Sinteza i in vitro antitumourska aktivnost novih mimetika goniofufurona sa tiofenskim prstenom na položaju C-7
Synthesis and in vitro antitumour activity of new goniofufurone mimics with thiophene ring at the C-7 position
2018
Authors
Popsavin, MirjanaKovačević, Ivana
Kekezović, Slađana
Svirčev, Miloš
Srećo Zelenović, Bojana
Kojić, Vesna V.
Jadranin, Milka
Popsavin, Velimir
Conference object (Published version)
Metadata
Show full item recordAbstract
Ostvarena je višefazna sinteza novih mimetika (+)-goniofufurona (1) sa tiofenskim prstenom umesto fenil grupe u položaju C-7 polazeći iz D-glukoze (Shema 1). Ispitana je in vitro citotoksična aktivnost novosintetizovanih mimetika prema odabranim tumorskim ćelijskim linijama, kao i prema jednoj normalnoj ćelijskoj liniji (fetalni fibroblasti pluća, MRC-5).
Multiphase synthesis of (+)-goniofufurone (1) mimetics with thiofene ring instead of phenyl group at the C-7 position is completed using D-glucose as a starting compound (Scheme 1). In vitro cytotoxicity of newly synthetized analogues against eleven human tumour cell lines and against a single normal cell line (MRC-5) was evaluated.
Keywords:
sinteza / synthesisSource:
Kratki izvodi radova - 55. Savetovanje Srpskog hemijskog društva, 8. i 9. juni 2018, Novi Sad / Book of abstracts - 55 Meeting of the Serbian Chemical Society, June 8-9, 2018, Novi Sad, 2018, 82-82Publisher:
- Belgrade : Serbian Chemical Society
Funding / projects:
- Synthesis and biological testing of new mimics or derivatives of selected cytotoxic lactones, antitumor agent tiazofurin and natural naphthenic acids (RS-MESTD-Basic Research (BR or ON)-172006)
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IHTMTY - CONF AU - Popsavin, Mirjana AU - Kovačević, Ivana AU - Kekezović, Slađana AU - Svirčev, Miloš AU - Srećo Zelenović, Bojana AU - Kojić, Vesna V. AU - Jadranin, Milka AU - Popsavin, Velimir PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7095 AB - Ostvarena je višefazna sinteza novih mimetika (+)-goniofufurona (1) sa tiofenskim prstenom umesto fenil grupe u položaju C-7 polazeći iz D-glukoze (Shema 1). Ispitana je in vitro citotoksična aktivnost novosintetizovanih mimetika prema odabranim tumorskim ćelijskim linijama, kao i prema jednoj normalnoj ćelijskoj liniji (fetalni fibroblasti pluća, MRC-5). AB - Multiphase synthesis of (+)-goniofufurone (1) mimetics with thiofene ring instead of phenyl group at the C-7 position is completed using D-glucose as a starting compound (Scheme 1). In vitro cytotoxicity of newly synthetized analogues against eleven human tumour cell lines and against a single normal cell line (MRC-5) was evaluated. PB - Belgrade : Serbian Chemical Society C3 - Kratki izvodi radova - 55. Savetovanje Srpskog hemijskog društva, 8. i 9. juni 2018, Novi Sad / Book of abstracts - 55 Meeting of the Serbian Chemical Society, June 8-9, 2018, Novi Sad T1 - Sinteza i in vitro antitumourska aktivnost novih mimetika goniofufurona sa tiofenskim prstenom na položaju C-7 T1 - Synthesis and in vitro antitumour activity of new goniofufurone mimics with thiophene ring at the C-7 position SP - 82 EP - 82 UR - https://hdl.handle.net/21.15107/rcub_cer_7095 ER -
@conference{ author = "Popsavin, Mirjana and Kovačević, Ivana and Kekezović, Slađana and Svirčev, Miloš and Srećo Zelenović, Bojana and Kojić, Vesna V. and Jadranin, Milka and Popsavin, Velimir", year = "2018", abstract = "Ostvarena je višefazna sinteza novih mimetika (+)-goniofufurona (1) sa tiofenskim prstenom umesto fenil grupe u položaju C-7 polazeći iz D-glukoze (Shema 1). Ispitana je in vitro citotoksična aktivnost novosintetizovanih mimetika prema odabranim tumorskim ćelijskim linijama, kao i prema jednoj normalnoj ćelijskoj liniji (fetalni fibroblasti pluća, MRC-5)., Multiphase synthesis of (+)-goniofufurone (1) mimetics with thiofene ring instead of phenyl group at the C-7 position is completed using D-glucose as a starting compound (Scheme 1). In vitro cytotoxicity of newly synthetized analogues against eleven human tumour cell lines and against a single normal cell line (MRC-5) was evaluated.", publisher = "Belgrade : Serbian Chemical Society", journal = "Kratki izvodi radova - 55. Savetovanje Srpskog hemijskog društva, 8. i 9. juni 2018, Novi Sad / Book of abstracts - 55 Meeting of the Serbian Chemical Society, June 8-9, 2018, Novi Sad", title = "Sinteza i in vitro antitumourska aktivnost novih mimetika goniofufurona sa tiofenskim prstenom na položaju C-7, Synthesis and in vitro antitumour activity of new goniofufurone mimics with thiophene ring at the C-7 position", pages = "82-82", url = "https://hdl.handle.net/21.15107/rcub_cer_7095" }
Popsavin, M., Kovačević, I., Kekezović, S., Svirčev, M., Srećo Zelenović, B., Kojić, V. V., Jadranin, M.,& Popsavin, V.. (2018). Sinteza i in vitro antitumourska aktivnost novih mimetika goniofufurona sa tiofenskim prstenom na položaju C-7. in Kratki izvodi radova - 55. Savetovanje Srpskog hemijskog društva, 8. i 9. juni 2018, Novi Sad / Book of abstracts - 55 Meeting of the Serbian Chemical Society, June 8-9, 2018, Novi Sad Belgrade : Serbian Chemical Society., 82-82. https://hdl.handle.net/21.15107/rcub_cer_7095
Popsavin M, Kovačević I, Kekezović S, Svirčev M, Srećo Zelenović B, Kojić VV, Jadranin M, Popsavin V. Sinteza i in vitro antitumourska aktivnost novih mimetika goniofufurona sa tiofenskim prstenom na položaju C-7. in Kratki izvodi radova - 55. Savetovanje Srpskog hemijskog društva, 8. i 9. juni 2018, Novi Sad / Book of abstracts - 55 Meeting of the Serbian Chemical Society, June 8-9, 2018, Novi Sad. 2018;:82-82. https://hdl.handle.net/21.15107/rcub_cer_7095 .
Popsavin, Mirjana, Kovačević, Ivana, Kekezović, Slađana, Svirčev, Miloš, Srećo Zelenović, Bojana, Kojić, Vesna V., Jadranin, Milka, Popsavin, Velimir, "Sinteza i in vitro antitumourska aktivnost novih mimetika goniofufurona sa tiofenskim prstenom na položaju C-7" in Kratki izvodi radova - 55. Savetovanje Srpskog hemijskog društva, 8. i 9. juni 2018, Novi Sad / Book of abstracts - 55 Meeting of the Serbian Chemical Society, June 8-9, 2018, Novi Sad (2018):82-82, https://hdl.handle.net/21.15107/rcub_cer_7095 .