From genotype to phenotype with biothermodynamics: Empirical formulas, biosynthesis reactions and thermodynamic properties of preproinsulin, proinsulin and insulin molecules
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2023
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Informa UK Limited, trading as Taylor & Francis Group
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Insulin was discovered 100 years ago and has been well studied from the perspectives of life and biomedical sciences. This paper reports chemical and biothermodynamic properties of biosynthesis of insulin. This paper reports for the first time the molecular and empirical formulas, biosynthesis reactions, and thermodynamic properties of molecules and their biosynthesis for human preproinsulin, proinsulin, insulin chain A, insulin chain B, insulin, signal peptide and intermediate peptide (C-peptide). Based on these, metabolic reactions were formulated for conversion of preproinsulin to insulin and their thermodynamic feasibility was analyzed.
Keywords:
Enthalpy / Entropy / Gibbs energy / Omics / Driving force / Chemical modelSource:
Journal of Biomolecular Structure and Dynamics, 2023Publisher:
- Taylor & Francis
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-MESTD-inst-2020-200026)
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IHTMTY - JOUR AU - Popović, Marko AU - Tadić, Vojin AU - Mihailović, Marija PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6813 AB - Insulin was discovered 100 years ago and has been well studied from the perspectives of life and biomedical sciences. This paper reports chemical and biothermodynamic properties of biosynthesis of insulin. This paper reports for the first time the molecular and empirical formulas, biosynthesis reactions, and thermodynamic properties of molecules and their biosynthesis for human preproinsulin, proinsulin, insulin chain A, insulin chain B, insulin, signal peptide and intermediate peptide (C-peptide). Based on these, metabolic reactions were formulated for conversion of preproinsulin to insulin and their thermodynamic feasibility was analyzed. PB - Taylor & Francis T2 - Journal of Biomolecular Structure and Dynamics T1 - From genotype to phenotype with biothermodynamics: Empirical formulas, biosynthesis reactions and thermodynamic properties of preproinsulin, proinsulin and insulin molecules DO - 10.1080/07391102.2023.2256880 ER -
@article{ author = "Popović, Marko and Tadić, Vojin and Mihailović, Marija", year = "2023", abstract = "Insulin was discovered 100 years ago and has been well studied from the perspectives of life and biomedical sciences. This paper reports chemical and biothermodynamic properties of biosynthesis of insulin. This paper reports for the first time the molecular and empirical formulas, biosynthesis reactions, and thermodynamic properties of molecules and their biosynthesis for human preproinsulin, proinsulin, insulin chain A, insulin chain B, insulin, signal peptide and intermediate peptide (C-peptide). Based on these, metabolic reactions were formulated for conversion of preproinsulin to insulin and their thermodynamic feasibility was analyzed.", publisher = "Taylor & Francis", journal = "Journal of Biomolecular Structure and Dynamics", title = "From genotype to phenotype with biothermodynamics: Empirical formulas, biosynthesis reactions and thermodynamic properties of preproinsulin, proinsulin and insulin molecules", doi = "10.1080/07391102.2023.2256880" }
Popović, M., Tadić, V.,& Mihailović, M.. (2023). From genotype to phenotype with biothermodynamics: Empirical formulas, biosynthesis reactions and thermodynamic properties of preproinsulin, proinsulin and insulin molecules. in Journal of Biomolecular Structure and Dynamics Taylor & Francis.. https://doi.org/10.1080/07391102.2023.2256880
Popović M, Tadić V, Mihailović M. From genotype to phenotype with biothermodynamics: Empirical formulas, biosynthesis reactions and thermodynamic properties of preproinsulin, proinsulin and insulin molecules. in Journal of Biomolecular Structure and Dynamics. 2023;. doi:10.1080/07391102.2023.2256880 .
Popović, Marko, Tadić, Vojin, Mihailović, Marija, "From genotype to phenotype with biothermodynamics: Empirical formulas, biosynthesis reactions and thermodynamic properties of preproinsulin, proinsulin and insulin molecules" in Journal of Biomolecular Structure and Dynamics (2023), https://doi.org/10.1080/07391102.2023.2256880 . .