@article{
author = "Ignjatović, Jelisaveta and Đuriš, Jelena and Đuriš, Mihal and Bočarski, Teodora and Vasiljević, Vanja and Aleksić, Ivana and Cvijić, Sandra",
year = "2021",
abstract = "Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated material. The selected substrates included highly soluble sodium chloride (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin. Experiments with sodium chloride revealed that pan-coating yielded particles of more regular shape, while mortar-coating yielded samples of more uniform coating layer. The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield in the coated samples was high (99%), the material showed satisfactory mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest that both pan-and mortar-coating can be used to sustain the release of drugs with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies., Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom
se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog
rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u
pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko
rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog
ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina.
Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice
pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom.
Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida
postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju.
Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu za oblaganje kofeina.
Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao
zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno,
dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje
rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju
i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.",
publisher = "Serbia : Pharmaceutical Association of Serbia",
journal = "Arhiv za Farmaciju",
title = "Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating, Procena metoda za oblaganje višečestičnih supstrata topljenjem: oblaganje u pateni vs. oblaganje u bubnju",
volume = "71",
number = "1",
pages = "35-54",
doi = "10.5937/arhfarm71-30266"
}
