Sinteza, karakterizacija i antioksidativna aktivnost 1,3-dihidro-3-[4-supstituisanih-(fenilmetil)imino]-2H-indol-2-ona

Abstract

Izvršena je sinteza četiri 1,3-dihidro-3-[4-supstituisanih-(fenilmetil)imino]-2H-indol-2-ona i to: 1,3-dihidro-3-[(fenilmetil)imino]-2H-indol-2-ona, 1,3-dihidro-3-[4-brom-(fenilmetil)imino]-2H-indol-2-ona, 1,3-dihidro-3-[4-hidroksi-(fenilmetil) imino]-2H-indol-2-ona, 1,3-dihidro-3-[4-metoksi-(fenilmetil)imino]-2H-indol-2-ona, kao i jedinjenja slične strukture, 1,3-dihidro-3-[(2-feniletil)imino]-2H-indol-2-ona. Urađena je karakterizacija sintetisanih jedinjenja primenom FTIR spektroskopije, određivanjem temperature topljenja i elementalnom analizom, nakon čega je izvršeno ispitivanje antioksidativne aktivnosti svih pet jedinjenja. Antioksidativna aktivnost je određena primenom DPPH (1,1-difenil-2-pikril-hidrazil radikal) metode, u cilju određivanja najefikasinijeg jedinjenja od značaja za dalje istraživanje.

The synthesis of 1,3-dihydro-3-[4-substituted-(phenylmethyl)imino]-2H-indole-2-ones: 1,3-dihydro-3-[(phenylmethyl)imino]-2H-indol-2-one, 1,3-dihydro-3-[4-bromo-(phenylmethyl)imino]-2H-indol-2-one, 1,3-dihydro-3-[4-hydroxy-phenyl-methyl)imino]-2H-indol-2-one, 1,3-dihydro-3-[4-methoxy-(phenylmethyl)imino]-2H-indol-2-one, as well as of the compound of similar structure, 1,3-dihydro-3-[(2-phenylethyl)imino]-2H-indol-2-one, was performed. The characterization of the obtained five compounds was carried out using FTIR, melting points and elemental analysis. Their antioxydative activity was then tested by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) method and the results were compared in order to determine the most efficient compound, significant for further research.