TY  - JOUR
AU  - Hmuda, Sleem
AU  - Trišović, Nemanja
AU  - Rogan, Jelena R.
AU  - Poleti, Dejan
AU  - Vitnik, Željko
AU  - Vitnik, Vesna
AU  - Valentić, Nataša V.
AU  - Bozic, Biljana
AU  - Ušćumlić, Gordana
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1518
AB  - Two new series of hydantoin derivatives, 3-(4-substituted benzyl)-5,5-diphenyl- and 3-(4-substituted benzyl)-5-ethyl-5-phenylhydantoins, were synthesized and their antiproliferative activity was tested against human colon cancer HCT-116 and breast cancer MDA-MB-231 cell lines. The presence of different substituents on both hydantoin and benzyl moieties changed the antiproliferative activity of the investigated hydantoins, whereby most of the compounds showed superior antiproliferative activity against MDA-MB-231 than against the HCT-116 cell line. The structure of three compounds was studied by single-crystal X-ray diffraction. The general structural characteristic is the presence of N-H center dot center dot center dot O hydrogen bonds in crystal packings. The molecular geometry and bonding features of the investigated hydantoins in the ground states were calculated using the density functional method. The relationship between structure and antiproliferative activity was discussed. The data presented in this investigation afford guidelines for the preparation of new hydantoin derivatives with greater antiproliferative activity.
PB  - Springer Wien, Wien
T2  - Monatshefte Fur Chemie
T1  - New derivatives of hydantoin as potential antiproliferative agents: biological and structural characterization in combination with quantum chemical calculations
VL  - 145
IS  - 5
SP  - 821
EP  - 833
DO  - 10.1007/s00706-013-1149-6
ER  - 

@article{
author = "Hmuda, Sleem and Trišović, Nemanja and Rogan, Jelena R. and Poleti, Dejan and Vitnik, Željko and Vitnik, Vesna and Valentić, Nataša V. and Bozic, Biljana and Ušćumlić, Gordana",
year = "2014",
abstract = "Two new series of hydantoin derivatives, 3-(4-substituted benzyl)-5,5-diphenyl- and 3-(4-substituted benzyl)-5-ethyl-5-phenylhydantoins, were synthesized and their antiproliferative activity was tested against human colon cancer HCT-116 and breast cancer MDA-MB-231 cell lines. The presence of different substituents on both hydantoin and benzyl moieties changed the antiproliferative activity of the investigated hydantoins, whereby most of the compounds showed superior antiproliferative activity against MDA-MB-231 than against the HCT-116 cell line. The structure of three compounds was studied by single-crystal X-ray diffraction. The general structural characteristic is the presence of N-H center dot center dot center dot O hydrogen bonds in crystal packings. The molecular geometry and bonding features of the investigated hydantoins in the ground states were calculated using the density functional method. The relationship between structure and antiproliferative activity was discussed. The data presented in this investigation afford guidelines for the preparation of new hydantoin derivatives with greater antiproliferative activity.",
publisher = "Springer Wien, Wien",
journal = "Monatshefte Fur Chemie",
title = "New derivatives of hydantoin as potential antiproliferative agents: biological and structural characterization in combination with quantum chemical calculations",
volume = "145",
number = "5",
pages = "821-833",
doi = "10.1007/s00706-013-1149-6"
}

Hmuda, S., Trišović, N., Rogan, J. R., Poleti, D., Vitnik, Ž., Vitnik, V., Valentić, N. V., Bozic, B.,& Ušćumlić, G.. (2014). New derivatives of hydantoin as potential antiproliferative agents: biological and structural characterization in combination with quantum chemical calculations. in Monatshefte Fur Chemie
Springer Wien, Wien., 145(5), 821-833.
https://doi.org/10.1007/s00706-013-1149-6

Hmuda S, Trišović N, Rogan JR, Poleti D, Vitnik Ž, Vitnik V, Valentić NV, Bozic B, Ušćumlić G. New derivatives of hydantoin as potential antiproliferative agents: biological and structural characterization in combination with quantum chemical calculations. in Monatshefte Fur Chemie. 2014;145(5):821-833.
doi:10.1007/s00706-013-1149-6 .

Hmuda, Sleem, Trišović, Nemanja, Rogan, Jelena R., Poleti, Dejan, Vitnik, Željko, Vitnik, Vesna, Valentić, Nataša V., Bozic, Biljana, Ušćumlić, Gordana, "New derivatives of hydantoin as potential antiproliferative agents: biological and structural characterization in combination with quantum chemical calculations" in Monatshefte Fur Chemie, 145, no. 5 (2014):821-833,
https://doi.org/10.1007/s00706-013-1149-6 . .