TY  - JOUR
AU  - Janjusevic, Ljiljana
AU  - Karaman, Maja
AU  - Sibul, Filip
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Jakovljević, Dragica
AU  - Pejin, Boris
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2062
AB  - This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.
PB  - Taylor & Francis Group
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
VL  - 32
IS  - 1
SP  - 355
EP  - 362
DO  - 10.1080/14756366.2016.1252759
ER  - 

@article{
author = "Janjusevic, Ljiljana and Karaman, Maja and Sibul, Filip and Tommonaro, Giuseppina and Iodice, Carmine and Jakovljević, Dragica and Pejin, Boris",
year = "2017",
abstract = "This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.",
publisher = "Taylor & Francis Group",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents",
volume = "32",
number = "1",
pages = "355-362",
doi = "10.1080/14756366.2016.1252759"
}

Janjusevic, L., Karaman, M., Sibul, F., Tommonaro, G., Iodice, C., Jakovljević, D.,& Pejin, B.. (2017). The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Group., 32(1), 355-362.
https://doi.org/10.1080/14756366.2016.1252759

Janjusevic L, Karaman M, Sibul F, Tommonaro G, Iodice C, Jakovljević D, Pejin B. The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):355-362.
doi:10.1080/14756366.2016.1252759 .

Janjusevic, Ljiljana, Karaman, Maja, Sibul, Filip, Tommonaro, Giuseppina, Iodice, Carmine, Jakovljević, Dragica, Pejin, Boris, "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):355-362,
https://doi.org/10.1080/14756366.2016.1252759 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Sabovljević, Marko
AU  - Bianco, Armandodoriano
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - De Rosa, Salvatore
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2741
AB  - Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to the angiosperms. In this article, the sugars of the moss Rhodobryum ontariense, an unstudied representative of the medicinally known genus, are reported. The chemical analysis revealed the usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1-kestose, which is reported first not only for the genus Rhodobryum, but also for mosses. The trisaccharides have been scantily reported in bryophytes hitherto. This gives more significance to this study for further investigation of its role in the moss species. The health-promoting effect of 1-kestose is also briefly discussed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.
VL  - 26
IS  - 3
SP  - 209
EP  - 215
DO  - 10.1080/14786419.2010.535163
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Sabovljević, Marko and Bianco, Armandodoriano and Tešević, Vele and Vajs, Vlatka and De Rosa, Salvatore",
year = "2012",
abstract = "Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to the angiosperms. In this article, the sugars of the moss Rhodobryum ontariense, an unstudied representative of the medicinally known genus, are reported. The chemical analysis revealed the usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1-kestose, which is reported first not only for the genus Rhodobryum, but also for mosses. The trisaccharides have been scantily reported in bryophytes hitherto. This gives more significance to this study for further investigation of its role in the moss species. The health-promoting effect of 1-kestose is also briefly discussed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.",
volume = "26",
number = "3",
pages = "209-215",
doi = "10.1080/14786419.2010.535163"
}

Pejin, B., Iodice, C., Tommonaro, G., Sabovljević, M., Bianco, A., Tešević, V., Vajs, V.,& De Rosa, S.. (2012). Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 26(3), 209-215.
https://doi.org/10.1080/14786419.2010.535163

Pejin B, Iodice C, Tommonaro G, Sabovljević M, Bianco A, Tešević V, Vajs V, De Rosa S. Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.. in Natural Product Research. 2012;26(3):209-215.
doi:10.1080/14786419.2010.535163 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Sabovljević, Marko, Bianco, Armandodoriano, Tešević, Vele, Vajs, Vlatka, De Rosa, Salvatore, "Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb." in Natural Product Research, 26, no. 3 (2012):209-215,
https://doi.org/10.1080/14786419.2010.535163 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - De Rosa, Salvatore
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4146
UR  - https://www.chalcogen.ro/1663_PEJIN.pdf
AB  - The continuation of our phytochemical survey of Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), has led to the isolation and identification of a new lichen depsidone (1) characterised by the normal analytical and spectroscopic techniques. Unlike previously isolated depsidone (2) from the same species, the compound 1 has not showed activity in the acetylcholinesterase inhibition test on Thin-layer chromatography plate.
PB  - Inst Materials Physics, Bucharest
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - A New Lichen Depsidone from  L Obaria Pulmonaria
VL  - 7
IS  - 4
SP  - 1663
EP  - 1666
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1566
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka and De Rosa, Salvatore",
year = "2012",
abstract = "The continuation of our phytochemical survey of Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), has led to the isolation and identification of a new lichen depsidone (1) characterised by the normal analytical and spectroscopic techniques. Unlike previously isolated depsidone (2) from the same species, the compound 1 has not showed activity in the acetylcholinesterase inhibition test on Thin-layer chromatography plate.",
publisher = "Inst Materials Physics, Bucharest",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "A New Lichen Depsidone from  L Obaria Pulmonaria",
volume = "7",
number = "4",
pages = "1663-1666",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1566"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V., Vajs, V.,& De Rosa, S.. (2012). A New Lichen Depsidone from  L Obaria Pulmonaria. in Digest Journal of Nanomaterials and Biostructures
Inst Materials Physics, Bucharest., 7(4), 1663-1666.
https://hdl.handle.net/21.15107/rcub_cherry_1566

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs V, De Rosa S. A New Lichen Depsidone from  L Obaria Pulmonaria. in Digest Journal of Nanomaterials and Biostructures. 2012;7(4):1663-1666.
https://hdl.handle.net/21.15107/rcub_cherry_1566 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka, De Rosa, Salvatore, "A New Lichen Depsidone from  L Obaria Pulmonaria" in Digest Journal of Nanomaterials and Biostructures, 7, no. 4 (2012):1663-1666,
https://hdl.handle.net/21.15107/rcub_cherry_1566 .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2742
AB  - As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria
VL  - 26
IS  - 17
SP  - 1634
EP  - 1637
DO  - 10.1080/14786419.2011.585989
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka",
year = "2012",
abstract = "As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria",
volume = "26",
number = "17",
pages = "1634-1637",
doi = "10.1080/14786419.2011.585989"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V.,& Vajs, V.. (2012). Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 26(17), 1634-1637.
https://doi.org/10.1080/14786419.2011.585989

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs V. Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria. in Natural Product Research. 2012;26(17):1634-1637.
doi:10.1080/14786419.2011.585989 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka, "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria" in Natural Product Research, 26, no. 17 (2012):1634-1637,
https://doi.org/10.1080/14786419.2011.585989 . .