Ceruloplasmin, copper and zinc in pulmonary emphysemia
Autori
Rebić, RadmilaRebić, Petar
Đurđić, Vidosava
Borozan, Sunčica
Stojanović, Srđan
Todorović, S.
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We analyzed the blood samples from 20 patients with global respiratory failure (10 males, mean age 56±7 yrs. and 10 females, mean age 60±5 yrs.). All patients were heavy cigarette smokers, in average 33±8 pack-years.
Spirometrics examinations suggested severe, irreversible pressure dependent airflow limitations; body plethysmographic measurements revealed overinflalion in increased total lung capacities, and transfer factors were greatly reduced. The control group consisted of 20 healthy smokers.
Slightly elevated alfa 1-PI in our patients, 3.55±0.76 g/L, indicated an acute phase reaction. As compared to the control group, we found significantly decreased concentration of zinc (74±24 : 105±34 pg/100 niL, p<0.001).
The mean values of ceruloplasmin were similar in the two groups (0.45±0.01 ; 0.37±0.05 g/L). Scrum copper levels were also similar in both groups (126±46 : 134±14pg/100mL). The other authors have stated that in inflammation the copper concentration was increased. However... our findings could not prove it. Decreased concentration of zinc pointed to the destabilization of lysosomal mem branes and increased macrophage activity that liberates proteases.
Ključne reči:
Ceruloplasmin / copper / zinc / pulmonary emphysemiaIzvor:
Balkan Journal of Clinical Laboratory, 1996, 3, 1, 157-157Izdavač:
- Bulgaria : Balkan Federation of Clinical Laboratory
Napomena:
- 4th Meeting of the Balkan Clinical Laboratory Federation, Budva, Yugoslavia
Institucija/grupa
IHTMTY - CONF AU - Rebić, Radmila AU - Rebić, Petar AU - Đurđić, Vidosava AU - Borozan, Sunčica AU - Stojanović, Srđan AU - Todorović, S. PY - 1996 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6541 AB - We analyzed the blood samples from 20 patients with global respiratory failure (10 males, mean age 56±7 yrs. and 10 females, mean age 60±5 yrs.). All patients were heavy cigarette smokers, in average 33±8 pack-years. Spirometrics examinations suggested severe, irreversible pressure dependent airflow limitations; body plethysmographic measurements revealed overinflalion in increased total lung capacities, and transfer factors were greatly reduced. The control group consisted of 20 healthy smokers. Slightly elevated alfa 1-PI in our patients, 3.55±0.76 g/L, indicated an acute phase reaction. As compared to the control group, we found significantly decreased concentration of zinc (74±24 : 105±34 pg/100 niL, p<0.001). The mean values of ceruloplasmin were similar in the two groups (0.45±0.01 ; 0.37±0.05 g/L). Scrum copper levels were also similar in both groups (126±46 : 134±14pg/100mL). The other authors have stated that in inflammation the copper concentration was increased. However our findings could not prove it. Decreased concentration of zinc pointed to the destabilization of lysosomal mem branes and increased macrophage activity that liberates proteases. PB - Bulgaria : Balkan Federation of Clinical Laboratory C3 - Balkan Journal of Clinical Laboratory T1 - Ceruloplasmin, copper and zinc in pulmonary emphysemia VL - 3 IS - 1 SP - 157 EP - 157 UR - https://hdl.handle.net/21.15107/rcub_cer_6541 ER -
@conference{ author = "Rebić, Radmila and Rebić, Petar and Đurđić, Vidosava and Borozan, Sunčica and Stojanović, Srđan and Todorović, S.", year = "1996", abstract = "We analyzed the blood samples from 20 patients with global respiratory failure (10 males, mean age 56±7 yrs. and 10 females, mean age 60±5 yrs.). All patients were heavy cigarette smokers, in average 33±8 pack-years. Spirometrics examinations suggested severe, irreversible pressure dependent airflow limitations; body plethysmographic measurements revealed overinflalion in increased total lung capacities, and transfer factors were greatly reduced. The control group consisted of 20 healthy smokers. Slightly elevated alfa 1-PI in our patients, 3.55±0.76 g/L, indicated an acute phase reaction. As compared to the control group, we found significantly decreased concentration of zinc (74±24 : 105±34 pg/100 niL, p<0.001). The mean values of ceruloplasmin were similar in the two groups (0.45±0.01 ; 0.37±0.05 g/L). Scrum copper levels were also similar in both groups (126±46 : 134±14pg/100mL). The other authors have stated that in inflammation the copper concentration was increased. However our findings could not prove it. Decreased concentration of zinc pointed to the destabilization of lysosomal mem branes and increased macrophage activity that liberates proteases.", publisher = "Bulgaria : Balkan Federation of Clinical Laboratory", journal = "Balkan Journal of Clinical Laboratory", title = "Ceruloplasmin, copper and zinc in pulmonary emphysemia", volume = "3", number = "1", pages = "157-157", url = "https://hdl.handle.net/21.15107/rcub_cer_6541" }
Rebić, R., Rebić, P., Đurđić, V., Borozan, S., Stojanović, S.,& Todorović, S.. (1996). Ceruloplasmin, copper and zinc in pulmonary emphysemia. in Balkan Journal of Clinical Laboratory Bulgaria : Balkan Federation of Clinical Laboratory., 3(1), 157-157. https://hdl.handle.net/21.15107/rcub_cer_6541
Rebić R, Rebić P, Đurđić V, Borozan S, Stojanović S, Todorović S. Ceruloplasmin, copper and zinc in pulmonary emphysemia. in Balkan Journal of Clinical Laboratory. 1996;3(1):157-157. https://hdl.handle.net/21.15107/rcub_cer_6541 .
Rebić, Radmila, Rebić, Petar, Đurđić, Vidosava, Borozan, Sunčica, Stojanović, Srđan, Todorović, S., "Ceruloplasmin, copper and zinc in pulmonary emphysemia" in Balkan Journal of Clinical Laboratory, 3, no. 1 (1996):157-157, https://hdl.handle.net/21.15107/rcub_cer_6541 .