TY  - JOUR
AU  - Zornić, Sanja
AU  - Simović Marković, Bojana
AU  - Franich, Andjela A.
AU  - Janjić, Goran
AU  - Jadranin, Milka
AU  - Avdalović, Jelena
AU  - Rajković, Snežana
AU  - Živković, Marija D.
AU  - Arsenijević, Nebojša N.
AU  - Radosavljević, Gordana D.
AU  - Pantić, Jelena
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7213
AB  - Platinum-based drugs are widely recognized efficient anti-tumor agents, but faced with multiple undesirable effects. Here, four dinuclear platinum(II) complexes, [{Pt(1,2-pn)Cl}2(μ-pydz)]Cl2 (C1), [{Pt(ibn)Cl}2(μ-pydz)]Cl2 (C2), [{Pt(1,3-pn)Cl}2(μ-pydz)]Cl2 (C3) and [{Pt(1,3-pnd)Cl}2(μ-pydz)]Cl2 (C4), were designed (pydz is pyridazine, 1,2-pn is ( ±)-1,2-propylenediamine, ibn is 1,2-diamino-2-methylpropane, 1,3-pn is 1,3-propylenediamine, and 1,3-pnd is 1,3-pentanediamine). Interactions and binding ability of C1–C4 complexes with calf thymus DNA (CT-DNA) has been monitored by viscosity measurements, UV–Vis, fluorescence emission spectroscopy and molecular docking. Binding affinities of C1–C4 complexes to the bovine serum albumin (BSA) has been monitored by fluorescence emission spectroscopy. The tested complexes exhibit variable cytotoxicity toward different mouse and human tumor cell lines. C2 shows the most potent cytotoxicity, especially against mouse (4T1) and human (MDA-MD468) breast cancer cells in the dose- and time-dependent manner. C2 induces 4T1 and MDA-MD468 cells apoptosis, further documented by the accumulation of cells at sub-G1 phase of cell cycle and increase of executive caspase 3 and caspase 9 levels in 4T1 cells. C2 exhibits anti-proliferative effect through the reduction of cyclin D3 and cyclin E expression and elevation of inhibitor p27 level. Also, C2 downregulates c-Myc and phosphorylated AKT, oncogenes involved in the control of tumor cell proliferation and death. In order to measure the amount of platinum(II) complexes taken up by the cells, the cellular platinum content were quantified. However, C2 failed to inhibit mouse breast cancer growth in vivo. Chemical modifications of tested platinum(II) complexes might be a valuable approach for the improvement of their anti-tumor activity, especially effects in vivo.
PB  - Springer
T2  - Journal of Biological Inorganic Chemistry
T1  - Characterization, modes of interactions with DNA/BSA biomolecules and anti-tumor activity of newly synthesized dinuclear platinum(II) complexes with pyridazine bridging ligand
DO  - 10.1007/s00775-023-02030-0
ER  - 

@article{
author = "Zornić, Sanja and Simović Marković, Bojana and Franich, Andjela A. and Janjić, Goran and Jadranin, Milka and Avdalović, Jelena and Rajković, Snežana and Živković, Marija D. and Arsenijević, Nebojša N. and Radosavljević, Gordana D. and Pantić, Jelena",
year = "2023",
abstract = "Platinum-based drugs are widely recognized efficient anti-tumor agents, but faced with multiple undesirable effects. Here, four dinuclear platinum(II) complexes, [{Pt(1,2-pn)Cl}2(μ-pydz)]Cl2 (C1), [{Pt(ibn)Cl}2(μ-pydz)]Cl2 (C2), [{Pt(1,3-pn)Cl}2(μ-pydz)]Cl2 (C3) and [{Pt(1,3-pnd)Cl}2(μ-pydz)]Cl2 (C4), were designed (pydz is pyridazine, 1,2-pn is ( ±)-1,2-propylenediamine, ibn is 1,2-diamino-2-methylpropane, 1,3-pn is 1,3-propylenediamine, and 1,3-pnd is 1,3-pentanediamine). Interactions and binding ability of C1–C4 complexes with calf thymus DNA (CT-DNA) has been monitored by viscosity measurements, UV–Vis, fluorescence emission spectroscopy and molecular docking. Binding affinities of C1–C4 complexes to the bovine serum albumin (BSA) has been monitored by fluorescence emission spectroscopy. The tested complexes exhibit variable cytotoxicity toward different mouse and human tumor cell lines. C2 shows the most potent cytotoxicity, especially against mouse (4T1) and human (MDA-MD468) breast cancer cells in the dose- and time-dependent manner. C2 induces 4T1 and MDA-MD468 cells apoptosis, further documented by the accumulation of cells at sub-G1 phase of cell cycle and increase of executive caspase 3 and caspase 9 levels in 4T1 cells. C2 exhibits anti-proliferative effect through the reduction of cyclin D3 and cyclin E expression and elevation of inhibitor p27 level. Also, C2 downregulates c-Myc and phosphorylated AKT, oncogenes involved in the control of tumor cell proliferation and death. In order to measure the amount of platinum(II) complexes taken up by the cells, the cellular platinum content were quantified. However, C2 failed to inhibit mouse breast cancer growth in vivo. Chemical modifications of tested platinum(II) complexes might be a valuable approach for the improvement of their anti-tumor activity, especially effects in vivo.",
publisher = "Springer",
journal = "Journal of Biological Inorganic Chemistry",
title = "Characterization, modes of interactions with DNA/BSA biomolecules and anti-tumor activity of newly synthesized dinuclear platinum(II) complexes with pyridazine bridging ligand",
doi = "10.1007/s00775-023-02030-0"
}

Zornić, S., Simović Marković, B., Franich, A. A., Janjić, G., Jadranin, M., Avdalović, J., Rajković, S., Živković, M. D., Arsenijević, N. N., Radosavljević, G. D.,& Pantić, J.. (2023). Characterization, modes of interactions with DNA/BSA biomolecules and anti-tumor activity of newly synthesized dinuclear platinum(II) complexes with pyridazine bridging ligand. in Journal of Biological Inorganic Chemistry
Springer..
https://doi.org/10.1007/s00775-023-02030-0

Zornić S, Simović Marković B, Franich AA, Janjić G, Jadranin M, Avdalović J, Rajković S, Živković MD, Arsenijević NN, Radosavljević GD, Pantić J. Characterization, modes of interactions with DNA/BSA biomolecules and anti-tumor activity of newly synthesized dinuclear platinum(II) complexes with pyridazine bridging ligand. in Journal of Biological Inorganic Chemistry. 2023;.
doi:10.1007/s00775-023-02030-0 .

Zornić, Sanja, Simović Marković, Bojana, Franich, Andjela A., Janjić, Goran, Jadranin, Milka, Avdalović, Jelena, Rajković, Snežana, Živković, Marija D., Arsenijević, Nebojša N., Radosavljević, Gordana D., Pantić, Jelena, "Characterization, modes of interactions with DNA/BSA biomolecules and anti-tumor activity of newly synthesized dinuclear platinum(II) complexes with pyridazine bridging ligand" in Journal of Biological Inorganic Chemistry (2023),
https://doi.org/10.1007/s00775-023-02030-0 . .

TY  - JOUR
AU  - Stanić, Petar
AU  - Vukićević, Nataša
AU  - Cvetković, Vesna S.
AU  - Pavlović, Miroslav
AU  - Dimitrijević, Silvana
AU  - Šmit, Biljana
AU  - Živković, Marija
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5845
AB  - Several 2-thiohydаntоin–Shiff base derivatives were prepared as ecofriendly
corrosion inhibitors for mild steel in acid environment. Their anticorrosion
properties were studied on mild steel in 0.5 M HCl solution as corrosion
electrolyte by using usuаl grаvimеtriс and different elесtrосhemicаl techniques
(wеight lоss mеаsurеmеnt, pоtеntiоdynаmiс pоlаrizаtiоn and pоtеntiоstаtiс
еlесtrосhеmicаl impеdаnсе sресtrоscору). Mild steel surface was characterized
using two analytical techniques, scanning electron microscopy for surface morphology
and elemental composition and atomic force microscopy. The study
has shown that the inhibiting action of these environmentally benign inhibitors
synthesized from inexpensive commercially available starting materials could
be attributed to adsorption on the metal surface.
AB  - Неколико деривата Шифових база 2-тиохидантоина су направљени као еколошки прихватљиви инхибитори корозије меког челика у киселој средини. Њихова антикорозиона својства су испитана на меком челику у 0,5 M раствору HCl као корозионом електролиту, користећи уобичајене гравиметријске и различите електрохемијске технике (мерење губитка масе, потенциодинамичка поларизација, потенциостатска спектроскопија електрохемијске импеданције). Површина меког челика је окарактерисана двема аналитичким техникама, скенирајућом електронском микроскопијом за морфологију површине и елементарни састав и микроскопијом атомске силе. Студија је показала да се инхибиторно деловање ових еколошки бенигних инхибитора, синтетисаних из јефтиних комерцијално доступних полазних материјала, може приписати адсорпцији инхибитора на површини меког челика.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Anticorrosion activity of 2-thiоhуdantoin–Shiff base derivatives for mild steel in 0.5 M HCl
T1  - Антикорозиона активност деривата шифових база 2-тиохидантоина за меки челик у 0,5 m hcl
VL  - 87
IS  - 12
SP  - 1409
EP  - 1423
DO  - 10.2298/JSC220412071S
ER  - 

@article{
author = "Stanić, Petar and Vukićević, Nataša and Cvetković, Vesna S. and Pavlović, Miroslav and Dimitrijević, Silvana and Šmit, Biljana and Živković, Marija",
year = "2022",
abstract = "Several 2-thiohydаntоin–Shiff base derivatives were prepared as ecofriendly
corrosion inhibitors for mild steel in acid environment. Their anticorrosion
properties were studied on mild steel in 0.5 M HCl solution as corrosion
electrolyte by using usuаl grаvimеtriс and different elесtrосhemicаl techniques
(wеight lоss mеаsurеmеnt, pоtеntiоdynаmiс pоlаrizаtiоn and pоtеntiоstаtiс
еlесtrосhеmicаl impеdаnсе sресtrоscору). Mild steel surface was characterized
using two analytical techniques, scanning electron microscopy for surface morphology
and elemental composition and atomic force microscopy. The study
has shown that the inhibiting action of these environmentally benign inhibitors
synthesized from inexpensive commercially available starting materials could
be attributed to adsorption on the metal surface., Неколико деривата Шифових база 2-тиохидантоина су направљени као еколошки прихватљиви инхибитори корозије меког челика у киселој средини. Њихова антикорозиона својства су испитана на меком челику у 0,5 M раствору HCl као корозионом електролиту, користећи уобичајене гравиметријске и различите електрохемијске технике (мерење губитка масе, потенциодинамичка поларизација, потенциостатска спектроскопија електрохемијске импеданције). Површина меког челика је окарактерисана двема аналитичким техникама, скенирајућом електронском микроскопијом за морфологију површине и елементарни састав и микроскопијом атомске силе. Студија је показала да се инхибиторно деловање ових еколошки бенигних инхибитора, синтетисаних из јефтиних комерцијално доступних полазних материјала, може приписати адсорпцији инхибитора на површини меког челика.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Anticorrosion activity of 2-thiоhуdantoin–Shiff base derivatives for mild steel in 0.5 M HCl, Антикорозиона активност деривата шифових база 2-тиохидантоина за меки челик у 0,5 m hcl",
volume = "87",
number = "12",
pages = "1409-1423",
doi = "10.2298/JSC220412071S"
}

Stanić, P., Vukićević, N., Cvetković, V. S., Pavlović, M., Dimitrijević, S., Šmit, B.,& Živković, M.. (2022). Anticorrosion activity of 2-thiоhуdantoin–Shiff base derivatives for mild steel in 0.5 M HCl. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 87(12), 1409-1423.
https://doi.org/10.2298/JSC220412071S

Stanić P, Vukićević N, Cvetković VS, Pavlović M, Dimitrijević S, Šmit B, Živković M. Anticorrosion activity of 2-thiоhуdantoin–Shiff base derivatives for mild steel in 0.5 M HCl. in Journal of the Serbian Chemical Society. 2022;87(12):1409-1423.
doi:10.2298/JSC220412071S .

Stanić, Petar, Vukićević, Nataša, Cvetković, Vesna S., Pavlović, Miroslav, Dimitrijević, Silvana, Šmit, Biljana, Živković, Marija, "Anticorrosion activity of 2-thiоhуdantoin–Shiff base derivatives for mild steel in 0.5 M HCl" in Journal of the Serbian Chemical Society, 87, no. 12 (2022):1409-1423,
https://doi.org/10.2298/JSC220412071S . .