TY  - JOUR
AU  - Popović, Marko
AU  - Popović, Marta
AU  - Šekularac, Gavrilo
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6819
AB  - From July to October, West Nile virus is the leading cause of mosquito born disease in Europe and North America. This paper reports for the first time a chemical and thermodynamic analysis of the West Nile virus particles, genome and proteins, as well as interactions with its host organism. The empirical formula of mature West Nile virus particles was found through the atom counting method. Based on the empirical formula, biosynthesis reactions were formulated, which describe the formation of new virus live matter. Based on the biosynthesis reactions, Gibbs energy of biosynthesis was determined, which represents the physical driving force for the production of viral and host cell components. Gibbs energy of biosynthesis of the West Nile virus was found to be several times more negative than that of its host tissues. Due to the more negative Gibbs energy of biosynthesis, the West Nile virus components are produced much faster than those of its host cells. This allows the virus to hijack the host cell metabolism. Therefore, the virus-host interactions of the West Nile virus were explained through chemical and thermodynamic analysis.
PB  - Elsevier
T2  - Microbial Risk Analysis
T1  - Death from the Nile: Empirical formula, molar mass, biosynthesis reaction and Gibbs energy of biosynthesis of the West Nile virus
VL  - 25
SP  - 100281
DO  - 10.1016/j.mran.2023.100281
ER  - 

@article{
author = "Popović, Marko and Popović, Marta and Šekularac, Gavrilo",
year = "2023",
abstract = "From July to October, West Nile virus is the leading cause of mosquito born disease in Europe and North America. This paper reports for the first time a chemical and thermodynamic analysis of the West Nile virus particles, genome and proteins, as well as interactions with its host organism. The empirical formula of mature West Nile virus particles was found through the atom counting method. Based on the empirical formula, biosynthesis reactions were formulated, which describe the formation of new virus live matter. Based on the biosynthesis reactions, Gibbs energy of biosynthesis was determined, which represents the physical driving force for the production of viral and host cell components. Gibbs energy of biosynthesis of the West Nile virus was found to be several times more negative than that of its host tissues. Due to the more negative Gibbs energy of biosynthesis, the West Nile virus components are produced much faster than those of its host cells. This allows the virus to hijack the host cell metabolism. Therefore, the virus-host interactions of the West Nile virus were explained through chemical and thermodynamic analysis.",
publisher = "Elsevier",
journal = "Microbial Risk Analysis",
title = "Death from the Nile: Empirical formula, molar mass, biosynthesis reaction and Gibbs energy of biosynthesis of the West Nile virus",
volume = "25",
pages = "100281",
doi = "10.1016/j.mran.2023.100281"
}

Popović, M., Popović, M.,& Šekularac, G.. (2023). Death from the Nile: Empirical formula, molar mass, biosynthesis reaction and Gibbs energy of biosynthesis of the West Nile virus. in Microbial Risk Analysis
Elsevier., 25, 100281.
https://doi.org/10.1016/j.mran.2023.100281

Popović M, Popović M, Šekularac G. Death from the Nile: Empirical formula, molar mass, biosynthesis reaction and Gibbs energy of biosynthesis of the West Nile virus. in Microbial Risk Analysis. 2023;25:100281.
doi:10.1016/j.mran.2023.100281 .

Popović, Marko, Popović, Marta, Šekularac, Gavrilo, "Death from the Nile: Empirical formula, molar mass, biosynthesis reaction and Gibbs energy of biosynthesis of the West Nile virus" in Microbial Risk Analysis, 25 (2023):100281,
https://doi.org/10.1016/j.mran.2023.100281 . .