TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijevic, Jelena
AU  - Avramov Ivić, Milka
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2313
AB  - Electrochemical behavior of sildenafil citrate (SC) at gold and cystein (Cys) modified gold electrode (AulCys) in 0.1 M H2SO4 was investigated by cyclic voltammetry (CV) and by square wave voltammetry (SWV). Effect of scan rate on the CVs of SC standard was performed in order to examine the mode of transport and irreversibility of process. SC as standard is determined by SWV in acid solution at Au electrode in a range: 10(-3), 10(-2) 0.1, 0.5, 1 mu M and on Au/Cys in a range: 10(-3), 10(-2) 0.05, 0.1 mu M. The presence of Cys causes two-time larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. In investigated range of concentration of SC standard in acid solution on modified and unmodified Au electrodes SWV method have excellent linear regression coefficient with value 0.997 promoting SWV for reliable determination of SC.
PB  - International Association of Physical Chemists (IAPC)
T2  - Journal of Electrochemical Science and Engineering
T1  - Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution
VL  - 8
IS  - 2
SP  - 163
EP  - 170
DO  - 10.5599/jese.481
ER  - 

@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijevic, Jelena and Avramov Ivić, Milka",
year = "2018",
abstract = "Electrochemical behavior of sildenafil citrate (SC) at gold and cystein (Cys) modified gold electrode (AulCys) in 0.1 M H2SO4 was investigated by cyclic voltammetry (CV) and by square wave voltammetry (SWV). Effect of scan rate on the CVs of SC standard was performed in order to examine the mode of transport and irreversibility of process. SC as standard is determined by SWV in acid solution at Au electrode in a range: 10(-3), 10(-2) 0.1, 0.5, 1 mu M and on Au/Cys in a range: 10(-3), 10(-2) 0.05, 0.1 mu M. The presence of Cys causes two-time larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. In investigated range of concentration of SC standard in acid solution on modified and unmodified Au electrodes SWV method have excellent linear regression coefficient with value 0.997 promoting SWV for reliable determination of SC.",
publisher = "International Association of Physical Chemists (IAPC)",
journal = "Journal of Electrochemical Science and Engineering",
title = "Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution",
volume = "8",
number = "2",
pages = "163-170",
doi = "10.5599/jese.481"
}

Lović, J., Trišović, N., Antanasijevic, J.,& Avramov Ivić, M.. (2018). Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution. in Journal of Electrochemical Science and Engineering
International Association of Physical Chemists (IAPC)., 8(2), 163-170.
https://doi.org/10.5599/jese.481

Lović J, Trišović N, Antanasijevic J, Avramov Ivić M. Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution. in Journal of Electrochemical Science and Engineering. 2018;8(2):163-170.
doi:10.5599/jese.481 .

Lović, Jelena, Trišović, Nemanja, Antanasijevic, Jelena, Avramov Ivić, Milka, "Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution" in Journal of Electrochemical Science and Engineering, 8, no. 2 (2018):163-170,
https://doi.org/10.5599/jese.481 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijevic, Jelena
AU  - Nikolić, Nebojša D.
AU  - Stevanović, Sanja
AU  - Mijin, Dušan
AU  - Vukovic, Dragan
AU  - Mladenović, Aleksandar R.
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4310
AB  - Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode
VL  - 782
SP  - 103
EP  - 107
DO  - 10.1016/j.jelechem.2016.10.022
ER  - 

@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijevic, Jelena and Nikolić, Nebojša D. and Stevanović, Sanja and Mijin, Dušan and Vukovic, Dragan and Mladenović, Aleksandar R. and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2016",
abstract = "Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode",
volume = "782",
pages = "103-107",
doi = "10.1016/j.jelechem.2016.10.022"
}

Lović, J., Trišović, N., Antanasijevic, J., Nikolić, N. D., Stevanović, S., Mijin, D., Vukovic, D., Mladenović, A. R., Petrović, S. D.,& Avramov Ivić, M.. (2016). Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry
Elsevier., 782, 103-107.
https://doi.org/10.1016/j.jelechem.2016.10.022

Lović J, Trišović N, Antanasijevic J, Nikolić ND, Stevanović S, Mijin D, Vukovic D, Mladenović AR, Petrović SD, Avramov Ivić M. Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry. 2016;782:103-107.
doi:10.1016/j.jelechem.2016.10.022 .

Lović, Jelena, Trišović, Nemanja, Antanasijevic, Jelena, Nikolić, Nebojša D., Stevanović, Sanja, Mijin, Dušan, Vukovic, Dragan, Mladenović, Aleksandar R., Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode" in Journal of Electroanalytical Chemistry, 782 (2016):103-107,
https://doi.org/10.1016/j.jelechem.2016.10.022 . .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Antanasijevic, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijevic, Davor
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Petrović, Slobodan D.
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1941
AB  - The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.
PB  - Esg, Belgrade
T2  - International Journal of Electrochemical Science
T1  - A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode
VL  - 11
IS  - 7
SP  - 5935
EP  - 5951
DO  - 10.20964/2016.07.48
ER  - 

@article{
author = "Avramov Ivić, Milka and Antanasijevic, Jelena and Trišović, Nemanja and Antanasijevic, Davor and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan D.",
year = "2016",
abstract = "The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode",
volume = "11",
number = "7",
pages = "5935-5951",
doi = "10.20964/2016.07.48"
}

Avramov Ivić, M., Antanasijevic, J., Trišović, N., Antanasijevic, D., Lović, J., Mijin, D.,& Petrović, S. D.. (2016). A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science
Esg, Belgrade., 11(7), 5935-5951.
https://doi.org/10.20964/2016.07.48

Avramov Ivić M, Antanasijevic J, Trišović N, Antanasijevic D, Lović J, Mijin D, Petrović SD. A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science. 2016;11(7):5935-5951.
doi:10.20964/2016.07.48 .

Avramov Ivić, Milka, Antanasijevic, Jelena, Trišović, Nemanja, Antanasijevic, Davor, Lović, Jelena, Mijin, Dušan, Petrović, Slobodan D., "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode" in International Journal of Electrochemical Science, 11, no. 7 (2016):5935-5951,
https://doi.org/10.20964/2016.07.48 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijevic, Jelena
AU  - Nikolić, Nebojša D.
AU  - Stevanović, Sanja
AU  - Mijin, Dušan
AU  - Vukovic, Dragan
AU  - Mladenović, Aleksandar R.
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1902
AB  - Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode
VL  - 782
SP  - 103
EP  - 107
DO  - 10.1016/j.jelechem.2016.10.022
ER  - 

@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijevic, Jelena and Nikolić, Nebojša D. and Stevanović, Sanja and Mijin, Dušan and Vukovic, Dragan and Mladenović, Aleksandar R. and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2016",
abstract = "Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode",
volume = "782",
pages = "103-107",
doi = "10.1016/j.jelechem.2016.10.022"
}

Lović, J., Trišović, N., Antanasijevic, J., Nikolić, N. D., Stevanović, S., Mijin, D., Vukovic, D., Mladenović, A. R., Petrović, S. D.,& Avramov Ivić, M.. (2016). Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry
Elsevier., 782, 103-107.
https://doi.org/10.1016/j.jelechem.2016.10.022

Lović J, Trišović N, Antanasijevic J, Nikolić ND, Stevanović S, Mijin D, Vukovic D, Mladenović AR, Petrović SD, Avramov Ivić M. Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry. 2016;782:103-107.
doi:10.1016/j.jelechem.2016.10.022 .

Lović, Jelena, Trišović, Nemanja, Antanasijevic, Jelena, Nikolić, Nebojša D., Stevanović, Sanja, Mijin, Dušan, Vukovic, Dragan, Mladenović, Aleksandar R., Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode" in Journal of Electroanalytical Chemistry, 782 (2016):103-107,
https://doi.org/10.1016/j.jelechem.2016.10.022 . .