TY  - JOUR
AU  - Gođevac, Dejan
AU  - Stanković, Jovana
AU  - Novaković, Miroslav
AU  - Anđelković, Boban D.
AU  - Dajić-Stevanović, Zora
AU  - Petrovic, Milica
AU  - Stanković, Miroslava
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1672
AB  - From the aerial parts of Atriplex littoralis, three new flavonoid glycosides named atriplexins I-III (1-3), a known flavonoid glycoside, spinacetin 3-O-beta-D-glucopyranoside (4), arbutin (5), and 4-hydroxybenzyl-beta-D-glucopyranoside (6) were isolated. Their structures were elucidated on the basis of detailed spectroscopic analysis, including ID and 2D NMR (COSY, NOESY, TOCSY, HSQC, HMBC) and HRESITOF MS data. The compounds were tested for in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using a cytochalasin-B-blocked micronucleus (MN) assay in a concentration range of 0.8-7.4 mu M of final culture solution. Chromosomal damage was induced by 2 Gy of gamma-radiation on binudeated human lymphocytes, and the effects of the compounds were tested 2 to 19 h after irradiation. The frequency of micronuclei (MNi) was scored in binudeated cells, and the nuclear proliferation index was calculated. The highest prevention of in vitro biochemical and cytogenetic damage of human lymphocytes induced by gamma-radiation was exhibited by 3 (reduction of MN frequency by 31%), followed by 4 and 6.
PB  - American Chemical Society (ACS)
T2  - Journal of Natural Products
T1  - Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity
VL  - 78
IS  - 9
SP  - 2198
EP  - 2204
DO  - 10.1021/acs.jnatprod.5b00273
ER  - 

@article{
author = "Gođevac, Dejan and Stanković, Jovana and Novaković, Miroslav and Anđelković, Boban D. and Dajić-Stevanović, Zora and Petrovic, Milica and Stanković, Miroslava",
year = "2015",
abstract = "From the aerial parts of Atriplex littoralis, three new flavonoid glycosides named atriplexins I-III (1-3), a known flavonoid glycoside, spinacetin 3-O-beta-D-glucopyranoside (4), arbutin (5), and 4-hydroxybenzyl-beta-D-glucopyranoside (6) were isolated. Their structures were elucidated on the basis of detailed spectroscopic analysis, including ID and 2D NMR (COSY, NOESY, TOCSY, HSQC, HMBC) and HRESITOF MS data. The compounds were tested for in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using a cytochalasin-B-blocked micronucleus (MN) assay in a concentration range of 0.8-7.4 mu M of final culture solution. Chromosomal damage was induced by 2 Gy of gamma-radiation on binudeated human lymphocytes, and the effects of the compounds were tested 2 to 19 h after irradiation. The frequency of micronuclei (MNi) was scored in binudeated cells, and the nuclear proliferation index was calculated. The highest prevention of in vitro biochemical and cytogenetic damage of human lymphocytes induced by gamma-radiation was exhibited by 3 (reduction of MN frequency by 31%), followed by 4 and 6.",
publisher = "American Chemical Society (ACS)",
journal = "Journal of Natural Products",
title = "Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity",
volume = "78",
number = "9",
pages = "2198-2204",
doi = "10.1021/acs.jnatprod.5b00273"
}

Gođevac, D., Stanković, J., Novaković, M., Anđelković, B. D., Dajić-Stevanović, Z., Petrovic, M.,& Stanković, M.. (2015). Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity. in Journal of Natural Products
American Chemical Society (ACS)., 78(9), 2198-2204.
https://doi.org/10.1021/acs.jnatprod.5b00273

Gođevac D, Stanković J, Novaković M, Anđelković BD, Dajić-Stevanović Z, Petrovic M, Stanković M. Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity. in Journal of Natural Products. 2015;78(9):2198-2204.
doi:10.1021/acs.jnatprod.5b00273 .

Gođevac, Dejan, Stanković, Jovana, Novaković, Miroslav, Anđelković, Boban D., Dajić-Stevanović, Zora, Petrovic, Milica, Stanković, Miroslava, "Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity" in Journal of Natural Products, 78, no. 9 (2015):2198-2204,
https://doi.org/10.1021/acs.jnatprod.5b00273 . .

TY  - JOUR
AU  - Stankovic, Milan S
AU  - Petrovic, Milica
AU  - Gođevac, Dejan
AU  - Dajić-Stevanović, Zora
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1659
AB  - This paper presents new data for secondary metabolites and biological activity of the insufficiently studied European inland halophytes as remarkable indicators of Balkan saline habitats. Phenolic content, flavonoid concentrations and antioxidant activity were analyzed in fifteen terrestrial salt tolerant plants collected from eight saline habitats situated in two distinct semiarid regions of Serbia. Total phenols ranged from 31.86 to 212.71 mg of GA/g of extract (gallic acid equivalent milligrams of gallic acid per gram of extract). Concentration of flavonoids ranged from 41.21 to 146.06 mg of RU/g of extract (rutin equivalent milligrams of rutin per gram of extract). Antioxidant activity was determined using 1,1-dipheny1-2-picrylhydrazyl radical reagent; obtained values was ranged from 1785.81 to 17.55 mu g/ml. A significant relation was noticed between the concentration of phenols and antioxidant activity. Parallel to the analysis of researched halophytes, Camellia sinensis and Ginkgo biloba were analyzed for comparison. The best antioxidant properties were determined for Statice gmelinii, Artemisia santonicum and Mentha pulegium. The results indicate a potential of studied halophytic species as candidates for natural sources of secondary metabolites with high biological activity, whereas their bioactive compounds might have a significant role in adaptations to salt and drought stress.
PB  - Academic Press Ltd- Elsevier Science Ltd, London
T2  - Journal of Arid Environments
T1  - Screening inland halophytes from the central Balkan for their antioxidant activity in relation to total phenolic compounds and flavonoids: Are there any prospective medicinal plants?
VL  - 120
SP  - 26
EP  - 32
DO  - 10.1016/j.jaridenv.2015.04.008
ER  - 

@article{
author = "Stankovic, Milan S and Petrovic, Milica and Gođevac, Dejan and Dajić-Stevanović, Zora",
year = "2015",
abstract = "This paper presents new data for secondary metabolites and biological activity of the insufficiently studied European inland halophytes as remarkable indicators of Balkan saline habitats. Phenolic content, flavonoid concentrations and antioxidant activity were analyzed in fifteen terrestrial salt tolerant plants collected from eight saline habitats situated in two distinct semiarid regions of Serbia. Total phenols ranged from 31.86 to 212.71 mg of GA/g of extract (gallic acid equivalent milligrams of gallic acid per gram of extract). Concentration of flavonoids ranged from 41.21 to 146.06 mg of RU/g of extract (rutin equivalent milligrams of rutin per gram of extract). Antioxidant activity was determined using 1,1-dipheny1-2-picrylhydrazyl radical reagent; obtained values was ranged from 1785.81 to 17.55 mu g/ml. A significant relation was noticed between the concentration of phenols and antioxidant activity. Parallel to the analysis of researched halophytes, Camellia sinensis and Ginkgo biloba were analyzed for comparison. The best antioxidant properties were determined for Statice gmelinii, Artemisia santonicum and Mentha pulegium. The results indicate a potential of studied halophytic species as candidates for natural sources of secondary metabolites with high biological activity, whereas their bioactive compounds might have a significant role in adaptations to salt and drought stress.",
publisher = "Academic Press Ltd- Elsevier Science Ltd, London",
journal = "Journal of Arid Environments",
title = "Screening inland halophytes from the central Balkan for their antioxidant activity in relation to total phenolic compounds and flavonoids: Are there any prospective medicinal plants?",
volume = "120",
pages = "26-32",
doi = "10.1016/j.jaridenv.2015.04.008"
}

Stankovic, M. S., Petrovic, M., Gođevac, D.,& Dajić-Stevanović, Z.. (2015). Screening inland halophytes from the central Balkan for their antioxidant activity in relation to total phenolic compounds and flavonoids: Are there any prospective medicinal plants?. in Journal of Arid Environments
Academic Press Ltd- Elsevier Science Ltd, London., 120, 26-32.
https://doi.org/10.1016/j.jaridenv.2015.04.008

Stankovic MS, Petrovic M, Gođevac D, Dajić-Stevanović Z. Screening inland halophytes from the central Balkan for their antioxidant activity in relation to total phenolic compounds and flavonoids: Are there any prospective medicinal plants?. in Journal of Arid Environments. 2015;120:26-32.
doi:10.1016/j.jaridenv.2015.04.008 .

Stankovic, Milan S, Petrovic, Milica, Gođevac, Dejan, Dajić-Stevanović, Zora, "Screening inland halophytes from the central Balkan for their antioxidant activity in relation to total phenolic compounds and flavonoids: Are there any prospective medicinal plants?" in Journal of Arid Environments, 120 (2015):26-32,
https://doi.org/10.1016/j.jaridenv.2015.04.008 . .