TY  - JOUR
AU  - Balijagic, Jasmina
AU  - Janković, Teodora
AU  - Zdunić, Gordana
AU  - Boskovic, Jelena
AU  - Savikin, Katarina
AU  - Gođevac, Dejan
AU  - Stanojković, Tatjana
AU  - Jovancevic, Miodrag
AU  - Menković, Nebojša
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1122
AB  - LC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustornorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of gamma-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells with an IC50 value of 41.1 mu g/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC50 values ranging from 5.7 to 8.8 mu g/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro
VL  - 7
IS  - 11
SP  - 1487
EP  - 1490
UR  - https://hdl.handle.net/21.15107/rcub_cer_1122
ER  - 

@article{
author = "Balijagic, Jasmina and Janković, Teodora and Zdunić, Gordana and Boskovic, Jelena and Savikin, Katarina and Gođevac, Dejan and Stanojković, Tatjana and Jovancevic, Miodrag and Menković, Nebojša",
year = "2012",
abstract = "LC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustornorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of gamma-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells with an IC50 value of 41.1 mu g/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC50 values ranging from 5.7 to 8.8 mu g/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro",
volume = "7",
number = "11",
pages = "1487-1490",
url = "https://hdl.handle.net/21.15107/rcub_cer_1122"
}

Balijagic, J., Janković, T., Zdunić, G., Boskovic, J., Savikin, K., Gođevac, D., Stanojković, T., Jovancevic, M.,& Menković, N.. (2012). Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro. in Natural Product Communications
Natural Products Inc, Westerville., 7(11), 1487-1490.
https://hdl.handle.net/21.15107/rcub_cer_1122

Balijagic J, Janković T, Zdunić G, Boskovic J, Savikin K, Gođevac D, Stanojković T, Jovancevic M, Menković N. Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro. in Natural Product Communications. 2012;7(11):1487-1490.
https://hdl.handle.net/21.15107/rcub_cer_1122 .

Balijagic, Jasmina, Janković, Teodora, Zdunić, Gordana, Boskovic, Jelena, Savikin, Katarina, Gođevac, Dejan, Stanojković, Tatjana, Jovancevic, Miodrag, Menković, Nebojša, "Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro" in Natural Product Communications, 7, no. 11 (2012):1487-1490,
https://hdl.handle.net/21.15107/rcub_cer_1122 .