TY  - JOUR
AU  - Tasic, Ljubica
AU  - Avramović, Nataša
AU  - Jadranin, Milka
AU  - Quintero, Melissa
AU  - Stanisic, Danijela
AU  - Martins, Lucas G.
AU  - Costa, Tássia Brena Barroso Carneiro
AU  - Novak, Estela
AU  - Odone, Vicente
AU  - Rivas, Maria
AU  - Aguiar, Talita
AU  - Carraro, Dirce Maria
AU  - Werneck da Cunha, Isabela
AU  - Lima da Costa, Cecilia Maria
AU  - Maschietto, Mariana
AU  - Krepischi, Ana
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5568
AB  - Cancer is one of the leading causes of death in children and adolescents worldwide; among the types of liver cancer, hepatoblastoma (HBL) is the most common in childhood. Although it affects only two to three individuals in a million, it is mostly asymptomatic at diagnosis, so by the time it is detected it has already advanced. There are specific recommendations regarding HBL treatment, and ongoing studies to stratify the risks of HBL, understand the pathology, and predict prognostics and survival rates. Although magnetic resonance imaging spectroscopy is frequently used in diagnostics of HBL, high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy of HBL tissues is scarce. Using this technique, we studied the alterations among tissue metabolites of ex vivo samples from (a) HBL and non-cancer liver tissues (NCL), (b) HBL and adjacent non-tumor samples, and (c) two regions of the same HBL samples, one more centralized and the other at the edge of the tumor. It was possible to identify metabolites in HBL, then metabolites from the HBL center and the border samples, and link them to altered metabolisms in tumor tissues, highlighting their potential as biochemical markers. Metabolites closely related to liver metabolisms such as some phospholipids, triacylglycerides, fatty acids, glucose, and amino acids showed differences between the tissues.
PB  - MDPI AG
T2  - Biomedicines
T1  - High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks
VL  - 10
IS  - 12
SP  - 3091
DO  - 10.3390/biomedicines10123091
ER  - 

@article{
author = "Tasic, Ljubica and Avramović, Nataša and Jadranin, Milka and Quintero, Melissa and Stanisic, Danijela and Martins, Lucas G. and Costa, Tássia Brena Barroso Carneiro and Novak, Estela and Odone, Vicente and Rivas, Maria and Aguiar, Talita and Carraro, Dirce Maria and Werneck da Cunha, Isabela and Lima da Costa, Cecilia Maria and Maschietto, Mariana and Krepischi, Ana",
year = "2022",
abstract = "Cancer is one of the leading causes of death in children and adolescents worldwide; among the types of liver cancer, hepatoblastoma (HBL) is the most common in childhood. Although it affects only two to three individuals in a million, it is mostly asymptomatic at diagnosis, so by the time it is detected it has already advanced. There are specific recommendations regarding HBL treatment, and ongoing studies to stratify the risks of HBL, understand the pathology, and predict prognostics and survival rates. Although magnetic resonance imaging spectroscopy is frequently used in diagnostics of HBL, high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy of HBL tissues is scarce. Using this technique, we studied the alterations among tissue metabolites of ex vivo samples from (a) HBL and non-cancer liver tissues (NCL), (b) HBL and adjacent non-tumor samples, and (c) two regions of the same HBL samples, one more centralized and the other at the edge of the tumor. It was possible to identify metabolites in HBL, then metabolites from the HBL center and the border samples, and link them to altered metabolisms in tumor tissues, highlighting their potential as biochemical markers. Metabolites closely related to liver metabolisms such as some phospholipids, triacylglycerides, fatty acids, glucose, and amino acids showed differences between the tissues.",
publisher = "MDPI AG",
journal = "Biomedicines",
title = "High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks",
volume = "10",
number = "12",
pages = "3091",
doi = "10.3390/biomedicines10123091"
}

Tasic, L., Avramović, N., Jadranin, M., Quintero, M., Stanisic, D., Martins, L. G., Costa, T. B. B. C., Novak, E., Odone, V., Rivas, M., Aguiar, T., Carraro, D. M., Werneck da Cunha, I., Lima da Costa, C. M., Maschietto, M.,& Krepischi, A.. (2022). High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks. in Biomedicines
MDPI AG., 10(12), 3091.
https://doi.org/10.3390/biomedicines10123091

Tasic L, Avramović N, Jadranin M, Quintero M, Stanisic D, Martins LG, Costa TBBC, Novak E, Odone V, Rivas M, Aguiar T, Carraro DM, Werneck da Cunha I, Lima da Costa CM, Maschietto M, Krepischi A. High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks. in Biomedicines. 2022;10(12):3091.
doi:10.3390/biomedicines10123091 .

Tasic, Ljubica, Avramović, Nataša, Jadranin, Milka, Quintero, Melissa, Stanisic, Danijela, Martins, Lucas G., Costa, Tássia Brena Barroso Carneiro, Novak, Estela, Odone, Vicente, Rivas, Maria, Aguiar, Talita, Carraro, Dirce Maria, Werneck da Cunha, Isabela, Lima da Costa, Cecilia Maria, Maschietto, Mariana, Krepischi, Ana, "High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks" in Biomedicines, 10, no. 12 (2022):3091,
https://doi.org/10.3390/biomedicines10123091 . .