Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and phenol. The Prato reaction of the glycine derivative, aromatic aldehydes with phenol subunit and the fullerene C60 provided desired products in satisfactory yields (Figure 1). DPPH radical scavenging activity and β–carotene-linoleic acid bleaching assay were used to determinate antioxidant activity, while for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained results indicated that performed synthesis gave rise to
compounds with dual activity.
Кључне речи:
fulleropyrrolidines / Prato reactionИзвор:
9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia, 2023, 76-76Издавач:
- Belgrade : Serbian Chemical Society
- Belgrade : Serbian Young Chemists’ Club
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
Институција/група
IHTMTY - CONF AU - Trifković, Željko AU - Kotlaja, Katarina AU - Kop, Tatjana AU - Milić, Dragana PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6895 AB - Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and phenol. The Prato reaction of the glycine derivative, aromatic aldehydes with phenol subunit and the fullerene C60 provided desired products in satisfactory yields (Figure 1). DPPH radical scavenging activity and β–carotene-linoleic acid bleaching assay were used to determinate antioxidant activity, while for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained results indicated that performed synthesis gave rise to compounds with dual activity. PB - Belgrade : Serbian Chemical Society PB - Belgrade : Serbian Young Chemists’ Club C3 - 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia T1 - Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit SP - 76 EP - 76 UR - https://hdl.handle.net/21.15107/rcub_cer_6895 ER -
@conference{ author = "Trifković, Željko and Kotlaja, Katarina and Kop, Tatjana and Milić, Dragana", year = "2023", abstract = "Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and phenol. The Prato reaction of the glycine derivative, aromatic aldehydes with phenol subunit and the fullerene C60 provided desired products in satisfactory yields (Figure 1). DPPH radical scavenging activity and β–carotene-linoleic acid bleaching assay were used to determinate antioxidant activity, while for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained results indicated that performed synthesis gave rise to compounds with dual activity.", publisher = "Belgrade : Serbian Chemical Society, Belgrade : Serbian Young Chemists’ Club", journal = "9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia", title = "Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit", pages = "76-76", url = "https://hdl.handle.net/21.15107/rcub_cer_6895" }
Trifković, Ž., Kotlaja, K., Kop, T.,& Milić, D.. (2023). Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia Belgrade : Serbian Chemical Society., 76-76. https://hdl.handle.net/21.15107/rcub_cer_6895
Trifković Ž, Kotlaja K, Kop T, Milić D. Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia. 2023;:76-76. https://hdl.handle.net/21.15107/rcub_cer_6895 .
Trifković, Željko, Kotlaja, Katarina, Kop, Tatjana, Milić, Dragana, "Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing phenol subunit" in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia (2023):76-76, https://hdl.handle.net/21.15107/rcub_cer_6895 .