Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti
Samo za registrovane korisnike
2010
Autori
Vujic, Jelena M.Cvijovic, Milica
Kaluđerović, Goran N.
Milovanovic, Marija
Zmejkovski, Bojana
Volarevic, Vladislav
Arsenijevic, Nebojsa
Sabo, Tibor
Trifunovic, Srecko R.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Four novel bidentate N,N'-ligand precursors, including O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1 center dot 2HCl-L4 center dot 2HCl, of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 and the corresponding palladium(II) complexes 1-4, were prepared and characterized by IR, H-1 NMR and C-13 NMR spectroscopy and elemental analysis. In vitro cytotoxicity of all compounds was determined against chronic lymphocytic leukemia cells (CLL). The compounds were found to exhibit higher antitumoral activity than cisplatin. The most active compound 2, [PdCl2{(S,S)-nPr(2)eddl}], was found to be 13.6 times more active than cisplatin on CLL cells.
Ključne reči:
Palladium(II) complexes / Edda-type ligands / Antitumoral activity / Chronic lymphocytic leukemia cellsIzvor:
European Journal of Medicinal Chemistry, 2010, 45, 9, 3601-3606Izdavač:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
Finansiranje / projekti:
- Sinteza, karakterizacija i aktivnost organskih i koordinacionih jedinjenja i njihova primena u (bio)nanotehnologiji (RS-142010)
- Struktura novih kompleksa jona prelaznih metala i mehanizam njihovih reakcija sa biološki značajnim ligandima (RS-142008)
- Imnoregulatorne interakcije u tumorskim i autoimunskim fenomenima (RS-145065)
- EC
DOI: 10.1016/j.ejmech.2010.05.005
ISSN: 0223-5234
PubMed: 20570025
WoS: 000281568600011
Scopus: 2-s2.0-77955558644
Institucija/grupa
IHTMTY - JOUR AU - Vujic, Jelena M. AU - Cvijovic, Milica AU - Kaluđerović, Goran N. AU - Milovanovic, Marija AU - Zmejkovski, Bojana AU - Volarevic, Vladislav AU - Arsenijevic, Nebojsa AU - Sabo, Tibor AU - Trifunovic, Srecko R. PY - 2010 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/710 AB - Four novel bidentate N,N'-ligand precursors, including O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1 center dot 2HCl-L4 center dot 2HCl, of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 and the corresponding palladium(II) complexes 1-4, were prepared and characterized by IR, H-1 NMR and C-13 NMR spectroscopy and elemental analysis. In vitro cytotoxicity of all compounds was determined against chronic lymphocytic leukemia cells (CLL). The compounds were found to exhibit higher antitumoral activity than cisplatin. The most active compound 2, [PdCl2{(S,S)-nPr(2)eddl}], was found to be 13.6 times more active than cisplatin on CLL cells. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris T2 - European Journal of Medicinal Chemistry T1 - Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti VL - 45 IS - 9 SP - 3601 EP - 3606 DO - 10.1016/j.ejmech.2010.05.005 ER -
@article{ author = "Vujic, Jelena M. and Cvijovic, Milica and Kaluđerović, Goran N. and Milovanovic, Marija and Zmejkovski, Bojana and Volarevic, Vladislav and Arsenijevic, Nebojsa and Sabo, Tibor and Trifunovic, Srecko R.", year = "2010", abstract = "Four novel bidentate N,N'-ligand precursors, including O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1 center dot 2HCl-L4 center dot 2HCl, of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 and the corresponding palladium(II) complexes 1-4, were prepared and characterized by IR, H-1 NMR and C-13 NMR spectroscopy and elemental analysis. In vitro cytotoxicity of all compounds was determined against chronic lymphocytic leukemia cells (CLL). The compounds were found to exhibit higher antitumoral activity than cisplatin. The most active compound 2, [PdCl2{(S,S)-nPr(2)eddl}], was found to be 13.6 times more active than cisplatin on CLL cells.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris", journal = "European Journal of Medicinal Chemistry", title = "Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti", volume = "45", number = "9", pages = "3601-3606", doi = "10.1016/j.ejmech.2010.05.005" }
Vujic, J. M., Cvijovic, M., Kaluđerović, G. N., Milovanovic, M., Zmejkovski, B., Volarevic, V., Arsenijevic, N., Sabo, T.,& Trifunovic, S. R.. (2010). Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 45(9), 3601-3606. https://doi.org/10.1016/j.ejmech.2010.05.005
Vujic JM, Cvijovic M, Kaluđerović GN, Milovanovic M, Zmejkovski B, Volarevic V, Arsenijevic N, Sabo T, Trifunovic SR. Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti. in European Journal of Medicinal Chemistry. 2010;45(9):3601-3606. doi:10.1016/j.ejmech.2010.05.005 .
Vujic, Jelena M., Cvijovic, Milica, Kaluđerović, Goran N., Milovanovic, Marija, Zmejkovski, Bojana, Volarevic, Vladislav, Arsenijevic, Nebojsa, Sabo, Tibor, Trifunovic, Srecko R., "Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti" in European Journal of Medicinal Chemistry, 45, no. 9 (2010):3601-3606, https://doi.org/10.1016/j.ejmech.2010.05.005 . .