Novel Immunomodulatory and Anti-inflammatory Nano Amorphous Calcium Phosphate@Chitosan Oligolactate coatings on titanium substrate for potential medical and dental use
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Background: Titanium (Ti) is widely used in medical and dental implants. Calcium phosphate (CPs) coatings enhance Ti implants' osteoinductive properties, and additives further improve these coatings. Recently, a nano amorphous calcium phosphate (nACP) coating decorated with chitosane oligolactate (ChOL) and selenium (Se) showed immunomodulatory effects. This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se release mechanism of the nACP/ChOL/Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the ACP/ChOL/Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Surface morphology was analyzed using SEM, AFM, XRD, and FTIR. The distribution of Se within the coating was examined with EDS. Bioactivity was evaluated in simulated body fluid (SBF), and adhesion was tested using a scratch test method. In vitro testing determined the release mechanism of Se. SEM images illustra...ted the surface morphology, while AFM provided a detailed analysis of surface roughness. XRD analysis revealed structural and phase composition, and EDS confirmed Se distribution within the coating. The coating exhibited bioactivity in SBF and showed good adhesion according to the scratch test. In vitro testing uncovered the release mechanism of Se from the coating. This study successfully characterized the surface morphology, composition, bioactivity, and Se release mechanism of the
nACP/ChOL/Se hybrid coating on Ti substrates, offering insights for developing immunomodulatory coatings for medical and dental applications.
Keywords:
deposition / hybrid coating / ion release / implants / inflammatory mediators / nano calcium phosphateSource:
Proceedings - Fifth International Symposium on Corrosion and Materials Protection, Environmental Protection and Protection Against Fire, September 26-29, Bar, Montenegro, 2023, 22-46Publisher:
- Podgorica, Crna Gora : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-MESTD-inst-2020-200026)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200175 (Institute of Technical Sciences of SASA, Belgrade) (RS-MESTD-inst-2020-200175)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
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- Plenary Lecture
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IHTMTY - CONF AU - Pavlović, Miroslav AU - Pantović-Pavlović, Marijana PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7033 AB - Background: Titanium (Ti) is widely used in medical and dental implants. Calcium phosphate (CPs) coatings enhance Ti implants' osteoinductive properties, and additives further improve these coatings. Recently, a nano amorphous calcium phosphate (nACP) coating decorated with chitosane oligolactate (ChOL) and selenium (Se) showed immunomodulatory effects. This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se release mechanism of the nACP/ChOL/Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the ACP/ChOL/Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Surface morphology was analyzed using SEM, AFM, XRD, and FTIR. The distribution of Se within the coating was examined with EDS. Bioactivity was evaluated in simulated body fluid (SBF), and adhesion was tested using a scratch test method. In vitro testing determined the release mechanism of Se. SEM images illustrated the surface morphology, while AFM provided a detailed analysis of surface roughness. XRD analysis revealed structural and phase composition, and EDS confirmed Se distribution within the coating. The coating exhibited bioactivity in SBF and showed good adhesion according to the scratch test. In vitro testing uncovered the release mechanism of Se from the coating. This study successfully characterized the surface morphology, composition, bioactivity, and Se release mechanism of the nACP/ChOL/Se hybrid coating on Ti substrates, offering insights for developing immunomodulatory coatings for medical and dental applications. PB - Podgorica, Crna Gora : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine C3 - Proceedings - Fifth International Symposium on Corrosion and Materials Protection, Environmental Protection and Protection Against Fire, September 26-29, Bar, Montenegro T1 - Novel Immunomodulatory and Anti-inflammatory Nano Amorphous Calcium Phosphate@Chitosan Oligolactate coatings on titanium substrate for potential medical and dental use SP - 22 EP - 46 UR - https://hdl.handle.net/21.15107/rcub_cer_7033 ER -
@conference{ author = "Pavlović, Miroslav and Pantović-Pavlović, Marijana", year = "2023", abstract = "Background: Titanium (Ti) is widely used in medical and dental implants. Calcium phosphate (CPs) coatings enhance Ti implants' osteoinductive properties, and additives further improve these coatings. Recently, a nano amorphous calcium phosphate (nACP) coating decorated with chitosane oligolactate (ChOL) and selenium (Se) showed immunomodulatory effects. This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se release mechanism of the nACP/ChOL/Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the ACP/ChOL/Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Surface morphology was analyzed using SEM, AFM, XRD, and FTIR. The distribution of Se within the coating was examined with EDS. Bioactivity was evaluated in simulated body fluid (SBF), and adhesion was tested using a scratch test method. In vitro testing determined the release mechanism of Se. SEM images illustrated the surface morphology, while AFM provided a detailed analysis of surface roughness. XRD analysis revealed structural and phase composition, and EDS confirmed Se distribution within the coating. The coating exhibited bioactivity in SBF and showed good adhesion according to the scratch test. In vitro testing uncovered the release mechanism of Se from the coating. This study successfully characterized the surface morphology, composition, bioactivity, and Se release mechanism of the nACP/ChOL/Se hybrid coating on Ti substrates, offering insights for developing immunomodulatory coatings for medical and dental applications.", publisher = "Podgorica, Crna Gora : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine", journal = "Proceedings - Fifth International Symposium on Corrosion and Materials Protection, Environmental Protection and Protection Against Fire, September 26-29, Bar, Montenegro", title = "Novel Immunomodulatory and Anti-inflammatory Nano Amorphous Calcium Phosphate@Chitosan Oligolactate coatings on titanium substrate for potential medical and dental use", pages = "22-46", url = "https://hdl.handle.net/21.15107/rcub_cer_7033" }
Pavlović, M.,& Pantović-Pavlović, M.. (2023). Novel Immunomodulatory and Anti-inflammatory Nano Amorphous Calcium Phosphate@Chitosan Oligolactate coatings on titanium substrate for potential medical and dental use. in Proceedings - Fifth International Symposium on Corrosion and Materials Protection, Environmental Protection and Protection Against Fire, September 26-29, Bar, Montenegro Podgorica, Crna Gora : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine., 22-46. https://hdl.handle.net/21.15107/rcub_cer_7033
Pavlović M, Pantović-Pavlović M. Novel Immunomodulatory and Anti-inflammatory Nano Amorphous Calcium Phosphate@Chitosan Oligolactate coatings on titanium substrate for potential medical and dental use. in Proceedings - Fifth International Symposium on Corrosion and Materials Protection, Environmental Protection and Protection Against Fire, September 26-29, Bar, Montenegro. 2023;:22-46. https://hdl.handle.net/21.15107/rcub_cer_7033 .
Pavlović, Miroslav, Pantović-Pavlović, Marijana, "Novel Immunomodulatory and Anti-inflammatory Nano Amorphous Calcium Phosphate@Chitosan Oligolactate coatings on titanium substrate for potential medical and dental use" in Proceedings - Fifth International Symposium on Corrosion and Materials Protection, Environmental Protection and Protection Against Fire, September 26-29, Bar, Montenegro (2023):22-46, https://hdl.handle.net/21.15107/rcub_cer_7033 .