Peroxisome Proliferator-Activated Receptors and Atherosclerosis
Samo za registrovane korisnike
2011
Autori
Soskic, Sanja S.Dobutovic, Branislava D.
Sudar, Emina M.
Obradovic, Milan M.
Nikolic, Dragana M.
Zarić, Božidarka
Stojanović, Srđan
Stokic, Edita J.
Mikhailidis, Dimitri P.
Isenovic, Esma R.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents... in the treatment of complex disease such as atherosclerosis.
Ključne reči:
peroxisome proliferator-activated receptors alpha / atherosclerosis / peroxisome proliferator-activated receptors gamma / atherosclerotic plaqueIzvor:
Angiology, 2011, 62, 7, 523-534Izdavač:
- Sage Publications Inc, Thousand Oaks
Finansiranje / projekti:
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
- Proučavanje fizičkohemijskih i biohemijskih procesa u životnoj sredini koji utiču na zagađenje i istraživanje mogućnosti za minimiziranje posledica (RS-MESTD-Basic Research (BR or ON)-172001)
DOI: 10.1177/0003319711401012
ISSN: 0003-3197
PubMed: 21467121
WoS: 000295729400003
Scopus: 2-s2.0-80054761005
Institucija/grupa
IHTMTY - JOUR AU - Soskic, Sanja S. AU - Dobutovic, Branislava D. AU - Sudar, Emina M. AU - Obradovic, Milan M. AU - Nikolic, Dragana M. AU - Zarić, Božidarka AU - Stojanović, Srđan AU - Stokic, Edita J. AU - Mikhailidis, Dimitri P. AU - Isenovic, Esma R. PY - 2011 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/762 AB - The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis. PB - Sage Publications Inc, Thousand Oaks T2 - Angiology T1 - Peroxisome Proliferator-Activated Receptors and Atherosclerosis VL - 62 IS - 7 SP - 523 EP - 534 DO - 10.1177/0003319711401012 ER -
@article{ author = "Soskic, Sanja S. and Dobutovic, Branislava D. and Sudar, Emina M. and Obradovic, Milan M. and Nikolic, Dragana M. and Zarić, Božidarka and Stojanović, Srđan and Stokic, Edita J. and Mikhailidis, Dimitri P. and Isenovic, Esma R.", year = "2011", abstract = "The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Angiology", title = "Peroxisome Proliferator-Activated Receptors and Atherosclerosis", volume = "62", number = "7", pages = "523-534", doi = "10.1177/0003319711401012" }
Soskic, S. S., Dobutovic, B. D., Sudar, E. M., Obradovic, M. M., Nikolic, D. M., Zarić, B., Stojanović, S., Stokic, E. J., Mikhailidis, D. P.,& Isenovic, E. R.. (2011). Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology Sage Publications Inc, Thousand Oaks., 62(7), 523-534. https://doi.org/10.1177/0003319711401012
Soskic SS, Dobutovic BD, Sudar EM, Obradovic MM, Nikolic DM, Zarić B, Stojanović S, Stokic EJ, Mikhailidis DP, Isenovic ER. Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology. 2011;62(7):523-534. doi:10.1177/0003319711401012 .
Soskic, Sanja S., Dobutovic, Branislava D., Sudar, Emina M., Obradovic, Milan M., Nikolic, Dragana M., Zarić, Božidarka, Stojanović, Srđan, Stokic, Edita J., Mikhailidis, Dimitri P., Isenovic, Esma R., "Peroxisome Proliferator-Activated Receptors and Atherosclerosis" in Angiology, 62, no. 7 (2011):523-534, https://doi.org/10.1177/0003319711401012 . .