TY  - JOUR
AU  - Kommera, Harish
AU  - Kaluđerović, Goran N.
AU  - Kalbitz, Jutta
AU  - Paschke, Reinhard
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3411
AB  - In the present investigation the antiproliferative
activity of thirteen derivatives of betulinic acid and
betulin was tested against five different tumor cell lines.
The toxicity against normal human fibroblasts
(WWO70327) and the mode of cell death on HT-29
(colon cancer) as well as caspase activity induced by the
most active compounds, 9 (3-O-chloroacetylbetulinic
acid) and 15 (28-O-chloroacetylbetulin) were determined.
Investigated derivatives exerted a dose dependent antiproliferative
action at micromolar concentrations toward
target tumor cell lines. Treatment of HT-29 cells for 24 h
with 9 and 15 induced apoptosis, as observed by dye
exclusion test (trypan blue) and confirmed by the
appearance of a typical ladder pattern in the DNA
fragmentation assay.
PB  - Netherlands : Springer
T2  - Investigational  New Drugs
T1  - Lupane Triterpenoids—Betulin and Betulinic acid derivatives induce apoptosis in tumor cells
VL  - 29
IS  - 2
SP  - 266
EP  - 272
DO  - 10.1007/s10637-009-9358-x
ER  - 

@article{
author = "Kommera, Harish and Kaluđerović, Goran N. and Kalbitz, Jutta and Paschke, Reinhard",
year = "2011",
abstract = "In the present investigation the antiproliferative
activity of thirteen derivatives of betulinic acid and
betulin was tested against five different tumor cell lines.
The toxicity against normal human fibroblasts
(WWO70327) and the mode of cell death on HT-29
(colon cancer) as well as caspase activity induced by the
most active compounds, 9 (3-O-chloroacetylbetulinic
acid) and 15 (28-O-chloroacetylbetulin) were determined.
Investigated derivatives exerted a dose dependent antiproliferative
action at micromolar concentrations toward
target tumor cell lines. Treatment of HT-29 cells for 24 h
with 9 and 15 induced apoptosis, as observed by dye
exclusion test (trypan blue) and confirmed by the
appearance of a typical ladder pattern in the DNA
fragmentation assay.",
publisher = "Netherlands : Springer",
journal = "Investigational  New Drugs",
title = "Lupane Triterpenoids—Betulin and Betulinic acid derivatives induce apoptosis in tumor cells",
volume = "29",
number = "2",
pages = "266-272",
doi = "10.1007/s10637-009-9358-x"
}

Kommera, H., Kaluđerović, G. N., Kalbitz, J.,& Paschke, R.. (2011). Lupane Triterpenoids—Betulin and Betulinic acid derivatives induce apoptosis in tumor cells. in Investigational  New Drugs
Netherlands : Springer., 29(2), 266-272.
https://doi.org/10.1007/s10637-009-9358-x

Kommera H, Kaluđerović GN, Kalbitz J, Paschke R. Lupane Triterpenoids—Betulin and Betulinic acid derivatives induce apoptosis in tumor cells. in Investigational  New Drugs. 2011;29(2):266-272.
doi:10.1007/s10637-009-9358-x .

Kommera, Harish, Kaluđerović, Goran N., Kalbitz, Jutta, Paschke, Reinhard, "Lupane Triterpenoids—Betulin and Betulinic acid derivatives induce apoptosis in tumor cells" in Investigational  New Drugs, 29, no. 2 (2011):266-272,
https://doi.org/10.1007/s10637-009-9358-x . .

TY  - JOUR
AU  - Kommera, Harish
AU  - Kaluđerović, Goran N.
AU  - Kalbitz, Jutta
AU  - Dräger, Birgit
AU  - Paschke, Reinhard
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3179
AB  - In the present investigations five new derivatives of betulinic and betulonic acid were synthesized and the effect of this structural variations on anticancer activity was studied and discussed. The antiproliferative activity of betulinic and betulonic acid derivatives was studied against eight tumor cell lines of different histogenic origin. The derivatives exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. The apoptotic mode of cell death on colon cancer cell line HT-29 was induced by the most active compounds 5, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl (3-O-acetyl)betulinate, and 9, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl betulonate. Treatment of HT-29 cells with 5 and 9 induced apoptosis, as observed by dye exclusion test (trypan blue) and by the appearance of a typical ladder pattern in the DNA fragmentation assay and FITC annexin V assay. Cell cycle perturbations caused by compound 5 are also presented.
PB  - Elsevier
T2  - European Journal of Medicinal Chemistry
T1  - Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties
VL  - 45
IS  - 8
SP  - 3346
EP  - 3353
DO  - 10.1016/j.ejmech.2010.04.018
ER  - 

@article{
author = "Kommera, Harish and Kaluđerović, Goran N. and Kalbitz, Jutta and Dräger, Birgit and Paschke, Reinhard",
year = "2010",
abstract = "In the present investigations five new derivatives of betulinic and betulonic acid were synthesized and the effect of this structural variations on anticancer activity was studied and discussed. The antiproliferative activity of betulinic and betulonic acid derivatives was studied against eight tumor cell lines of different histogenic origin. The derivatives exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. The apoptotic mode of cell death on colon cancer cell line HT-29 was induced by the most active compounds 5, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl (3-O-acetyl)betulinate, and 9, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl betulonate. Treatment of HT-29 cells with 5 and 9 induced apoptosis, as observed by dye exclusion test (trypan blue) and by the appearance of a typical ladder pattern in the DNA fragmentation assay and FITC annexin V assay. Cell cycle perturbations caused by compound 5 are also presented.",
publisher = "Elsevier",
journal = "European Journal of Medicinal Chemistry",
title = "Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties",
volume = "45",
number = "8",
pages = "3346-3353",
doi = "10.1016/j.ejmech.2010.04.018"
}

Kommera, H., Kaluđerović, G. N., Kalbitz, J., Dräger, B.,& Paschke, R.. (2010). Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties. in European Journal of Medicinal Chemistry
Elsevier., 45(8), 3346-3353.
https://doi.org/10.1016/j.ejmech.2010.04.018

Kommera H, Kaluđerović GN, Kalbitz J, Dräger B, Paschke R. Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties. in European Journal of Medicinal Chemistry. 2010;45(8):3346-3353.
doi:10.1016/j.ejmech.2010.04.018 .

Kommera, Harish, Kaluđerović, Goran N., Kalbitz, Jutta, Dräger, Birgit, Paschke, Reinhard, "Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties" in European Journal of Medicinal Chemistry, 45, no. 8 (2010):3346-3353,
https://doi.org/10.1016/j.ejmech.2010.04.018 . .