TY  - JOUR
AU  - Spasojević, Ivan
AU  - Obradović, Budimir
AU  - Spasić, Snežana
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1047
AB  - The present review is aimed at elucidating the neonatal 'sepsis redox cycle' - the cascade of inflammatory and redox events involved in the pathogenesis of sepsis in neonates. While adult and neonatal sepses share some common features, there are some substantial differences: higher mortality rates occur in adult sepsis and worse long-term effects are evident in neonatal sepsis survivors. Such epidemiological data may be explained by the lower ability of IL6 and IL8 to activate NF-kappa B-regulated transcription in neonatal sepsis in comparison to TNF-alpha, which is involved in the mechanisms of adult sepsis. The activation of NF-kappa B in neonatal sepsis is further promoted by hydrogen peroxide and results in mitochondrial dysfunction and energy failure as septic neonates experience decreased O-2 consumption as well as lower heat production and body temperature in comparison to healthy peers. In neonates, specific organs that are still under development are vulnerable to sepsis-provoked stress, which may lead to brain, lung, and heart injury, as well as vision and hearing impairments. In the light of the processes integrated here, it is clear that therapeutic approaches should also target specific steps in the neonatal 'sepsis redox cycle' in addition to the current therapeutic approach that is mainly focused on pathogen eradication.
PB  - Biomed Central Ltd, London
T2  - Critical Care
T1  - Bench-to-bedside review: Neonatal sepsis - redox processes in pathogenesis
VL  - 16
IS  - 3
DO  - 10.1186/cc11183
ER  - 

@article{
author = "Spasojević, Ivan and Obradović, Budimir and Spasić, Snežana",
year = "2012",
abstract = "The present review is aimed at elucidating the neonatal 'sepsis redox cycle' - the cascade of inflammatory and redox events involved in the pathogenesis of sepsis in neonates. While adult and neonatal sepses share some common features, there are some substantial differences: higher mortality rates occur in adult sepsis and worse long-term effects are evident in neonatal sepsis survivors. Such epidemiological data may be explained by the lower ability of IL6 and IL8 to activate NF-kappa B-regulated transcription in neonatal sepsis in comparison to TNF-alpha, which is involved in the mechanisms of adult sepsis. The activation of NF-kappa B in neonatal sepsis is further promoted by hydrogen peroxide and results in mitochondrial dysfunction and energy failure as septic neonates experience decreased O-2 consumption as well as lower heat production and body temperature in comparison to healthy peers. In neonates, specific organs that are still under development are vulnerable to sepsis-provoked stress, which may lead to brain, lung, and heart injury, as well as vision and hearing impairments. In the light of the processes integrated here, it is clear that therapeutic approaches should also target specific steps in the neonatal 'sepsis redox cycle' in addition to the current therapeutic approach that is mainly focused on pathogen eradication.",
publisher = "Biomed Central Ltd, London",
journal = "Critical Care",
title = "Bench-to-bedside review: Neonatal sepsis - redox processes in pathogenesis",
volume = "16",
number = "3",
doi = "10.1186/cc11183"
}

Spasojević, I., Obradović, B.,& Spasić, S.. (2012). Bench-to-bedside review: Neonatal sepsis - redox processes in pathogenesis. in Critical Care
Biomed Central Ltd, London., 16(3).
https://doi.org/10.1186/cc11183

Spasojević I, Obradović B, Spasić S. Bench-to-bedside review: Neonatal sepsis - redox processes in pathogenesis. in Critical Care. 2012;16(3).
doi:10.1186/cc11183 .

Spasojević, Ivan, Obradović, Budimir, Spasić, Snežana, "Bench-to-bedside review: Neonatal sepsis - redox processes in pathogenesis" in Critical Care, 16, no. 3 (2012),
https://doi.org/10.1186/cc11183 . .