Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids
Optimizacija sinteze i in vitro proučavanje antimikrobnog dejstva α,β-nezasićenih i α-bromkarboksilnih kiselina
dc.creator | Vitnik, Vesna | |
dc.creator | Milenković, Marina | |
dc.creator | Dilber, Sanda P. | |
dc.creator | Vitnik, Željko | |
dc.creator | Juranić, Ivan | |
dc.date.accessioned | 2019-01-30T17:29:34Z | |
dc.date.available | 2019-01-30T17:29:34Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/964 | |
dc.description.abstract | A series of α,β-unsaturated and α-bromo carboxylic acids were identified as potent antimicrobial agents. The antimicrobial activity was evaluated using the broth microdilution method. All acids 1-12 exhibited a significant activity against nine laboratory control strains of bacteria and two strains of yeast Candida albicans. The tested acids were efficiently prepared by optimized phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent with triethylbenzyl ammonium chloride (TEBA) as catalyst. | en |
dc.description.abstract | U ovom radu je prikazano in vitro ispitivanje antimikrobnog dejstva serije α,β-nezasićenih i α-bromkarboksilnih kiselina i pokazano je da su one potencijalno dobri antimikrobni agensi. Sve kiseline 1-12 pokazale su značajnu aktivnost prema devet sojeva bakterija i dva soja gljivica Candida albicans. Ispitivane kiseline sintetisane su u optimizovanoj reakciji ketona sa bromoformom i litijum-hidroksidom u smesi rastvarača (terc-butanol/voda). Kao katalizator za prenos između faza upotrebljen je trietilbenzilamonijum-hlorid (TEBA). | sr |
dc.publisher | Serbian Chemical Society | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | antimicrobial activity | en |
dc.subject | one-pot synthesis | en |
dc.subject | ketones | en |
dc.subject | bromoform | en |
dc.title | Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids | en |
dc.title | Optimizacija sinteze i in vitro proučavanje antimikrobnog dejstva α,β-nezasićenih i α-bromkarboksilnih kiselina | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Јураниц, Иван О.; Витник, Жељко; Витник, Весна; Дилбер, Санда П.; Миленковиц, Марина Т.; Оптимизација синтезе и ин витро проучавање антимикробног дејства α,β-незасићених и α-бромкарбоксилних киселина; Оптимизација синтезе и ин витро проучавање антимикробног дејства α,β-незасићених и α-бромкарбоксилних киселина; | |
dc.citation.volume | 77 | |
dc.citation.issue | 6 | |
dc.citation.spage | 741 | |
dc.citation.epage | 750 | |
dc.citation.other | 77(6): 741-750 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.2298/JSC111104016V | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/9535/962.pdf | |
dc.identifier.scopus | 2-s2.0-84864535005 | |
dc.identifier.wos | 000306093300004 | |
dc.type.version | publishedVersion |