Peroxisome Proliferator-Activated Receptors and Atherosclerosis
Само за регистроване кориснике
2011
Аутори
Soskic, Sanja S.Dobutovic, Branislava D.
Sudar, Emina M.
Obradovic, Milan M.
Nikolic, Dragana M.
Zarić, Božidarka
Stojanović, Srđan
Stokic, Edita J.
Mikhailidis, Dimitri P.
Isenovic, Esma R.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents... in the treatment of complex disease such as atherosclerosis.
Кључне речи:
peroxisome proliferator-activated receptors alpha / atherosclerosis / peroxisome proliferator-activated receptors gamma / atherosclerotic plaqueИзвор:
Angiology, 2011, 62, 7, 523-534Издавач:
- Sage Publications Inc, Thousand Oaks
Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
- Проучавање физичкохемијских и биохемијских процеса у животној средини који утичу на загађење и истраживање могућности за минимизирање последица (RS-MESTD-Basic Research (BR or ON)-172001)
DOI: 10.1177/0003319711401012
ISSN: 0003-3197
PubMed: 21467121
WoS: 000295729400003
Scopus: 2-s2.0-80054761005
Институција/група
IHTMTY - JOUR AU - Soskic, Sanja S. AU - Dobutovic, Branislava D. AU - Sudar, Emina M. AU - Obradovic, Milan M. AU - Nikolic, Dragana M. AU - Zarić, Božidarka AU - Stojanović, Srđan AU - Stokic, Edita J. AU - Mikhailidis, Dimitri P. AU - Isenovic, Esma R. PY - 2011 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/762 AB - The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis. PB - Sage Publications Inc, Thousand Oaks T2 - Angiology T1 - Peroxisome Proliferator-Activated Receptors and Atherosclerosis VL - 62 IS - 7 SP - 523 EP - 534 DO - 10.1177/0003319711401012 ER -
@article{ author = "Soskic, Sanja S. and Dobutovic, Branislava D. and Sudar, Emina M. and Obradovic, Milan M. and Nikolic, Dragana M. and Zarić, Božidarka and Stojanović, Srđan and Stokic, Edita J. and Mikhailidis, Dimitri P. and Isenovic, Esma R.", year = "2011", abstract = "The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Angiology", title = "Peroxisome Proliferator-Activated Receptors and Atherosclerosis", volume = "62", number = "7", pages = "523-534", doi = "10.1177/0003319711401012" }
Soskic, S. S., Dobutovic, B. D., Sudar, E. M., Obradovic, M. M., Nikolic, D. M., Zarić, B., Stojanović, S., Stokic, E. J., Mikhailidis, D. P.,& Isenovic, E. R.. (2011). Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology Sage Publications Inc, Thousand Oaks., 62(7), 523-534. https://doi.org/10.1177/0003319711401012
Soskic SS, Dobutovic BD, Sudar EM, Obradovic MM, Nikolic DM, Zarić B, Stojanović S, Stokic EJ, Mikhailidis DP, Isenovic ER. Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology. 2011;62(7):523-534. doi:10.1177/0003319711401012 .
Soskic, Sanja S., Dobutovic, Branislava D., Sudar, Emina M., Obradovic, Milan M., Nikolic, Dragana M., Zarić, Božidarka, Stojanović, Srđan, Stokic, Edita J., Mikhailidis, Dimitri P., Isenovic, Esma R., "Peroxisome Proliferator-Activated Receptors and Atherosclerosis" in Angiology, 62, no. 7 (2011):523-534, https://doi.org/10.1177/0003319711401012 . .