TY  - JOUR
AU  - Bulatović, Mirna
AU  - Kaluderovic, Milena R
AU  - Mojic, Marija
AU  - Zmejkovski, Bojana
AU  - Hey-Hawkins, Evamarie
AU  - Vidakovic, Melita
AU  - Grdovic, Nevena
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela D.
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1650
AB  - (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV), [PtCl4(iBu(2)eddp)]. shows an improved pharmacological profile in comparison to cisplatin. This is manifested through accelerated dying process led by necrotic cell death, reflected through mitochondrial collapse, strong ATP depletion and reactive oxygen species production. Loss of mitochondrial potential was further followed with intensive apoptosis that finalized with DNA fragmentation. Different dynamic of tumoricidal action could be partly ascribed to less affected repair mechanisms in comparison to cisplatin. Importantly, [PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts suggesting different intracellular response of normal vs. tumor cells. This selectivity toward malignant phenotype is further confirmed by retained tumoricidal potential in hypoxic conditions, while cisplatin became completely inefficient.
PB  - Elsevier
T2  - European Journal of Pharmacology
T1  - Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions
VL  - 760
SP  - 136
EP  - 144
DO  - 10.1016/j.ejphar.2015.04.012
ER  - 

@article{
author = "Bulatović, Mirna and Kaluderovic, Milena R and Mojic, Marija and Zmejkovski, Bojana and Hey-Hawkins, Evamarie and Vidakovic, Melita and Grdovic, Nevena and Kaluđerović, Goran N. and Mijatović, Sanja and Maksimović-Ivanić, Danijela D.",
year = "2015",
abstract = "(O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV), [PtCl4(iBu(2)eddp)]. shows an improved pharmacological profile in comparison to cisplatin. This is manifested through accelerated dying process led by necrotic cell death, reflected through mitochondrial collapse, strong ATP depletion and reactive oxygen species production. Loss of mitochondrial potential was further followed with intensive apoptosis that finalized with DNA fragmentation. Different dynamic of tumoricidal action could be partly ascribed to less affected repair mechanisms in comparison to cisplatin. Importantly, [PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts suggesting different intracellular response of normal vs. tumor cells. This selectivity toward malignant phenotype is further confirmed by retained tumoricidal potential in hypoxic conditions, while cisplatin became completely inefficient.",
publisher = "Elsevier",
journal = "European Journal of Pharmacology",
title = "Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions",
volume = "760",
pages = "136-144",
doi = "10.1016/j.ejphar.2015.04.012"
}

Bulatović, M., Kaluderovic, M. R., Mojic, M., Zmejkovski, B., Hey-Hawkins, E., Vidakovic, M., Grdovic, N., Kaluđerović, G. N., Mijatović, S.,& Maksimović-Ivanić, D. D.. (2015). Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology
Elsevier., 760, 136-144.
https://doi.org/10.1016/j.ejphar.2015.04.012

Bulatović M, Kaluderovic MR, Mojic M, Zmejkovski B, Hey-Hawkins E, Vidakovic M, Grdovic N, Kaluđerović GN, Mijatović S, Maksimović-Ivanić DD. Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology. 2015;760:136-144.
doi:10.1016/j.ejphar.2015.04.012 .

Bulatović, Mirna, Kaluderovic, Milena R, Mojic, Marija, Zmejkovski, Bojana, Hey-Hawkins, Evamarie, Vidakovic, Melita, Grdovic, Nevena, Kaluđerović, Goran N., Mijatović, Sanja, Maksimović-Ivanić, Danijela D., "Improved in vitro antitumor potential of (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplatinum(IV) complex under normoxic and hypoxic conditions" in European Journal of Pharmacology, 760 (2015):136-144,
https://doi.org/10.1016/j.ejphar.2015.04.012 . .