Cyclic voltammetry in diagnosis of ALS
2012
Authors
Mudrinić, TihanaMojović, Zorica
Jovanović, Dušan
Ignjatović, Aleksandar
Mojović, Miloš
Bačić, Goran
Conference object (Published version)
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The diagnosis of amyotrophic lateral sclerosis (ALS) based on ALS functional rating scale-revised (ALSFRS-R) scores is often shown be unreliable and false. On the other hand, magnetic resonance imaging (MRI) studies of a brain of ALS patients showed the presence of iron deposits in the precentral gyruses of gray matter (PGGM) and also the potential leakage of iron to cerebro-spinal fluid (CSF) through compromised blood-brain barrier. The aim of this study was to determine if there is a specific feature in CSF that distinguishes patients with ALS from the control subjects. CSF obtained from ALS patients and normal controls were analyzed using the technique of cyclic voltammetry. The results show that at the potential of 1.1 – 1.2 V vs. Ag/AgCl electrode, the plateau appeared and the potential of oxygen evolution with shifted toward more positive values from the ALS patients. These voltammogram features were not present for the control patients showing this technique to be promising cand...idate for evaluating new biomarkers for ALS.
Keywords:
amyotrophic lateral sclerosis / cerebro-spinal fluid / cyclic voltammetry / biomarkersSource:
Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia, 2012, 23-25Publisher:
- Biophysical Society of Serbia
Funding / projects:
- Nanostructured Functional and Composite Materials in Catalytic and Sorption Processes (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45001)
- Biomarkers in neurodegenerative and malignant processes (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41005)
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IHTMTY - CONF AU - Mudrinić, Tihana AU - Mojović, Zorica AU - Jovanović, Dušan AU - Ignjatović, Aleksandar AU - Mojović, Miloš AU - Bačić, Goran PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6826 AB - The diagnosis of amyotrophic lateral sclerosis (ALS) based on ALS functional rating scale-revised (ALSFRS-R) scores is often shown be unreliable and false. On the other hand, magnetic resonance imaging (MRI) studies of a brain of ALS patients showed the presence of iron deposits in the precentral gyruses of gray matter (PGGM) and also the potential leakage of iron to cerebro-spinal fluid (CSF) through compromised blood-brain barrier. The aim of this study was to determine if there is a specific feature in CSF that distinguishes patients with ALS from the control subjects. CSF obtained from ALS patients and normal controls were analyzed using the technique of cyclic voltammetry. The results show that at the potential of 1.1 – 1.2 V vs. Ag/AgCl electrode, the plateau appeared and the potential of oxygen evolution with shifted toward more positive values from the ALS patients. These voltammogram features were not present for the control patients showing this technique to be promising candidate for evaluating new biomarkers for ALS. PB - Biophysical Society of Serbia C3 - Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia T1 - Cyclic voltammetry in diagnosis of ALS SP - 23 EP - 25 UR - https://hdl.handle.net/21.15107/rcub_cer_6826 ER -
@conference{ author = "Mudrinić, Tihana and Mojović, Zorica and Jovanović, Dušan and Ignjatović, Aleksandar and Mojović, Miloš and Bačić, Goran", year = "2012", abstract = "The diagnosis of amyotrophic lateral sclerosis (ALS) based on ALS functional rating scale-revised (ALSFRS-R) scores is often shown be unreliable and false. On the other hand, magnetic resonance imaging (MRI) studies of a brain of ALS patients showed the presence of iron deposits in the precentral gyruses of gray matter (PGGM) and also the potential leakage of iron to cerebro-spinal fluid (CSF) through compromised blood-brain barrier. The aim of this study was to determine if there is a specific feature in CSF that distinguishes patients with ALS from the control subjects. CSF obtained from ALS patients and normal controls were analyzed using the technique of cyclic voltammetry. The results show that at the potential of 1.1 – 1.2 V vs. Ag/AgCl electrode, the plateau appeared and the potential of oxygen evolution with shifted toward more positive values from the ALS patients. These voltammogram features were not present for the control patients showing this technique to be promising candidate for evaluating new biomarkers for ALS.", publisher = "Biophysical Society of Serbia", journal = "Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia", title = "Cyclic voltammetry in diagnosis of ALS", pages = "23-25", url = "https://hdl.handle.net/21.15107/rcub_cer_6826" }
Mudrinić, T., Mojović, Z., Jovanović, D., Ignjatović, A., Mojović, M.,& Bačić, G.. (2012). Cyclic voltammetry in diagnosis of ALS. in Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia Biophysical Society of Serbia., 23-25. https://hdl.handle.net/21.15107/rcub_cer_6826
Mudrinić T, Mojović Z, Jovanović D, Ignjatović A, Mojović M, Bačić G. Cyclic voltammetry in diagnosis of ALS. in Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia. 2012;:23-25. https://hdl.handle.net/21.15107/rcub_cer_6826 .
Mudrinić, Tihana, Mojović, Zorica, Jovanović, Dušan, Ignjatović, Aleksandar, Mojović, Miloš, Bačić, Goran, "Cyclic voltammetry in diagnosis of ALS" in Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia (2012):23-25, https://hdl.handle.net/21.15107/rcub_cer_6826 .