TY  - CONF
AU  - Žižak, Željko
AU  - Juranić, Zorica
AU  - Opsenica, Dejan
AU  - Šolaja, Bogdan
AU  - Besu, I.
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/692
AB  - It was demonstrated that mixed steroidal tetraoxanes inhibit cancer cell proliferation at micromolar level through an apoptotic mechanism. It will be interesting to see if these compounds may possibly induce oxidative stress, which could lead to induction of apoptosis in tumour cells. As tumour cells contain more iron than other normal tissues it is reasonable to suggest that tetraoxanes could react with iron, generating alkoxy radicals or even highly reactive hydroxyl radicals in a Fenton-like reaction. To gain further insight into the mechanism of cell death induced by tetraoxane endoperoxides, we tested production of reactive oxygen species (ROS) and level of activation of caspase 3 in tumour cells treated with several newly synthesized tetraoxanes.
PB  - Oxford : Pergamon-Elsevier Science Ltd
C3  - European Journal of Cancer Supplements
T1  - Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells
VL  - 8
IS  - 5
SP  - 131
EP  - 131
DO  - 10.1016/S1359-6349(10)71313-6
ER  - 

@conference{
author = "Žižak, Željko and Juranić, Zorica and Opsenica, Dejan and Šolaja, Bogdan and Besu, I.",
year = "2010",
abstract = "It was demonstrated that mixed steroidal tetraoxanes inhibit cancer cell proliferation at micromolar level through an apoptotic mechanism. It will be interesting to see if these compounds may possibly induce oxidative stress, which could lead to induction of apoptosis in tumour cells. As tumour cells contain more iron than other normal tissues it is reasonable to suggest that tetraoxanes could react with iron, generating alkoxy radicals or even highly reactive hydroxyl radicals in a Fenton-like reaction. To gain further insight into the mechanism of cell death induced by tetraoxane endoperoxides, we tested production of reactive oxygen species (ROS) and level of activation of caspase 3 in tumour cells treated with several newly synthesized tetraoxanes.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "European Journal of Cancer Supplements",
title = "Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells",
volume = "8",
number = "5",
pages = "131-131",
doi = "10.1016/S1359-6349(10)71313-6"
}

Žižak, Ž., Juranić, Z., Opsenica, D., Šolaja, B.,& Besu, I.. (2010). Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells. in European Journal of Cancer Supplements
Oxford : Pergamon-Elsevier Science Ltd., 8(5), 131-131.
https://doi.org/10.1016/S1359-6349(10)71313-6

Žižak Ž, Juranić Z, Opsenica D, Šolaja B, Besu I. Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells. in European Journal of Cancer Supplements. 2010;8(5):131-131.
doi:10.1016/S1359-6349(10)71313-6 .

Žižak, Željko, Juranić, Zorica, Opsenica, Dejan, Šolaja, Bogdan, Besu, I., "Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells" in European Journal of Cancer Supplements, 8, no. 5 (2010):131-131,
https://doi.org/10.1016/S1359-6349(10)71313-6 . .