TY  - JOUR
AU  - Savikin, Katarina
AU  - Zdunić, Gordana
AU  - Janković, Teodora
AU  - Gođevac, Dejan
AU  - Stanojković, Tatjana
AU  - Pljevljakusic, Dejan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1584
AB  - A detailed phenolic composition analysis of dry chokeberry, bilberry and black currant fruit teas prepared on the most common ways-decoction and infusion, was performed, together with evaluation of cytotoxic activity. The most abundant in phenolics were chokeberry teas, followed by bilberry and black currant teas, while the highest anthocyanin amount was determined in bilberry samples. LC/DAD/MS method was used for identification of 17 anthocyanins, 11 flavonoids and 4 hydroxycinnamic acid derivatives. Quantitative analysis of investigated teas was carried out by HPLC analysis, and major phenolic compounds in berry fruit teas were chlorogenic acids, quercetin glycosides and anthocyanin glycosides. Berry teas were investigated for cytotoxic activity against cervix carcinoma, melanoma, colon, and chronic myelogenous leukemia cell lines, and chokebeny decoction was the most effective against all cell lines. According to the results obtained in this study, pure chokeberry, bilberry and black currant teas could be valuable sources of flavonoids and anthocyanins.
PB  - Elsevier
T2  - Food Research International
T1  - Berry fruit teas: Phenolic composition and cytotoxic activity
VL  - 62
SP  - 677
EP  - 683
DO  - 10.1016/j.foodres.2014.04.017
ER  - 

@article{
author = "Savikin, Katarina and Zdunić, Gordana and Janković, Teodora and Gođevac, Dejan and Stanojković, Tatjana and Pljevljakusic, Dejan",
year = "2014",
abstract = "A detailed phenolic composition analysis of dry chokeberry, bilberry and black currant fruit teas prepared on the most common ways-decoction and infusion, was performed, together with evaluation of cytotoxic activity. The most abundant in phenolics were chokeberry teas, followed by bilberry and black currant teas, while the highest anthocyanin amount was determined in bilberry samples. LC/DAD/MS method was used for identification of 17 anthocyanins, 11 flavonoids and 4 hydroxycinnamic acid derivatives. Quantitative analysis of investigated teas was carried out by HPLC analysis, and major phenolic compounds in berry fruit teas were chlorogenic acids, quercetin glycosides and anthocyanin glycosides. Berry teas were investigated for cytotoxic activity against cervix carcinoma, melanoma, colon, and chronic myelogenous leukemia cell lines, and chokebeny decoction was the most effective against all cell lines. According to the results obtained in this study, pure chokeberry, bilberry and black currant teas could be valuable sources of flavonoids and anthocyanins.",
publisher = "Elsevier",
journal = "Food Research International",
title = "Berry fruit teas: Phenolic composition and cytotoxic activity",
volume = "62",
pages = "677-683",
doi = "10.1016/j.foodres.2014.04.017"
}

Savikin, K., Zdunić, G., Janković, T., Gođevac, D., Stanojković, T.,& Pljevljakusic, D.. (2014). Berry fruit teas: Phenolic composition and cytotoxic activity. in Food Research International
Elsevier., 62, 677-683.
https://doi.org/10.1016/j.foodres.2014.04.017

Savikin K, Zdunić G, Janković T, Gođevac D, Stanojković T, Pljevljakusic D. Berry fruit teas: Phenolic composition and cytotoxic activity. in Food Research International. 2014;62:677-683.
doi:10.1016/j.foodres.2014.04.017 .

Savikin, Katarina, Zdunić, Gordana, Janković, Teodora, Gođevac, Dejan, Stanojković, Tatjana, Pljevljakusic, Dejan, "Berry fruit teas: Phenolic composition and cytotoxic activity" in Food Research International, 62 (2014):677-683,
https://doi.org/10.1016/j.foodres.2014.04.017 . .

TY  - JOUR
AU  - Pljevljakusic, Dejan
AU  - Janković, Teodora
AU  - Jelačić, Slavica C.
AU  - Novaković, Miroslav
AU  - Menković, Nebojša
AU  - Beatovic, Damir
AU  - Dajić-Stevanović, Zora
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1536
AB  - Arnica (Arnica montana L) is a perennial mountain plant whose flower heads are mainly used for topical treatment of bruises and sprains in phytopharmaceutical preparations such as ointments, creams and gels. In this study, different models of arnica cultivation have been tested in three-year field trial arranged in 2 x 3 x 2 factorial design. Planting date (spring and autumn), fertilizater type (manure, NPK and control) and mode of reproduction (generative and clonal) were induced factors on the trial. The variation of the rosette diameter, flowering stem count and height, flower heads count and diameter, together with flower heads yield and chemical properties were investigated as morphological parameters. Spring planting of clonally propagated plants was showed to be the least successful model due to the low percent of rooted plants and weak shoot development. Other models yielded from 59.8 to 143.6 kg ha(-1) and 116.3 to 258.7 kg ha(-1) flower heads (dw) in the second and third year, respectively. Total sesquiterpene lactones content in flower heads of all tested variants was above the minimum of pharmacopeia quality regulation and ranged from 4.6 to 13.9 mg g(-1) depending on factor levels, while the amounts of two dominant flavonoid compounds quercetin-3-O-glucoside and kaempferol-3-O-glucoside ranged from 7.8 to 13.9 mg g(-1) and from 2.1 to 4.7 mg g(-1), respectively. All induced factors in the field trial significantly influenced variation in both morphological and chemical parameters, where fertilized variants from autumn planting have shown to be superior in flower heads yield with satisfying levels of the secondary metabolites content. Factorial analysis distinguished that half of morphological parameters positively correlated with flower heads yield. First three ranks of sequential classification of cultivation models with desirable properties were captured by variants planted in autumn, while the last rated variants were those from clonal propagation planted in spring. This attempt of arnica domestication in agroecological conditions of western Serbia has proven to be successful in ensuring high quality raw material, providing at the same time answers to the questions that have not been reviewed so far.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Morphological and chemical characterization of Arnica montana L. under different cultivation models
VL  - 52
SP  - 233
EP  - 244
DO  - 10.1016/j.indcrop.2013.10.035
ER  - 

@article{
author = "Pljevljakusic, Dejan and Janković, Teodora and Jelačić, Slavica C. and Novaković, Miroslav and Menković, Nebojša and Beatovic, Damir and Dajić-Stevanović, Zora",
year = "2014",
abstract = "Arnica (Arnica montana L) is a perennial mountain plant whose flower heads are mainly used for topical treatment of bruises and sprains in phytopharmaceutical preparations such as ointments, creams and gels. In this study, different models of arnica cultivation have been tested in three-year field trial arranged in 2 x 3 x 2 factorial design. Planting date (spring and autumn), fertilizater type (manure, NPK and control) and mode of reproduction (generative and clonal) were induced factors on the trial. The variation of the rosette diameter, flowering stem count and height, flower heads count and diameter, together with flower heads yield and chemical properties were investigated as morphological parameters. Spring planting of clonally propagated plants was showed to be the least successful model due to the low percent of rooted plants and weak shoot development. Other models yielded from 59.8 to 143.6 kg ha(-1) and 116.3 to 258.7 kg ha(-1) flower heads (dw) in the second and third year, respectively. Total sesquiterpene lactones content in flower heads of all tested variants was above the minimum of pharmacopeia quality regulation and ranged from 4.6 to 13.9 mg g(-1) depending on factor levels, while the amounts of two dominant flavonoid compounds quercetin-3-O-glucoside and kaempferol-3-O-glucoside ranged from 7.8 to 13.9 mg g(-1) and from 2.1 to 4.7 mg g(-1), respectively. All induced factors in the field trial significantly influenced variation in both morphological and chemical parameters, where fertilized variants from autumn planting have shown to be superior in flower heads yield with satisfying levels of the secondary metabolites content. Factorial analysis distinguished that half of morphological parameters positively correlated with flower heads yield. First three ranks of sequential classification of cultivation models with desirable properties were captured by variants planted in autumn, while the last rated variants were those from clonal propagation planted in spring. This attempt of arnica domestication in agroecological conditions of western Serbia has proven to be successful in ensuring high quality raw material, providing at the same time answers to the questions that have not been reviewed so far.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Morphological and chemical characterization of Arnica montana L. under different cultivation models",
volume = "52",
pages = "233-244",
doi = "10.1016/j.indcrop.2013.10.035"
}

Pljevljakusic, D., Janković, T., Jelačić, S. C., Novaković, M., Menković, N., Beatovic, D.,& Dajić-Stevanović, Z.. (2014). Morphological and chemical characterization of Arnica montana L. under different cultivation models. in Industrial Crops and Products
Elsevier., 52, 233-244.
https://doi.org/10.1016/j.indcrop.2013.10.035

Pljevljakusic D, Janković T, Jelačić SC, Novaković M, Menković N, Beatovic D, Dajić-Stevanović Z. Morphological and chemical characterization of Arnica montana L. under different cultivation models. in Industrial Crops and Products. 2014;52:233-244.
doi:10.1016/j.indcrop.2013.10.035 .

Pljevljakusic, Dejan, Janković, Teodora, Jelačić, Slavica C., Novaković, Miroslav, Menković, Nebojša, Beatovic, Damir, Dajić-Stevanović, Zora, "Morphological and chemical characterization of Arnica montana L. under different cultivation models" in Industrial Crops and Products, 52 (2014):233-244,
https://doi.org/10.1016/j.indcrop.2013.10.035 . .

TY  - CHAP
AU  - Konić-Ristić, A.
AU  - Šavikin, Katarina
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Janković, Teodora
AU  - Menković, Nebojša
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1387
AB  - The biological value of berries relies on their nutritive and non-nutritive constituents. They are good sources of vitamins (vitamin A, C, E, folic acid), pro-vitamins and related compounds (carotene and lutein), minerals (calcium and selenium) and phytosterols, but the proposed health benefit is usually connected with phenolics as the main biologically active compound of berries. Berry phenolics include anthocyanins, flavonols, flavanols, condensed tannins (proanthocyanidins), hidrolyzable tannins (ellagitannins and gallotannins) and phenolic acids. Berries are recognized as the best dietary sources of anthocyanins. Different berries are distinguished by the presence of different classes of phenolics or compounds within the same class, their content and chemical structure (substituents, glycosylation, conjugation), potentially influencing their physiological properties and health effects. Analytical assessment of the phytochemical content of berries, the effects of storage and processing and putative interaction with other dietary compounds is essential for evaluation of their health benefit. It is of great importance to emphasize the biodiversity in the context of different phytochemical content in wild versus cultivated species, different varieties of the same species, or influenced by different cultivating conditions. Beneficial effects of berries consumption in health promotion and prevention of chronic diseases, such as cancer or cardiovascular diseases are shown in numerous epidemiological studies. In in vitro and animals studies berry fruits, their extracts and isolated compounds showed antioxidant, anticancer, antidiabetic, hypoholesterolemic, anti-inflammatory, vasoprotective, cardioprotecive, antiplatelet, antitrombotic or antimicrobial effects. Some of these effects are also shown in clinical trials in humans. Phenolic compounds of berries and their extracts have strong antioxidant potential that is often used to explain their health-promoting properties. Recent studies postulated that their antioxidant potential, as a basic mechanism of biological activity, is compromised by their low bioavailability. Consequently further research in this area is targeted towards other mechanisms of action, the evaluation of main sites of action and further elucidation of potential of berry phenolic compounds as antioxidants, based on their structure or metabolism, both in vitro and within the human body.
PB  - Nova Science Publishers, Inc.
T2  - Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties
T1  - Phenolic compounds, health effects and antioxidant properties of berries
SP  - 69
EP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_cer_1387
ER  - 

@inbook{
author = "Konić-Ristić, A. and Šavikin, Katarina and Zdunić, Gordana and Gođevac, Dejan and Janković, Teodora and Menković, Nebojša",
year = "2013",
abstract = "The biological value of berries relies on their nutritive and non-nutritive constituents. They are good sources of vitamins (vitamin A, C, E, folic acid), pro-vitamins and related compounds (carotene and lutein), minerals (calcium and selenium) and phytosterols, but the proposed health benefit is usually connected with phenolics as the main biologically active compound of berries. Berry phenolics include anthocyanins, flavonols, flavanols, condensed tannins (proanthocyanidins), hidrolyzable tannins (ellagitannins and gallotannins) and phenolic acids. Berries are recognized as the best dietary sources of anthocyanins. Different berries are distinguished by the presence of different classes of phenolics or compounds within the same class, their content and chemical structure (substituents, glycosylation, conjugation), potentially influencing their physiological properties and health effects. Analytical assessment of the phytochemical content of berries, the effects of storage and processing and putative interaction with other dietary compounds is essential for evaluation of their health benefit. It is of great importance to emphasize the biodiversity in the context of different phytochemical content in wild versus cultivated species, different varieties of the same species, or influenced by different cultivating conditions. Beneficial effects of berries consumption in health promotion and prevention of chronic diseases, such as cancer or cardiovascular diseases are shown in numerous epidemiological studies. In in vitro and animals studies berry fruits, their extracts and isolated compounds showed antioxidant, anticancer, antidiabetic, hypoholesterolemic, anti-inflammatory, vasoprotective, cardioprotecive, antiplatelet, antitrombotic or antimicrobial effects. Some of these effects are also shown in clinical trials in humans. Phenolic compounds of berries and their extracts have strong antioxidant potential that is often used to explain their health-promoting properties. Recent studies postulated that their antioxidant potential, as a basic mechanism of biological activity, is compromised by their low bioavailability. Consequently further research in this area is targeted towards other mechanisms of action, the evaluation of main sites of action and further elucidation of potential of berry phenolic compounds as antioxidants, based on their structure or metabolism, both in vitro and within the human body.",
publisher = "Nova Science Publishers, Inc.",
journal = "Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties",
booktitle = "Phenolic compounds, health effects and antioxidant properties of berries",
pages = "69-85",
url = "https://hdl.handle.net/21.15107/rcub_cer_1387"
}

Konić-Ristić, A., Šavikin, K., Zdunić, G., Gođevac, D., Janković, T.,& Menković, N.. (2013). Phenolic compounds, health effects and antioxidant properties of berries. in Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties
Nova Science Publishers, Inc.., 69-85.
https://hdl.handle.net/21.15107/rcub_cer_1387

Konić-Ristić A, Šavikin K, Zdunić G, Gođevac D, Janković T, Menković N. Phenolic compounds, health effects and antioxidant properties of berries. in Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties. 2013;:69-85.
https://hdl.handle.net/21.15107/rcub_cer_1387 .

Konić-Ristić, A., Šavikin, Katarina, Zdunić, Gordana, Gođevac, Dejan, Janković, Teodora, Menković, Nebojša, "Phenolic compounds, health effects and antioxidant properties of berries" in Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties (2013):69-85,
https://hdl.handle.net/21.15107/rcub_cer_1387 .

TY  - JOUR
AU  - Balijagic, Jasmina
AU  - Janković, Teodora
AU  - Zdunić, Gordana
AU  - Boskovic, Jelena
AU  - Savikin, Katarina
AU  - Gođevac, Dejan
AU  - Stanojković, Tatjana
AU  - Jovancevic, Miodrag
AU  - Menković, Nebojša
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1122
AB  - LC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustornorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of gamma-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells with an IC50 value of 41.1 mu g/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC50 values ranging from 5.7 to 8.8 mu g/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro
VL  - 7
IS  - 11
SP  - 1487
EP  - 1490
UR  - https://hdl.handle.net/21.15107/rcub_cer_1122
ER  - 

@article{
author = "Balijagic, Jasmina and Janković, Teodora and Zdunić, Gordana and Boskovic, Jelena and Savikin, Katarina and Gođevac, Dejan and Stanojković, Tatjana and Jovancevic, Miodrag and Menković, Nebojša",
year = "2012",
abstract = "LC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustornorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of gamma-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells with an IC50 value of 41.1 mu g/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC50 values ranging from 5.7 to 8.8 mu g/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro",
volume = "7",
number = "11",
pages = "1487-1490",
url = "https://hdl.handle.net/21.15107/rcub_cer_1122"
}

Balijagic, J., Janković, T., Zdunić, G., Boskovic, J., Savikin, K., Gođevac, D., Stanojković, T., Jovancevic, M.,& Menković, N.. (2012). Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro. in Natural Product Communications
Natural Products Inc, Westerville., 7(11), 1487-1490.
https://hdl.handle.net/21.15107/rcub_cer_1122

Balijagic J, Janković T, Zdunić G, Boskovic J, Savikin K, Gođevac D, Stanojković T, Jovancevic M, Menković N. Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro. in Natural Product Communications. 2012;7(11):1487-1490.
https://hdl.handle.net/21.15107/rcub_cer_1122 .

Balijagic, Jasmina, Janković, Teodora, Zdunić, Gordana, Boskovic, Jelena, Savikin, Katarina, Gođevac, Dejan, Stanojković, Tatjana, Jovancevic, Miodrag, Menković, Nebojša, "Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro" in Natural Product Communications, 7, no. 11 (2012):1487-1490,
https://hdl.handle.net/21.15107/rcub_cer_1122 .

TY  - JOUR
AU  - Pljevljakusic, Dejan
AU  - Savikin, Katarina
AU  - Janković, Teodora
AU  - Zdunić, Gordana
AU  - Ristic, Mihailo
AU  - Gođevac, Dejan
AU  - Konic-Ristic, Aleksandra
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/867
AB  - Phytochemical analyses of the cultivated Sideritis raeseri subsp. raeseri in four different stages of flower development were performed. Traditionally used infusion and decoction were also prepared from aerial parts in full flowering stage, and analyses of active compounds and radical scavenging capacity were performed. The highest yield of the essential oil, obtained by hydrodistillation, was noticed in the full flowering phase (0.11%), with sesquiterpene bicyclogermacrene as the main constituent (42.5%). All examined extracts contained phenolic compounds and their amounts varied from 15.3 to 34.1 mg GAE/g DW. The amounts of total phenolics in infusion and decoction were similar (46.5 and 43.9 mg GAE/100 ml, respectively). LC-ESI-MS analyses of all samples allowed the characterisation of 22 phenolic compounds. Two dominant flavone glycosides, 4'-O-methylhypolaetin-7-O-[6"'-O-acetyl-beta-D-allopyranosyl (1 -> 2)-beta-D-glucopyranoside (17) and 4'-O-methylisoscutellarein-7-O-[6"'-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (19) were quantified using HPLC. Moreover, the mineral content and the percent of transportation were investigated.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri
VL  - 124
IS  - 1
SP  - 226
EP  - 233
DO  - 10.1016/j.foodchem.2010.06.023
ER  - 

@article{
author = "Pljevljakusic, Dejan and Savikin, Katarina and Janković, Teodora and Zdunić, Gordana and Ristic, Mihailo and Gođevac, Dejan and Konic-Ristic, Aleksandra",
year = "2011",
abstract = "Phytochemical analyses of the cultivated Sideritis raeseri subsp. raeseri in four different stages of flower development were performed. Traditionally used infusion and decoction were also prepared from aerial parts in full flowering stage, and analyses of active compounds and radical scavenging capacity were performed. The highest yield of the essential oil, obtained by hydrodistillation, was noticed in the full flowering phase (0.11%), with sesquiterpene bicyclogermacrene as the main constituent (42.5%). All examined extracts contained phenolic compounds and their amounts varied from 15.3 to 34.1 mg GAE/g DW. The amounts of total phenolics in infusion and decoction were similar (46.5 and 43.9 mg GAE/100 ml, respectively). LC-ESI-MS analyses of all samples allowed the characterisation of 22 phenolic compounds. Two dominant flavone glycosides, 4'-O-methylhypolaetin-7-O-[6"'-O-acetyl-beta-D-allopyranosyl (1 -> 2)-beta-D-glucopyranoside (17) and 4'-O-methylisoscutellarein-7-O-[6"'-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (19) were quantified using HPLC. Moreover, the mineral content and the percent of transportation were investigated.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri",
volume = "124",
number = "1",
pages = "226-233",
doi = "10.1016/j.foodchem.2010.06.023"
}

Pljevljakusic, D., Savikin, K., Janković, T., Zdunić, G., Ristic, M., Gođevac, D.,& Konic-Ristic, A.. (2011). Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri. in Food Chemistry
Elsevier Sci Ltd, Oxford., 124(1), 226-233.
https://doi.org/10.1016/j.foodchem.2010.06.023

Pljevljakusic D, Savikin K, Janković T, Zdunić G, Ristic M, Gođevac D, Konic-Ristic A. Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri. in Food Chemistry. 2011;124(1):226-233.
doi:10.1016/j.foodchem.2010.06.023 .

Pljevljakusic, Dejan, Savikin, Katarina, Janković, Teodora, Zdunić, Gordana, Ristic, Mihailo, Gođevac, Dejan, Konic-Ristic, Aleksandra, "Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri" in Food Chemistry, 124, no. 1 (2011):226-233,
https://doi.org/10.1016/j.foodchem.2010.06.023 . .

TY  - JOUR
AU  - Isaković, Aleksandra
AU  - Janković, Teodora
AU  - Harhaji, Ljubica
AU  - Kostić Rajačić, Slađana
AU  - Nikolić, Zoran
AU  - Vajs, Vlatka
AU  - Trajković, Vladimir
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/478
AB  - The present study identifies xanthones gentiakochianin and gentiacaulein as the active principles responsible for the in vitro antiglioma action of ether and methanolic extracts of the plant Gentiana kochiana. Gentiakochianin and gentiacaulein induced cell cycle arrest in G2/M and G0/G1 phases, respectively, in both C6 rat glioma and U251 human glioma cell lines. The more efficient antiproliferative action of gentiakochianin was associated with its ability to induce microtubule stabilization in a cell-free assay. Both the xanthones reduced mitochondrial membrane potential and increased the production of reactive oxygen species in glioma cells, but only the effects of gentiakochianin were pronounced enough to cause caspase activation and subsequent apoptotic cell death. The assessment of structure-activity relationship in a series of structurally related xanthones from G. kochiana and Gentianella austriaca revealed dihydroxylation at positions 7, 8 of the xanthonic nucleus as the key structural feature responsible for the ability of gentiakochianin to induce microtubule-associated G2/M cell block and apoptotic cell death in glioma cells.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Bioorganic and Medicinal Chemistry
T1  - Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements
VL  - 16
IS  - 10
SP  - 5683
EP  - 5694
DO  - 10.1016/j.bmc.2008.03.069
ER  - 

@article{
author = "Isaković, Aleksandra and Janković, Teodora and Harhaji, Ljubica and Kostić Rajačić, Slađana and Nikolić, Zoran and Vajs, Vlatka and Trajković, Vladimir",
year = "2008",
abstract = "The present study identifies xanthones gentiakochianin and gentiacaulein as the active principles responsible for the in vitro antiglioma action of ether and methanolic extracts of the plant Gentiana kochiana. Gentiakochianin and gentiacaulein induced cell cycle arrest in G2/M and G0/G1 phases, respectively, in both C6 rat glioma and U251 human glioma cell lines. The more efficient antiproliferative action of gentiakochianin was associated with its ability to induce microtubule stabilization in a cell-free assay. Both the xanthones reduced mitochondrial membrane potential and increased the production of reactive oxygen species in glioma cells, but only the effects of gentiakochianin were pronounced enough to cause caspase activation and subsequent apoptotic cell death. The assessment of structure-activity relationship in a series of structurally related xanthones from G. kochiana and Gentianella austriaca revealed dihydroxylation at positions 7, 8 of the xanthonic nucleus as the key structural feature responsible for the ability of gentiakochianin to induce microtubule-associated G2/M cell block and apoptotic cell death in glioma cells.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Bioorganic and Medicinal Chemistry",
title = "Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements",
volume = "16",
number = "10",
pages = "5683-5694",
doi = "10.1016/j.bmc.2008.03.069"
}

Isaković, A., Janković, T., Harhaji, L., Kostić Rajačić, S., Nikolić, Z., Vajs, V.,& Trajković, V.. (2008). Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. in Bioorganic and Medicinal Chemistry
Oxford : Pergamon-Elsevier Science Ltd., 16(10), 5683-5694.
https://doi.org/10.1016/j.bmc.2008.03.069

Isaković A, Janković T, Harhaji L, Kostić Rajačić S, Nikolić Z, Vajs V, Trajković V. Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. in Bioorganic and Medicinal Chemistry. 2008;16(10):5683-5694.
doi:10.1016/j.bmc.2008.03.069 .

Isaković, Aleksandra, Janković, Teodora, Harhaji, Ljubica, Kostić Rajačić, Slađana, Nikolić, Zoran, Vajs, Vlatka, Trajković, Vladimir, "Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements" in Bioorganic and Medicinal Chemistry, 16, no. 10 (2008):5683-5694,
https://doi.org/10.1016/j.bmc.2008.03.069 . .