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Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti
dc.creator | Vujic, Jelena M. | |
dc.creator | Cvijovic, Milica | |
dc.creator | Kaluđerović, Goran N. | |
dc.creator | Milovanovic, Marija | |
dc.creator | Zmejkovski, Bojana | |
dc.creator | Volarevic, Vladislav | |
dc.creator | Arsenijevic, Nebojsa | |
dc.creator | Sabo, Tibor | |
dc.creator | Trifunovic, Srecko R. | |
dc.date.accessioned | 2019-01-30T17:24:05Z | |
dc.date.available | 2019-01-30T17:24:05Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/710 | |
dc.description.abstract | Four novel bidentate N,N'-ligand precursors, including O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1 center dot 2HCl-L4 center dot 2HCl, of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 and the corresponding palladium(II) complexes 1-4, were prepared and characterized by IR, H-1 NMR and C-13 NMR spectroscopy and elemental analysis. In vitro cytotoxicity of all compounds was determined against chronic lymphocytic leukemia cells (CLL). The compounds were found to exhibit higher antitumoral activity than cisplatin. The most active compound 2, [PdCl2{(S,S)-nPr(2)eddl}], was found to be 13.6 times more active than cisplatin on CLL cells. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Paris | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142008/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145065/RS// | |
dc.relation | EC | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Medicinal Chemistry | |
dc.subject | Palladium(II) complexes | en |
dc.subject | Edda-type ligands | en |
dc.subject | Antitumoral activity | en |
dc.subject | Chronic lymphocytic leukemia cells | en |
dc.title | Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Трифуновиц, Срецко Р.; Вујиц, Јелена М.; Цвијовиц, Милица; Миловановиц, Марија; Aрсенијевиц, Небојса; Воларевиц, Владислав; Змејковски, Бојана; Сабо, Тибор Ј.; Калудеровиц, Горан Н.; | |
dc.citation.volume | 45 | |
dc.citation.issue | 9 | |
dc.citation.spage | 3601 | |
dc.citation.epage | 3606 | |
dc.citation.other | 45(9): 3601-3606 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 20570025 | |
dc.identifier.doi | 10.1016/j.ejmech.2010.05.005 | |
dc.identifier.scopus | 2-s2.0-77955558644 | |
dc.identifier.wos | 000281568600011 | |
dc.type.version | publishedVersion |