Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering
Апстракт
Magnesium (Mg) is an essential element in the human body primarily stored in bones. Mg ions have many potential benefits for bone tissue showing excellent osteogenic inductivity [1]. The aim of this study was to synthesize Mg substituted hydroxyapatite (Mg-HAP) for application in bone tissue engineering and to assess its behaviour in conditions mimicking physiological ones. Mg-HAP was synthesized using reflux method and its structural and morphological characterization was performed by XRD, FTIR and SEM. The changes in local structure and composition after irradiation and immersion in physiological solution and simulated fluid were assessed by electron paramagnetic resonance (EPR) spectroscopy. The results of EPR analysis pointed out that irradiation did not change the composition and structure of Mg-HAP. After immersion in model media (simulated body fluid and saline solution), the small amount of by-product of synthesis disappeared after 24 h and Mg-HAP remained the only phase. Also,... the radical signals in EPR spectra faded away after 28 days in model media, showing that the structure and composition of Mg-HAP both went through a kind of stabilization in simulated physiological conditions. These results make the investigated Mg-HAP promising material for application in bone tissue engineering.
Извор:
Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade, 2023, 83-83Издавач:
- Belgrade : University of Belgrade, Institute for Multidisciplinary Research
Институција/група
IHTMTY - CONF AU - Petrović, Božana AU - Krstić, Maja AU - Mudrinić, Tihana AU - Čebela, Maria AU - Dutour Sikirić, Maja PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7361 AB - Magnesium (Mg) is an essential element in the human body primarily stored in bones. Mg ions have many potential benefits for bone tissue showing excellent osteogenic inductivity [1]. The aim of this study was to synthesize Mg substituted hydroxyapatite (Mg-HAP) for application in bone tissue engineering and to assess its behaviour in conditions mimicking physiological ones. Mg-HAP was synthesized using reflux method and its structural and morphological characterization was performed by XRD, FTIR and SEM. The changes in local structure and composition after irradiation and immersion in physiological solution and simulated fluid were assessed by electron paramagnetic resonance (EPR) spectroscopy. The results of EPR analysis pointed out that irradiation did not change the composition and structure of Mg-HAP. After immersion in model media (simulated body fluid and saline solution), the small amount of by-product of synthesis disappeared after 24 h and Mg-HAP remained the only phase. Also, the radical signals in EPR spectra faded away after 28 days in model media, showing that the structure and composition of Mg-HAP both went through a kind of stabilization in simulated physiological conditions. These results make the investigated Mg-HAP promising material for application in bone tissue engineering. PB - Belgrade : University of Belgrade, Institute for Multidisciplinary Research C3 - Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade T1 - Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering SP - 83 EP - 83 UR - https://hdl.handle.net/21.15107/rcub_cer_7361 ER -
@conference{ author = "Petrović, Božana and Krstić, Maja and Mudrinić, Tihana and Čebela, Maria and Dutour Sikirić, Maja", year = "2023", abstract = "Magnesium (Mg) is an essential element in the human body primarily stored in bones. Mg ions have many potential benefits for bone tissue showing excellent osteogenic inductivity [1]. The aim of this study was to synthesize Mg substituted hydroxyapatite (Mg-HAP) for application in bone tissue engineering and to assess its behaviour in conditions mimicking physiological ones. Mg-HAP was synthesized using reflux method and its structural and morphological characterization was performed by XRD, FTIR and SEM. The changes in local structure and composition after irradiation and immersion in physiological solution and simulated fluid were assessed by electron paramagnetic resonance (EPR) spectroscopy. The results of EPR analysis pointed out that irradiation did not change the composition and structure of Mg-HAP. After immersion in model media (simulated body fluid and saline solution), the small amount of by-product of synthesis disappeared after 24 h and Mg-HAP remained the only phase. Also, the radical signals in EPR spectra faded away after 28 days in model media, showing that the structure and composition of Mg-HAP both went through a kind of stabilization in simulated physiological conditions. These results make the investigated Mg-HAP promising material for application in bone tissue engineering.", publisher = "Belgrade : University of Belgrade, Institute for Multidisciplinary Research", journal = "Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade", title = "Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering", pages = "83-83", url = "https://hdl.handle.net/21.15107/rcub_cer_7361" }
Petrović, B., Krstić, M., Mudrinić, T., Čebela, M.,& Dutour Sikirić, M.. (2023). Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering. in Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade Belgrade : University of Belgrade, Institute for Multidisciplinary Research., 83-83. https://hdl.handle.net/21.15107/rcub_cer_7361
Petrović B, Krstić M, Mudrinić T, Čebela M, Dutour Sikirić M. Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering. in Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade. 2023;:83-83. https://hdl.handle.net/21.15107/rcub_cer_7361 .
Petrović, Božana, Krstić, Maja, Mudrinić, Tihana, Čebela, Maria, Dutour Sikirić, Maja, "Mg Substituted Hydroxyapatite for Application in Bone Tissue Engineering" in Programme and the Book of Abstracts / 7th Conference of The Serbian Society for Ceramic Materials, 7CSCS-2023, June 14-16, 2023 Belgrade (2023):83-83, https://hdl.handle.net/21.15107/rcub_cer_7361 .