Inhibition potency of disulphides and trisulphides on various tumor cell lines growth
2021
Authors
Mandić, BorisSimić, Katarina
Trifunović, Snežana
Vujisić, Ljubodrag
Novaković, Miroslav
Tešević, Vele
Miljanić, Ognjen Š.
Article (Published version)
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Tumor is one of the leading diseases of today. Chemotherapy and radiation therapy healing chances are limited, so some alternative methods are resorted to. Many papers indicated that garlic and organosulphur compounds diallyldisulphide (DADS) and diallyltrisulphide, which are main components of garlic decrease the cancer risk and inhibit the cell proliferation. In this paper inhibition potency of disulphides (DADS and its synthetic analogues) and trisulphides with different alkyl and phenyl substituents on growth of various tumor (Non-Small cell Lung Cancer, Colon cancer, CNS Cancer, Melanoma, Ovarian Cancer, Renal Cancer, Prostate Cancer, Breast Cancer, Leukemia) cell lines was investigated. Concentration of each compound (DADS, diethyl disulphide, dipropyl disulphide, diphenyl disulphide, tetraethylthiuram disulphide (TETUDS), dimetil trisulphide, dipropyl trisulphide and metilpropyl trisulphide (MPTS) was 10 µmol/L. It was found that DADS has an inhibitory effect on the growth of se...veral cancer cell lines, but synthetic analogues TETUDS and MPTS exhibit stronger effect on certain cells lines. MPTS inhibits the growth of even 12 cell lines for more than 10%, especially leukemia cell line SR and NCI-H522 cell line of Non-Small cell Lung Cancer (reduction of growth for 24% and 47%, resp.). Trisulphide analogues exhibit little higher inhibitory effects in comparison to disulphide ones.
Keywords:
Diallyl disulphide and its synthetic analogues / Garlic / Trisulphides / Tumor cell lines inhibitionSource:
Digest Journal of Nanomaterials and Biostructures, 2021, 16, 2, 585-592Publisher:
- S.C. Virtual Company of Phisics S.R.L
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-MESTD-inst-2020-200168)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-MESTD-inst-2020-200026)
- Department of Chemistry, University of Houston, 112 Fleming Building, Houston TX 77204- 5003, USA
DOI: 10.15251/DJNB.2021.162.585
ISSN: 1842-3582
WoS: 000669553000024
Scopus: 2-s2.0-85148659289
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IHTMTY - JOUR AU - Mandić, Boris AU - Simić, Katarina AU - Trifunović, Snežana AU - Vujisić, Ljubodrag AU - Novaković, Miroslav AU - Tešević, Vele AU - Miljanić, Ognjen Š. PY - 2021 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7389 AB - Tumor is one of the leading diseases of today. Chemotherapy and radiation therapy healing chances are limited, so some alternative methods are resorted to. Many papers indicated that garlic and organosulphur compounds diallyldisulphide (DADS) and diallyltrisulphide, which are main components of garlic decrease the cancer risk and inhibit the cell proliferation. In this paper inhibition potency of disulphides (DADS and its synthetic analogues) and trisulphides with different alkyl and phenyl substituents on growth of various tumor (Non-Small cell Lung Cancer, Colon cancer, CNS Cancer, Melanoma, Ovarian Cancer, Renal Cancer, Prostate Cancer, Breast Cancer, Leukemia) cell lines was investigated. Concentration of each compound (DADS, diethyl disulphide, dipropyl disulphide, diphenyl disulphide, tetraethylthiuram disulphide (TETUDS), dimetil trisulphide, dipropyl trisulphide and metilpropyl trisulphide (MPTS) was 10 µmol/L. It was found that DADS has an inhibitory effect on the growth of several cancer cell lines, but synthetic analogues TETUDS and MPTS exhibit stronger effect on certain cells lines. MPTS inhibits the growth of even 12 cell lines for more than 10%, especially leukemia cell line SR and NCI-H522 cell line of Non-Small cell Lung Cancer (reduction of growth for 24% and 47%, resp.). Trisulphide analogues exhibit little higher inhibitory effects in comparison to disulphide ones. PB - S.C. Virtual Company of Phisics S.R.L T2 - Digest Journal of Nanomaterials and Biostructures T1 - Inhibition potency of disulphides and trisulphides on various tumor cell lines growth VL - 16 IS - 2 SP - 585 EP - 592 DO - 10.15251/DJNB.2021.162.585 ER -
@article{ author = "Mandić, Boris and Simić, Katarina and Trifunović, Snežana and Vujisić, Ljubodrag and Novaković, Miroslav and Tešević, Vele and Miljanić, Ognjen Š.", year = "2021", abstract = "Tumor is one of the leading diseases of today. Chemotherapy and radiation therapy healing chances are limited, so some alternative methods are resorted to. Many papers indicated that garlic and organosulphur compounds diallyldisulphide (DADS) and diallyltrisulphide, which are main components of garlic decrease the cancer risk and inhibit the cell proliferation. In this paper inhibition potency of disulphides (DADS and its synthetic analogues) and trisulphides with different alkyl and phenyl substituents on growth of various tumor (Non-Small cell Lung Cancer, Colon cancer, CNS Cancer, Melanoma, Ovarian Cancer, Renal Cancer, Prostate Cancer, Breast Cancer, Leukemia) cell lines was investigated. Concentration of each compound (DADS, diethyl disulphide, dipropyl disulphide, diphenyl disulphide, tetraethylthiuram disulphide (TETUDS), dimetil trisulphide, dipropyl trisulphide and metilpropyl trisulphide (MPTS) was 10 µmol/L. It was found that DADS has an inhibitory effect on the growth of several cancer cell lines, but synthetic analogues TETUDS and MPTS exhibit stronger effect on certain cells lines. MPTS inhibits the growth of even 12 cell lines for more than 10%, especially leukemia cell line SR and NCI-H522 cell line of Non-Small cell Lung Cancer (reduction of growth for 24% and 47%, resp.). Trisulphide analogues exhibit little higher inhibitory effects in comparison to disulphide ones.", publisher = "S.C. Virtual Company of Phisics S.R.L", journal = "Digest Journal of Nanomaterials and Biostructures", title = "Inhibition potency of disulphides and trisulphides on various tumor cell lines growth", volume = "16", number = "2", pages = "585-592", doi = "10.15251/DJNB.2021.162.585" }
Mandić, B., Simić, K., Trifunović, S., Vujisić, L., Novaković, M., Tešević, V.,& Miljanić, O. Š.. (2021). Inhibition potency of disulphides and trisulphides on various tumor cell lines growth. in Digest Journal of Nanomaterials and Biostructures S.C. Virtual Company of Phisics S.R.L., 16(2), 585-592. https://doi.org/10.15251/DJNB.2021.162.585
Mandić B, Simić K, Trifunović S, Vujisić L, Novaković M, Tešević V, Miljanić OŠ. Inhibition potency of disulphides and trisulphides on various tumor cell lines growth. in Digest Journal of Nanomaterials and Biostructures. 2021;16(2):585-592. doi:10.15251/DJNB.2021.162.585 .
Mandić, Boris, Simić, Katarina, Trifunović, Snežana, Vujisić, Ljubodrag, Novaković, Miroslav, Tešević, Vele, Miljanić, Ognjen Š., "Inhibition potency of disulphides and trisulphides on various tumor cell lines growth" in Digest Journal of Nanomaterials and Biostructures, 16, no. 2 (2021):585-592, https://doi.org/10.15251/DJNB.2021.162.585 . .