.9 μM uz LOD of 2.6  10-8 M i LOQ od 8.8  10-8 μM. Analizom eksperimentalnih podataka može se zaklučiti da je osetljivost electrode od zlata za određivanje sertraline porasla više od pet puta kada je lek vezan u inkluzioni kompleks. Primenljivost razvijene metode je potvrđena uspešnim određivanjem leka u farmaceutskim oblicima.",
publisher = "Belgrade : Serbian Society of Corrosion and Materials Protection UISKOZAM",
journal = "Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija",
title = "Electrochemical quantitative determination of sertraline in pharmaceutical formulation using a gold electrode in bicarbonate solution, Elektrohemijsko kvantitativno određivanje sertralina u farmaceutskim proizvodima na elektrod iod zlata u bikarbonatnom elektrolitu",
pages = "Oral 37-Oral 41",
url = "https://hdl.handle.net/21.15107/rcub_cer_4875"
}

Lović, J., Mijin, D.,& Avramov -  Ivić, M.. (2021). Electrochemical quantitative determination of sertraline in pharmaceutical formulation using a gold electrode in bicarbonate solution. in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija
Belgrade : Serbian Society of Corrosion and Materials Protection UISKOZAM., Oral 37-Oral 41.
https://hdl.handle.net/21.15107/rcub_cer_4875

Lović J, Mijin D, Avramov -  Ivić M. Electrochemical quantitative determination of sertraline in pharmaceutical formulation using a gold electrode in bicarbonate solution. in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija. 2021;:Oral 37-Oral 41.
https://hdl.handle.net/21.15107/rcub_cer_4875 .

Lović, Jelena, Mijin, Dušan, Avramov -  Ivić, Milka, "Electrochemical quantitative determination of sertraline in pharmaceutical formulation using a gold electrode in bicarbonate solution" in Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings XXII YuCorr International Conference / Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine : knjiga radova XXII YuCorr [Jugoslovenska korozija] Međunarodna konferencija (2021):Oral 37-Oral 41,
https://hdl.handle.net/21.15107/rcub_cer_4875 .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Šekuljica, Sanja
AU  - Guzsvány, Valéria
AU  - Nagy, László
AU  - Kónya, Zoltán
AU  - Avramov Ivić, Milka
AU  - Mijin, Dušan
AU  - Petrović, Slobodan D.
AU  - Anojčić, Jasmina
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3615
AB  - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surface
of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive 
 spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%
and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration
range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
VL  - 873
SP  - 114324
DO  - 10.1016/j.jelechem.2020.114324
ER  - 

@article{
author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov Ivić, Milka and Mijin, Dušan and Petrović, Slobodan D. and Anojčić, Jasmina",
year = "2020",
abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surface
of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive 
 spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%
and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration
range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations",
volume = "873",
pages = "114324",
doi = "10.1016/j.jelechem.2020.114324"
}

Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov Ivić, M., Mijin, D., Petrović, S. D.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry
Elsevier., 873, 114324.
https://doi.org/10.1016/j.jelechem.2020.114324

Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov Ivić M, Mijin D, Petrović SD, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873:114324.
doi:10.1016/j.jelechem.2020.114324 .

Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov Ivić, Milka, Mijin, Dušan, Petrović, Slobodan D., Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020):114324,
https://doi.org/10.1016/j.jelechem.2020.114324 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Šekuljica, Sanja
AU  - Guzsvány, Valéria
AU  - Nagy, László
AU  - Kónya, Zoltán
AU  - Avramov Ivić, Milka
AU  - Mijin, Dušan
AU  - Petrović, Slobodan D.
AU  - Anojčić, Jasmina
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3619
AB  - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surfaceof working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive  spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentrationrange, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
VL  - 873
SP  - 114324
DO  - 10.1016/j.jelechem.2020.114324
ER  - 

@article{
author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov Ivić, Milka and Mijin, Dušan and Petrović, Slobodan D. and Anojčić, Jasmina",
year = "2020",
abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surfaceof working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive  spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentrationrange, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations",
volume = "873",
pages = "114324",
doi = "10.1016/j.jelechem.2020.114324"
}

Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov Ivić, M., Mijin, D., Petrović, S. D.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry
Elsevier., 873, 114324.
https://doi.org/10.1016/j.jelechem.2020.114324

Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov Ivić M, Mijin D, Petrović SD, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873:114324.
doi:10.1016/j.jelechem.2020.114324 .

Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov Ivić, Milka, Mijin, Dušan, Petrović, Slobodan D., Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020):114324,
https://doi.org/10.1016/j.jelechem.2020.114324 . .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša D.
AU  - Trišović, Nemanja
AU  - Lađarević, Jelena
AU  - Vuković, Dragan
AU  - Drmanić, Saša Ž.
AU  - Mladenović, Aleksandar R.
AU  - Jadranin, Milka
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3062
AB  - Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 μg mL−1 with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 μg mL−1, respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 μm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation
VL  - 848
SP  - 113303
DO  - 10.1016/j.jelechem.2019.113303
ER  - 

@article{
author = "Avramov Ivić, Milka and Lović, Jelena and Stevanović, Sanja and Nikolić, Nebojša D. and Trišović, Nemanja and Lađarević, Jelena and Vuković, Dragan and Drmanić, Saša Ž. and Mladenović, Aleksandar R. and Jadranin, Milka and Petrović, Slobodan D. and Mijin, Dušan",
year = "2019",
abstract = "Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 μg mL−1 with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 μg mL−1, respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 μm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation",
volume = "848",
pages = "113303",
doi = "10.1016/j.jelechem.2019.113303"
}

Avramov Ivić, M., Lović, J., Stevanović, S., Nikolić, N. D., Trišović, N., Lađarević, J., Vuković, D., Drmanić, S. Ž., Mladenović, A. R., Jadranin, M., Petrović, S. D.,& Mijin, D.. (2019). Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry
Elsevier., 848, 113303.
https://doi.org/10.1016/j.jelechem.2019.113303

Avramov Ivić M, Lović J, Stevanović S, Nikolić ND, Trišović N, Lađarević J, Vuković D, Drmanić SŽ, Mladenović AR, Jadranin M, Petrović SD, Mijin D. Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry. 2019;848:113303.
doi:10.1016/j.jelechem.2019.113303 .

Avramov Ivić, Milka, Lović, Jelena, Stevanović, Sanja, Nikolić, Nebojša D., Trišović, Nemanja, Lađarević, Jelena, Vuković, Dragan, Drmanić, Saša Ž., Mladenović, Aleksandar R., Jadranin, Milka, Petrović, Slobodan D., Mijin, Dušan, "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation" in Journal of Electroanalytical Chemistry, 848 (2019):113303,
https://doi.org/10.1016/j.jelechem.2019.113303 . .

TY  - CONF
AU  - Lović, Jelena
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan
AU  - Reljin, Branimir
AU  - Reljin, Irini
AU  - Mijin, Dušan
AU  - Stevanović, Sanja
AU  - Vuković, Dragan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6208
AB  - The constant need to find increasing number of diagnostic more sensitive technique by which we would be able to determine an altered substrate as characteristic of the disease suspected is everyday clinical problem.
PB  - Serbian society of corrosion and materials protection (UISKOZAM) / Udruženje inženjera Srbije za koroziju i zaštitu materijala
C3  - Proceedings - XXI YUCORR International Conference, Meeting point of the science and practice in the fields of corrosion, materials and environmental protection, September 17-19, 2019, Tara Mountain, Serbia
T1  - Computer–aided decision–assistant system for diagnosis of different diseases
SP  - 2
EP  - 2
UR  - https://hdl.handle.net/21.15107/rcub_cer_6208
ER  - 

@conference{
author = "Lović, Jelena and Avramov Ivić, Milka and Petrović, Slobodan and Reljin, Branimir and Reljin, Irini and Mijin, Dušan and Stevanović, Sanja and Vuković, Dragan",
year = "2019",
abstract = "The constant need to find increasing number of diagnostic more sensitive technique by which we would be able to determine an altered substrate as characteristic of the disease suspected is everyday clinical problem.",
publisher = "Serbian society of corrosion and materials protection (UISKOZAM) / Udruženje inženjera Srbije za koroziju i zaštitu materijala",
journal = "Proceedings - XXI YUCORR International Conference, Meeting point of the science and practice in the fields of corrosion, materials and environmental protection, September 17-19, 2019, Tara Mountain, Serbia",
title = "Computer–aided decision–assistant system for diagnosis of different diseases",
pages = "2-2",
url = "https://hdl.handle.net/21.15107/rcub_cer_6208"
}

Lović, J., Avramov Ivić, M., Petrović, S., Reljin, B., Reljin, I., Mijin, D., Stevanović, S.,& Vuković, D.. (2019). Computer–aided decision–assistant system for diagnosis of different diseases. in Proceedings - XXI YUCORR International Conference, Meeting point of the science and practice in the fields of corrosion, materials and environmental protection, September 17-19, 2019, Tara Mountain, Serbia
Serbian society of corrosion and materials protection (UISKOZAM) / Udruženje inženjera Srbije za koroziju i zaštitu materijala., 2-2.
https://hdl.handle.net/21.15107/rcub_cer_6208

Lović J, Avramov Ivić M, Petrović S, Reljin B, Reljin I, Mijin D, Stevanović S, Vuković D. Computer–aided decision–assistant system for diagnosis of different diseases. in Proceedings - XXI YUCORR International Conference, Meeting point of the science and practice in the fields of corrosion, materials and environmental protection, September 17-19, 2019, Tara Mountain, Serbia. 2019;:2-2.
https://hdl.handle.net/21.15107/rcub_cer_6208 .

Lović, Jelena, Avramov Ivić, Milka, Petrović, Slobodan, Reljin, Branimir, Reljin, Irini, Mijin, Dušan, Stevanović, Sanja, Vuković, Dragan, "Computer–aided decision–assistant system for diagnosis of different diseases" in Proceedings - XXI YUCORR International Conference, Meeting point of the science and practice in the fields of corrosion, materials and environmental protection, September 17-19, 2019, Tara Mountain, Serbia (2019):2-2,
https://hdl.handle.net/21.15107/rcub_cer_6208 .

TY  - CONF
AU  - Avramov -  Ivić, Milka
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Lađarević, Jelena
AU  - Mladenović, Aleksandar R.
AU  - Jadranin, Milka
AU  - Petrović, Slobodan
AU  - Mijin, Dušan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5656
AB  - The electrochemical activity of esomeprazole at the gold electrode was investigated by CV and the development of an electroanalytical procedure for its quantitative determination was established with the aid of SWV measurements. The study of the electrochemical degradation of the drug was
performed at Au and IrOx electrodes.
PB  - International Association of Physical Chemists
C3  - Book of abstracts - 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, May 27 – 30, 2019, Split, Croatia
T1  - The SWV determination of esomeprazole at Au and its degradation at IrOx followed by HPLC and LC-MS
SP  - EAS-P-11
UR  - https://hdl.handle.net/21.15107/rcub_cer_5656
ER  - 

@conference{
author = "Avramov -  Ivić, Milka and Lović, Jelena and Trišović, Nemanja and Lađarević, Jelena and Mladenović, Aleksandar R. and Jadranin, Milka and Petrović, Slobodan and Mijin, Dušan",
year = "2019",
abstract = "The electrochemical activity of esomeprazole at the gold electrode was investigated by CV and the development of an electroanalytical procedure for its quantitative determination was established with the aid of SWV measurements. The study of the electrochemical degradation of the drug was
performed at Au and IrOx electrodes.",
publisher = "International Association of Physical Chemists",
journal = "Book of abstracts - 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, May 27 – 30, 2019, Split, Croatia",
title = "The SWV determination of esomeprazole at Au and its degradation at IrOx followed by HPLC and LC-MS",
pages = "EAS-P-11",
url = "https://hdl.handle.net/21.15107/rcub_cer_5656"
}

Avramov -  Ivić, M., Lović, J., Trišović, N., Lađarević, J., Mladenović, A. R., Jadranin, M., Petrović, S.,& Mijin, D.. (2019). The SWV determination of esomeprazole at Au and its degradation at IrOx followed by HPLC and LC-MS. in Book of abstracts - 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, May 27 – 30, 2019, Split, Croatia
International Association of Physical Chemists., EAS-P-11.
https://hdl.handle.net/21.15107/rcub_cer_5656

Avramov -  Ivić M, Lović J, Trišović N, Lađarević J, Mladenović AR, Jadranin M, Petrović S, Mijin D. The SWV determination of esomeprazole at Au and its degradation at IrOx followed by HPLC and LC-MS. in Book of abstracts - 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, May 27 – 30, 2019, Split, Croatia. 2019;:EAS-P-11.
https://hdl.handle.net/21.15107/rcub_cer_5656 .

Avramov -  Ivić, Milka, Lović, Jelena, Trišović, Nemanja, Lađarević, Jelena, Mladenović, Aleksandar R., Jadranin, Milka, Petrović, Slobodan, Mijin, Dušan, "The SWV determination of esomeprazole at Au and its degradation at IrOx followed by HPLC and LC-MS" in Book of abstracts - 7th Regional Symposium on Electrochemistry – South East Europe & 8th Kurt Schwabe Symposium, May 27 – 30, 2019, Split, Croatia (2019):EAS-P-11,
https://hdl.handle.net/21.15107/rcub_cer_5656 .

TY  - JOUR
AU  - Lović, Jelena
AU  - Avramov Ivić, Milka
AU  - Božić, Bojan
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2874
AB  - The inclusion complexes of the selected, potentially biologically active, succinimides with β-cyclodextrin (βCD) and
(2-hydroxypropyl)-β-cyclodextrin (HPβCD) were prepared. the formation of the inclusion complexes of the investigated
monophenyl and diphenyl succinimide derivatives was confirmed using attenuated total reflection (ATR) study. Their
electrochemical behavior was examined by cyclic voltammetry (CV) and square wave voltammetry (SWV) in 0.05 M
NaHCO3 on a gold electrode. The stability constants for compound 1 were determined by cyclic voltammetry and calculated
as KβCD = 350.87 M–1 and KHPβCD = 250.67 M–1. The SWV measurements reveal well defined peak at potential Ep =
~ 60 mV and the higher currents at Ep for both inclusion complex of the succinimides compared to the free compounds.
The impact of chlorine atom in the phenyl moiety of succinimide derivatives on the activity in electrooxidation reaction
is presented. Among the studied succinimides, according to SWV measurements, the most active is the monophenyl
succinimide derivative (compound 1) in complex with βCD. The difference of peak current of compound 1 + βCD compared
to compound 1 + HPβCD and free compound is 6.3 and 35.2 μA cm–2, respectively.
PB  - Ljubljana : Slovenian Chemical Society
T2  - Acta Chimica Slovenica
T1  - Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin
VL  - 66
SP  - 182
EP  - 189
DO  - 10.17344/acsi.2018.4767
ER  - 

@article{
author = "Lović, Jelena and Avramov Ivić, Milka and Božić, Bojan and Lađarević, Jelena and Mijin, Dušan",
year = "2019",
abstract = "The inclusion complexes of the selected, potentially biologically active, succinimides with β-cyclodextrin (βCD) and
(2-hydroxypropyl)-β-cyclodextrin (HPβCD) were prepared. the formation of the inclusion complexes of the investigated
monophenyl and diphenyl succinimide derivatives was confirmed using attenuated total reflection (ATR) study. Their
electrochemical behavior was examined by cyclic voltammetry (CV) and square wave voltammetry (SWV) in 0.05 M
NaHCO3 on a gold electrode. The stability constants for compound 1 were determined by cyclic voltammetry and calculated
as KβCD = 350.87 M–1 and KHPβCD = 250.67 M–1. The SWV measurements reveal well defined peak at potential Ep =
~ 60 mV and the higher currents at Ep for both inclusion complex of the succinimides compared to the free compounds.
The impact of chlorine atom in the phenyl moiety of succinimide derivatives on the activity in electrooxidation reaction
is presented. Among the studied succinimides, according to SWV measurements, the most active is the monophenyl
succinimide derivative (compound 1) in complex with βCD. The difference of peak current of compound 1 + βCD compared
to compound 1 + HPβCD and free compound is 6.3 and 35.2 μA cm–2, respectively.",
publisher = "Ljubljana : Slovenian Chemical Society",
journal = "Acta Chimica Slovenica",
title = "Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin",
volume = "66",
pages = "182-189",
doi = "10.17344/acsi.2018.4767"
}

Lović, J., Avramov Ivić, M., Božić, B., Lađarević, J.,& Mijin, D.. (2019). Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin. in Acta Chimica Slovenica
Ljubljana : Slovenian Chemical Society., 66, 182-189.
https://doi.org/10.17344/acsi.2018.4767

Lović J, Avramov Ivić M, Božić B, Lađarević J, Mijin D. Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin. in Acta Chimica Slovenica. 2019;66:182-189.
doi:10.17344/acsi.2018.4767 .

Lović, Jelena, Avramov Ivić, Milka, Božić, Bojan, Lađarević, Jelena, Mijin, Dušan, "Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin" in Acta Chimica Slovenica, 66 (2019):182-189,
https://doi.org/10.17344/acsi.2018.4767 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Jadranin, Milka
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3159
AB  - In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis.
AB  - У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан је
цикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 М
раствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овим
условима, предложена је трансформација лека до одговарајућег N-карбонил гуанидина
преко оксима као интермедијера. Стабилност метформина тестирана је и под условима
електрохемијске оксидације на IrOx електроди у присуству натријум сулфата као
електолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-
метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процеса
на све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен је
анализом укупног органског угљеника.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes
T1  - Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама
VL  - 84
IS  - 11
SP  - 1319
EP  - 1327
DO  - 10.2298/JSC190731091L
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Jadranin, Milka and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2019",
abstract = "In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis., У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан је
цикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 М
раствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овим
условима, предложена је трансформација лека до одговарајућег N-карбонил гуанидина
преко оксима као интермедијера. Стабилност метформина тестирана је и под условима
електрохемијске оксидације на IrOx електроди у присуству натријум сулфата као
електолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-
метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процеса
на све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен је
анализом укупног органског угљеника.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes, Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама",
volume = "84",
number = "11",
pages = "1319-1327",
doi = "10.2298/JSC190731091L"
}

Lović, J., Lađarević, J., Mijin, D., Jadranin, M., Petrović, S. D.,& Avramov Ivić, M.. (2019). Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 84(11), 1319-1327.
https://doi.org/10.2298/JSC190731091L

Lović J, Lađarević J, Mijin D, Jadranin M, Petrović SD, Avramov Ivić M. Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society. 2019;84(11):1319-1327.
doi:10.2298/JSC190731091L .

Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Jadranin, Milka, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1319-1327,
https://doi.org/10.2298/JSC190731091L . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Jadranin, Milka
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3383
AB  - In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis.
AB  - У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан јецикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 Мраствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овимусловима, предложена је трансформација лека до одговарајућег N-карбонил гуанидинапреко оксима као интермедијера. Стабилност метформина тестирана је и под условимаелектрохемијске оксидације на IrOx електроди у присуству натријум сулфата каоелектолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процесана све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен јеанализом укупног органског угљеника.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes
T1  - Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама
VL  - 84
IS  - 11
SP  - 1319
EP  - 1327
DO  - 10.2298/JSC190731091L
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Jadranin, Milka and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2019",
abstract = "In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis., У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан јецикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 Мраствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овимусловима, предложена је трансформација лека до одговарајућег N-карбонил гуанидинапреко оксима као интермедијера. Стабилност метформина тестирана је и под условимаелектрохемијске оксидације на IrOx електроди у присуству натријум сулфата каоелектолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процесана све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен јеанализом укупног органског угљеника.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes, Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама",
volume = "84",
number = "11",
pages = "1319-1327",
doi = "10.2298/JSC190731091L"
}

Lović, J., Lađarević, J., Mijin, D., Jadranin, M., Petrović, S. D.,& Avramov Ivić, M.. (2019). Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 84(11), 1319-1327.
https://doi.org/10.2298/JSC190731091L

Lović J, Lađarević J, Mijin D, Jadranin M, Petrović SD, Avramov Ivić M. Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society. 2019;84(11):1319-1327.
doi:10.2298/JSC190731091L .

Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Jadranin, Milka, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1319-1327,
https://doi.org/10.2298/JSC190731091L . .

TY  - CONF
AU  - Lović, Jelena
AU  - Avramov Ivić, Milka
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša D.
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6319
AB  - Esomeprazole has been shown to be the most effective oral PPI for controlling
intragastric pH. The persistence of esomeprasole in environmental systems
could be solved by different types of its degradation. In this work
electrocatalytic degradation of esomeprasole has been investigated in the
presence of sodium sulfate and sodium chloride using IrOx electrode and was
monitored using UV-Vis spectrophotometer at 303 nm. Also the electro
degradation process was examined and on Au electrode. NanoScope III A
(Veeco, USA) microscope was used to study the morphology of Esomeprazole
on the gold surface by atomic force microscopy. By optical microscopy the
morphology of Esomeprazole dissolved in human serum on the gold surface
was studied as well.
PB  - Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine
C3  - Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018
T1  - Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection
SP  - 61
EP  - 65
UR  - https://hdl.handle.net/21.15107/rcub_cer_6319
ER  - 

@conference{
author = "Lović, Jelena and Avramov Ivić, Milka and Lađarević, Jelena and Mijin, Dušan and Stevanović, Sanja and Nikolić, Nebojša D. and Vuković, Dragan and Petrović, Slobodan",
year = "2018",
abstract = "Esomeprazole has been shown to be the most effective oral PPI for controlling
intragastric pH. The persistence of esomeprasole in environmental systems
could be solved by different types of its degradation. In this work
electrocatalytic degradation of esomeprasole has been investigated in the
presence of sodium sulfate and sodium chloride using IrOx electrode and was
monitored using UV-Vis spectrophotometer at 303 nm. Also the electro
degradation process was examined and on Au electrode. NanoScope III A
(Veeco, USA) microscope was used to study the morphology of Esomeprazole
on the gold surface by atomic force microscopy. By optical microscopy the
morphology of Esomeprazole dissolved in human serum on the gold surface
was studied as well.",
publisher = "Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine",
journal = "Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018",
title = "Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection",
pages = "61-65",
url = "https://hdl.handle.net/21.15107/rcub_cer_6319"
}

Lović, J., Avramov Ivić, M., Lađarević, J., Mijin, D., Stevanović, S., Nikolić, N. D., Vuković, D.,& Petrović, S.. (2018). Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection. in Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018
Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine., 61-65.
https://hdl.handle.net/21.15107/rcub_cer_6319

Lović J, Avramov Ivić M, Lađarević J, Mijin D, Stevanović S, Nikolić ND, Vuković D, Petrović S. Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection. in Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018. 2018;:61-65.
https://hdl.handle.net/21.15107/rcub_cer_6319 .

Lović, Jelena, Avramov Ivić, Milka, Lađarević, Jelena, Mijin, Dušan, Stevanović, Sanja, Nikolić, Nebojša D., Vuković, Dragan, Petrović, Slobodan, "Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection" in Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018 (2018):61-65,
https://hdl.handle.net/21.15107/rcub_cer_6319 .

TY  - JOUR
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Anđelković, Boban D.
AU  - Petrovic, S.
AU  - Vukovic, D.
AU  - Prlainović, Nevena Ž.
AU  - Mijin, Dušan
AU  - Nikolić, Nebojša D.
AU  - Avramov Ivić, Milka
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2364
AB  - Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.
PB  - Esg, Belgrade
T2  - International Journal of Electrochemical Science
T1  - Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode
VL  - 13
IS  - 12
SP  - 12340
EP  - 12348
DO  - 10.20964/2018.12.59
ER  - 

@article{
author = "Lović, Jelena and Stevanović, Sanja and Anđelković, Boban D. and Petrovic, S. and Vukovic, D. and Prlainović, Nevena Ž. and Mijin, Dušan and Nikolić, Nebojša D. and Avramov Ivić, Milka",
year = "2018",
abstract = "Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode",
volume = "13",
number = "12",
pages = "12340-12348",
doi = "10.20964/2018.12.59"
}

Lović, J., Stevanović, S., Anđelković, B. D., Petrovic, S., Vukovic, D., Prlainović, N. Ž., Mijin, D., Nikolić, N. D.,& Avramov Ivić, M.. (2018). Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science
Esg, Belgrade., 13(12), 12340-12348.
https://doi.org/10.20964/2018.12.59

Lović J, Stevanović S, Anđelković BD, Petrovic S, Vukovic D, Prlainović NŽ, Mijin D, Nikolić ND, Avramov Ivić M. Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science. 2018;13(12):12340-12348.
doi:10.20964/2018.12.59 .

Lović, Jelena, Stevanović, Sanja, Anđelković, Boban D., Petrovic, S., Vukovic, D., Prlainović, Nevena Ž., Mijin, Dušan, Nikolić, Nebojša D., Avramov Ivić, Milka, "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode" in International Journal of Electrochemical Science, 13, no. 12 (2018):12340-12348,
https://doi.org/10.20964/2018.12.59 . .

TY  - JOUR
AU  - Božić, Bojan
AU  - Lović, Jelena
AU  - Banjac, Nebojša R.
AU  - Vitnik, Željko
AU  - Vitnik, Vesna
AU  - Mijin, Dušan
AU  - Ušćumlić, Gordana
AU  - Avramov Ivić, Milka
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2300
AB  - A series of succinimide derivatives were studied using the cyclic and square wave voltammetry. Density function theory was used in order to determinate which of the structural parameters influence the electrochemical activity. The quantum chemical calculations of the investigated succinimides were linked with the experimental electrochemical data and used to propose the oxidation mechanism. The most active among studied succinimides is 1,3-diphenylsuccinimide. The results obtained from the cyclic and square wave voltammetry and quantum chemical calculations indicate that the investigated compounds undergo oxidation by irreversible, diffusion controlled process including transfer of 1e(-) and 1 proton. The voltammetric and DFT results signify that the mechanism of electrochemical oxidation of all compounds involve the conversion of carbonyl-methyne-phenyl segment or methylene group in free radical. This conversion proceeds by the loss of one proton one electron process.
PB  - Esg, Belgrade
T2  - International Journal of Electrochemical Science
T1  - Voltammetric and Quantum Investigation of Selected Succinimides
VL  - 13
IS  - 5
SP  - 4285
EP  - 4297
DO  - 10.20964/2018.05.54
ER  - 

@article{
author = "Božić, Bojan and Lović, Jelena and Banjac, Nebojša R. and Vitnik, Željko and Vitnik, Vesna and Mijin, Dušan and Ušćumlić, Gordana and Avramov Ivić, Milka",
year = "2018",
abstract = "A series of succinimide derivatives were studied using the cyclic and square wave voltammetry. Density function theory was used in order to determinate which of the structural parameters influence the electrochemical activity. The quantum chemical calculations of the investigated succinimides were linked with the experimental electrochemical data and used to propose the oxidation mechanism. The most active among studied succinimides is 1,3-diphenylsuccinimide. The results obtained from the cyclic and square wave voltammetry and quantum chemical calculations indicate that the investigated compounds undergo oxidation by irreversible, diffusion controlled process including transfer of 1e(-) and 1 proton. The voltammetric and DFT results signify that the mechanism of electrochemical oxidation of all compounds involve the conversion of carbonyl-methyne-phenyl segment or methylene group in free radical. This conversion proceeds by the loss of one proton one electron process.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "Voltammetric and Quantum Investigation of Selected Succinimides",
volume = "13",
number = "5",
pages = "4285-4297",
doi = "10.20964/2018.05.54"
}

Božić, B., Lović, J., Banjac, N. R., Vitnik, Ž., Vitnik, V., Mijin, D., Ušćumlić, G.,& Avramov Ivić, M.. (2018). Voltammetric and Quantum Investigation of Selected Succinimides. in International Journal of Electrochemical Science
Esg, Belgrade., 13(5), 4285-4297.
https://doi.org/10.20964/2018.05.54

Božić B, Lović J, Banjac NR, Vitnik Ž, Vitnik V, Mijin D, Ušćumlić G, Avramov Ivić M. Voltammetric and Quantum Investigation of Selected Succinimides. in International Journal of Electrochemical Science. 2018;13(5):4285-4297.
doi:10.20964/2018.05.54 .

Božić, Bojan, Lović, Jelena, Banjac, Nebojša R., Vitnik, Željko, Vitnik, Vesna, Mijin, Dušan, Ušćumlić, Gordana, Avramov Ivić, Milka, "Voltammetric and Quantum Investigation of Selected Succinimides" in International Journal of Electrochemical Science, 13, no. 5 (2018):4285-4297,
https://doi.org/10.20964/2018.05.54 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijevic, Jelena
AU  - Avramov Ivić, Milka
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2313
AB  - Electrochemical behavior of sildenafil citrate (SC) at gold and cystein (Cys) modified gold electrode (AulCys) in 0.1 M H2SO4 was investigated by cyclic voltammetry (CV) and by square wave voltammetry (SWV). Effect of scan rate on the CVs of SC standard was performed in order to examine the mode of transport and irreversibility of process. SC as standard is determined by SWV in acid solution at Au electrode in a range: 10(-3), 10(-2) 0.1, 0.5, 1 mu M and on Au/Cys in a range: 10(-3), 10(-2) 0.05, 0.1 mu M. The presence of Cys causes two-time larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. In investigated range of concentration of SC standard in acid solution on modified and unmodified Au electrodes SWV method have excellent linear regression coefficient with value 0.997 promoting SWV for reliable determination of SC.
PB  - International Association of Physical Chemists (IAPC)
T2  - Journal of Electrochemical Science and Engineering
T1  - Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution
VL  - 8
IS  - 2
SP  - 163
EP  - 170
DO  - 10.5599/jese.481
ER  - 

@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijevic, Jelena and Avramov Ivić, Milka",
year = "2018",
abstract = "Electrochemical behavior of sildenafil citrate (SC) at gold and cystein (Cys) modified gold electrode (AulCys) in 0.1 M H2SO4 was investigated by cyclic voltammetry (CV) and by square wave voltammetry (SWV). Effect of scan rate on the CVs of SC standard was performed in order to examine the mode of transport and irreversibility of process. SC as standard is determined by SWV in acid solution at Au electrode in a range: 10(-3), 10(-2) 0.1, 0.5, 1 mu M and on Au/Cys in a range: 10(-3), 10(-2) 0.05, 0.1 mu M. The presence of Cys causes two-time larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. In investigated range of concentration of SC standard in acid solution on modified and unmodified Au electrodes SWV method have excellent linear regression coefficient with value 0.997 promoting SWV for reliable determination of SC.",
publisher = "International Association of Physical Chemists (IAPC)",
journal = "Journal of Electrochemical Science and Engineering",
title = "Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution",
volume = "8",
number = "2",
pages = "163-170",
doi = "10.5599/jese.481"
}

Lović, J., Trišović, N., Antanasijevic, J.,& Avramov Ivić, M.. (2018). Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution. in Journal of Electrochemical Science and Engineering
International Association of Physical Chemists (IAPC)., 8(2), 163-170.
https://doi.org/10.5599/jese.481

Lović J, Trišović N, Antanasijevic J, Avramov Ivić M. Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution. in Journal of Electrochemical Science and Engineering. 2018;8(2):163-170.
doi:10.5599/jese.481 .

Lović, Jelena, Trišović, Nemanja, Antanasijevic, Jelena, Avramov Ivić, Milka, "Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution" in Journal of Electrochemical Science and Engineering, 8, no. 2 (2018):163-170,
https://doi.org/10.5599/jese.481 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša D.
AU  - Petrovic, S.
AU  - Vukovic, D.
AU  - Prlainović, Nevena Ž.
AU  - Mijin, Dušan
AU  - Avramov Ivić, Milka
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2141
AB  - The method to develop a stable glucose biosensor with successive attachment of cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is presented. The cyclic voltammetry (CV) suggests the diffusion control of the glucose oxidation. The obtained biosensor shows a fast electron transfer of k(0) = 20.4 s(-1), high affinity for glucose with the apparent MichaelisMenten constant K-M(app) = 1.15 mM, a low detection limit of 0.94 mM in a linear range 1.5-7 mM. This biosensor exhibits good stability and reproducibility. Good biocompatibility of modified electrode surface, which enhances the covalent bonded enzyme and consequently glucose oxidation, resulted in biosensor with excellent performances. Biosensor was tested in samples containing human serum.
PB  - Esg, Belgrade
T2  - International Journal of Electrochemical Science
T1  - Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode
VL  - 12
IS  - 7
SP  - 5806
EP  - 5817
DO  - 10.20964/2017.07.65
ER  - 

@article{
author = "Lović, Jelena and Stevanović, Sanja and Nikolić, Nebojša D. and Petrovic, S. and Vukovic, D. and Prlainović, Nevena Ž. and Mijin, Dušan and Avramov Ivić, Milka",
year = "2017",
abstract = "The method to develop a stable glucose biosensor with successive attachment of cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is presented. The cyclic voltammetry (CV) suggests the diffusion control of the glucose oxidation. The obtained biosensor shows a fast electron transfer of k(0) = 20.4 s(-1), high affinity for glucose with the apparent MichaelisMenten constant K-M(app) = 1.15 mM, a low detection limit of 0.94 mM in a linear range 1.5-7 mM. This biosensor exhibits good stability and reproducibility. Good biocompatibility of modified electrode surface, which enhances the covalent bonded enzyme and consequently glucose oxidation, resulted in biosensor with excellent performances. Biosensor was tested in samples containing human serum.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode",
volume = "12",
number = "7",
pages = "5806-5817",
doi = "10.20964/2017.07.65"
}

Lović, J., Stevanović, S., Nikolić, N. D., Petrovic, S., Vukovic, D., Prlainović, N. Ž., Mijin, D.,& Avramov Ivić, M.. (2017). Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode. in International Journal of Electrochemical Science
Esg, Belgrade., 12(7), 5806-5817.
https://doi.org/10.20964/2017.07.65

Lović J, Stevanović S, Nikolić ND, Petrovic S, Vukovic D, Prlainović NŽ, Mijin D, Avramov Ivić M. Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode. in International Journal of Electrochemical Science. 2017;12(7):5806-5817.
doi:10.20964/2017.07.65 .

Lović, Jelena, Stevanović, Sanja, Nikolić, Nebojša D., Petrovic, S., Vukovic, D., Prlainović, Nevena Ž., Mijin, Dušan, Avramov Ivić, Milka, "Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode" in International Journal of Electrochemical Science, 12, no. 7 (2017):5806-5817,
https://doi.org/10.20964/2017.07.65 . .

TY  - JOUR
AU  - Radosavljevic, Kristina D.
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Petrović, Slobodan D.
AU  - Jadranin, Milka
AU  - Mladenović, Aleksandar R.
AU  - Avramov Ivić, Milka
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2233
AB  - The electrodegradation of azithromycin was studied by its indirect oxidation using dimensionally stable Ti/RuO2 anode as catalyst in the electrolyte containing methanol, 0.05 M NaHCO3, sodium chloride and deionized water. The optimal conditions for galvanostatic electrodegradation for the azithromycin concentration of 0.472 mg cm(-3) were found to be NaCl concentration of 7 mg cm(-3) and the applied current of 300 mA. The differential pulse voltammetry using glassy carbon electrode was performed for the first time in the above-mentioned content of electrolyte for the nine concentration of azithromycin (0.075-0.675 mg cm(-3)) giving the limits of azithromycin detection and of quantification as: LOD 0.044 mg cm(-3) and LOQ 0.145 mg cm(-3). The calibration curve was constructed enabling the electrolyte analysis during its electrodegradation process. The electrolyte was analyzed by high-performance liquid chromatography and electrospray ionization time-of-flight mass spectrometry. The electrooxidation products were identified and after 180 min there was no azithromycin in the electrolyte while TOC analysis showed that 79% of azithromycin was mineralized. The proposed degradation scheme is presented.
PB  - Versita, Warsaw
T2  - Chemical Papers
T1  - Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis
VL  - 71
IS  - 7
SP  - 1217
EP  - 1224
DO  - 10.1007/s11696-016-0115-2
ER  - 

@article{
author = "Radosavljevic, Kristina D. and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan D. and Jadranin, Milka and Mladenović, Aleksandar R. and Avramov Ivić, Milka",
year = "2017",
abstract = "The electrodegradation of azithromycin was studied by its indirect oxidation using dimensionally stable Ti/RuO2 anode as catalyst in the electrolyte containing methanol, 0.05 M NaHCO3, sodium chloride and deionized water. The optimal conditions for galvanostatic electrodegradation for the azithromycin concentration of 0.472 mg cm(-3) were found to be NaCl concentration of 7 mg cm(-3) and the applied current of 300 mA. The differential pulse voltammetry using glassy carbon electrode was performed for the first time in the above-mentioned content of electrolyte for the nine concentration of azithromycin (0.075-0.675 mg cm(-3)) giving the limits of azithromycin detection and of quantification as: LOD 0.044 mg cm(-3) and LOQ 0.145 mg cm(-3). The calibration curve was constructed enabling the electrolyte analysis during its electrodegradation process. The electrolyte was analyzed by high-performance liquid chromatography and electrospray ionization time-of-flight mass spectrometry. The electrooxidation products were identified and after 180 min there was no azithromycin in the electrolyte while TOC analysis showed that 79% of azithromycin was mineralized. The proposed degradation scheme is presented.",
publisher = "Versita, Warsaw",
journal = "Chemical Papers",
title = "Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis",
volume = "71",
number = "7",
pages = "1217-1224",
doi = "10.1007/s11696-016-0115-2"
}

Radosavljevic, K. D., Lović, J., Mijin, D., Petrović, S. D., Jadranin, M., Mladenović, A. R.,& Avramov Ivić, M.. (2017). Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis. in Chemical Papers
Versita, Warsaw., 71(7), 1217-1224.
https://doi.org/10.1007/s11696-016-0115-2

Radosavljevic KD, Lović J, Mijin D, Petrović SD, Jadranin M, Mladenović AR, Avramov Ivić M. Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis. in Chemical Papers. 2017;71(7):1217-1224.
doi:10.1007/s11696-016-0115-2 .

Radosavljevic, Kristina D., Lović, Jelena, Mijin, Dušan, Petrović, Slobodan D., Jadranin, Milka, Mladenović, Aleksandar R., Avramov Ivić, Milka, "Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis" in Chemical Papers, 71, no. 7 (2017):1217-1224,
https://doi.org/10.1007/s11696-016-0115-2 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Guzsvány, Valéria
AU  - Škorić, Dušan
AU  - Csanadi, Janos
AU  - Petkovic, Milos
AU  - Avramov Ivić, Milka
AU  - Kónya, Zoltán
AU  - Petrović, Slobodan D.
AU  - Bobrowski, Andrzej
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2187
AB  - The renewable silver-amalgam film electrode (Hg(Ag)FE) was applied for voltammetric characterization and determination of semi-synthetic macrolide antibiotics azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) in the Britton-Robinson buffer as supporting electrolyte ranging the pH from 4.0 to 11.9. All three macrolides showed reduction signals in fairly negative potential range. During direct cathodic square wave voltammetric (SWV) investigations conducted over the potential range from -0.75 V to -2.00V vs SCE, either one or two reduction peaks were obtained in the potential range from -1.5 to -1.9 V. The shapes and intensities of the signals depend on the applied pH values in wider pH ranges. For analytical purposes concerning the development of direct cathodic SWV and adsorptive stripping SWV (SW-AdSV) methods the neutral and slightly alkaline media were suitable as pH 7.2, pH 7.4 and pH 7.0 for AZI, CIA and ROX, respectively. Based on the cyclic voltammograms recorded at these pH values, adsorption-controlled electrode kinetics process can be proposed for all three macrolides. Furthermore, the water suppressed H-1 NMR measurements in the pH range between 6.0 and 10.5 indicated that the macrolide molecules at the optimal analytical conditions are predominantly in protonated form via their tertiary amino groups which supported in all three cases their adsorption on the appropriately polarized Hg(Ag)FE electrode. The optimized direct cathodic SWV methods showed good linearity in concentration ranges 4.81-23.3 mu gmL(-1), 1.96-28.6 mu gmL(-1) and 1.48-25.9 mu gmL(-1) for AZI, CIA and ROX, respectively. The development of the SW-AdSV methods resulted in the linear responses at lower concentration ranges as 1.0-2.46 mu gmL(-1), 0.05-0.99 mu gmL(-1) and 0.10-0.99 mu gmL(-1), for AZI, CIA and ROX, respectively. The relative standard deviation for all developed methods was not higher than 1.0% except the SWV method for AZI with 4.7%. In the case of all three investigated macrolide antibiotics the protonated form of the tertiary amino group(s) at appropriate accumulation potential and time favored the adsorption of the ionic form of the target molecules offering the opportunity for the development of SW-AdSV methods for their trace level analysis on Hg(Ag)FE. Optimized SW-AdSV method was applied for determination of ROX in pharmaceutical preparation Runac.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Electrochimica Acta
T1  - Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode
VL  - 229
SP  - 334
EP  - 344
DO  - 10.1016/j.electacta.2017.01.146
ER  - 

@article{
author = "Vajdle, Olga and Guzsvány, Valéria and Škorić, Dušan and Csanadi, Janos and Petkovic, Milos and Avramov Ivić, Milka and Kónya, Zoltán and Petrović, Slobodan D. and Bobrowski, Andrzej",
year = "2017",
abstract = "The renewable silver-amalgam film electrode (Hg(Ag)FE) was applied for voltammetric characterization and determination of semi-synthetic macrolide antibiotics azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) in the Britton-Robinson buffer as supporting electrolyte ranging the pH from 4.0 to 11.9. All three macrolides showed reduction signals in fairly negative potential range. During direct cathodic square wave voltammetric (SWV) investigations conducted over the potential range from -0.75 V to -2.00V vs SCE, either one or two reduction peaks were obtained in the potential range from -1.5 to -1.9 V. The shapes and intensities of the signals depend on the applied pH values in wider pH ranges. For analytical purposes concerning the development of direct cathodic SWV and adsorptive stripping SWV (SW-AdSV) methods the neutral and slightly alkaline media were suitable as pH 7.2, pH 7.4 and pH 7.0 for AZI, CIA and ROX, respectively. Based on the cyclic voltammograms recorded at these pH values, adsorption-controlled electrode kinetics process can be proposed for all three macrolides. Furthermore, the water suppressed H-1 NMR measurements in the pH range between 6.0 and 10.5 indicated that the macrolide molecules at the optimal analytical conditions are predominantly in protonated form via their tertiary amino groups which supported in all three cases their adsorption on the appropriately polarized Hg(Ag)FE electrode. The optimized direct cathodic SWV methods showed good linearity in concentration ranges 4.81-23.3 mu gmL(-1), 1.96-28.6 mu gmL(-1) and 1.48-25.9 mu gmL(-1) for AZI, CIA and ROX, respectively. The development of the SW-AdSV methods resulted in the linear responses at lower concentration ranges as 1.0-2.46 mu gmL(-1), 0.05-0.99 mu gmL(-1) and 0.10-0.99 mu gmL(-1), for AZI, CIA and ROX, respectively. The relative standard deviation for all developed methods was not higher than 1.0% except the SWV method for AZI with 4.7%. In the case of all three investigated macrolide antibiotics the protonated form of the tertiary amino group(s) at appropriate accumulation potential and time favored the adsorption of the ionic form of the target molecules offering the opportunity for the development of SW-AdSV methods for their trace level analysis on Hg(Ag)FE. Optimized SW-AdSV method was applied for determination of ROX in pharmaceutical preparation Runac.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode",
volume = "229",
pages = "334-344",
doi = "10.1016/j.electacta.2017.01.146"
}

Vajdle, O., Guzsvány, V., Škorić, D., Csanadi, J., Petkovic, M., Avramov Ivić, M., Kónya, Z., Petrović, S. D.,& Bobrowski, A.. (2017). Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 229, 334-344.
https://doi.org/10.1016/j.electacta.2017.01.146

Vajdle O, Guzsvány V, Škorić D, Csanadi J, Petkovic M, Avramov Ivić M, Kónya Z, Petrović SD, Bobrowski A. Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode. in Electrochimica Acta. 2017;229:334-344.
doi:10.1016/j.electacta.2017.01.146 .

Vajdle, Olga, Guzsvány, Valéria, Škorić, Dušan, Csanadi, Janos, Petkovic, Milos, Avramov Ivić, Milka, Kónya, Zoltán, Petrović, Slobodan D., Bobrowski, Andrzej, "Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode" in Electrochimica Acta, 229 (2017):334-344,
https://doi.org/10.1016/j.electacta.2017.01.146 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijevic, Jelena
AU  - Nikolić, Nebojša D.
AU  - Stevanović, Sanja
AU  - Mijin, Dušan
AU  - Vukovic, Dragan
AU  - Mladenović, Aleksandar R.
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4310
AB  - Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode
VL  - 782
SP  - 103
EP  - 107
DO  - 10.1016/j.jelechem.2016.10.022
ER  - 

@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijevic, Jelena and Nikolić, Nebojša D. and Stevanović, Sanja and Mijin, Dušan and Vukovic, Dragan and Mladenović, Aleksandar R. and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2016",
abstract = "Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode",
volume = "782",
pages = "103-107",
doi = "10.1016/j.jelechem.2016.10.022"
}

Lović, J., Trišović, N., Antanasijevic, J., Nikolić, N. D., Stevanović, S., Mijin, D., Vukovic, D., Mladenović, A. R., Petrović, S. D.,& Avramov Ivić, M.. (2016). Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry
Elsevier., 782, 103-107.
https://doi.org/10.1016/j.jelechem.2016.10.022

Lović J, Trišović N, Antanasijevic J, Nikolić ND, Stevanović S, Mijin D, Vukovic D, Mladenović AR, Petrović SD, Avramov Ivić M. Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry. 2016;782:103-107.
doi:10.1016/j.jelechem.2016.10.022 .

Lović, Jelena, Trišović, Nemanja, Antanasijevic, Jelena, Nikolić, Nebojša D., Stevanović, Sanja, Mijin, Dušan, Vukovic, Dragan, Mladenović, Aleksandar R., Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode" in Journal of Electroanalytical Chemistry, 782 (2016):103-107,
https://doi.org/10.1016/j.jelechem.2016.10.022 . .

TY  - CHAP
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3644
AB  - Electrochemistry is rapidly growing area with a number of possible applications in the pharmaceutical analysis. Modern electrochemical methods are selective, sensitive, rapid, and provide easy techniques applicable to analyses in the pharmaceutical fi eld. It is evident that the electroanalytical techniques at varying levels of sensitivity are required to solve analytical–pharmaceutical problems. The advantages of electrochemical methods are the simple procedures of the sample preparation and in most cases lack of interferences from excipients in the pharmaceutical dosage forms.
PB  - Springer Science and Business Media LLC
T2  - Modern Aspects of Electrochemistry
T1  - Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals
VL  - 60
SP  - 89
EP  - 195
DO  - 10.1007/978-3-319-31849-3_2
ER  - 

@inbook{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan",
year = "2016",
abstract = "Electrochemistry is rapidly growing area with a number of possible applications in the pharmaceutical analysis. Modern electrochemical methods are selective, sensitive, rapid, and provide easy techniques applicable to analyses in the pharmaceutical fi eld. It is evident that the electroanalytical techniques at varying levels of sensitivity are required to solve analytical–pharmaceutical problems. The advantages of electrochemical methods are the simple procedures of the sample preparation and in most cases lack of interferences from excipients in the pharmaceutical dosage forms.",
publisher = "Springer Science and Business Media LLC",
journal = "Modern Aspects of Electrochemistry",
booktitle = "Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals",
volume = "60",
pages = "89-195",
doi = "10.1007/978-3-319-31849-3_2"
}

Avramov Ivić, M., Petrović, S. D.,& Mijin, D.. (2016). Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals. in Modern Aspects of Electrochemistry
Springer Science and Business Media LLC., 60, 89-195.
https://doi.org/10.1007/978-3-319-31849-3_2

Avramov Ivić M, Petrović SD, Mijin D. Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals. in Modern Aspects of Electrochemistry. 2016;60:89-195.
doi:10.1007/978-3-319-31849-3_2 .

Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, "Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals" in Modern Aspects of Electrochemistry, 60 (2016):89-195,
https://doi.org/10.1007/978-3-319-31849-3_2 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Guzsvány, Valéria
AU  - Škorić, Dušan
AU  - Anojčić, Jasmina
AU  - Jovanov, Pavle
AU  - Avramov Ivić, Milka
AU  - Csanadi, Janos
AU  - Kónya, Zoltán
AU  - Petrović, Slobodan D.
AU  - Bobrowski, Andrzej
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4319
AB  - Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Electrochimica Acta
T1  - Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation
VL  - 191
SP  - 44
EP  - 54
DO  - 10.1016/j.electacta.2015.12.207
ER  - 

@article{
author = "Vajdle, Olga and Guzsvány, Valéria and Škorić, Dušan and Anojčić, Jasmina and Jovanov, Pavle and Avramov Ivić, Milka and Csanadi, Janos and Kónya, Zoltán and Petrović, Slobodan D. and Bobrowski, Andrzej",
year = "2016",
abstract = "Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation",
volume = "191",
pages = "44-54",
doi = "10.1016/j.electacta.2015.12.207"
}

Vajdle, O., Guzsvány, V., Škorić, D., Anojčić, J., Jovanov, P., Avramov Ivić, M., Csanadi, J., Kónya, Z., Petrović, S. D.,& Bobrowski, A.. (2016). Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 191, 44-54.
https://doi.org/10.1016/j.electacta.2015.12.207

Vajdle O, Guzsvány V, Škorić D, Anojčić J, Jovanov P, Avramov Ivić M, Csanadi J, Kónya Z, Petrović SD, Bobrowski A. Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta. 2016;191:44-54.
doi:10.1016/j.electacta.2015.12.207 .

Vajdle, Olga, Guzsvány, Valéria, Škorić, Dušan, Anojčić, Jasmina, Jovanov, Pavle, Avramov Ivić, Milka, Csanadi, Janos, Kónya, Zoltán, Petrović, Slobodan D., Bobrowski, Andrzej, "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation" in Electrochimica Acta, 191 (2016):44-54,
https://doi.org/10.1016/j.electacta.2015.12.207 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Guzsvány, Valéria
AU  - Škorić, Dušan
AU  - Anojčić, Jasmina
AU  - Jovanov, Pavle
AU  - Avramov Ivić, Milka
AU  - Csanadi, Janos
AU  - Kónya, Zoltán
AU  - Petrović, Slobodan D.
AU  - Bobrowski, Andrzej
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1964
AB  - Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Electrochimica Acta
T1  - Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation
VL  - 191
SP  - 44
EP  - 54
DO  - 10.1016/j.electacta.2015.12.207
ER  - 

@article{
author = "Vajdle, Olga and Guzsvány, Valéria and Škorić, Dušan and Anojčić, Jasmina and Jovanov, Pavle and Avramov Ivić, Milka and Csanadi, Janos and Kónya, Zoltán and Petrović, Slobodan D. and Bobrowski, Andrzej",
year = "2016",
abstract = "Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation",
volume = "191",
pages = "44-54",
doi = "10.1016/j.electacta.2015.12.207"
}

Vajdle, O., Guzsvány, V., Škorić, D., Anojčić, J., Jovanov, P., Avramov Ivić, M., Csanadi, J., Kónya, Z., Petrović, S. D.,& Bobrowski, A.. (2016). Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 191, 44-54.
https://doi.org/10.1016/j.electacta.2015.12.207

Vajdle O, Guzsvány V, Škorić D, Anojčić J, Jovanov P, Avramov Ivić M, Csanadi J, Kónya Z, Petrović SD, Bobrowski A. Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta. 2016;191:44-54.
doi:10.1016/j.electacta.2015.12.207 .

Vajdle, Olga, Guzsvány, Valéria, Škorić, Dušan, Anojčić, Jasmina, Jovanov, Pavle, Avramov Ivić, Milka, Csanadi, Janos, Kónya, Zoltán, Petrović, Slobodan D., Bobrowski, Andrzej, "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation" in Electrochimica Acta, 191 (2016):44-54,
https://doi.org/10.1016/j.electacta.2015.12.207 . .