TY  - CONF
AU  - Tasić, Ljubica
AU  - Martins, Lucas
AU  - Braga, Erik Sobrinho
AU  - Novais, M.
AU  - Jadranin, Milka
AU  - Stanišić, Danijela
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7277
AB  - The infection with SARS-CoV-2 mostly leads to mild disease, but some individuals progress to severe disease with death outcome [1]. These severe cases are driven by the host response to the infection, with multisystem dysfunctions [1,2]. Timely intervention in patients in critical conditions could be crucial for their survival. Therefore, it is of paramount importance to understand the disease phase and its progression markers. Serum samples from two cohorts of patients, with mild (n = 92) and severe disease (n = 41) were analyzed, with two subgroups in each cohort, positive and negative to the virus. The samples were age and gender-matched to healthy volunteers (n = 87), too. Three NMR data sets (1H-NMR, T2, and edited by diffusion) were recorded on a 600 MHz Bruker AVANCE III spectrometer, and analyzed in MetaboAnalyst 5.0. Serum metabolomics showed that proteins, very low and low-density lipoproteins (VLDL and LDL), phospholipids, 
lysophosphatidylcholines among other 50 metabolites were disrupted. Furthermore, changes in the levels of NAD(P)+, hyperglycemia and dysregulated glucose were detrimental in people with COVID-19. Glu cose excess, increased levels of VLDL, and decreased proteins were related to the disease severity, and might be important for determining a patient’s phase of the disease, and NMR can greatly add to the differentiation between severe and mild symptoms.
PB  - NMR Group (GERMN) of the Spanish Royal Society of Chemistry (RSEQ)
C3  - 10th GERMN biennial NMR meeting, 9th IberoAmerican NMR meeting, 7th Iberian NMR meeting, 26 to 29 April 2021, virtual event
T1  - Impressions on COVID-19 by NMR
SP  - OC24
UR  - https://hdl.handle.net/21.15107/rcub_cer_7277
ER  - 

@conference{
author = "Tasić, Ljubica and Martins, Lucas and Braga, Erik Sobrinho and Novais, M. and Jadranin, Milka and Stanišić, Danijela",
year = "2021",
abstract = "The infection with SARS-CoV-2 mostly leads to mild disease, but some individuals progress to severe disease with death outcome [1]. These severe cases are driven by the host response to the infection, with multisystem dysfunctions [1,2]. Timely intervention in patients in critical conditions could be crucial for their survival. Therefore, it is of paramount importance to understand the disease phase and its progression markers. Serum samples from two cohorts of patients, with mild (n = 92) and severe disease (n = 41) were analyzed, with two subgroups in each cohort, positive and negative to the virus. The samples were age and gender-matched to healthy volunteers (n = 87), too. Three NMR data sets (1H-NMR, T2, and edited by diffusion) were recorded on a 600 MHz Bruker AVANCE III spectrometer, and analyzed in MetaboAnalyst 5.0. Serum metabolomics showed that proteins, very low and low-density lipoproteins (VLDL and LDL), phospholipids, 
lysophosphatidylcholines among other 50 metabolites were disrupted. Furthermore, changes in the levels of NAD(P)+, hyperglycemia and dysregulated glucose were detrimental in people with COVID-19. Glu cose excess, increased levels of VLDL, and decreased proteins were related to the disease severity, and might be important for determining a patient’s phase of the disease, and NMR can greatly add to the differentiation between severe and mild symptoms.",
publisher = "NMR Group (GERMN) of the Spanish Royal Society of Chemistry (RSEQ)",
journal = "10th GERMN biennial NMR meeting, 9th IberoAmerican NMR meeting, 7th Iberian NMR meeting, 26 to 29 April 2021, virtual event",
title = "Impressions on COVID-19 by NMR",
pages = "OC24",
url = "https://hdl.handle.net/21.15107/rcub_cer_7277"
}

Tasić, L., Martins, L., Braga, E. S., Novais, M., Jadranin, M.,& Stanišić, D.. (2021). Impressions on COVID-19 by NMR. in 10th GERMN biennial NMR meeting, 9th IberoAmerican NMR meeting, 7th Iberian NMR meeting, 26 to 29 April 2021, virtual event
NMR Group (GERMN) of the Spanish Royal Society of Chemistry (RSEQ)., OC24.
https://hdl.handle.net/21.15107/rcub_cer_7277

Tasić L, Martins L, Braga ES, Novais M, Jadranin M, Stanišić D. Impressions on COVID-19 by NMR. in 10th GERMN biennial NMR meeting, 9th IberoAmerican NMR meeting, 7th Iberian NMR meeting, 26 to 29 April 2021, virtual event. 2021;:OC24.
https://hdl.handle.net/21.15107/rcub_cer_7277 .

Tasić, Ljubica, Martins, Lucas, Braga, Erik Sobrinho, Novais, M., Jadranin, Milka, Stanišić, Danijela, "Impressions on COVID-19 by NMR" in 10th GERMN biennial NMR meeting, 9th IberoAmerican NMR meeting, 7th Iberian NMR meeting, 26 to 29 April 2021, virtual event (2021):OC24,
https://hdl.handle.net/21.15107/rcub_cer_7277 .